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Protein

Pre-mRNA-splicing factor CWC22 homolog

Gene

ncm

Organism
Musca domestica (House fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders eIF4AIII from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-splicing factor CWC22 homologCurated
Alternative name(s):
Nucampholin1 Publication
Gene namesi
Name:ncm1 Publication
OrganismiMusca domestica (House fly)
Taxonomic identifieri7370 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaMuscoideaMuscidaeMusca
Proteomesi
  • UP000095301 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Early lethality in both males and females.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004413201 – 1292Pre-mRNA-splicing factor CWC22 homologAdd BLAST1292

Interactioni

Subunit structurei

Component of the spliceosome C complex.By similarity

Structurei

3D structure databases

SMRiA0A1I8M2I8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini483 – 666MIF4GPROSITE-ProRule annotationAdd BLAST184
Domaini776 – 892MIPROSITE-ProRule annotationAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi85 – 375Ser-richPROSITE-ProRule annotationAdd BLAST291
Compositional biasi992 – 1139Ser-richPROSITE-ProRule annotationAdd BLAST148
Compositional biasi1039 – 1152Lys-richPROSITE-ProRule annotationAdd BLAST114
Compositional biasi1164 – 1285Arg-richPROSITE-ProRule annotationAdd BLAST122

Sequence similaritiesi

Belongs to the CWC22 family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR003891. Initiation_fac_eIF4g_MI.
IPR003890. MIF4G-like_typ-3.
PfamiView protein in Pfam
PF02847. MA3. 1 hit.
SMARTiView protein in SMART
SM00544. MA3. 1 hit.
SM00543. MIF4G. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS51366. MI. 1 hit.

Sequencei

Sequence statusi: Complete.

A0A1I8M2I8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGSQSENNT STSSNSSEDT NNDSRNESET NADKNVVETK TTSDNNNKMM
60 70 80 90 100
NAAETAANEE KNGRQKKEKS KTPSKEDKKS RKKKSESSSE SSSSSDSDSS
110 120 130 140 150
ESSSSSSDGE VSTSSGSSSD SEKVKSKVKN KSKSPSAQRE VVQKETVTDT
160 170 180 190 200
PDNISKETQE KLVEDIPKEN ELNVNLAKED SVNAKQNDTE ASNENVAEEI
210 220 230 240 250
TKPPQKQPDT EEGEITENNE KNSSARSPSK EKQLSANRSR SRERRSHSGD
260 270 280 290 300
SRGAHSGDKG SPSRLKRSPS RSKKSPSRSK RSVSRNRSSS RHGRDSSRNR
310 320 330 340 350
RSVSGDKENQ LRRKSRSRSS RSRSRSRSRS RSRRPERKHR SRTPRRSRSR
360 370 380 390 400
ERRHERRRSV SSDYDARRRS RRSESIERRR EERKRRHAER DEREKSKRSR
410 420 430 440 450
RDEDDSFKTN KVSAEMEKDK ENDNATVTDP KAKITERQRK TVDILTSRTG
460 470 480 490 500
GAYIPPAKLR MMQAEITDKA SAAYQRIAWE ALKKSIHGYI NKVNVDNIAI
510 520 530 540 550
ITRELLKENI VRGRGLLCRS IIQAQAASPT FTHVYAALVA IINSKFPNIG
560 570 580 590 600
ELLLKRLVIQ FKRAFRRNDK TVCLSSSRFI AHLVNQRVAH EILALEILTL
610 620 630 640 650
LVESPTDDSV EVAIAFLKEC GMKLTEVSSK GIGAIFEMLK NILHEGKLDK
660 670 680 690 700
RVQYMIEVVF QVRKDGFKDH QSVIESLELV EEDDQFTHLL MLDDATSPED
710 720 730 740 750
VLNAFKFDEQ YEANEEKYKG LSKEILGSDA SDSDGSSGSG SDSDSESSDS
760 770 780 790 800
DEDKNEGDEK PTAGDIIDNT ETNLIALRRT IYLTINSSLD YEECAHKLMK
810 820 830 840 850
MQLKPGQEIE LCHMFLDCCA EQRTYEKFYG LLAQRFCNIN KSYIEPFEEI
860 870 880 890 900
FKDTYQTTHR LDTNRLRNVS KFFAHLLFTD AISWDVLDCI KLNEDDTTSS
910 920 930 940 950
SRIFIKILFQ ELAEYMGLGQ LNKKLKDEVL AESLAGLFPK DNPRNTRFSI
960 970 980 990 1000
NFFTSIGLGG LTDELRQFLK NAPKSVPAIN AEILANKPVD VSNSSSSSSS
1010 1020 1030 1040 1050
SSSSTSSSSS SSSSSSESSA SSSSSDSSSD SSSDSEVDKK KRKGKVKKTK
1060 1070 1080 1090 1100
KKKTSNKKEK TKKSKSKNKK DAKKKAKKRK SKKGSTSSED DSSKSESSSS
1110 1120 1130 1140 1150
ESKSSDSSDS EQSGNDKSKK KTKSKSKTKP NKKSKRSDSE DVENERDIKR
1160 1170 1180 1190 1200
KKREDFGNYI HEDRRRDEEY SKNGGRDRKK DNHGNNKEKR EIPQRRDSEI
1210 1220 1230 1240 1250
ERRREEREKR HRERERNFSR SRSRSRGGSG RKDRDRRETN GRSERKDRER
1260 1270 1280 1290
DRDSDHRRYR KDYDRSRSRD RNEKREREYS RSKLRNTSKE RG
Length:1,292
Mass (Da):147,084
Last modified:January 18, 2017 - v1
Checksum:i158618C7CB06D797
GO

Genome annotation databases

VectorBaseiMDOA000598-RA; MDOA000598-PA; MDOA000598.

Similar proteinsi

Entry informationi

Entry nameiCWC22_MUSDO
AccessioniPrimary (citable) accession number: A0A1I8M2I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2017
Last sequence update: January 18, 2017
Last modified: November 22, 2017
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families