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Introduction

Number of entries
New entries 253
Updated entries 88,437
Unchanged entries 461,862
Total 550,552
Entries with updated sequences 19
With a fragmented AA sequence 9,151
With known alternative products 24,482
Protein Existence (PE) Number of entries
1 Evidence at protein level 91,883
2 Evidence at transcript level 57,698
3 Inferred from homology 387,610
4 Predicted 11,411
5 Uncertain 1,950

Taxonomic Origin

Swiss-Prot entries per taxonomic group


Statistics on the number of species

Number of species in
New entries 78
Updated entries 1,568
Unchanged entries 10,149
Total 10,379

Sequence data

The shortest sequence is P83570 at 2 AA while the longest sequence is A2ASS6 at 35,213 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 692 692
Alternative products 24,482 24,482
Biophysicochemical properties 6,891 6,891
Biotechnological use 474 472
Catalytic activity 256,234 230,031
Caution 31,701 59,206
Cofactor 210,451 121,124
Developmental stage 10,840 10,840
Involvement in disease 6,152 4,117
Disruption phenotype 9,725 9,725
Domain 43,902 38,009
Enzyme regulation 13,388 13,388
Function 445,576 427,210
Induction 17,909 17,909
Mass spectrometry 6,063 4,572
Miscellaneous 35,119 32,298
Pathway 135,194 122,528
Pharmaceutical use 99 99
Polymorphism 1,044 988
Post-translational modification 50,604 38,643
RNA Editing 627 627
Sequence caution 59,194 42,943
Sequence similarities 666,366 525,630
Subcellular Location 640,194 329
Subunit structure 263,743 263,743
Tissue specificity 42,396 42,396
Toxic dose 622 576

Sequence Annotation (features)

Annotations Entries
Molecule processing 649,898 550,552
Chain 558,111 544,137
Initiator methionine 18,378 18,337
Peptide 10,712 7,276
Propeptide 13,434 11,518
Signal peptide 40,204 40,194
Transit peptide 9,059 8,946
Regions 1,260,996 303,330
Calcium binding 3,985 1,676
Coiled-coil 21,344 14,723
Compositional bias 57,346 30,674
DNA binding 11,182 10,158
Domain 178,419 108,040
Motif 39,850 25,719
Nucleotide binding 139,303 79,812
Repeat 100,371 14,305
Region 176,207 83,673
Topological domain 135,509 27,907
Transmembrane 365,121 75,702
Zinc finger 29,959 13,250
Sites 913,243 197,606
Active site 156,456 95,510
Metal binding 354,343 87,984
Binding site 350,334 93,042
Other 52,110 29,128
Amino acid modifications 470,204 110,775
Cross-link 11,124 5,569
Disulfide bond 117,404 32,114
Glycosylation 111,808 28,632
Lipidation 12,572 8,084
Modified residue 216,938 68,401
Non-standard residue 358 283
Natural variations 142,899 30,808
Natural variant 142,899 30,808
Alternative sequence 50,917 21,419
Experimental info 224,776 63,393
Mutagenesis 55,863 12,693
Non-adjacent residues 2,238 776
Non-terminal residue 12,283 9,399
Sequence conflict 150,115 46,318
Sequence uncertainty 4,277 756
Secondary structure 494,010 21,203
Helix 216,208 20,421
Turn 52,155 16,549
Beta strand 225,647 19,247

Citation usage

Citation type Citations Entries
Submission192,549167,829
Journal article939,148439,327
Book1,4921,478
Thesis428425
Patent192189
Unpublished observations384380
Online journal article610597

