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Protein

Protein A33

Gene

A33R

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Coordinates the incorporation of A36 into intracellular enveloped virion (IEV) membranes and, subsequently, the production of actin tails. Therefore plays an essential role in efficient cell-to-cell spread of viral particles (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Protein A33
Gene namesi
ORF Names:A33R
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008269 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33IntravirionBy similarityAdd BLAST33
Transmembranei34 – 56HelicalSequence analysisAdd BLAST23
Topological domaini57 – 185Virion surfaceBy similarityAdd BLAST129

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000993161 – 185Protein A33Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi62Interchain
Glycosylationi125N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with B5. Interacts (via C-terminus) with protein A36 (By similarity).By similarity

Structurei

3D structure databases

SMRiP68616.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni98 – 185C-type lectin-like domainAdd BLAST88

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG09000150.

Family and domain databases

InterProiView protein in InterPro
IPR009238. Chordopox_A33R.
PfamiView protein in Pfam
PF05966. Chordopox_A33R. 1 hit.

Sequencei

Sequence statusi: Complete.

P68616-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTPENDEEQ TSVFSATVYG DKIQGKNKRK RVIGLCIRIS MVISLLSMIT
60 70 80 90 100
MSAFLIVRLN QCMSANEAAI TDAAVAVAAA SSTHRKVASS TTQYDHKESC
110 120 130 140 150
NGLYYQGSCY ILHSDYQLFS DAKANCTAES STLPNKSDVL ITWLIDYVED
160 170 180
TWGSDGNPIT KTTSDYQDSD VSQEVRKYFC VKTMN
Length:185
Mass (Da):20,506
Last modified:December 7, 2004 - v1
Checksum:i201CF65C2D2076A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA. Translation: AAA48160.1.
PIRiH42520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA. Translation: AAA48160.1.
PIRiH42520.

3D structure databases

SMRiP68616.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG09000150.

Family and domain databases

InterProiView protein in InterPro
IPR009238. Chordopox_A33R.
PfamiView protein in Pfam
PF05966. Chordopox_A33R. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA33_VACCC
AccessioniPrimary (citable) accession number: P68616
Secondary accession number(s): P21056
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: May 10, 2017
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.