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Introduction

Number of entries
New entries 319
Updated entries 453,172
Unchanged entries 98,496
Total 551,987
Entries with updated sequences 49
With a fragmented AA sequence 9,150
With known alternative products 24,607
Protein Existence (PE) Number of entries
1 Evidence at protein level 93,176
2 Evidence at transcript level 57,818
3 Inferred from homology 387,730
4 Predicted 11,318
5 Uncertain 1,945

Taxonomic Origin

Swiss-Prot entries per taxonomic group


Statistics on the number of species

Number of species in
New entries 57
Updated entries 4,915
Unchanged entries 8,364
Total 10,420

Sequence data

The shortest sequence is P83570 at 2 AA while the longest sequence is A2ASS6 at 35,213 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 708 708
Alternative products 24,607 24,607
Biophysicochemical properties 7,122 7,122
Biotechnological use 688 686
Catalytic activity 257,971 231,568
Caution 31,804 57,513
Cofactor 212,404 551,987
Developmental stage 11,063 11,063
Involvement in disease 6,341 4,231
Disruption phenotype 10,638 10,638
Domain 44,443 38,483
Enzyme regulation 13,544 13,543
Function 448,248 429,706
Induction 18,437 18,436
Mass spectrometry 6,124 4,624
Miscellaneous 35,866 33,042
Pathway 135,702 122,958
Pharmaceutical use 99 99
Polymorphism 1,053 997
Post-translational modification 51,204 38,999
RNA Editing 627 627
Sequence caution 59,883 43,349
Sequence similarities 670,367 527,110
Subcellular Location 646,136 551,987
Subunit structure 265,371 265,226
Tissue specificity 42,967 42,967
Toxic dose 623 577

Sequence Annotation (features)

Annotations Entries
Molecule processing 651,855 551,987
Chain 559,577 545,548
Initiator methionine 18,447 18,406
Peptide 10,749 7,302
Propeptide 13,507 11,589
Signal peptide 40,453 40,443
Transit peptide 9,122 9,009
Regions 1,276,445 306,606
Calcium binding 3,992 1,679
Coiled-coil 21,576 14,869
Compositional bias 57,754 30,934
DNA binding 11,308 10,279
Domain 181,423 109,992
Motif 40,173 25,974
Nucleotide binding 143,859 81,363
Repeat 101,018 14,382
Region 180,403 85,411
Topological domain 136,452 28,113
Transmembrane 366,082 75,956
Zinc finger 29,975 13,205
Sites 936,737 199,128
Active site 157,586 96,307
Metal binding 362,525 90,078
Binding site 363,928 95,667
Other 52,698 29,411
Amino acid modifications 492,956 112,622
Cross-link 13,014 6,390
Disulfide bond 118,377 32,298
Glycosylation 112,497 28,831
Lipidation 12,665 8,125
Modified residue 236,044 70,130
Non-standard residue 359 284
Natural variations 144,568 30,918
Natural variant 144,568 30,918
Alternative sequence 51,120 21,522
Experimental info 227,840 63,898
Mutagenesis 58,217 13,171
Non-adjacent residues 2,238 777
Non-terminal residue 12,267 9,384
Sequence conflict 150,788 46,513
Sequence uncertainty 4,330 757
Secondary structure 508,161 21,697
Helix 222,733 20,904
Turn 53,551 16,948
Beta strand 231,877 19,711

Citation usage

Citation type Citations Entries
Submission192,678167,729
Journal article960,695441,436
Book1,4921,478
Thesis428425
Patent197193
Unpublished observations389385
Online journal article610597

