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Protein

p-hydroxybenzoic acid efflux pump subunit AaeB

Gene

aaeB

Organism
Escherichia coli O8 (strain IAI1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms an efflux pump with AaeA. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell.UniRule annotation

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
p-hydroxybenzoic acid efflux pump subunit AaeBUniRule annotation
Short name:
pHBA efflux pump protein BUniRule annotation
Gene namesi
Name:aaeBUniRule annotation
Ordered Locus Names:ECIAI1_3382
OrganismiEscherichia coli O8 (strain IAI1)
Taxonomic identifieri585034 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

B7M0V2:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21
Transmembranei69 – 89HelicalUniRule annotationAdd BLAST21
Transmembranei93 – 113HelicalUniRule annotationAdd BLAST21
Transmembranei121 – 141HelicalUniRule annotationAdd BLAST21
Transmembranei152 – 172HelicalUniRule annotationAdd BLAST21
Transmembranei370 – 390HelicalUniRule annotationAdd BLAST21
Transmembranei407 – 427HelicalUniRule annotationAdd BLAST21
Transmembranei431 – 451HelicalUniRule annotationAdd BLAST21
Transmembranei459 – 479HelicalUniRule annotationAdd BLAST21
Transmembranei482 – 502HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001467351 – 655p-hydroxybenzoic acid efflux pump subunit AaeBAdd BLAST655

Expressioni

Inductioni

Positively coregulated with aaeA and aaeX by AaeR.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7M0V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000268026.
KOiK03468.
OMAiMITQACE.

Family and domain databases

HAMAPiMF_01545. AaeB. 1 hit.
InterProiView protein in InterPro
IPR006726. PHBA_efflux_AaeB/fusaric-R.
IPR023706. PHBA_efflux_pump_AaeB.
PANTHERiPTHR30509:SF10. PTHR30509:SF10. 1 hit.
PfamiView protein in Pfam
PF04632. FUSC. 1 hit.

Sequencei

Sequence statusi: Complete.

B7M0V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIFSIANQH IRFAVKLATA IVLALFVGFH FQLETPRWAV LTAAIVAAGP
60 70 80 90 100
AFAAGGEPYS GAIRYRGFLR IIGTFIGCIA GLVIIIAMIR APLLMILVCC
110 120 130 140 150
IWAGFCTWIS SLVRIENSYA WGLAGYTALI IVITIQPEPL LTPQFAVERC
160 170 180 190 200
SEIVIGIVCA IMADLLFSPR SIKQEVDREL ESLLVAQYQL MQLCIKHGDG
210 220 230 240 250
EVVDKAWGDL VRRTTALQGM RSNLNMESSR WARANRRLKA INTLSLTLIT
260 270 280 290 300
QSCETYLIQN TRPELITDTF REFFDTPVET AQDVHKQLKR LRRVIAWTGE
310 320 330 340 350
RETPVTIYSW VAAATRYQLL KRGVISNTKI NATEEEILQG EPEVKVESAE
360 370 380 390 400
RHHAMVNFWR TTLSCILGTL FWLWTGWTSG SGAMVMIAVV TSLAMRLPNP
410 420 430 440 450
RMVAIDFIYG TLAALPLGLL YFLVIIPNTQ QSMLLLCISL AVLGFFLGIE
460 470 480 490 500
VQKRRLGSMG ALASTINIIV LDNPMTFHFS QFLDSALGQI VGCVLAFTVI
510 520 530 540 550
LLVRDKSRDR TGRVLLNQFV SAAVSAMTTN VARRKENHLP ALYQQLFLLM
560 570 580 590 600
NKFPGDLPKF RLALTMIIAH QRLRDAPIPV NEDLSAFHRQ MRRTADHVIS
610 620 630 640 650
ARSDDKRRRY FGQLLEELEI YQEKLRIWQA PPQVTEPVHR LAGMLHKYQH

ALTDS
Length:655
Mass (Da):73,611
Last modified:March 24, 2009 - v1
Checksum:i41F02829C82454E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU928160 Genomic DNA. Translation: CAR00196.1.
RefSeqiWP_000510962.1. NC_011741.1.

Genome annotation databases

EnsemblBacteriaiCAR00196; CAR00196; ECIAI1_3382.
KEGGiecr:ECIAI1_3382.

Similar proteinsi

Entry informationi

Entry nameiAAEB_ECO8A
AccessioniPrimary (citable) accession number: B7M0V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: March 24, 2009
Last modified: October 25, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families