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Protein

DNA-directed RNA polymerase subunit

Gene

L4R

Organism
Monkeypox virus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates. Responsible for the transcription of early, intermediate and late genes.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:L4RImported
ORF Names:MPXV-CAM1990_02-080Imported, MPXV-Congo_8-081Imported, MPXV-COP-082Imported, MPXV-GAB1988_001-081Imported, MPXV-Ikubi-080Imported, MPXV-Nig_SEV71_2_82-081Imported, MPXV-PCH-083Imported, MPXV-SL-082Imported, MPXV-UTC-077Imported, MPXV-W_Nigeria-081Imported, MPXV-WRAIR082Imported, MPXV297957_077Imported, MPXV298464_068Imported, MPXV_DRC_Yandongi_089Imported, MPXV_LIB1970_184_093Imported, MPXV_RCG2003_358_093Imported, MPXV_ROC_2010_032Imported, MPXV_SUD2005_01_089Imported, MPXV_USA2003_039_093Imported, MPXV_USA2003_044_093Imported, MPXV_ZAI1979_005_093Imported, MPXVgp088Imported
OrganismiMonkeypox virusImported
Taxonomic identifieri10244 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirus
Virus hostiCynomys gunnisoni (Gunnison's prairie dog) [TaxID: 45479]
Cynomys leucurus (White-tailed prairie dog) [TaxID: 99825]
Cynomys ludovicianus (Black-tailed prairie dog) [TaxID: 45480]
Cynomys mexicanus (Mexican prairie dog) [TaxID: 99826]
Cynomys parvidens (Utah prairie dog) [TaxID: 99827]
Gliridae (dormice) [TaxID: 30650]
Heliosciurus ruwenzorii (Ruwenzori sun squirrel) [TaxID: 226685]
Homo sapiens (Human) [TaxID: 9606]
Mus musculus (Mouse) [TaxID: 10090]
Proteomesi
  • UP000126777 Componenti: Genome
  • UP000130227 Componenti: Genome
  • UP000158033 Componenti: Genome
  • UP000124163 Componenti: Genome
  • UP000117246 Componenti: Genome
  • UP000151462 Componenti: Genome
  • UP000104730 Componenti: Genome
  • UP000170119 Componenti: Genome
  • UP000172279 Componenti: Genome
  • UP000117086 Componenti: Genome
  • UP000127566 Componenti: Genome
  • UP000169092 Componenti: Genome
  • UP000155574 Componenti: Genome
  • UP000153809 Componenti: Genome
  • UP000150530 Componenti: Genome
  • UP000140016 Componenti: Genome
  • UP000141425 Componenti: Genome
  • UP000172985 Componenti: Genome
  • UP000116946 Componenti: Genome
  • UP000149280 Componenti: Genome
  • UP000102730 Componenti: Genome
  • UP000153264 Componenti: Genome
  • UP000133385 Componenti: Genome
  • UP000138604 Componenti: Genome
  • UP000102049 Componenti: Genome
  • UP000118284 Componenti: Genome
  • UP000151120 Componenti: Genome
  • UP000143488 Componenti: Genome
  • UP000099051 Componenti: Genome
  • UP000121251 Componenti: Genome
  • UP000099021 Componenti: Genome
  • UP000168391 Componenti: Genome
  • UP000143949 Componenti: Genome
  • UP000117231 Componenti: Genome
  • UP000133567 Componenti: Genome
  • UP000143786 Componenti: Genome
  • UP000151594 Componenti: Genome
  • UP000150603 Componenti: Genome
  • UP000154371 Componenti: Genome
  • UP000148165 Componenti: Genome
  • UP000112333 Componenti: Genome
  • UP000114038 Componenti: Genome
  • UP000170318 Componenti: Genome
  • UP000166832 Componenti: Genome
  • UP000113810 Componenti: Genome
  • UP000164300 Componenti: Genome
  • UP000100082 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-UniRule

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation, VirionUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae DNA-directed RNA polymerase 22 kDa subunit family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR007937 RNA_Pol_22kDa_poxvir
PfamiView protein in Pfam
PF05273 Pox_RNA_Pol_22, 1 hit
PIRSFiPIRSF000744 RPO22, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD011187 RNA_Pol_22kDa_poxvir, 1 hit

Sequencei

Sequence statusi: Complete.

