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Introduction

Number of entries
New entries 1,848,898
Updated entries 21,368,174
Unchanged entries 37,754,417
Total 60,971,489
Entries with updated sequences 10,266
With a fragmented AA sequence 7,339,454
With known alternative products 0
Protein Existence (PE) Number of entries
1 Evidence at protein level 124,667
2 Evidence at transcript level 1,007,009
3 Inferred from homology 13,264,093
4 Predicted 46,575,720
5 Uncertain 0

Taxonomic Origin


Statistics on the number of species

Number of species in
New entries 21,529
Updated entries 210,067
Unchanged entries 378,607
Total 463,595

Sequence data

The shortest sequence is C4PYW0 at 2 AA while the longest sequence is A0A0Q3ZJN0 at 37,363 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 0 0
Alternative products 0 0
Biophysicochemical properties 0 0
Biotechnological use 0 0
Catalytic activity 6,318,311 5,850,684
Caution 29,805,053 29,768,506
Cofactor 4,583,884 2,804,163
Developmental stage 0 0
Involvement in disease 0 0
Disruption phenotype 0 0
Domain 350,156 333,825
Enzyme regulation 104,094 104,094
Function 7,208,686 6,780,646
Induction 31,279 31,279
Mass spectrometry 0 0
Miscellaneous 206,987 206,987
Pathway 3,125,971 2,832,520
Pharmaceutical use 0 0
Polymorphism 0 0
Post-translational modification 259,344 234,467
RNA Editing 0 0
Sequence caution 0 0
Sequence similarities 19,277,095 16,535,324
Subcellular Location 0 0
Subunit structure 3,781,488 3,730,272
Tissue specificity 0 0
Toxic dose 0 0

Sequence Annotation (featues)

Annotations Entries
Molecule processing 8,836,564 4,423,446
Chain 4,431,612 4,409,790
Initiator methionine 13,028 13,028
Peptide 51 51
Propeptide 5,649 5,649
Signal peptide 4,385,638 4,385,622
Transit peptide 586 586
Regions 108,152,199 38,341,503
Calcium binding 0 0
Coiled-coil 10,260,151 6,802,373
Compositional bias 12,783 12,622
DNA binding 51,894 49,832
Domain 39,367,447 28,226,472
Motif 288,545 188,600
Nucleotide binding 1,844,484 1,085,542
Repeat 100,336 25,461
Region 1,617,505 857,225
Topological domain 174,911 47,513
Transmembrane 54,337,268 11,993,336
Zinc finger 96,616 81,077
Sites 12,881,006 2,893,829
Active site 2,492,144 1,524,471
Metal binding 4,661,618 1,241,744
Binding site 5,127,895 1,353,484
Other 599,349 323,785
Amino acid modifications 572,674 483,605
Cross-link 13,656 9,611
Disulfide bond 113,747 78,222
Glycosylation 1,368 507
Lipidation 53,440 26,998
Modified residue 388,287 372,295
Non-standard residue 2,176 2,010
Experimental info 11,428,850 7,355,792
Mutagenesis 0 0
Non-adjacent residues 0 0
Non-terminal residue 11,384,560 7,347,723
Sequence conflict 0 0
Sequence uncertainty 44,290 37,661

Citation usage

Citation type Citations Entries
Submission47,206,71139,683,613
Journal article27,126,06925,389,914
Book15,35915,299
Thesis11,44611,387
Patent11
Unpublished observations00
Online journal article00

