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Introduction

Number of entries
New entries 199
Updated entries 477,257
Unchanged entries 72,376
Total 549,832
Entries with updated sequences 29
With a fragmented AA sequence 9,152
With known alternative products 24,406
Protein Existence (PE) Number of entries
1 Evidence at protein level 91,145
2 Evidence at transcript level 57,676
3 Inferred from homology 387,608
4 Predicted 11,449
5 Uncertain 1,954

Taxonomic Origin

Swiss-Prot entries per taxonomic group


Statistics on the number of species

Number of species in
New entries 54
Updated entries 3,976
Unchanged entries 8,972
Total 10,366

Sequence data

The shortest sequence is P83570 at 2 AA while the longest sequence is A2ASS6 at 35,213 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 678 678
Alternative products 24,406 24,406
Biophysicochemical properties 6,753 6,753
Biotechnological use 463 461
Catalytic activity 254,767 229,457
Caution 31,604 59,001
Cofactor 209,739 120,653
Developmental stage 10,755 10,755
Involvement in disease 6,142 4,119
Disruption phenotype 9,367 9,367
Domain 43,613 37,781
Enzyme regulation 13,297 13,297
Function 443,296 425,036
Induction 17,711 17,711
Mass spectrometry 6,016 4,547
Miscellaneous 34,827 32,019
Pathway 134,948 122,298
Pharmaceutical use 99 99
Polymorphism 1,049 992
Post-translational modification 49,488 37,703
RNA Editing 627 627
Sequence caution 58,943 42,784
Sequence similarities 664,449 524,935
Subcellular Location 635,491 334
Subunit structure 262,500 262,500
Tissue specificity 42,139 42,139
Toxic dose 620 574

Sequence Annotation (features)

Annotations Entries
Molecule processing 648,679 549,832
Chain 557,355 543,437
Initiator methionine 18,354 18,318
Peptide 10,663 7,249
Propeptide 13,275 11,413
Signal peptide 40,000 39,990
Transit peptide 9,032 8,919
Regions 1,252,410 301,318
Calcium binding 3,985 1,678
Coiled-coil 21,279 14,684
Compositional bias 57,143 30,553
DNA binding 11,170 10,148
Domain 177,000 107,413
Motif 39,138 25,312
Nucleotide binding 138,180 79,509
Repeat 100,022 14,418
Region 172,739 82,128
Topological domain 135,013 27,795
Transmembrane 364,454 75,544
Zinc finger 29,887 13,214
Sites 902,910 196,439
Active site 153,871 94,321
Metal binding 351,533 87,501
Binding site 346,263 92,038
Other 51,243 28,373
Amino acid modifications 467,087 110,237
Cross-link 9,949 5,168
Disulfide bond 116,692 31,891
Glycosylation 111,162 28,491
Lipidation 12,505 8,036
Modified residue 216,421 68,174
Non-standard residue 358 283
Natural variations 142,210 30,748
Natural variant 142,210 30,748
Alternative sequence 50,778 21,358
Experimental info 223,362 63,147
Mutagenesis 54,794 12,475
Non-adjacent residues 2,225 775
Non-terminal residue 12,290 9,401
Sequence conflict 149,848 46,220
Sequence uncertainty 4,205 753
Secondary structure 486,184 20,889
Helix 212,765 20,114
Turn 51,353 16,313
Beta strand 222,066 18,965

Citation usage

Citation type Citations Entries
Submission192,114167,508
Journal article933,779438,596
Book1,4851,471
Thesis428425
Patent192189
Unpublished observations374370
Online journal article610597

