Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.



         UniProtKB/Swiss-Prot protein knowledgebase release 2014_01 statistics





1.  INTRODUCTION



Release 2014_01 of 22-Jan-14 of UniProtKB/Swiss-Prot contains 542258 sequence entries,

comprising 192776118 amino acids abstracted from 225339 references. 



317 sequences have been added since release 2013_12, the sequence data of

36 existing entries has been updated and the annotations of

134065 entries have been revised.



Number of fragments: 9089

Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 35774





Protein existence (PE):           entries     %



1: Evidence at protein level        81499     15%

2: Evidence at transcript level     62330   11.5%

3: Inferred from homology          380804   70.2%

4: Predicted                        15733    2.9%

5: Uncertain                         1892    0.3%



The growth of the database is summarized below.



   





2.  TAXONOMIC ORIGIN



   Total number of species represented in this release of UniProtKB/Swiss-Prot: 13052



   The first twenty species represent 114230 sequences:  21.1 % of the total

   number of entries.





   2.1 Table of the frequency of occurrence of species



        Species represented 1x: 5446

                            2x: 1896

                            3x:  994

                            4x:  646

                            5x:  468

                            6x:  393

                            7x:  289

                            8x:  223

                            9x:  211

                           10x:  122

                       11- 20x:  694

                       21- 50x:  414

                       51-100x:  214

                         >100x: 1042





   2.2  Table of the most represented species



  ------  ---------  --------------------------------------------

  Number  Frequency  Species

  ------  ---------  --------------------------------------------

       1      20272  Homo sapiens (Human)

       2      16649  Mus musculus (Mouse)

       3      12581  Arabidopsis thaliana (Mouse-ear cress)

       4       7880  Rattus norvegicus (Rat)

       5       6621  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

       6       5983  Bos taurus (Bovine)

       7       5097  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

       8       4431  Escherichia coli (strain K12)

       9       4185  Bacillus subtilis (strain 168)

      10       4127  Dictyostelium discoideum (Slime mold)

      11       3461  Caenorhabditis elegans

      12       3379  Xenopus laevis (African clawed frog)

      13       3218  Drosophila melanogaster (Fruit fly)

      14       3118  Oryza sativa subsp. japonica (Rice)

      15       2910  Danio rerio (Zebrafish) (Brachydanio rerio)

      16       2256  Gallus gallus (Chicken)

      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

      18       2042  Mycobacterium tuberculosis

      19       2015  Escherichia coli O157:H7

      20       1787  Methanocaldococcus jannaschii  

      21       1772  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

      23       1698  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

      24       1684  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

      25       1679  Shigella flexneri

      26       1413  Sus scrofa (Pig)

      27       1346  Salmonella typhi

      28       1258  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)

      29       1242  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)

      30       1169  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

      31       1043  Synechocystis sp. (strain PCC 6803 / Kazusa)

      32       1019  Yersinia pestis

      33       1017  Archaeoglobus fulgidus 

      34        953  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

      35        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)

      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  

      37        925  Staphylococcus aureus (strain N315)

      38        924  Staphylococcus aureus (strain Mu50 / ATCC 700699)

      39        909  Acanthamoeba polyphaga mimivirus (APMV)

      40        905  Kluyveromyces lactis   

      41        899  Staphylococcus aureus (strain COL)

      42        895  Staphylococcus aureus (strain MW2)

      43        889  Escherichia coli O6:K15:H31 (strain 536 / UPEC)

      44        889  Staphylococcus aureus (strain MSSA476)

      45        888  Staphylococcus aureus (strain MRSA252)

      46        888  Oryctolagus cuniculus (Rabbit)

      47        882  Salmonella choleraesuis (strain SC-B67)

      48        878  Shigella sonnei (strain Ss046)

      49        870  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)

      50        863  Yersinia pseudotuberculosis serotype I (strain IP32953)

      51        862  Candida glabrata   

      52        851  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

      53        841  Escherichia coli O9:H4 (strain HS)

      54        837  Neurospora crassa 

      55        834  Escherichia coli O139:H28 (strain E24377A / ETEC)

      56        829  Shigella boydii serotype 4 (strain Sb227)

      57        825  Escherichia coli (strain UTI89 / UPEC)

      58        821  Shigella dysenteriae serotype 1 (strain Sd197)

      59        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)

      60        807  Canis familiaris (Dog) (Canis lupus familiaris)

