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Introduction

Number of entries
New entries 673
Updated entries 420,991
Unchanged entries 131,220
Total 552,884
Entries with updated sequences 65
With a fragmented AA sequence 9,141
With known alternative products 24,701
Protein Existence (PE) Number of entries
1 Evidence at protein level 94,017
2 Evidence at transcript level 57,828
3 Inferred from homology 387,850
4 Predicted 11,237
5 Uncertain 1,952

Taxonomic Origin

Swiss-Prot entries per taxonomic group


Statistics on the number of species

Number of species in
New entries 85
Updated entries 5,829
Unchanged entries 8,025
Total 10,436

Sequence data

The shortest sequence is P83570 at 2 AA while the longest sequence is A2ASS6 at 35,213 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 708 708
Alternative products 24,701 24,701
Biophysicochemical properties 7,228 7,228
Biotechnological use 770 768
Catalytic activity 258,078 232,118
Caution 33,692 59,531
Cofactor 212,046 552,884
Developmental stage 11,191 11,191
Involvement in disease 6,373 4,253
Disruption phenotype 11,057 11,057
Domain 44,820 38,811
Enzyme regulation 13,655 13,653
Function 449,676 431,009
Induction 18,803 18,796
Mass spectrometry 6,186 4,672
Miscellaneous 35,842 33,042
Pathway 135,991 123,259
Pharmaceutical use 99 99
Polymorphism 1,108 1,051
Post-translational modification 51,718 39,208
RNA Editing 627 627
Sequence caution 60,167 43,552
Sequence similarities 674,343 528,071
Subcellular Location 649,342 552,884
Subunit structure 266,672 266,501
Tissue specificity 43,297 43,296
Toxic dose 628 582

Sequence Annotation (features)

Annotations Entries
Molecule processing 653,116 552,884
Chain 560,527 546,405
Initiator methionine 18,461 18,419
Peptide 10,790 7,340
Propeptide 13,575 11,654
Signal peptide 40,604 40,594
Transit peptide 9,159 9,046
Regions 1,286,456 309,921
Calcium binding 4,096 1,706
Coiled-coil 21,675 14,946
Compositional bias 58,018 31,090
DNA binding 11,355 10,322
Domain 184,612 112,771
Motif 40,577 26,201
Nucleotide binding 147,191 82,097
Repeat 101,341 14,428
Region 183,224 86,957
Topological domain 136,949 28,202
Transmembrane 364,860 76,097
Zinc finger 30,123 13,228
Sites 948,941 199,729
Active site 158,502 96,655
Metal binding 361,640 90,272
Binding site 375,856 98,931
Other 52,943 29,506
Amino acid modifications 497,985 113,214
Cross-link 12,505 6,105
Disulfide bond 119,031 32,487
Glycosylation 112,874 28,919
Lipidation 12,761 8,215
Modified residue 240,455 70,578
Non-standard residue 359 284
Natural variations 144,932 30,995
Natural variant 144,932 30,995
Alternative sequence 51,250 21,598
Experimental info 229,803 64,092
Mutagenesis 59,233 13,380
Non-adjacent residues 2,234 775
Non-terminal residue 12,207 9,327
Sequence conflict 151,788 46,659
Sequence uncertainty 4,341 760
Secondary structure 511,056 21,768
Helix 224,001 20,984
Turn 53,815 17,010
Beta strand 233,240 19,785

Citation usage

Citation type Citations Entries
Submission193,161168,069
Journal article968,141442,352
Book1,5521,535
Thesis428425
Patent197193
Unpublished observations392388
Online journal article610597