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 699,758 1,029,564

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
CCDS46,51633,534
EMBL932,674538,547
PIR122,614112,341
RefSeq595,727459,529
UniGene104,56793,340
3D structure databases
DisProt605602
PDB121,70822,709
PDBsum121,70822,709
ProteinModelPortal354,723354,723
SMR225,575225,575
Protein-protein interaction databases
BioGrid43,19542,824
DIP16,43216,375
IntAct44,55544,555
MINT31,67031,670
STRING325,158325,158
Chemistry
BindingDB5,6475,647
ChEMBL6,1606,160
DrugBank11,4131,807
GuidetoPHARMACOLOGY2,2662,266
Protein family/group databases
Allergome1,6621,082
CAZy7,8747,083
ESTHER2,4212,419
MEROPS12,83012,830
MoonProt6363
PeroxiBase771755
REBASE388388
TCDB5,6465,622
mycoCLAP347343
PTM databases
DEPOD239239
PhosphoSite33,54533,545
UniCarbKB272272
Polymorphism and mutation databases
BioMuta17,24917,248
DMDM16,38316,382
dbSNP38,22611,679
2D gel databases
COMPLUYEAST-2DPAGE9998
DOSAC-COBS-2DPAGE148146
OGP375375
REPRODUCTION-2DPAGE1,2591,038
SWISS-2DPAGE1,1811,180
UCD-2DPAGE508499
World-2DPAGE923912
Proteomic databases
MaxQB32,19732,197
PRIDE123,734123,734
PaxDb110,244110,244
PeptideAtlas5,1605,160
ProMEX418418
Protocols and materials databases
DNASU18,83818,767
Genome annotation databases
Ensembl83,69848,304
EnsemblBacteria354,325335,256
EnsemblFungi29,55827,475
EnsemblMetazoa7,9356,643
EnsemblPlants21,51818,330
EnsemblProtists9,0504,761
GeneID278,846269,288
KEGG483,547450,908
PATRIC308,053308,018
UCSC60,31145,003
VectorBase615597
WBParaSite2121
Organism-specific databases
ArachnoServer1,1461,136
CGD967936
CTD73,15272,420
ConoServer949866
EchoBASE4,1614,161
EcoGene4,2944,292
EuPathDB16,81516,815
FlyBase5,9545,592
GeneCards20,03319,858
GeneFarm3,3733,361
GeneReviews1,1561,153
GenoList7,0757,063
Gramene6,3946,394
H-InvDB5,5894,768
HGNC20,00119,850
HPA24,70716,213
LegioList765763
Leproma672669
MGI16,64916,605
MIM19,54814,352
MaizeGDB506501
Orphanet6,1483,289
PharmGKB18,38618,345
PomBase5,1395,120
PseudoCAP1,3021,293
RGD7,8647,861
SGD6,7396,734
TAIR14,29014,234
TubercuList2,1102,074
WormBase5,3754,175
Xenbase4,7734,767
ZFIN2,8012,800
dictyBase4,2074,092
euHCVdb5544
neXtProt20,04820,048
Phylogenomic databases
GeneTree52,73852,706
HOGENOM388,058388,058
HOVERGEN75,73475,734
InParanoid135,690135,690
KO375,914375,455
OMA406,384406,384
OrthoDB390,504390,504
PhylomeDB94,54694,546
TreeFam44,88944,884
eggNOG655,520327,102
Enzyme and pathway databases
BRENDA12,70611,939
BioCyc325,185307,921
Reactome93,55327,726
SABIO-RK3,2743,274
SignaLink3,0402,997
UniPathway134,733122,092
Other
ChiTaRS16,46216,452
EvolutionaryTrace16,53416,532
GeneWiki10,36810,282
GenomeRNAi21,72921,729
NextBio71,52371,523
PMAP-CutDB1,4611,461
PRO89,86989,869
Gene expression databases
Bgee38,84438,844
CleanEx30,05029,410
ExpressionAtlas30,65030,650
Genevisible55,10955,109
Ontologies
GO2,700,500521,394
Family and domain databases
Gene3D454,742337,026
HAMAP324,889321,817
InterPro1,923,336529,703
PANTHER167,612161,548
PIRSF104,295103,257
PRINTS134,159118,240
PROSITE450,289289,639
Pfam735,562506,050
ProDom29,31629,137
SMART171,072128,142
SUPFAM459,768351,464
TIGRFAMs292,193271,950

Web resource

6,871 UniProtKB/Swiss-Prot entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

  • 8.2%Alanine
  • 5.5%Arginine
  • 4.0%Asparagine
  • 5.4%Aspartate
  • 1.3%Cysteine
  • 3.9%Glutamine
  • 6.7%Glutamate
  • 7.0%Glycine
  • 2.2%Histidine
  • 5.9%Isoleucine
  • 9.6%Leucine
  • 5.8%Lysine
  • 2.4%Methionine
  • 3.8%Phenylalanine
  • 4.7%Proline
  • 6.5%Serine
  • 5.3%Threonine
  • 1.0%Tryptophan
  • 2.9%Tyrosine
  • 6.8%Valine
  • Aliphatic
  • Acidic
  • Small hydroxy
  • Basic
  • Amide
  • Aromatic
  • Sulfur

Miscellaneous Statistics

15,921 entries are encoded on a mitochondrion, and 3,764 are encoded on a plasmid.

12,188 entries are encoded on a plastid, of which 21 are encoded on apicoplasts, 11,623 on chloroplasts, 51 on organellar chromatophores, 145 on cyanelles, 149 on non-photosynthetic plastids and 16 on unspecified types of plastid.