      61        791  Escherichia coli (strain SMS-3-5 / SECEC)

      62        788  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

      63        783  Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) 

      64        783  Aquifex aeolicus (strain VF5)

      65        777  Emericella nidulans  

      66        775  Pasteurella multocida (strain Pm70)

      67        771  Escherichia coli (strain K12 / DH10B)

      68        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)

      69        765  Escherichia coli (strain K12 / MC4100 / BW2952)

      70        765  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

      71        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)

      72        762  Escherichia coli (strain 55989 / EAEC)

      73        761  Escherichia coli O8 (strain IAI1)

      74        760  Shigella flexneri serotype 5b (strain 8401)

      75        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)

      76        758  Staphylococcus epidermidis (strain ATCC 12228)

      77        756  Escherichia coli (strain SE11)

      78        756  Escherichia coli O45:K1 (strain S88 / ExPEC)

      79        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)

      80        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)

      81        745  Photorhabdus luminescens subsp. laumondii (strain TT01)

      82        740  Staphylococcus aureus (strain NCTC 8325)

      83        736  Bacillus anthracis

      84        736  Bacillus halodurans 

      85        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

      86        735  Zea mays (Maize)

      87        733  Vibrio vulnificus (strain CMCP6)

      88        731  Escherichia coli O81 (strain ED1a)

      89        721  Salmonella enteritidis PT4 (strain P125109)

      90        717  Vibrio vulnificus (strain YJ016)

      91        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)

      92        715  Yersinia pestis bv. Antiqua (strain Nepal516)

      93        714  Salmonella paratyphi A (strain AKU_12601)

      94        713  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

      95        713  Enterobacter sp. (strain 638)

      96        713  Salmonella agona (strain SL483)

      97        713  Escherichia coli O1:K1 / APEC

      98        713  Salmonella newport (strain SL254)

      99        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)

     100        712  Salmonella schwarzengrund (strain CVM19633)

     101        711  Yersinia pestis bv. Antiqua (strain Antiqua)

     102        710  Salmonella heidelberg (strain SL476)

     103        702  Salmonella dublin (strain CT_02021853)

     104        699  Pseudomonas putida (strain KT2440)

     105        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)

     106        696  Klebsiella pneumoniae (strain 342)

     107        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)

     108        690  Nostoc sp. (strain PCC 7120 / UTEX 2576)

     109        689  Pan troglodytes (Chimpanzee)

     110        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)

     111        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)

     112        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

     113        675  Pseudomonas syringae pv. tomato (strain DC3000)

     114        670  Serratia proteamaculans (strain 568)

     115        668  Mycobacterium leprae (strain TN)

     116        667  Yersinia pestis (strain Pestoides F)

     117        666  Staphylococcus aureus (strain USA300)

     118        664  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 

     119        659  Bradyrhizobium diazoefficiens 

     120        658  Rhizobium sp. (strain NGR234)

     121        655  Escherichia coli

     122        654  Bacillus cereus (strain ATCC 14579 / DSM 31)

     123        653  Debaryomyces hansenii   

     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)

     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)

     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)

     128        637  Oryza sativa subsp. indica (Rice)

     129        635  Shewanella oneidensis (strain MR-1)

     130        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)

     131        634  Agrobacterium tumefaciens (strain C58 / ATCC 33970)

     132        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)

     133        616  Methanothermobacter thermautotrophicus  

     134        616  Treponema pallidum (strain Nichols)

     135        613  Staphylococcus haemolyticus (strain JCSC1435)

     136        607  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)

     137        605  Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)

     138        604  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)

     139        602  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)

     140        602  Photobacterium profundum (Photobacterium sp. (strain SS9))

     141        602  Staphylococcus saprophyticus subsp. saprophyticus 

     142        601  Salmonella paratyphi C (strain RKS4594)

     143        600  Yersinia pestis bv. Antiqua (strain Angola)

     144        591  Bacillus cereus (strain ATCC 10987)

     145        591  Listeria innocua serovar 6a (strain CLIP 11262)

     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)

     147        587  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)

     148        586  Rickettsia prowazekii (strain Madrid E)

     149        579  Neisseria meningitidis serogroup B (strain MC58)

     150        576  Brucella suis biovar 1 (strain 1330)

     151        573  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 

     153        568  Caenorhabditis briggsae

     154        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)

