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Protein

Probable acyl-activating enzyme 12, peroxisomal

Gene

AAE12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT1G65890-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acyl-activating enzyme 12, peroxisomal (EC:6.2.1.-)
Gene namesi
Name:AAE12
Ordered Locus Names:At1g65890
ORF Names:F12P19.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G65890.
TAIRilocus:2009714. AT1G65890.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004157231 – 578Probable acyl-activating enzyme 12, peroxisomalAdd BLAST578

Proteomic databases

PaxDbiQ9SS00.

Expressioni

Tissue specificityi

Expressed at low levels in leaves.1 Publication

Gene expression databases

GenevisibleiQ9SS00. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G65890.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SS00.
SMRiQ9SS00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi576 – 578Microbody targeting signalSequence analysis3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1176. Eukaryota.
COG0318. LUCA.
HOGENOMiHOG000230005.
InParanoidiQ9SS00.
OMAiFYYTANG.
OrthoDBiEOG09360AHB.
PhylomeDBiQ9SS00.

Family and domain databases

InterProiView protein in InterPro
IPR025110. AMP-bd_C.
IPR000873. AMP-dep_Synth/Lig.
PfamiView protein in Pfam
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9SS00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNLALCEAN NVPLTPITFL KRASECYPNR TSIIYGKTRF TWPQTYDRCC
60 70 80 90 100
RLAASLISLN IGKNDVVSVV APNTPAMYEM HFAVPMAGAV LNPINTRLDA
110 120 130 140 150
TSIAAILRHA KPKILFIYRS FEPLAREILQ LLSSEDSNLN LPVIFIHEID
160 170 180 190 200
FPKRVSSEES DYECLIQRGE PTPLLLARMF CIQDEHDPIS LNYTSGTTAD
210 220 230 240 250
PKGVVISHRG AYLSTLSAII GWEMGTCPVY LWTLPMFHCN GWTFTWGTAA
260 270 280 290 300
RGGTSVCMRH VTAPEIYKNI EMHNVTHMCC VPTVFNILLK GNSLDLSHRS
310 320 330 340 350
GPVHVLTGGS PPPAALVKKV QRLGFQVMHA YGLTEATGPV LFCEWQDEWN
360 370 380 390 400
RLPENQQMEL KARQGLSILG LTEVDVRNKE TQESVPRDGK TMGEIVMKGS
410 420 430 440 450
SIMKGYLKNP KATYEAFKHG WLNSGDVGVI HPDGHVEIKD RSKDIIISGG
460 470 480 490 500
ENISSVEVEN IIYKYPKVLE TAVVAMPHPT WGETPCAFVV LEKGETNNED
510 520 530 540 550
REDKLVTKER DLIEYCRENL PHFMCPRKVV FLDELPKNGN GKILKPKLRD
560 570
IAKGLVAEDE VNVRSKVQRP VEHFTSRL
Length:578
Mass (Da):64,725
Last modified:May 1, 2000 - v1
Checksum:iF13BC4757BA2C85E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118Y → D in AAP03023 (PubMed:12805634).Curated1
Sequence conflicti174L → S in AAP03023 (PubMed:12805634).Curated1
Sequence conflicti478H → Y in AAK91428 (PubMed:14593172).Curated1
Sequence conflicti478H → Y in AAL31150 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY250840 mRNA. Translation: AAP03023.1.
AC009513 Genomic DNA. Translation: AAF06050.1.
CP002684 Genomic DNA. Translation: AEE34437.1.
AY050412 mRNA. Translation: AAK91428.1.
AY059657 mRNA. Translation: AAL31150.1.
PIRiB96683.
RefSeqiNP_176764.1. NM_105261.2.
UniGeneiAt.26580.

Genome annotation databases

EnsemblPlantsiAT1G65890.1; AT1G65890.1; AT1G65890.
GeneIDi842901.
GrameneiAT1G65890.1; AT1G65890.1; AT1G65890.
KEGGiath:AT1G65890.

Similar proteinsi

Entry informationi

Entry nameiAAE12_ARATH
AccessioniPrimary (citable) accession number: Q9SS00
Secondary accession number(s): Q84P20, Q94A35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families