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 759,202 566,316

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
CCDS47,12433,681
EMBL946,002541,583
PIR123,304112,920
RefSeq604,670464,738
UniGene107,75495,365
3D structure databases
DisProt605602
PDB136,04424,092
PDBsum136,04424,092
ProteinModelPortal456,715456,715
SMR108,571108,571
Protein-protein interaction databases
BioGrid48,50448,050
DIP17,18317,127
IntAct46,50246,502
MINT31,79731,797
STRING326,879326,879
Chemistry
BindingDB4,7404,740
ChEMBL6,0536,053
DrugBank11,7851,910
GuidetoPHARMACOLOGY1,9101,910
SwissLipids1,1081,029
Protein family/group databases
Allergome1,7121,120
CAZy9,3978,475
ESTHER2,4552,453
MEROPS12,97212,971
MoonProt6363
PeroxiBase771755
REBASE406406
TCDB6,1396,104
mycoCLAP349345
PTM databases
DEPOD239239
PhosphoSitePlus38,57038,570
SwissPalm5,9475,947
UniCarbKB584584
iPTMnet45,93545,935
Polymorphism and mutation databases
BioMuta17,24517,241
DMDM16,37016,307
dbSNP56,62212,337
2D gel databases
COMPLUYEAST-2DPAGE9998
DOSAC-COBS-2DPAGE146146
OGP375375
REPRODUCTION-2DPAGE1,2591,038
SWISS-2DPAGE1,1801,180
UCD-2DPAGE508499
World-2DPAGE925914
Proteomic databases
EPD19,90119,901
MaxQB28,57728,577
PRIDE141,539141,539
PaxDb111,199110,934
PeptideAtlas31,06631,066
ProMEX441441
TopDownProteomics3,2232,945
Protocols and materials databases
DNASU18,89818,826
Genome annotation databases
Ensembl84,84548,613
EnsemblBacteria353,602334,562
EnsemblFungi30,91228,366
EnsemblMetazoa13,50210,017
EnsemblPlants21,58118,939
EnsemblProtists5,0024,827
GeneDB404365
GeneID281,420271,871
Gramene21,58118,939
KEGG503,396471,561
PATRIC308,361308,326
UCSC49,24645,044
VectorBase694636
WBParaSite3030
Organism-specific databases
ArachnoServer1,1461,136
CGD1,7101,693
CTD73,89173,133
ConoServer949866
DisGeNET14,92114,702
EchoBASE4,1614,161
EcoGene4,2944,292
EuPathDB18,19318,190
FlyBase6,0765,714
GeneCards20,01319,838
GeneReviews1,1561,153
H-InvDB5,5884,767
HGNC20,05419,906
HPA26,77117,133
LegioList765763
Leproma672669
MGI16,74616,702
MIM19,97714,579
MaizeGDB506501
MalaCards3,7743,772
OpenTargets20,37518,494
Orphanet6,1483,289
PharmGKB18,37818,337
PomBase5,1335,129
PseudoCAP1,3111,302
RGD7,8957,892
SGD6,7396,734
TAIR14,97014,914
TubercuList2,1632,127
WormBase5,6464,348
Xenbase4,4504,444
ZFIN2,8192,819
dictyBase4,2084,093
euHCVdb5544
neXtProt20,05120,051
Phylogenomic databases
GeneTree57,46657,423
HOGENOM389,476389,476
HOVERGEN75,74275,742
InParanoid136,239136,239
KO397,329396,869
OMA412,775412,775
OrthoDB262,421262,421
PhylomeDB95,13095,130
TreeFam45,02245,016
eggNOG659,212328,940
Enzyme and pathway databases
BRENDA12,78712,015
BioCyc71,18962,602
Reactome104,39331,954
SABIO-RK3,3853,385
SIGNOR3,3393,339
SignaLink3,0083,008
UniPathway135,430122,711
Other
ChiTaRS16,48916,479
EvolutionaryTrace16,56916,566
GeneWiki10,36810,282
GenomeRNAi21,87221,872
PMAP-CutDB1,4611,461
PRO90,18790,187
Gene expression databases
Bgee54,87754,877
CleanEx30,03929,399
CollecTF133133
ExpressionAtlas33,33433,334
Genevisible55,15955,159
Ontologies
Family and domain databases
CDD110,788108,356
Gene3D461,211343,203
HAMAP326,196323,430
InterPro1,950,561533,066
PANTHER175,800168,517
PIRSF104,316103,277
PRINTS134,003118,181
PROSITE454,876292,277
Pfam745,506510,168
ProDom29,16128,980
SMART189,846140,118
SUPFAM480,514364,178
TIGRFAMs292,101272,087

Web resource

6,841 UniProtKB/Swiss-Prot entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

  • 8.2%Alanine
  • 5.5%Arginine
  • 4.0%Asparagine
  • 5.4%Aspartate
  • 1.3%Cysteine
  • 3.9%Glutamine
  • 6.7%Glutamate
  • 7.0%Glycine
  • 2.2%Histidine
  • 5.9%Isoleucine
  • 9.6%Leucine
  • 5.8%Lysine
  • 2.4%Methionine
  • 3.8%Phenylalanine
  • 4.7%Proline
  • 6.6%Serine
  • 5.3%Threonine
  • 1.0%Tryptophan
  • 2.9%Tyrosine
  • 6.8%Valine
  • Aliphatic
  • Acidic
  • Small hydroxy
  • Basic
  • Amide
  • Aromatic
  • Sulfur

Miscellaneous Statistics

16,041 entries are encoded on a mitochondrion, and 3,779 are encoded on a plasmid.

12,188 entries are encoded on a plastid, of which 21 are encoded on apicoplasts, 11,623 on chloroplasts, 51 on organellar chromatophores, 145 on cyanelles, 149 on non-photosynthetic plastids and 17 on unspecified types of plastid.