     155        566  Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99)

     156        566  Pseudomonas syringae pv. syringae (strain B728a)

     157        565  Caulobacter crescentus (strain ATCC 19089 / CB15)

     158        564  Bacillus licheniformis (strain DSM 13 / ATCC 14580)

     159        564  Vibrio fischeri (strain ATCC 700601 / ES114)

     160        564  Pseudomonas aeruginosa (strain UCBPP-PA14)

     161        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)

     162        561  Bacillus cereus (strain ZK / E33L)

     163        557  Clostridium acetobutylicum 

     164        556  Xanthomonas axonopodis pv. citri (strain 306)

     165        552  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)

     166        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)

     167        552  Pseudomonas fluorescens (strain Pf0-1)

     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)

     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)

     170        534  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

     171        533  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

     172        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)

     173        529  Sodalis glossinidius (strain morsitans)

     174        529  Listeria monocytogenes serotype 4b (strain F2365)

     175        525  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 

     176        522  Xylella fastidiosa (strain 9a5c)

     177        515  Chromobacterium violaceum 

     178        515  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)

     179        513  Corynebacterium glutamicum 

     180        513  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)

     181        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)

     182        511  Pseudomonas aeruginosa (strain PA7)

     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)

     184        508  Staphylococcus aureus (strain Newman)

     185        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)

     186        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)

     187        507  Geobacillus kaustophilus (strain HTA426)

     188        506  Streptomyces avermitilis 

     189        502  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

     190        502  Deinococcus radiodurans 

     191        500  Pseudomonas entomophila (strain L48)

     192        499  Brucella abortus biovar 1 (strain 9-941)

     193        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)

     194        496  Bacillus clausii (strain KSM-K16)

     195        495  Burkholderia pseudomallei (strain K96243)

     196        495  Haemophilus influenzae (strain 86-028NP)

     197        494  Proteus mirabilis (strain HI4320)

     198        492  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)

     199        492  Bacillus amyloliquefaciens (strain FZB42)

     200        491  Xanthomonas campestris pv. campestris (strain 8004)

     201        490  Vibrio campbellii (strain ATCC BAA-1116 / BB120)

     202        487  Shewanella sp. (strain MR-7)

     203        486  Mannheimia succiniciproducens (strain MBEL55E)

     204        484  Pseudomonas aeruginosa (strain LESB58)

     205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)

     206        484  Shewanella sp. (strain MR-4)

     207        483  Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

     208        483  Methanosarcina mazei  

     209        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)

     210        482  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

     211        482  Thermosynechococcus elongatus (strain BP-1)

     212        479  Pyrococcus horikoshii 

     213        478  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)

     214        477  Pseudomonas putida (strain F1 / ATCC 700007)

     215        475  Brucella abortus (strain 2308)

     216        475  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)

     217        474  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

     218        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 

     219        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)

     220        469  Pyrococcus abyssi (strain GE5 / Orsay)

     221        468  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 

     222        468  Clostridium perfringens (strain 13 / Type A)

     223        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)

     224        466  Shewanella frigidimarina (strain NCIMB 400)

     225        466  Pseudomonas putida (strain GB-1)

     226        466  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 

     227        464  Nicotiana tabacum (Common tobacco)

     228        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)

     229        463  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)

     230        463  Shewanella sp. (strain ANA-3)

     231        462  Burkholderia mallei (strain ATCC 23344)

     232        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)

     233        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)

     234        461  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)

     235        459  Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha 

     236        458  Enterococcus faecalis (strain ATCC 700802 / V583)

     237        456  Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)

     238        455  Staphylococcus aureus (strain JH1)

     239        454  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)

     240        454  Ovis aries (Sheep)

     241        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)

     242        453  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)

     243        453  Pseudomonas putida (strain W619)

     244        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)

     245        452  Shewanella baltica (strain OS185)

     246        451  Aeromonas salmonicida (strain A449)

     247        450  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)

     248        450  Dechloromonas aromatica (strain RCB)

     249        449  Thermoanaerobacter tengcongensis  

     250        449  Staphylococcus aureus (strain JH9)





   

   2.3  Taxonomic distribution of the sequences



   



   Kingdom        sequences (% of the database)

    Archaea           19068 (  4%)

    Bacteria         329312 ( 61%)

    Eukaryota        177455 ( 33%)

    Viruses           16423 (  3%)