Q5IXT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQYNVKYLA KILCLKTEIA RDPYAVINRN VLLRYTTDIE YNDLVTLITV
60 70 80 90 100
RHKIDSMKTV FQVFNESSIN YTPVDDDYGE PIIITSYLQK GHNKFPVNFL
110 120 130 140 150
YIDVVISDLF PSFVRLDTTE TNIVNSVLQT GDGKKTLRLP KMLETEIVVK
160 170 180
ILYRPNIPLK IVRFFRNNMV TGVEIADRSV ISVAD
Length:185
Mass (Da):21,342
Last modified:April 14, 2009 - v1
Checksum:iE4A289D674B3B9E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY603973 Genomic DNA Translation: AAU01292.1
AY741551 Genomic DNA Translation: AAW67840.1
AY753185 Genomic DNA Translation: AAX09183.1
DQ011153 Genomic DNA Translation: AAY96887.1
DQ011154 Genomic DNA Translation: AAY97087.1
DQ011155 Genomic DNA Translation: AAY97288.1
DQ011156 Genomic DNA Translation: AAY97486.1
DQ011157 Genomic DNA Translation: AAY97685.1
HM172544 Genomic DNA Translation: ADK39113.1
HQ857562 Genomic DNA Translation: ADX22735.1
HQ857563 Genomic DNA Translation: ADX22931.1
KC257459 Genomic DNA Translation: AGF36644.1
KC257460 Genomic DNA Translation: AGF36851.1
KC257461 Genomic DNA Translation: AGF36992.1
JX878407 Genomic DNA Translation: AGR34449.1
JX878408 Genomic DNA Translation: AGR34639.1
JX878409 Genomic DNA Translation: AGR34830.1
JX878410 Genomic DNA Translation: AGR35021.1
JX878411 Genomic DNA Translation: AGR35212.1
JX878412 Genomic DNA Translation: AGR35403.1
JX878413 Genomic DNA Translation: AGR35594.1
JX878414 Genomic DNA Translation: AGR35785.1
JX878415 Genomic DNA Translation: AGR35976.1
JX878416 Genomic DNA Translation: AGR36167.1
JX878417 Genomic DNA Translation: AGR36358.1
JX878418 Genomic DNA Translation: AGR36549.1
JX878419 Genomic DNA Translation: AGR36740.1
JX878420 Genomic DNA Translation: AGR36931.1
JX878421 Genomic DNA Translation: AGR37122.1
JX878422 Genomic DNA Translation: AGR37313.1
JX878423 Genomic DNA Translation: AGR37504.1
JX878424 Genomic DNA Translation: AGR37694.1
JX878425 Genomic DNA Translation: AGR37884.1
JX878426 Genomic DNA Translation: AGR38074.1
JX878427 Genomic DNA Translation: AGR38265.1
JX878428 Genomic DNA Translation: AGR38456.1
JX878429 Genomic DNA Translation: AGR38647.1
KJ642612 Genomic DNA Translation: AIE40173.1
KJ642613 Genomic DNA Translation: AIE40351.1
KJ642614 Genomic DNA Translation: AIE40525.1
KJ642615 Genomic DNA Translation: AIE40701.1
KJ642616 Genomic DNA Translation: AIE40879.1
KJ642617 Genomic DNA Translation: AIE41055.1
KJ642618 Genomic DNA Translation: AIE41230.1
KJ642619 Genomic DNA Translation: AIE41408.1
KP849469 Genomic DNA Translation: AKG51063.1
KP849470 Genomic DNA Translation: AKG51249.1
KP849471 Genomic DNA Translation: AKG51436.1
MG693723 Genomic DNA Translation: AUW64169.1
MG693724 Genomic DNA Translation: AUW64321.1

Similar proteinsi

Entry informationi

Entry nameiQ5IXT7_MONPV
AccessioniPrimary (citable) accession number: Q5IXT7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 14, 2009
Last sequence update: April 14, 2009
Last modified: April 25, 2018
This is version 26 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health