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Introduction

Number of entries
New entries 247
Updated entries 318,715
Unchanged entries 229,246
Total 548,208
Entries with updated sequences 51
With a fragmented AA sequence 9,118
With known alternative products 24,178
Protein Existence (PE) Number of entries
1 Evidence at protein level 85,854
2 Evidence at transcript level 62,618
3 Inferred from homology 386,290
4 Predicted 11,480
5 Uncertain 1,966

Taxonomic Origin

Swiss-Prot entries per taxonomic group


Statistics on the number of species

Number of species in
New entries 71
Updated entries 5,778
Unchanged entries 7,887
Total 10,321

Sequence data

The shortest sequence is P83570 at 2 AA while the longest sequence is A2ASS6 at 35,213 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 664 664
Alternative products 24,178 24,178
Biophysicochemical properties 6,430 6,430
Biotechnological use 438 436
Catalytic activity 253,931 228,930
Caution 31,618 58,602
Cofactor 208,534 120,207
Developmental stage 10,503 10,503
Involvement in disease 5,948 4,002
Disruption phenotype 8,482 8,482
Domain 42,929 37,255
Enzyme regulation 13,102 13,102
Function 440,379 422,392
Induction 17,179 17,179
Mass spectrometry 5,908 4,479
Miscellaneous 34,450 31,660
Pathway 134,661 122,099
Pharmaceutical use 98 98
Polymorphism 1,045 987
Post-translational modification 48,632 37,201
RNA Editing 627 627
Sequence caution 58,477 42,494
Sequence similarities 661,245 523,313
Subcellular Location 637,297 332
Subunit structure 258,944 258,944
Tissue specificity 41,338 41,338
Toxic dose 605 559

Sequence Annotation (features)

Annotations Entries
Molecule processing 645,770 548,208
Chain 555,684 541,841
Initiator methionine 17,960 17,960
Peptide 10,574 7,209
Propeptide 13,075 11,267
Signal peptide 39,619 39,609
Transit peptide 8,858 8,745
Regions 1,237,323 298,107
Calcium binding 3,985 1,678
Coiled-coil 21,015 14,489
Compositional bias 56,653 30,234
DNA binding 10,811 9,815
Domain 175,469 106,361
Motif 38,725 25,017
Nucleotide binding 134,831 78,793
Repeat 99,198 14,355
Region 167,632 80,297
Topological domain 134,405 27,607
Transmembrane 362,424 75,116
Zinc finger 29,835 13,180
Sites 891,173 193,340
Active site 152,224 93,242
Metal binding 347,314 86,203
Binding site 341,230 90,114
Other 50,405 28,051
Amino acid modifications 431,401 106,802
Cross-link 7,600 4,164
Disulfide bond 115,789 31,601
Glycosylation 109,819 28,209
Lipidation 12,280 7,884
Modified residue 185,555 64,071
Non-standard residue 358 283
Natural variations 139,942 30,530
Natural variant 0 0
Alternative sequence 50,411 21,174
Experimental info 219,056 62,457
Mutagenesis 52,125 11,904
Non-adjacent residues 2,051 757
Non-terminal residue 12,274 9,383
Sequence conflict 148,963 45,955
Sequence uncertainty 3,643 734
Secondary structure 470,344 20,295
Helix 205,682 19,540
Turn 49,736 15,845
Beta strand 214,926 18,433

Citation usage

Citation type Citations Entries
Submission190,998166,780
Journal article906,936436,484
Book1,4831,469
Thesis426423
Patent191188
Unpublished observations341337
Online journal article608595

