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Protein

High-energy light unresponsive protein 1

Gene

lite-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior (PubMed:18687026, PubMed:20436480, PubMed:27863243). Directly senses and absorbs both UV-A and UV-B light with very high efficiency (PubMed:27863243). Absorption of UV-B but not UV-A light shows resistance to photobleaching (PubMed:27863243). In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation (PubMed:27863243).3 Publications

GO - Molecular functioni

  • blue light photoreceptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: UniProtKB-KW
  • transmembrane signaling receptor activity Source: WormBase

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
  • locomotory behavior Source: WormBase
  • negative phototaxis Source: UniProtKB
  • phototransduction Source: UniProtKB
  • response to blue light Source: WormBase
  • response to UV Source: WormBase
  • response to UV-A Source: UniProtKB
  • sensory perception Source: GO_Central
  • sensory perception of taste Source: InterPro

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Transducer
Biological processSensory transduction
LigandChromophore

Protein family/group databases

TCDBi1.A.69.3.5. the heteromeric odorant receptor channel (horc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
High-energy light unresponsive protein 1
Gene namesi
Name:lite-1Imported
Synonyms:gur-2Imported
ORF Names:C14F11.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC14F11.3; CE29579; WBGene00001803; lite-1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67Cytoplasmic1 PublicationAdd BLAST67
Transmembranei68 – 88Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini89 – 114Extracellular1 PublicationAdd BLAST26
Transmembranei115 – 135Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini136 – 164Cytoplasmic1 PublicationAdd BLAST29
Transmembranei165 – 185Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini186 – 211Extracellular1 PublicationAdd BLAST26
Transmembranei212 – 232Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini233 – 290Cytoplasmic1 PublicationAdd BLAST58
Transmembranei291 – 311Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini312 – 324Extracellular1 PublicationAdd BLAST13
Transmembranei325 – 345Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini346 – 402Cytoplasmic1 PublicationAdd BLAST57
Transmembranei403 – 423Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini424 – 439Extracellular1 PublicationAdd BLAST16

GO - Cellular componenti

  • axon Source: GO_Central
  • dendrite Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: WormBase
  • neuron projection Source: WormBase
  • plasma membrane Source: UniProtKB

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Worms exhibit no response to blue-violet light but respond to physical stimulation.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi77W → A: Nearly abolished photoreceptor activity. 1 Publication1
Mutagenesisi226S → F in xu10; loss of phototaxis behavior due to impaired photoreceptor activity. 2 Publications1
Mutagenesisi328W → A: Nearly abolished photoreceptor activity. 1 Publication1
Mutagenesisi332A → V in xu8; loss of phototaxis behavior due to impaired photoreceptor activity. 2 Publications1
Mutagenesisi401R → H in xu7; loss of phototaxis behavior. Loss of phototransduction in ASJ neurons. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003527771 – 439High-energy light unresponsive protein 1Add BLAST439

Proteomic databases

PaxDbiQ17990.

Expressioni

Tissue specificityi

Expressed in the AVG and PVT neurons of the tail.1 Publication

Gene expression databases

BgeeiWBGene00001803.

Interactioni

Protein-protein interaction databases

STRINGi6239.C14F11.3.

Structurei

3D structure databases

SMRiQ17990.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

In contrast to other members of the family, adopts a reversed membrane topology.1 Publication

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410K8NK. Eukaryota.
ENOG4110K6D. LUCA.
GeneTreeiENSGT00390000011625.
HOGENOMiHOG000017639.
InParanoidiQ17990.
OMAiTFHEERD.
OrthoDBiEOG091G0901.

Family and domain databases

InterProiView protein in InterPro
IPR013604. 7TM_chemorcpt.
PfamiView protein in Pfam
PF08395. 7tm_7. 1 hit.

Sequencei

Sequence statusi: Complete.

Q17990-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPPSSHSNI FHSTFKHTVK ETMANAKKTM IAKILSSRNK WAICDRTLYP
60 70 80 90 100
IYYLLLILGL NQSIRPNNSL LFRIYSWLVF CLLLFTTLRK FNQVGVRPNG
110 120 130 140 150
TRENLQEFFA NPRSMITLCN ALIMLSGLLA SLQLYTLGAK RLKPLKILCQ
160 170 180 190 200
FSLNVRTKQA ERRQFMINTF LAVFSGLLAL TMAATYAMSK WGYILYIVGT
210 220 230 240 250
PNLDTETIFC VLLDSYALFV SRAAISALAI LFYQHCSVIR RSIKHLINEM
260 270 280 290 300
VPAEQDECPL PESSLQKIHD CQISYQRIFN GKAVIEEYYS FVLFYSYGVC
310 320 330 340 350
IPIFCFLMFV GMSAQSICWS EVVSIVIWIV NAILVLLLFS LPAFMINEDG
360 370 380 390 400
DRLVASSFRM YHETFHEERD LTVLSQMTFF TFQIHSTKLT LSACNYFYMD
410 420 430
RSILLSLFSA ILTYFLILWE FDIKNNQSLQ NIANHTIHT
Length:439
Mass (Da):50,554
Last modified:December 1, 2001 - v3
Checksum:i92D68C2A67572914
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080544 Genomic DNA. Translation: CCD64541.1.
AF387605 mRNA. Translation: AAK70488.1.
PIRiT15490.
RefSeqiNP_509043.3. NM_076642.5.
UniGeneiCel.802.

Genome annotation databases

EnsemblMetazoaiC14F11.3; C14F11.3; WBGene00001803.
GeneIDi180894.
KEGGicel:CELE_C14F11.3.
UCSCiC14F11.3. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLITE1_CAEEL
AccessioniPrimary (citable) accession number: Q17990
Secondary accession number(s): Q963E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 107 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Caution

Was intially thought to play a role in the gustatory response (PubMed:18687026). However, it was later shown that it acts as a photoreceptor for short wavelength (UV) light (PubMed:27863243).2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families