   Within Eukaryota:



   



    Category            sequences (% of Eukaryota) (% of the complete database)

     Human                  20273 ( 11%)           (  4%)

     Other Mammalia         45994 ( 26%)           (  8%)

     Other Vertebrata       17567 ( 10%)           (  3%)

     Viridiplantae          34711 ( 20%)           (  6%)

     Fungi                  31056 ( 18%)           (  6%)

     Insecta                 8725 (  5%)           (  2%)

     Nematoda                4337 (  2%)           (  1%)

     Other                  14792 (  8%)           (  3%)







3.  SEQUENCE SIZE



   Repartition of the sequences by size (excluding fragments)



               From   To  Number             From   To   Number

                  1-  50    9083             1001-1100     3767

                 51- 100   41483             1101-1200     2612

                101- 150   57888             1201-1300     2034

                151- 200   57852             1301-1400     1897

                201- 250   56624             1401-1500     1523

                251- 300   50166             1501-1600      741

                301- 350   50342             1601-1700      573

                351- 400   43584             1701-1800      473

                401- 450   35660             1801-1900      435

                451- 500   28701             1901-2000      354

                501- 550   20453             2001-2100      215

                551- 600   14676             2101-2200      295

                601- 650   12314             2201-2300      299

                651- 700    8891             2301-2400      184

                701- 750    7325             2401-2500      139

                751- 800    5221             >2500         1099

                801- 850    4559

                851- 900    5049

                901- 950    3890

                951-1000    2768



   





   The average sequence length in UniProtKB/Swiss-Prot is 355 amino acids.



   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.

   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.





4.  JOURNAL CITATIONS



   Note: the following citation statistics reflect the number of distinct

         journal citations.



   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2368





   4.1 Table of the frequency of journal citations



        Journals cited 1x:  764

                       2x:  312

                       3x:  162

                       4x:  115

                       5x:   86

                       6x:   81

                       7x:   54

                       8x:   47

                       9x:   36

                      10x:   35

                  11- 20x:  186

                  21- 50x:  192

                  51-100x:  107

                    >100x:  191





   4.2  List of the most cited journals in UniProtKB/Swiss-Prot



   Nb    Citations   Journal name

   --    ---------   -------------------------------------------------------------

    1        21660   Journal of Biological Chemistry

    2         9793   Proceedings of the National Academy of Sciences of the U.S.A.