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 712,413 1,054,717

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
CCDS46,54733,564
EMBL934,711539,231
PIR122,819112,534
RefSeq597,158460,320
UniGene105,17693,763
3D structure databases
DisProt605602
PDB124,77623,052
PDBsum124,77623,052
ProteinModelPortal443,633443,633
SMR225,879225,879
Protein-protein interaction databases
BioGrid47,27646,832
DIP16,69816,641
IntAct45,40445,404
MINT31,69131,691
STRING325,614325,614
Chemistry
BindingDB5,6875,687
ChEMBL6,1626,162
DrugBank11,6011,891
GuidetoPHARMACOLOGY1,8291,829
SwissLipids923852
Protein family/group databases
Allergome1,6861,103
CAZy7,8777,086
ESTHER2,4302,428
MEROPS12,90312,903
MoonProt6363
PeroxiBase771755
REBASE413413
TCDB5,9275,897
mycoCLAP347343
PTM databases
DEPOD239239
PhosphoSite33,54433,544
SwissPalm4,9194,919
UniCarbKB584584
iPTMnet35,77535,775
Polymorphism and mutation databases
BioMuta17,24617,245
DMDM16,37616,375
dbSNP38,59711,715
2D gel databases
COMPLUYEAST-2DPAGE9998
DOSAC-COBS-2DPAGE146146
OGP375375
REPRODUCTION-2DPAGE1,2591,038
SWISS-2DPAGE1,1801,180
UCD-2DPAGE508499
World-2DPAGE924913
Proteomic databases
MaxQB33,37833,378
PRIDE123,832123,832
PaxDb110,424110,407
PeptideAtlas5,1605,160
ProMEX428428
Protocols and materials databases
DNASU18,86218,791
Genome annotation databases
Ensembl84,16148,384
EnsemblBacteria354,404335,388
EnsemblFungi29,98927,626
EnsemblMetazoa13,1709,757
EnsemblPlants21,78618,566
EnsemblProtists4,8714,708
GeneDB388349
GeneID273,522264,478
Gramene18,01315,642
KEGG492,287459,360
PATRIC308,159308,124
UCSC60,42145,074
VectorBase615597
WBParaSite2222
Organism-specific databases
ArachnoServer1,1461,136
CGD1,7071,691
CTD73,27272,528
ConoServer949866
EchoBASE4,1614,161
EcoGene4,2944,292
EuPathDB16,70016,700
FlyBase5,9715,609
GeneCards20,02619,851
GeneReviews1,1561,153
H-InvDB5,5894,768
HGNC20,01019,861
HPA24,70016,208
LegioList765763
Leproma672669
MGI16,68116,637
MIM19,67414,456
MaizeGDB506501
MalaCards3,7753,773
Orphanet6,1483,289
PharmGKB18,38318,342
PomBase5,1395,120
PseudoCAP1,3071,298
RGD7,8707,867
SGD6,7396,734
TAIR14,48314,427
TubercuList2,1212,085
WormBase5,4324,212
Xenbase4,7734,767
ZFIN2,8002,800
dictyBase4,2074,092
euHCVdb5544
neXtProt20,04020,040
Phylogenomic databases
GeneTree55,45955,415
HOGENOM388,390388,390
HOVERGEN75,75775,757
InParanoid135,815135,815
KO383,749383,311
OMA406,820406,820
OrthoDB390,772390,772
PhylomeDB94,58694,586
TreeFam44,91944,914
eggNOG656,130327,493
Enzyme and pathway databases
BRENDA12,73111,963
BioCyc325,401308,117
Reactome93,42128,482
SABIO-RK3,2743,274
SignaLink2,9972,997
UniPathway134,948122,293
Other
ChiTaRS16,46816,458
EvolutionaryTrace16,54316,541
GeneWiki10,36810,282
GenomeRNAi21,74421,744
NextBio71,56971,569
PMAP-CutDB1,4611,461
PRO88,80288,802
Gene expression databases
Bgee38,85738,857
CleanEx30,04529,405
CollecTF133133
ExpressionAtlas31,37831,378
Genevisible55,12355,123
Ontologies
GO2,730,666522,347
Family and domain databases
Gene3D471,551347,582
HAMAP325,506322,433
InterPro1,933,684530,626
PANTHER167,769161,502
PIRSF104,333103,295
PRINTS134,181118,264
PROSITE451,833290,474
Pfam744,169508,824
ProDom28,59828,417
SMART171,335128,291
SUPFAM478,555363,147
TIGRFAMs291,476271,242

Web resource

6,889 UniProtKB/Swiss-Prot entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

  • 8.2%Alanine
  • 5.5%Arginine
  • 4.0%Asparagine
  • 5.4%Aspartate
  • 1.3%Cysteine
  • 3.9%Glutamine
  • 6.7%Glutamate
  • 7.0%Glycine
  • 2.2%Histidine
  • 5.9%Isoleucine
  • 9.6%Leucine
  • 5.8%Lysine
  • 2.4%Methionine
  • 3.8%Phenylalanine
  • 4.7%Proline
  • 6.5%Serine
  • 5.3%Threonine
  • 1.0%Tryptophan
  • 2.9%Tyrosine
  • 6.8%Valine
  • Aliphatic
  • Acidic
  • Small hydroxy
  • Basic
  • Amide
  • Aromatic
  • Sulfur

Miscellaneous Statistics

15,940 entries are encoded on a mitochondrion, and 3,768 are encoded on a plasmid.

12,188 entries are encoded on a plastid, of which 21 are encoded on apicoplasts, 11,623 on chloroplasts, 51 on organellar chromatophores, 145 on cyanelles, 149 on non-photosynthetic plastids and 16 on unspecified types of plastid.