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Protein

Protein K7

Gene

MVA028R

Organism
Vaccinia virus (strain Ankara) (VACV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation. Contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein K7
Gene namesi
Ordered Locus Names:MVA028R, ACAM3000_MVA_028
OrganismiVaccinia virus (strain Ankara) (VACV)
Taxonomic identifieri126794 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000172909 Componenti: Genome
  • UP000159908 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000996071 – 149Protein K7Add BLAST149

Interactioni

Subunit structurei

Interacts with DDDX3; this interaction inhibits DDX3 and suppresses DDX3-mediated IFN-beta promoter induction. Interacts with TRAF6 and IRAK2; these interactions suppress TLR-dependent NF-KappaB activation (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ76ZX2
SMRiQ76ZX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiView protein in InterPro
IPR009174 Orthopox_K7
IPR022819 Poxvirus
PfamiView protein in Pfam
PF06227 Poxvirus, 1 hit
PIRSFiPIRSF003764 VAC_K7R, 1 hit

Sequencei

Sequence statusi: Complete.

Q76ZX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKLDYEDA VFYFVDDDKI CSRDSIIDLI DEYITWRNHV IVFNKDITSC
60 70 80 90 100
GRLYKELMKF DDVAIRYYGI DKINEIVEAM SEGDHYINFT KVHDQESLFA
110 120 130 140
TIGICAKITE HWGYKKISES RFQSLGNITD LMTDDNINIL ILFLEKKLN
Length:149
Mass (Da):17,468
Last modified:July 5, 2004 - v1
Checksum:iB3E972A93DF97DC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94848 Genomic DNA Translation: AAB96484.1
AY603355 Genomic DNA Translation: AAT10426.1
RefSeqiYP_232921.1, NC_006998.1

Genome annotation databases

GeneIDi3707496
KEGGivg:3707496

Similar proteinsi

Entry informationi

Entry nameiK7_VACCA
AccessioniPrimary (citable) accession number: Q76ZX2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: February 15, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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