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Introduction

Number of entries
New entries 200
Updated entries 52,688
Unchanged entries 503,680
Total 556,568
Entries with updated sequences 38
With a fragmented AA sequence 9,126
With known alternative products 25,082
Protein Existence (PE) Number of entries
1 Evidence at protein level 97,904
2 Evidence at transcript level 57,073
3 Inferred from homology 386,055
4 Predicted 13,673
5 Uncertain 1,863

Taxonomic Origin

Swiss-Prot entries per taxonomic group


Statistics on the number of species

Number of species in
New entries 70
Updated entries 2,923
Unchanged entries 9,871
Total 10,633

Sequence data

The shortest sequence is P83570 at 2 AA while the longest sequence is A2ASS6 at 35,213 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 715 715
Alternative products 25,082 25,082
Biophysicochemical properties 7,878 7,878
Biotechnological use 835 833
Catalytic activity 264,877 234,814
Caution 34,394 62,541
Cofactor 214,139 0
Developmental stage 11,773 11,772
Involvement in disease 6,800 4,543
Disruption phenotype 13,004 13,004
Domain 47,213 40,715
Enzyme regulation 14,212 14,210
Function 460,619 440,759
Induction 20,003 19,995
Mass spectrometry 6,635 5,017
Miscellaneous 37,972 35,111
Pathway 137,444 124,655
Pharmaceutical use 104 104
Polymorphism 1,200 1,144
Post-translational modification 54,536 40,685
RNA Editing 627 627
Sequence caution 60,628 43,985
Sequence similarities 504,938 500,792
Subcellular Location 668,665 0
Subunit structure 273,998 273,714
Tissue specificity 44,853 44,852
Toxic dose 655 604

Sequence Annotation (features)

Annotations Entries
Molecule processing 656,979 556,568
Chain 564,375 549,725
Initiator methionine 17,180 17,133
Peptide 11,267 7,729
Propeptide 13,888 11,900
Signal peptide 41,244 41,234
Transit peptide 9,025 8,909
Regions 1,320,033 319,267
Calcium binding 4,165 1,726
Coiled-coil 21,957 15,176
Compositional bias 58,777 31,594
DNA binding 11,577 10,474
Domain 191,028 117,730
Motif 42,031 27,565
Nucleotide binding 154,800 84,368
Repeat 103,498 14,669
Region 191,577 91,393
Topological domain 139,036 28,531
Transmembrane 368,573 76,865
Zinc finger 30,392 13,368
Sites 989,546 205,299
Active site 162,174 98,246
Metal binding 373,719 93,245
Binding site 397,867 104,486
Other 55,786 31,122
Amino acid modifications 522,334 114,558
Cross-link 23,344 8,325
Disulfide bond 122,078 32,979
Glycosylation 115,255 29,507
Lipidation 12,969 8,365
Modified residue 248,328 71,255
Non-standard residue 360 285
Natural variations 147,814 31,174
Natural variant 147,814 31,174
Alternative sequence 51,772 21,885
Experimental info 237,666 65,445
Mutagenesis 65,474 14,542
Non-adjacent residues 2,248 783
Non-terminal residue 12,275 9,390
Sequence conflict 153,240 47,188
Sequence uncertainty 4,429 788
Secondary structure 553,237 23,405
Helix 242,217 22,551
Turn 58,302 18,278
Beta strand 252,718 21,241

Citation usage

Citation type Citations Entries
Submission190,599164,873
Journal article1,005,236450,519
Book1,6521,629
Thesis432429
Patent199195
Unpublished observations397393
Online journal article621607

