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Introduction

Number of entries
New entries 3,031,100
Updated entries 20,906,527
Unchanged entries 49,774,254
Total 73,711,881
Entries with updated sequences 746
With a fragmented AA sequence 8,492,670
With known alternative products 0
Protein Existence (PE) Number of entries
1 Evidence at protein level 125,544
2 Evidence at transcript level 1,063,419
3 Inferred from homology 17,236,726
4 Predicted 55,286,192
5 Uncertain 0

Taxonomic Origin


Statistics on the number of species

Number of species in
New entries 8,595
Updated entries 379,887
Unchanged entries 293,396
Total 530,255

Sequence data

The shortest sequence is C4PYW0 at 2 AA while the longest sequence is Q3ASY8 at 36,805 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 0 0
Alternative products 0 0
Biophysicochemical properties 0 0
Biotechnological use 0 0
Catalytic activity 7,963,620 7,342,142
Caution 36,956,222 36,173,747
Cofactor 5,292,268 73,711,881
Developmental stage 0 0
Involvement in disease 0 0
Disruption phenotype 0 0
Domain 499,783 480,492
Enzyme regulation 159,595 159,595
Function 8,835,022 8,556,278
Induction 34,226 34,226
Mass spectrometry 0 0
Miscellaneous 269,908 265,888
Pathway 4,095,806 3,733,819
Pharmaceutical use 0 0
Polymorphism 0 0
Post-translational modification 377,260 340,192
RNA Editing 0 0
Sequence caution 0 0
Sequence similarities 24,481,629 21,687,260
Subcellular Location 0 0
Subunit structure 4,750,710 4,726,486
Tissue specificity 0 0
Toxic dose 0 0

Sequence Annotation (featues)

Annotations Entries
Molecule processing 10,321,814 5,171,000
Chain 5,149,227 5,147,440
Initiator methionine 17,612 17,612
Peptide 56 56
Propeptide 9,174 9,174
Signal peptide 5,145,660 5,145,659
Transit peptide 85 85
Regions 132,661,808 46,558,448
Calcium binding 0 0
Coiled-coil 4,904,980 3,268,831
Compositional bias 3,043 3,043
DNA binding 1,772,120 1,567,918
Domain 51,317,401 36,952,417
Motif 415,981 319,510
Nucleotide binding 3,605,578 2,353,132
Repeat 2,871,356 695,718
Region 2,274,962 1,208,745
Topological domain 75,295 23,355
Transmembrane 65,161,730 14,451,033
Zinc finger 259,046 201,772
Sites 18,494,465 4,083,897
Active site 3,662,638 2,259,169
Metal binding 6,247,400 1,682,094
Binding site 7,729,126 1,987,211
Other 855,301 457,743
Amino acid modifications 1,945,178 1,293,640
Cross-link 15,444 14,367
Disulfide bond 725,931 193,664
Glycosylation 3,790 2,031
Lipidation 13,821 12,125
Modified residue 1,183,801 1,082,035
Non-standard residue 2,391 2,200
Experimental info 13,325,096 8,513,522
Mutagenesis 0 0
Non-adjacent residues 0 0
Non-terminal residue 13,268,977 8,501,601
Sequence conflict 0 0
Sequence uncertainty 56,119 47,168

Citation usage

Citation type Citations Entries
Submission58,630,13450,537,097
Journal article29,660,64727,896,878
Book11,25911,194
Thesis11,69011,631
Patent11
Unpublished observations00
Online journal article00