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 614,153 445,456

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
EMBL70,776,82559,408,500
PIR162,536130,317
RefSeq29,548,31528,813,472
UniGene584,318535,578
3D structure databases
PDB28,86114,951
PDBsum28,37714,603
ProteinModelPortal7,675,8127,675,724
SMR923,650923,650
Protein-protein interaction databases
DIP3,2013,196
IntAct15,98215,982
MINT9,9659,964
STRING7,413,5457,413,332
Chemistry
BindingDB26,09126,091
ChEMBL782782
DrugBank15766
GuidetoPHARMACOLOGY44
SwissLipids5656
Protein family/group databases
Allergome3,8413,137
CAZy68,20364,112
ESTHER55,04754,944
MEROPS190,342190,342
MoonProt55
PeroxiBase2,4772,469
REBASE33,92133,905
TCDB6,8626,852
mycoCLAP448448
PTM databases
PhosphoSite1,0751,075
SwissPalm1,2461,246
UniCarbKB1818
iPTMnet6,3936,393
Polymorphism and mutation databases
2D gel databases
COMPLUYEAST-2DPAGE44
OGP33
REPRODUCTION-2DPAGE6564
SWISS-2DPAGE11
World-2DPAGE322317
Proteomic databases
MaxQB4,2524,252
PRIDE267,032267,014
PaxDb691,855691,587
PeptideAtlas126126
ProMEX3,3133,313
Protocols and materials databases
DNASU39,91939,597
Genome annotation databases
Ensembl1,201,6321,180,858
EnsemblBacteria29,347,63625,961,143
EnsemblFungi4,838,6624,735,358
EnsemblMetazoa940,165919,510
EnsemblPlants1,475,7131,410,573
EnsemblProtists1,575,5181,486,208
GeneDB56,49355,564
GeneID6,812,5276,725,411
Gramene1,475,4471,409,798
KEGG11,717,07011,319,740
PATRIC5,657,4715,657,363
UCSC56,40156,235
VectorBase78,24077,723
WBParaSite335,951334,924
Organism-specific databases
ArachnoServer204204
CGD26,95823,753
CTD686,532684,852
ConoServer159159
EuPathDB364,658364,632
FlyBase182,012180,567
H-InvDB591444
HGNC49,25849,155
LegioList2,4962,483
Leproma1,2711,269
MGI57,39256,937
MIM44
MalaCards1212
PharmGKB3,1743,174
PseudoCAP4,4774,471
RGD24,70423,424
SGD77
TAIR19,79019,673
TubercuList1,0321,031
WormBase55,21155,056
Xenbase25,60825,544
ZFIN51,45250,983
dictyBase7,9927,770
euHCVdb75,26775,264
Phylogenomic databases
GeneTree1,173,3701,173,269
HOGENOM3,084,1383,084,087
HOVERGEN301,723301,713
InParanoid2,581,6302,581,587
KO4,889,9094,868,892
OMA6,311,8696,311,851
OrthoDB4,644,3034,644,295
PhylomeDB455,197455,178
TreeFam581,816581,806
eggNOG14,732,0987,384,684
Enzyme and pathway databases
BRENDA9,7169,424
BioCyc4,476,9824,412,432
Reactome187,19569,042
SABIO-RK522522
SignaLink3,9533,953
UniPathway3,121,0332,827,582
Other
ChiTaRS86,63686,476
EvolutionaryTrace6,1096,109
GenomeRNAi27,58427,584
NextBio195,731195,718
PMAP-CutDB137137
PRO2,4032,403
Gene expression databases
Bgee94,21394,081
CollecTF202202
ExpressionAtlas203,650203,641
Genevisible16,66816,668
Ontologies
GO101,758,99236,744,089
Family and domain databases
Gene3D36,602,74528,811,340
HAMAP5,817,8655,741,017
InterPro136,038,27947,141,524
PANTHER8,458,1278,194,332
PIRSF4,969,8064,925,274
PRINTS8,458,0707,566,177
PROSITE30,567,74420,179,085
Pfam59,821,84443,558,564
ProDom983,699935,112
SMART13,871,67910,553,160
SUPFAM38,047,65730,252,693
TIGRFAMs12,162,34311,153,563

Web resource

0 UniProtKB/TrEMBL entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

  • 8.8%Alanine
  • 5.6%Arginine
  • 4.0%Asparagine
  • 5.4%Aspartate
  • 1.2%Cysteine
  • 3.8%Glutamine
  • 6.1%Glutamate
  • 7.1%Glycine
  • 2.2%Histidine
  • 5.7%Isoleucine
  • 9.8%Leucine
  • 5.1%Lysine
  • 2.4%Methionine
  • 3.9%Phenylalanine
  • 4.8%Proline
  • 6.8%Serine
  • 5.5%Threonine
  • 1.2%Tryptophan
  • 2.9%Tyrosine
  • 6.7%Valine
  • Aliphatic
  • Acidic
  • Small hydroxy
  • Basic
  • Amide
  • Aromatic
  • Sulfur

Miscellaneous Statistics

1,111,647 entries are encoded on a mitochondrion, and 481,738 are encoded on a plasmid.

439,764 entries are encoded on a plastid, of which 721 are encoded on apicoplasts, 377,262 on chloroplasts, 0 on organellar chromatophores, 10 on cyanelles, 1,606 on non-photosynthetic plastids and 3,169 on unspecified types of plastid.