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 748,185 1,047,629

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
CCDS46,62833,623
EMBL943,445540,637
PIR123,116112,795
RefSeq596,562462,766
UniGene106,98794,912
3D structure databases
DisProt605602
PDB132,30323,696
PDBsum132,30323,696
ProteinModelPortal444,105444,105
SMR226,129226,129
Protein-protein interaction databases
BioGrid48,38347,931
DIP16,92216,866
IntAct46,42246,422
MINT31,75031,750
STRING326,367326,367
Chemistry
BindingDB4,6104,610
ChEMBL6,3916,391
DrugBank11,7841,909
GuidetoPHARMACOLOGY1,8891,889
SwissLipids1,064986
Protein family/group databases
Allergome1,7031,114
CAZy9,3898,467
ESTHER2,4432,441
MEROPS12,94712,947
MoonProt6363
PeroxiBase771755
REBASE405405
TCDB6,0706,039
mycoCLAP349345
PTM databases
DEPOD239239
PhosphoSite38,69338,693
SwissPalm5,9475,947
UniCarbKB584584
iPTMnet45,90545,905
Polymorphism and mutation databases
BioMuta17,24517,241
DMDM16,37316,352
dbSNP51,13112,317
2D gel databases
COMPLUYEAST-2DPAGE9998
DOSAC-COBS-2DPAGE146146
OGP375375
REPRODUCTION-2DPAGE1,2591,038
SWISS-2DPAGE1,1801,180
UCD-2DPAGE508499
World-2DPAGE925914
Proteomic databases
EPD19,57519,575
MaxQB32,29532,295
PRIDE123,973123,973
PaxDb110,930110,754
PeptideAtlas28,66028,660
ProMEX437437
TopDownProteomics3,2222,944
Protocols and materials databases
DNASU18,88518,813
Genome annotation databases
Ensembl84,59248,504
EnsemblBacteria354,865335,851
EnsemblFungi30,36527,922
EnsemblMetazoa13,2859,889
EnsemblPlants22,25718,953
EnsemblProtists4,8824,719
GeneDB390351
GeneID274,667265,912
Gramene18,36715,969
KEGG501,515465,101
PATRIC308,293308,258
UCSC48,80444,789
VectorBase731666
WBParaSite3030
Organism-specific databases
ArachnoServer1,1461,136
CGD1,7101,693
CTD73,70372,954
ConoServer949866
EchoBASE4,1614,161
EcoGene4,2944,292
EuPathDB18,11518,113
FlyBase6,0305,668
GeneCards20,01719,842
GeneReviews1,1561,153
H-InvDB5,5894,768
HGNC20,00919,861
HPA26,77317,134
LegioList765763
Leproma672669
MGI16,72616,682
MIM19,89914,521
MaizeGDB506501
MalaCards3,7733,771
Orphanet6,1483,289
PharmGKB18,37818,337
PomBase5,1405,136
PseudoCAP1,3091,300
RGD7,8907,887
SGD6,7396,734
TAIR14,77514,719
TubercuList2,1302,095
WormBase5,5574,289
Xenbase4,4504,444
ZFIN2,8122,812
dictyBase4,2084,093
euHCVdb5544
neXtProt20,03720,034
Phylogenomic databases
GeneTree56,07756,033
HOGENOM389,071389,071
HOVERGEN75,77875,778
InParanoid136,094136,094
KO390,610390,166
OMA412,135412,135
OrthoDB261,859261,859
PhylomeDB94,89594,895
TreeFam44,98344,977
eggNOG657,810328,322
Enzyme and pathway databases
BRENDA12,77111,999
BioCyc325,667308,357
Reactome100,98330,635
SABIO-RK3,3843,384
SIGNOR2,9412,941
SignaLink3,0023,002
UniPathway135,340122,608
Other
ChiTaRS16,47716,467
EvolutionaryTrace16,55816,556
GeneWiki10,36810,282
GenomeRNAi21,82821,828
PMAP-CutDB1,4611,461
PRO90,18290,182
Gene expression databases
Bgee54,78454,784
CleanEx30,04129,401
CollecTF133133
ExpressionAtlas33,16733,167
Genevisible55,15155,151
Ontologies
Family and domain databases
CDD76,91876,071
Gene3D472,646348,366
HAMAP325,933323,124
InterPro1,949,015532,280
PANTHER174,501167,225
PIRSF104,453103,415
PRINTS133,837118,042
PROSITE453,684291,627
Pfam745,185510,051
ProDom29,15528,974
SMART189,490139,891
SUPFAM480,252364,171
TIGRFAMs291,985271,972

Web resource

6,801 UniProtKB/Swiss-Prot entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

  • 8.2%Alanine
  • 5.5%Arginine
  • 4.0%Asparagine
  • 5.4%Aspartate
  • 1.3%Cysteine
  • 3.9%Glutamine
  • 6.7%Glutamate
  • 7.0%Glycine
  • 2.2%Histidine
  • 5.9%Isoleucine
  • 9.6%Leucine
  • 5.8%Lysine
  • 2.4%Methionine
  • 3.8%Phenylalanine
  • 4.7%Proline
  • 6.6%Serine
  • 5.3%Threonine
  • 1.0%Tryptophan
  • 2.9%Tyrosine
  • 6.8%Valine
  • Aliphatic
  • Acidic
  • Small hydroxy
  • Basic
  • Amide
  • Aromatic
  • Sulfur

Miscellaneous Statistics

15,999 entries are encoded on a mitochondrion, and 3,779 are encoded on a plasmid.

12,188 entries are encoded on a plastid, of which 21 are encoded on apicoplasts, 11,623 on chloroplasts, 51 on organellar chromatophores, 145 on cyanelles, 149 on non-photosynthetic plastids and 16 on unspecified types of plastid.