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 656,881 478,011

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
EMBL81,223,71671,254,314
PIR161,807129,623
RefSeq37,652,58136,860,149
UniGene685,716590,308
3D structure databases
PDB30,67915,618
PDBsum30,75215,625
ProteinModelPortal7,780,0577,779,467
SMR552,575552,575
Protein-protein interaction databases
DIP3,2773,272
IntAct19,61919,619
MINT9,8109,809
STRING7,230,0327,225,679
Chemistry
BindingDB509509
ChEMBL858858
DrugBank16070
GuidetoPHARMACOLOGY44
SwissLipids6969
Protein family/group databases
Allergome3,8463,128
CAZy129,532121,229
ESTHER54,86354,746
MEROPS202,826202,825
MoonProt44
PeroxiBase2,4712,463
REBASE32,79532,781
TCDB7,5877,571
mycoCLAP448448
PTM databases
PhosphoSitePlus3,5893,589
SwissPalm1,2221,221
UniCarbKB1717
iPTMnet5,0215,021
Polymorphism and mutation databases
2D gel databases
COMPLUYEAST-2DPAGE44
OGP33
REPRODUCTION-2DPAGE6463
SWISS-2DPAGE11
World-2DPAGE318313
Proteomic databases
EPD7,6627,662
MaxQB39,14739,147
PRIDE290,700290,694
PaxDb605,478605,075
PeptideAtlas127,314127,314
ProMEX3,3143,314
TopDownProteomics283283
Protocols and materials databases
DNASU39,71739,395
Genome annotation databases
Ensembl1,219,2521,198,985
EnsemblBacteria36,265,57132,095,708
EnsemblFungi4,527,3454,352,889
EnsemblMetazoa1,068,9041,041,909
EnsemblPlants1,742,5591,628,476
EnsemblProtists1,832,2151,704,749
GeneDB62,11961,155
GeneID8,056,9057,965,084
Gramene1,758,0731,643,761
KEGG12,900,79112,525,579
PATRIC5,580,8015,580,697
UCSC94,62794,434
VectorBase567,863551,435
WBParaSite866,109856,978
Organism-specific databases
ArachnoServer204204
CGD16,32716,270
CTD734,266732,544
ConoServer159159
EuPathDB564,062564,062
FlyBase222,957221,489
H-InvDB591444
HGNC49,89349,802
LegioList2,4962,483
Leproma1,2711,269
MGI58,97758,574
MIM44
MalaCards99
OpenTargets53,72950,787
PharmGKB3,1683,168
PomBase3333
PseudoCAP4,4734,467
RGD24,85123,587
SGD77
TAIR18,97618,859
TubercuList1,0081,007
WormBase66,31565,781
Xenbase25,53825,477
ZFIN52,78052,112
dictyBase7,9907,768
euHCVdb75,26775,264
Phylogenomic databases
GeneTree1,202,1641,202,025
HOGENOM3,054,4173,054,303
HOVERGEN300,932300,921
InParanoid2,539,8252,539,712
KO5,493,5685,470,520
OMA6,496,9866,496,947
OrthoDB13,836,51813,836,450
PhylomeDB500,422500,422
TreeFam577,949577,936
eggNOG14,337,4067,185,617
Enzyme and pathway databases
BRENDA9,6329,343
BioCyc3,591,8623,586,786
Reactome218,64080,818
SABIO-RK557557
SIGNOR55
SignaLink3,8373,837
UniPathway4,088,6393,726,652
Other
ChiTaRS86,37086,210
EvolutionaryTrace6,0516,051
GenomeRNAi30,42930,429
PMAP-CutDB131131
PRO2,2812,281
Gene expression databases
Bgee360,459360,417
CollecTF199199
ExpressionAtlas225,587225,587
Genevisible16,40516,405
Ontologies
Family and domain databases
CDD7,690,7887,400,886
Gene3D43,987,44034,756,019
HAMAP6,888,3536,799,032
InterPro163,068,06556,322,615
PANTHER10,981,96010,612,450
PIRSF5,815,3145,763,039
PRINTS10,163,6419,139,796
PROSITE36,647,07824,262,204
Pfam70,959,64451,662,315
ProDom1,167,5661,108,830
SFLD66,84566,790
SMART17,252,79813,148,770
SUPFAM45,652,47236,331,723
TIGRFAMs14,324,15113,148,657

Web resource

0 UniProtKB/TrEMBL entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

  • 8.9%Alanine
  • 5.6%Arginine
  • 3.9%Asparagine
  • 5.4%Aspartate
  • 1.2%Cysteine
  • 3.8%Glutamine
  • 6.1%Glutamate
  • 7.1%Glycine
  • 2.2%Histidine
  • 5.7%Isoleucine
  • 9.8%Leucine
  • 5.0%Lysine
  • 2.4%Methionine
  • 3.9%Phenylalanine
  • 4.8%Proline
  • 6.8%Serine
  • 5.5%Threonine
  • 1.2%Tryptophan
  • 2.9%Tyrosine
  • 6.8%Valine
  • Aliphatic
  • Acidic
  • Small hydroxy
  • Basic
  • Amide
  • Aromatic
  • Sulfur

Miscellaneous Statistics

1,542,894 entries are encoded on a mitochondrion, and 533,443 are encoded on a plasmid.

536,700 entries are encoded on a plastid, of which 791 are encoded on apicoplasts, 458,564 on chloroplasts, 1 on organellar chromatophores, 10 on cyanelles, 1,601 on non-photosynthetic plastids and 3,170 on unspecified types of plastid.