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Protein

Ribonucleoside-diphosphate reductase

Gene

I4L

Organism
Vaccinia virus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processDNA replicationUniRule annotation
LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductaseUniRule annotation (EC:1.17.4.1UniRule annotation)
Gene namesi
Name:I4LImported
Synonyms:VACV_BRZ_SERRO2_071Imported
ORF Names:51.1rMVA_086Imported, LIVPclone14_081Imported, m8089LImported, mO089LImported, VAC_DPP15_084Imported, VAC_DPP16_084Imported, VAC_DPP20_084Imported, VAC_IHDW1_075Imported, VAC_TP3_078Imported, VAC_TP5_078Imported, VACAC2_084Imported, VACV-DUKE-081Imported, VACV_069Imported, VACV_IOC_B141_099Imported, VACV_IOC_B388_099Imported, VACV_TT8_091Imported
OrganismiVaccinia virusImported
Taxonomic identifieri10245 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Proteomesi

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92ATP-coneInterPro annotationAdd BLAST92

Sequence similaritiesi

Belongs to the ribonucleoside diphosphate reductase large chain family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR005144 ATP-cone_dom
IPR013346 NrdE_NrdA
IPR000788 RNR_lg_C
IPR013509 RNR_lsu_N
IPR008926 RNR_R1-su_N
IPR039718 Rrm1
PANTHERiPTHR11573 PTHR11573, 1 hit
PfamiView protein in Pfam
PF03477 ATP-cone, 1 hit
PF02867 Ribonuc_red_lgC, 1 hit
PF00317 Ribonuc_red_lgN, 1 hit
PRINTSiPR01183 RIBORDTASEM1
SUPFAMiSSF48168 SSF48168, 1 hit
TIGRFAMsiTIGR02506 NrdE_NrdA, 1 hit
PROSITEiView protein in PROSITE
PS51161 ATP_CONE, 1 hit
PS00089 RIBORED_LARGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q49QJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFVIKRNGYK ENVMFDKITS RIRKLCYGLN TDHIDPIKIA MKVIQGIYNG
60 70 80 90 100
VTTVELDTLA AEIAATCTTQ HPDYAILAAR IAVSNLHKET KKLFSEVMED
110 120 130 140 150
LFNYVNPKNG KHSPIISSIT MDIVNKYKDK LNSVIIYERD FSYNYFGFKT
160 170 180 190 200
LEKSYLLKIN NKIVERPQHM LMRVAVGIHQ WDIDSAIETY NLLSEKWFTH
210 220 230 240 250
ASPTLFNAGT SRHQMSSCFL LNMIDDSIEG IYDTLKRCAL ISKMAGGIGL
260 270 280 290 300
SISNIRASGS YISGTNGISN GIIPMLRVYN NTARYIDQGG NKRPGVMAIY
310 320 330 340 350
LEPWHSDIMA FLDLKKNTGN EEHRTRDLFI ALWIPDLFMK RVKDDGEWSL
360 370 380 390 400
MCPDECPGLD NVWGDEFERL YTLYERERRY KSIIKARVVW KAIIESQIET
410 420 430 440 450
GTPFILYKDA CNKKSNQQNL GTIKCSNLCT EIIQYADANE VAVCNLASVA
460 470 480 490 500
LNMFVIDGRF DFLKLKDVVK VIVRNLNKII DINYYPIPEA EISNKRHRPI
510 520 530 540 550
GIGVQGLADA FILLNYPFDS LEAQDLNKKI FETIYYGALE ASCELAEKEG
560 570 580 590 600
PYDTYVGSYA SNGILQYDLW NVVPSDLWNW EPLKDKIRTY GLRNSLLVAP
610 620 630 640 650
MPTASTAQIL GNNESVEPYT SNIYTRRVLS GEFQVVNPHL LRVLTERKLW
660 670 680 690 700
NDEIKNRIMA DGGSIQNTNL PEDIKRVYKT IWEIPQKTII KMAADRGAFI
710 720 730 740 750
DQSQSMNIHI ADPSYSKLTS MHFYGWSLGL KTGMYYLRTK PASAPIQFTL
760 770
DKDKIKPLVV CDSEICTSCS G
Length:771
Mass (Da):87,754
Last modified:September 13, 2005 - v1
Checksum:i6CA07F0C58EDC4F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313847 Genomic DNA Translation: AAR17916.1
AY678275 Genomic DNA Translation: AAW23481.1
AY678277 Genomic DNA Translation: AAW23763.1
DQ377945 Genomic DNA Translation: ABD57603.1
DQ439815 Genomic DNA Translation: ABD98543.1
JN654981 Genomic DNA Translation: AEY73831.1
JN654982 Genomic DNA Translation: AEY74071.1
JN654985 Genomic DNA Translation: AEY74780.1
KC201194 Genomic DNA Translation: AGB75794.1
JX489135 Genomic DNA Translation: AGJ91238.1
KC207810 Genomic DNA Translation: AGK06542.1
KC207811 Genomic DNA Translation: AGK06755.1
KF179385 Genomic DNA Translation: AHB35711.1
KJ125439 Genomic DNA Translation: AIX98990.1
KT184690 Genomic DNA Translation: ALF05069.1
KT184691 Genomic DNA Translation: ALF05320.1
KX061501 Genomic DNA Translation: AND73907.1
KX781953 Genomic DNA Translation: AQY54847.1
MG663594 Genomic DNA Translation: AUO38372.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313847 Genomic DNA Translation: AAR17916.1
AY678275 Genomic DNA Translation: AAW23481.1
AY678277 Genomic DNA Translation: AAW23763.1
DQ377945 Genomic DNA Translation: ABD57603.1
DQ439815 Genomic DNA Translation: ABD98543.1
JN654981 Genomic DNA Translation: AEY73831.1
JN654982 Genomic DNA Translation: AEY74071.1
JN654985 Genomic DNA Translation: AEY74780.1
KC201194 Genomic DNA Translation: AGB75794.1
JX489135 Genomic DNA Translation: AGJ91238.1
KC207810 Genomic DNA Translation: AGK06542.1
KC207811 Genomic DNA Translation: AGK06755.1
KF179385 Genomic DNA Translation: AHB35711.1
KJ125439 Genomic DNA Translation: AIX98990.1
KT184690 Genomic DNA Translation: ALF05069.1
KT184691 Genomic DNA Translation: ALF05320.1
KX061501 Genomic DNA Translation: AND73907.1
KX781953 Genomic DNA Translation: AQY54847.1
MG663594 Genomic DNA Translation: AUO38372.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00326

Family and domain databases

InterProiView protein in InterPro
IPR005144 ATP-cone_dom
IPR013346 NrdE_NrdA
IPR000788 RNR_lg_C
IPR013509 RNR_lsu_N
IPR008926 RNR_R1-su_N
IPR039718 Rrm1
PANTHERiPTHR11573 PTHR11573, 1 hit
PfamiView protein in Pfam
PF03477 ATP-cone, 1 hit
PF02867 Ribonuc_red_lgC, 1 hit
PF00317 Ribonuc_red_lgN, 1 hit
PRINTSiPR01183 RIBORDTASEM1
SUPFAMiSSF48168 SSF48168, 1 hit
TIGRFAMsiTIGR02506 NrdE_NrdA, 1 hit
PROSITEiView protein in PROSITE
PS51161 ATP_CONE, 1 hit
PS00089 RIBORED_LARGE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ49QJ3_9POXV
AccessioniPrimary (citable) accession number: Q49QJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 13, 2005
Last sequence update: September 13, 2005
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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