Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Introduction

Number of entries
New entries 3,139,035
Updated entries 19,836,013
Unchanged entries 57,229,411
Total 80,204,459
Entries with updated sequences 704
With a fragmented AA sequence 8,693,683
With known alternative products 0
Protein Existence (PE) Number of entries
1 Evidence at protein level 124,951
2 Evidence at transcript level 1,073,270
3 Inferred from homology 18,994,277
4 Predicted 60,011,961
5 Uncertain 0

Taxonomic Origin


Statistics on the number of species

Number of species in
New entries 13,376
Updated entries 158,659
Unchanged entries 501,104
Total 543,552

Sequence data

The shortest sequence is C4PYW0 at 2 AA while the longest sequence is Q3ASY8 at 36,805 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 0 0
Alternative products 0 0
Biophysicochemical properties 0 0
Biotechnological use 0 0
Catalytic activity 8,795,677 8,103,143
Caution 40,375,849 39,501,128
Cofactor 5,870,164 0
Developmental stage 0 0
Involvement in disease 0 0
Disruption phenotype 0 0
Domain 547,724 526,632
Enzyme regulation 173,706 173,704
Function 9,782,703 9,461,782
Induction 37,632 37,632
Mass spectrometry 0 0
Miscellaneous 298,970 294,772
Pathway 4,496,251 4,093,178
Pharmaceutical use 0 0
Polymorphism 0 0
Post-translational modification 403,627 363,964
RNA Editing 0 0
Sequence caution 0 0
Sequence similarities 19,095,322 18,859,505
Subcellular Location 0 0
Subunit structure 5,294,585 5,266,746
Tissue specificity 0 0
Toxic dose 0 0

Sequence Annotation (featues)

Annotations Entries
Molecule processing 11,132,828 5,577,506
Chain 5,553,701 5,551,874
Initiator methionine 19,349 19,349
Peptide 57 57
Propeptide 9,586 9,586
Signal peptide 5,550,050 5,550,049
Transit peptide 85 85
Regions 143,749,158 50,829,597
Calcium binding 188,397 92,663
Coiled-coil 5,280,648 3,535,729
Compositional bias 3,379 3,379
DNA binding 1,884,262 1,665,029
Domain 55,930,593 40,362,792
Motif 349,451 242,464
Nucleotide binding 3,945,755 2,601,823
Repeat 2,145,032 606,663
Region 2,554,607 1,353,578
Topological domain 77,909 24,906
Transmembrane 71,138,644 15,764,877
Zinc finger 250,162 189,381
Sites 20,288,121 4,410,718
Active site 3,893,996 2,398,745
Metal binding 6,920,050 1,858,912
Binding site 8,543,257 2,193,439
Other 930,818 496,068
Amino acid modifications 1,426,473 814,665
Cross-link 16,521 15,443
Disulfide bond 778,406 210,900
Glycosylation 3,893 2,100
Lipidation 15,101 13,429
Modified residue 610,100 584,829
Non-standard residue 2,452 2,261
Experimental info 13,617,103 8,714,789
Mutagenesis 0 0
Non-adjacent residues 0 0
Non-terminal residue 13,559,115 8,702,693
Sequence conflict 0 0
Sequence uncertainty 57,988 48,715

Citation usage

Citation type Citations Entries
Submission63,329,00954,913,377
Journal article31,988,89330,239,276
Book11,26011,195
Thesis11,73211,673
Patent11
Unpublished observations00
Online journal article00