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 825,035 622,217

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
CCDS47,60633,880
EMBL954,454544,995
PIR123,963113,528
RefSeq610,417465,833
UniGene109,25995,996
3D structure databases
DisProt708703
PDB155,67725,865
PDBsum155,67725,865
ProteinModelPortal447,682447,682
SMR438,230438,230
Protein-protein interaction databases
BioGrid50,18049,701
CORUM5,1685,168
DIP17,33217,300
ELM1,8071,807
IntAct50,86450,864
MINT31,89831,898
STRING331,879331,879
Chemistry
BindingDB4,9014,901
ChEMBL6,5236,523
DrugBank18,7493,637
GuidetoPHARMACOLOGY2,0132,013
SwissLipids1,2921,207
Protein family/group databases
Allergome1,7321,130
CAZy9,4468,520
ESTHER2,4852,483
IMGT_GENE-DB142142
MEROPS11,36211,362
MoonProt6363
PeroxiBase772756
REBASE403403
TCDB6,5746,539
mycoCLAP359354
PTM databases
DEPOD239239
PhosphoSitePlus39,00739,007
SwissPalm5,9475,947
UniCarbKB584584
iPTMnet51,22251,222
Polymorphism and mutation databases
BioMuta17,24217,237
DMDM16,36416,300
dbSNP59,58612,438
2D gel databases
COMPLUYEAST-2DPAGE9797
DOSAC-COBS-2DPAGE145145
OGP374374
REPRODUCTION-2DPAGE1,2591,038
SWISS-2DPAGE1,1781,178
UCD-2DPAGE497497
World-2DPAGE929918
Proteomic databases
EPD20,19320,193
MaxQB29,72529,725
PRIDE141,698141,698
PaxDb124,247124,247
PeptideAtlas31,88631,886
ProMEX453453
TopDownProteomics3,2482,968
Protocols and materials databases
DNASU18,94918,878
Genome annotation databases
Ensembl87,78649,554
EnsemblBacteria355,126336,029
EnsemblFungi30,40628,683
EnsemblMetazoa15,86410,581
EnsemblPlants28,04620,785
EnsemblProtists4,9604,784
GeneDB571657
GeneID292,496281,812
Gramene28,04620,785
KEGG503,424475,053
PATRIC91,71391,713
UCSC49,68445,433
VectorBase674587
WBParaSite3434
Organism-specific databases
ArachnoServer1,1491,140
Araport15,64115,547
CGD1,9781,961
CTD74,63573,758
ConoServer949866
DisGeNET14,85614,619
EchoBASE4,1594,159
EcoGene4,2944,293
EuPathDB37,55537,375
FlyBase6,1825,827
GeneCards20,20620,037
GeneReviews1,1551,152
H-InvDB5,5884,767
HGNC20,19120,049
HPA27,05616,797
LegioList765763
Leproma672669
MGI16,86216,822
MIM20,70114,923
MaizeGDB509505
MalaCards4,1654,163
OpenTargets18,16318,008
Orphanet6,1443,286
PharmGKB18,37318,331
PomBase5,1335,129
PseudoCAP1,3321,323
RGD7,9467,945
SGD6,7396,734
TAIR14,44514,390
TubercuList2,1862,150
WormBase5,9584,551
Xenbase4,5154,509
ZFIN2,9982,998
dictyBase4,2124,097
euHCVdb5544
neXtProt20,19520,195
Phylogenomic databases
GeneTree58,41858,385
HOGENOM390,809390,809
HOVERGEN75,91075,910
InParanoid136,713136,713
KO402,239401,792
OMA403,396403,396
OrthoDB292,548292,548
PhylomeDB95,51595,515
TreeFam45,22845,220
eggNOG663,077330,844
Enzyme and pathway databases
BRENDA12,85812,086
BioCyc44,43241,118
Reactome117,08535,011
SABIO-RK3,6493,649
SIGNOR4,0254,025
SignaLink3,0263,026
UniPathway136,183123,408
Other
ChiTaRS16,52616,518
EvolutionaryTrace16,60816,608
GeneWiki10,36610,282
GenomeRNAi21,98021,978
PMAP-CutDB1,4611,461
PRO95,14995,149
Gene expression databases
Bgee56,07956,078
CleanEx30,02329,393
CollecTF133133
ExpressionAtlas50,99650,996
Genevisible55,21155,211
Ontologies
Family and domain databases
CDD178,713164,131
Gene3D344,331279,292
HAMAP328,730326,092
InterPro2,189,109537,701
PANTHER263,290251,174
PIRSF108,639107,611
PRINTS132,779117,313
PROSITE462,480296,274
Pfam753,933512,915
ProDom29,11728,934
SFLD14,1056,486
SMART191,391141,265
SUPFAM503,616378,767
TIGRFAMs292,424272,418

Web resource

5,755 UniProtKB/Swiss-Prot entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

  • 8.2%Alanine
  • 5.5%Arginine
  • 4.0%Asparagine
  • 5.4%Aspartate
  • 1.3%Cysteine
  • 3.9%Glutamine
  • 6.7%Glutamate
  • 7.0%Glycine
  • 2.2%Histidine
  • 5.9%Isoleucine
  • 9.6%Leucine
  • 5.8%Lysine
  • 2.4%Methionine
  • 3.8%Phenylalanine
  • 4.7%Proline
  • 6.6%Serine
  • 5.3%Threonine
  • 1.0%Tryptophan
  • 2.9%Tyrosine
  • 6.8%Valine
  • Aliphatic
  • Acidic
  • Small hydroxy
  • Basic
  • Amide
  • Aromatic
  • Sulfur

Miscellaneous Statistics

16,265 entries are encoded on a mitochondrion, and 3,801 are encoded on a plasmid.

12,188 entries are encoded on a plastid, of which 21 are encoded on apicoplasts, 11,623 on chloroplasts, 51 on organellar chromatophores, 145 on cyanelles, 149 on non-photosynthetic plastids and 17 on unspecified types of plastid.

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