    3         5844   Journal of Bacteriology

    4         5124   Biochemical and Biophysical Research Communications

    5         4628   Gene

    6         4625   Nucleic Acids Research

    7         4576   Biochemistry

    8         4429   FEBS Letters

    9         4305   The EMBO Journal

   10         3990   Molecular and Cellular Biology

   11         3823   Nature

   12         3683   Journal of Molecular Biology

   13         3276   Biochimica et Biophysica Acta

   14         3261   European Journal of Biochemistry

   15         3120   Cell

   16         2658   Journal of Virology

   17         2560   Biochemical Journal

   18         2543   Science

   19         2513   Genomics

   20         2133   Molecular Microbiology

   21         1948   Plant Physiology

   22         1927   Journal of Cell Biology

   23         1687   The American Journal of Human Genetics

   24         1674   Plant Molecular Biology

   25         1639   Genes and Development

   26         1548   Virology

   27         1542   Nature Genetics

   28         1498   Human Molecular Genetics

   29         1456   Oncogene

   30         1403   Molecular Biology of the Cell

   31         1392   The Plant Cell

   32         1384   Development

   33         1353   Molecular and General Genetics

   34         1330   Human Mutation

   35         1258   Journal of Biochemistry

   36         1257   The Plant Journal

   37         1226   Molecular Cell

   38         1201   Journal of Immunology

   39         1125   Genetics

   40         1117   Structure

   41         1042   Journal of General Virology

   42         1001   Blood

   43          985   Journal of Cell Science

   44          978   Infection and Immunity

   45          948   Archives of Biochemistry and Biophysics

   46          905   Microbiology

   47          857   Developmental Biology

   48          827   Current Biology

   49          823   Cancer Research

   50          796   Yeast

   51          752   PLoS ONE

   52          748   FEMS Microbiology Letters

   53          707   Acta Crystallographica, Section D

   54          677   Protein Science

   55          672   Applied and Environmental Microbiology

   56          671   Journal of Neuroscience

   57          669   Toxicon

   58          631   Human Genetics

   59          629   Nature Structural Biology

   60          626   Mechanisms of Development

   61          604   Neuron

   62          585   Journal of Clinical Investigation

   63          569   American Journal of Physiology

   64          542   Current Genetics

   65          542   The Journal of Experimental Medicine

   66          518   Proteins

   67          505   Plant and Cell Physiology

   68          501   Molecular Endocrinology

   69          480   Mammalian Genome

   70          476   Journal of Neurochemistry

   71          463   Nature Cell Biology

   72          460   Immunogenetics

   73          459   Bioscience, Biotechnology, and Biochemistry

   74          452   Endocrinology

   75          448   The Journal of Clinical Endocrinology and Metabolism

   76          444   Journal of Medical Genetics

   77          435   Molecular and Biochemical Parasitology

   78          402   Journal of Molecular Evolution

   79          389   Experimental Cell Research

   80          380   Molecular Biology and Evolution

   81          377   DNA and Cell Biology

   82          367   DNA Sequence

   83          364   Peptides

   84          363   Nature Structural and Molecular Biology

   85          348   The FEBS Journal

   86          344   RNA

   87          339   Developmental Cell

   88          333   Antimicrobial Agents and Chemotherapy

   89          330   Brain Research. Molecular Brain Research

   90          326   Tissue Antigens

   91          323   Eukaryotic Cell

   92          320   Comparative Biochemistry and Physiology

   93          316   Planta

   94          314   Journal of Investigative Dermatology

   95          313   Molecular Pharmacology

   96          294   Biological Chemistry Hoppe-Seyler

   97          294   Biology of Reproduction

   98          289   Neurology

   99          280   Cytogenetics and Cell Genetics

  100          277   Developmental Dynamics

  101          272   EMBO Reports

  102          270   Virus Research

  103          269   Biochimie

  104          267   Genome Research

  105          266   Immunity

  106          263   Genes to Cells

  107          259   Journal of General Microbiology

  108          258   The FASEB Journal

  109          251   The New England Journal of Medicine

  110          247   Molecular Plant-Microbe Interactions

  111          235   Journal of the American Chemical Society

  112          234   European Journal of Immunology

  113          233   Annals of Neurology

  114          232   European Journal of Human Genetics

  115          223   Acta Crystallographica, Section F

  116          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie

  117          216   DNA Research

  118          214   Journal of Human Genetics

  119          212   PLoS Genetics

  120          211   Investigative Ophthalmology and Visual Science

  121          208   Archives of Microbiology

  122          205   Journal of Experimental Botany

  123          205   Nature Immunology

  124          203   BMC Genomics

  125          202   Journal of Cellular Biochemistry

  126          195   American Journal of Medical Genetics. Part A

  127          191   Journal of Medicinal Chemistry

  128          191   Molecular and Cellular Endocrinology

  129          191   Glycobiology

  130          191   Archives of Virology

  131          187   Molecular Immunology

  132          185   Clinical Genetics

  133          182   Circulation Research

  134          178   Diabetes

  135          174   Insect Biochemistry and Molecular Biology

  136          174   Traffic

  137          169   Phytochemistry

  138          169   Molecular Phylogenetics and Evolution

  139          168   American Journal of Medical Genetics

  140          167   Molecular Genetics and Metabolism

  141          166   International Journal of Cancer

  142          165   Cell Cycle

  143          161   PLoS Pathogens

  144          160   Molecular Reproduction and Development

  145          160   Protein Expression and Purification

  146          159   DNA

  147          157   Applied Microbiology and Biotechnology

  148          157   Biological Chemistry

  149          156   Molecular Genetics and Genomics

  150          156   Molecular and Cellular Neuroscience





5.  STATISTICS FOR SOME LINE TYPES



The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,

as well as the number of entries with at least one such line, and the

frequency of the lines.



