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Protein

Gustatory receptor family protein 3

Gene

gur-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Chemoreceptor involved in light-induced avoidance behavior (PubMed:25640076). Probably acts as a molecular sensor in I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide (PubMed:25640076). Involved in circadian rhythms, probably by acting as a light sensor (PubMed:27849618). In contrast to lite-1, does not act as a photoreceptor (PubMed:27863243).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Gustatory receptor family protein 3
Gene namesi
Name:gur-3Imported
ORF Names:ZC504.5Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiZC504.5; CE30223; WBGene00001804; gur-3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 69ExtracellularCuratedAdd BLAST69
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 116CytoplasmicCuratedAdd BLAST26
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 171ExtracellularCuratedAdd BLAST34
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 211CytoplasmicCuratedAdd BLAST19
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Topological domaini233 – 292ExtracellularCuratedAdd BLAST60
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Topological domaini314 – 328CytoplasmicCuratedAdd BLAST15
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Topological domaini350 – 405ExtracellularCuratedAdd BLAST56
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 447CytoplasmicCuratedAdd BLAST21

GO - Cellular componenti

  • axon Source: GO_Central
  • dendrite Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: GO_Central
  • nucleus Source: WormBase

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi79Y → W: Induces sensitivity to UV-B light. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004390371 – 447Gustatory receptor family protein 3Add BLAST447

Proteomic databases

PaxDbiO18280.

Expressioni

Tissue specificityi

Expressed in I2 pharyngeal neurons.1 Publication

Gene expression databases

BgeeiWBGene00001804.
ExpressionAtlasiO18280. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6239.ZC504.5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410K8YV. Eukaryota.
ENOG4110JVV. LUCA.
GeneTreeiENSGT00390000011625.
HOGENOMiHOG000017639.
InParanoidiO18280.
OMAiKERAGEC.
OrthoDBiEOG091G0901.

Family and domain databases

InterProiView protein in InterPro
IPR013604. 7TM_chemorcpt.
PfamiView protein in Pfam
PF08395. 7tm_7. 1 hit.

Sequencei

Sequence statusi: Complete.

O18280-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITASNTLE FKWTSPRSSR SSFRTTTDAE QKISIDMSNT YCDQVLGPLY
60 70 80 90 100
SYMMVLGLNH THSSARNTMF KWPLTIYNYL TLAILTAATI RRISQIKQKS
110 120 130 140 150
ATNEEKDAAF HVLNPTFVLT LCHALLMFSG LAAGFLLLKL QKQREKMYHV
160 170 180 190 200
LDQGLGRNRN EEHDSHHFKL NKLFISISFS FAAALSFVQI ATKMRYLDLP
210 220 230 240 250
DTPDLINRKI YFVILEGYVI FIASSCISLV AILFFQLCRI LQFSIGQLIE
260 270 280 290 300
EMVPKEKEEC PLPEQSLQQI HDVQIHYQEI SNAKLYIEQN FSFSLFYTYG
310 320 330 340 350
CCIPLTCLLG YIAFRNGIQA DMAETFSVAI WLTNTMLALM LFSIPAFMIA
360 370 380 390 400
EEGDKLLTAS FKMYHETLCE ERDLLVLSQM SFLSFQMHAT KLTLTAGNFF
410 420 430 440
MMNRKIMISL FSAIFTYFLI LVQFDAEKER AGECNNQSRV LIVQPPV
Length:447
Mass (Da):51,228
Last modified:March 1, 2002 - v3
Checksum:iE916BEAA7C14C80C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7N → S in AAK70489 (Ref. 1) Curated1
Sequence conflicti62H → L in AAK70489 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387606 mRNA. Translation: AAK70489.1.
BX284606 Genomic DNA. Translation: CAA90343.3.
PIRiT27621.
RefSeqiNP_509743.2. NM_077342.4.
UniGeneiCel.5225.

Genome annotation databases

EnsemblMetazoaiZC504.5; ZC504.5; WBGene00001804.
GeneIDi181245.
KEGGicel:CELE_ZC504.5.
UCSCiZC504.5. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiGUR3_CAEEL
AccessioniPrimary (citable) accession number: O18280
Secondary accession number(s): Q963E7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: March 1, 2002
Last modified: July 5, 2017
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families