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Protein

Core protein VP8

Gene

L4R

Organism
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Major core structural protein.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Core protein VP8
Alternative name(s):
25 kDa major core protein
L4 core protein
P25K
Gene namesi
ORF Names:L4R
OrganismiVariola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus)
Taxonomic identifieri587200 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000119805 Componenti: Genome
  • UP000002060 Componenti: Genome

Subcellular locationi

  • Virion By similarity
  • Note: Localizes to the virion core.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000405931 – 32By similarityAdd BLAST32
ChainiPRO_000004059433 – 251Core protein VP8Add BLAST219

Post-translational modificationi

Undergoes morphogenesis-associated proteolysis which cleaves the 28 kDa to a 25-kDa product. Proteolytic cleavage of major core proteins P4a (A10L), P4b (A3L), and VP8 (L4R), which occurs at a late stage of core formation, is required for production of infectious mature virions (MV) (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei18 – 19Cleavage; by core protease I7By similarity2
Sitei32 – 33Cleavage; by core protease I7By similarity2

Proteomic databases

PRIDEiP33039

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Keywords - Developmental stagei

Late protein

Family & Domainsi

Sequence similaritiesi

Belongs to the chordopoxvirinae VP8 family.Curated

Phylogenomic databases

OrthoDBiVOG090000OK

Family and domain databases

InterProiView protein in InterPro
IPR007586 VP8_pox_nuc-bd
PfamiView protein in Pfam
PF04498 Pox_VP8_L4R, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011473 VP8_pox_nuc_bd, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P33039-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLLLENLIE EDTIFFAGSI SEYDDLQMVI AGAKSKFPRS MLSIFNIVPR
60 70 80 90 100
TMSKYELELI HNENITGAMF TTMYNIRNNL GLGDDKLTIE AIENYFLDPN
110 120 130 140 150
NEVMPLIINN TDMTAVIPKK SGRRKNKNMV IFRQGSSPIL CIFETRKKIN
160 170 180 190 200
IYKENMESAS TEYTPIGDNK ALISKYAGIN VLNVYSPSTS MRLNAIYGFT
210 220 230 240 250
NKNKLEKLST NKELELYSSS PLQEPIRLND FLGLLECVKK NIPLTDIPTK

D
Length:251
Mass (Da):28,487
Last modified:October 1, 1993 - v1
Checksum:iBA34201F43FBD5B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67119 Genomic DNA Translation: CAA47575.1
S55844 Genomic DNA Translation: AAB24672.1
X69198 Genomic DNA Translation: CAA49017.1
L22579 Genomic DNA Translation: AAA60824.1
PIRiA36845
T28514
RefSeqiNP_042120.1, NC_001611.1

Genome annotation databases

GeneIDi1486473
KEGGivg:1486473

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67119 Genomic DNA Translation: CAA47575.1
S55844 Genomic DNA Translation: AAB24672.1
X69198 Genomic DNA Translation: CAA49017.1
L22579 Genomic DNA Translation: AAA60824.1
PIRiA36845
T28514
RefSeqiNP_042120.1, NC_001611.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP33039

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1486473
KEGGivg:1486473

Phylogenomic databases

OrthoDBiVOG090000OK

Family and domain databases

InterProiView protein in InterPro
IPR007586 VP8_pox_nuc-bd
PfamiView protein in Pfam
PF04498 Pox_VP8_L4R, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011473 VP8_pox_nuc_bd, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVP8_VAR67
AccessioniPrimary (citable) accession number: P33039
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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