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 665,000 466,278

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
EMBL90,930,49677,732,988
PIR161,710129,528
RefSeq40,336,55339,496,892
UniGene709,698611,684
3D structure databases
PDB31,99315,958
PDBsum32,13415,996
ProteinModelPortal7,661,2437,661,243
SMR928,000928,000
Protein-protein interaction databases
DIP3,2793,274
IntAct15,51615,516
MINT9,7819,780
STRING7,220,7097,216,336
Chemistry
BindingDB493493
ChEMBL859859
DrugBank538317
GuidetoPHARMACOLOGY66
SwissLipids7373
Protein family/group databases
Allergome3,8703,144
CAZy129,419121,129
ESTHER54,66454,548
MEROPS253,273253,272
MoonProt44
PeroxiBase2,4712,463
REBASE32,60832,599
TCDB7,6817,665
mycoCLAP448448
PTM databases
PhosphoSitePlus2,3162,316
SwissPalm1,2201,220
UniCarbKB1717
iPTMnet5,0095,009
Polymorphism and mutation databases
2D gel databases
COMPLUYEAST-2DPAGE44
OGP33
REPRODUCTION-2DPAGE6463
SWISS-2DPAGE11
World-2DPAGE318313
Proteomic databases
EPD7,3317,331
MaxQB38,26438,264
PRIDE285,612285,612
PaxDb604,344604,344
PeptideAtlas128,043128,043
ProMEX2,6582,658
TopDownProteomics283283
Protocols and materials databases
DNASU39,70939,387
Genome annotation databases
Ensembl1,225,6621,203,133
EnsemblBacteria35,640,03431,689,789
EnsemblFungi4,527,1824,348,170
EnsemblMetazoa1,068,7681,041,806
EnsemblPlants1,742,3061,628,250
EnsemblProtists1,831,4171,703,954
GeneDB81,60180,273
GeneID8,713,6168,616,006
Gramene1,758,0371,643,752
KEGG13,130,01912,740,555
PATRIC5,555,9795,555,875
UCSC90,07589,886
VectorBase567,892551,464
WBParaSite867,290858,150
Organism-specific databases
ArachnoServer204204
Araport16,29616,228
CGD16,32716,270
CTD743,260741,484
ConoServer159159
EuPathDB563,659563,659
FlyBase222,887221,420
H-InvDB591444
HGNC49,90149,805
LegioList2,4962,483
Leproma1,2711,269
MGI59,64659,235
MIM44
MalaCards99
OpenTargets48,09448,043
PharmGKB3,1643,164
PomBase3232
PseudoCAP4,4704,464
RGD24,95823,596
SGD77
TAIR12,81212,749
TubercuList1,0061,005
WormBase68,56468,174
Xenbase26,40226,339
ZFIN52,86152,212
dictyBase7,9887,766
euHCVdb75,26775,264
Phylogenomic databases
GeneTree1,206,0451,205,909
HOGENOM3,047,5343,047,415
HOVERGEN300,899300,887
InParanoid2,539,6082,539,494
KO5,610,3705,586,759
OMA6,478,9216,478,853
OrthoDB14,683,86514,683,865
PhylomeDB478,934478,934
TreeFam577,830577,816
eggNOG14,318,5837,176,180
Enzyme and pathway databases
BRENDA9,6139,324
BioCyc3,496,6843,495,436
Reactome231,54184,681
SABIO-RK569569
SIGNOR55
SignaLink3,8313,831
UniPathway4,487,3744,084,301
Other
ChiTaRS86,33286,172
EvolutionaryTrace6,0406,040
GenomeRNAi30,37330,373
PMAP-CutDB131131
PRO2,2652,265
Gene expression databases
Bgee360,157360,106
CollecTF199199
ExpressionAtlas232,002232,002
Genevisible16,38516,385
Ontologies
Family and domain databases
CDD9,253,4628,835,020
Gene3D48,105,80037,919,554
HAMAP7,721,8947,623,462
InterPro178,168,66961,549,539
PANTHER12,566,89412,081,664
PIRSF6,423,9286,365,776
PRINTS10,956,3669,878,349
PROSITE39,731,82326,356,315
Pfam77,556,63356,461,321
ProDom1,250,8051,189,934
SFLD406,322300,070
SMART18,828,33714,349,741
SUPFAM50,022,30439,791,403
TIGRFAMs15,971,40814,679,719

Web resource

0 UniProtKB/TrEMBL entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

  • 8.9%Alanine
  • 5.6%Arginine
  • 3.9%Asparagine
  • 5.4%Aspartate
  • 1.2%Cysteine
  • 3.8%Glutamine
  • 6.1%Glutamate
  • 7.1%Glycine
  • 2.2%Histidine
  • 5.7%Isoleucine
  • 9.8%Leucine
  • 5.0%Lysine
  • 2.3%Methionine
  • 3.9%Phenylalanine
  • 4.8%Proline
  • 6.7%Serine
  • 5.5%Threonine
  • 1.2%Tryptophan
  • 2.9%Tyrosine
  • 6.8%Valine
  • Aliphatic
  • Acidic
  • Small hydroxy
  • Basic
  • Amide
  • Aromatic
  • Sulfur

Miscellaneous Statistics

1,572,618 entries are encoded on a mitochondrion, and 573,928 are encoded on a plasmid.

554,857 entries are encoded on a plastid, of which 785 are encoded on apicoplasts, 472,986 on chloroplasts, 1 on organellar chromatophores, 10 on cyanelles, 1,601 on non-photosynthetic plastids and 3,157 on unspecified types of plastid.