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 668,675 529,002

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
CCDS45,68533,432
EMBL927,885536,980
PIR122,155111,916
RefSeq645,632480,646
UniGene103,36793,083
3D structure databases
DisProt605602
PDB112,33521,835
PDBsum112,33521,835
ProteinModelPortal373,374373,374
SMR224,338224,338
Protein-protein interaction databases
BioGrid40,73940,371
DIP15,98915,929
IntAct43,29943,299
MINT31,61631,616
STRING403,759403,759
Chemistry
BindingDB5,4725,472
ChEMBL6,1586,158
DrugBank11,2131,762
GuidetoPHARMACOLOGY2,0682,067
Protein family/group databases
Allergome1,6391,065
CAZy7,8017,020
MEROPS12,86712,867
MoonProt6363
PeroxiBase770754
REBASE407407
TCDB5,3955,374
mycoCLAP322317
PTM databases
DEPOD239239
PhosphoSite33,55633,556
UniCarbKB272272
Polymorphism and mutation databases
DMDM16,40016,400
dbSNP38,18411,678
2D gel databases
COMPLUYEAST-2DPAGE9998
DOSAC-COBS-2DPAGE149147
OGP376376
REPRODUCTION-2DPAGE1,2581,037
SWISS-2DPAGE1,1821,181
UCD-2DPAGE509500
World-2DPAGE922911
Proteomic databases
MaxQB31,64931,649
PRIDE123,356123,356
PaxDb66,68166,680
PeptideAtlas5,1605,160
ProMEX402402
Protocols and materials databases
DNASU18,80018,730
Genome annotation databases
Ensembl82,90948,348
EnsemblBacteria343,315325,101
EnsemblFungi19,32818,990
EnsemblMetazoa12,6709,497
EnsemblPlants20,45317,459
EnsemblProtists4,4404,315
GeneID306,177287,671
KEGG485,414458,052
PATRIC307,902307,867
UCSC59,38744,822
VectorBase615597
Organism-specific databases
ArachnoServer789781
CGD965935
CTD72,44871,755
CYGD5,5965,593
ConoServer949866
EchoBASE4,1614,161
EcoGene4,2944,292
EuPathDB820820
FlyBase5,9475,573
GeneCards20,86919,793
GeneFarm3,3733,361
GeneReviews1,1561,153
GenoList7,0757,063
Gramene6,2656,265
H-InvDB5,5904,770
HGNC20,01219,850
HPA24,72116,225
LegioList765763
Leproma671668
MGI16,62316,579
MIM19,22014,197
MaizeGDB505500
Orphanet6,1483,289
PharmGKB18,39118,359
PomBase5,1395,103
PseudoCAP1,2911,282
RGD7,8447,840
SGD6,7376,732
TAIR13,80513,749
TubercuList2,0782,042
WormBase5,1244,050
Xenbase4,7694,763
ZFIN2,7802,780
dictyBase4,2074,091
euHCVdb5544
neXtProt20,05620,056
Phylogenomic databases
GeneTree55,19655,172
HOGENOM387,297387,297
HOVERGEN75,69075,690
InParanoid135,165135,165
KO380,060379,570
OMA408,330408,330
OrthoDB390,025390,025
PhylomeDB93,93593,935
TreeFam44,81044,805
eggNOG431,530431,530
Enzyme and pathway databases
BRENDA12,67411,907
BioCyc324,897307,663
Reactome87,90326,447
SABIO-RK3,0033,003
SignaLink2,9852,970
UniPathway134,450121,897
Other
ChiTaRS16,45216,443
EvolutionaryTrace16,50716,507
GeneWiki10,36710,281
GenomeRNAi21,69221,692
NextBio71,32471,324
PMAP-CutDB1,4611,461
PRO58,14658,146
Gene expression databases
Bgee38,84038,840
CleanEx30,06029,421
ExpressionAtlas33,84633,846
Genevestigator68,75568,755
Ontologies
GO2,644,203519,638
Family and domain databases
Gene3D463,713341,784
HAMAP324,414321,460
InterPro1,910,680527,259
PANTHER180,987173,976
PIRSF104,173103,144
PRINTS136,825120,545
PROSITE447,910288,558
Pfam740,304507,872
ProDom29,26129,082
SMART170,366127,612
SUPFAM441,789340,685
TIGRFAMs291,412271,233

Web resource

6,940 UniProtKB/Swiss-Prot entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

  • 8.2%Alanine
  • 5.5%Arginine
  • 4.0%Asparagine
  • 5.4%Aspartate
  • 1.3%Cysteine
  • 3.9%Glutamine
  • 6.7%Glutamate
  • 7.0%Glycine
  • 2.2%Histidine
  • 5.9%Isoleucine
  • 9.6%Leucine
  • 5.8%Lysine
  • 2.4%Methionine
  • 3.8%Phenylalanine
  • 4.7%Proline
  • 6.5%Serine
  • 5.3%Threonine
  • 1.0%Tryptophan
  • 2.9%Tyrosine
  • 6.8%Valine
  • Aliphatic
  • Acidic
  • Small hydroxy
  • Basic
  • Amide
  • Aromatic
  • Sulfur

Miscellaneous Statistics

15,790 entries are encoded on a mitochondrion, and 3,748 are encoded on a plasmid.

12,188 entries are encoded on a plastid, of which 21 are encoded on apicoplasts, 11,623 on chloroplasts, 51 on organellar chromatophores, 145 on cyanelles, 149 on non-photosynthetic plastids and 16 on unspecified types of plastid.