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry

------------------------------------  -------- ---------  ---------



References (RL)                      1063906                 1.96                                         

   Journal                            859452     423389      1.58       1                                 

   Submitted to EMBL/GenBank/DDBJ     195280     174293      0.36       2                                 

   Submitted to other databases         6926       6449      0.01       3                                 

   Book citation                         724        710     <0.01       4                                 

   Plant Gene Register                   590        578     <0.01       5                                 

   Thesis                                418        415     <0.01       6                                 

   Unpublished observations              320        316     <0.01       7                                 

   Patent                                190        187     <0.01       8                                 

   Worm Breeder's Gazette                  6          6     <0.01       9                                 



Total number of distinct authors cited in UniProtKB/Swiss-Prot: 345397



                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Comments (CC)                        2466449                 4.55                                         

   ALLERGEN                              661        661     <0.01      25                                 

   ALTERNATIVE PRODUCTS                22520      22520      0.04      13                                 

   BIOPHYSICOCHEMICAL PROPERTIES        5407       5407      0.01      23                                 

   BIOTECHNOLOGY                         363        361     <0.01      28                                 

   CATALYTIC ACTIVITY                 246714     222678      0.45       5                                 

   CAUTION                              9736       9551      0.02      18                                 

   COFACTOR                           111869     102266      0.21       7                                 

   DEVELOPMENTAL STAGE                 10149      10149      0.02      17                                 

   DISEASE                              5495       3691      0.01      22                                 

   DISRUPTION PHENOTYPE                 6610       6610      0.01      20                                 

   DOMAIN                              41238      35952      0.08      10                                 

   ENZYME REGULATION                   12112      12112      0.02      16                                 

   FUNCTION                           428013     410370      0.79       2                                 

   INDUCTION                           15828      15828      0.03      14                                 

   INTERACTION                         12420      12420      0.02      15                                 

   MASS SPECTROMETRY                    5675       4329      0.01      21                                 

   MISCELLANEOUS                       33182      30639      0.06      12                                 

   PATHWAY                            132461     120569      0.24       6                                 

   PHARMACEUTICAL                         95         95     <0.01      29                                 

   POLYMORPHISM                         1027        973     <0.01      24                                 

   PTM                                 45889      35709      0.08       8                                 

   RNA EDITING                           627        627     <0.01      26                                 

   SEQUENCE CAUTION                    41547      41547      0.08       9                                 

   SIMILARITY                         646312     517717      1.19       1                                 

   SUBCELLULAR LOCATION               329992     323840      0.61       3                                 

   SUBUNIT                            250786     250786      0.46       4                                 

   TISSUE SPECIFICITY                  39673      39673      0.07      11                                 

   TOXIC DOSE                            567        530     <0.01      27                                 

   WEB RESOURCE                         9481       7542      0.02      19                                 



Total number of comment topics: 29





                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank

------------------------------------  -------- ---------  ---------  ----

Features (FT)                        3808226                 7.02                                         

   ACT_SITE                           145829      89311      0.27       9                                 

   BINDING                            307767      82544      0.57       4                                 

   CA_BIND                              3926       1644      0.01      35                                 

   CARBOHYD                           108462      27747      0.20      15                                 

   CHAIN                              549310     535979      1.01       1                                 

   COILED                              20530      14109      0.04      26                                 

   COMPBIAS                            55186      29345      0.10      18                                 

   CONFLICT                           129065      45206      0.24      12                                 

   CROSSLNK                             7011       4019      0.01      34                                 

   DISULFID                           112088      30670      0.21      14                                 

   DNA_BIND                            10508       9577      0.02      31                                 

   DOMAIN                             164127      97675      0.30       7                                 

   HELIX                              189823      18309      0.35       6                                 

   INIT_MET                            16891      16891      0.03      27                                 

   INTRAMEM                             2193        951     <0.01      37                                 

   LIPID                               12140       7731      0.02      30                                 

   METAL                              330379      81743      0.61       3                                 

   MOD_RES                            161649      60943      0.30       8                                 

   MOTIF                               36945      23967      0.07      24                                 

   MUTAGEN                             46730      10766      0.09      20                                 

   NON_CONS                             2049        751     <0.01      38                                 

   NON_STD                               356        281     <0.01      39                                 

   NON_TER                             12234       9353      0.02      29                                 

   NP_BIND                            124440      75224      0.23      13                                 

   PEPTIDE                             10388       7093      0.02      32                                 

   PROPEP                              12846      11063      0.02      28                                 

   REGION                             142120      72011      0.26      10                                 

   REPEAT                              96704      14260      0.18      16                                 

   SIGNAL                              38608      38598      0.07      23                                 

   SITE                                48065      26627      0.09      19                                 

   STRAND                             199072      17286      0.37       5                                 

   TOPO_DOM                           131941      27308      0.24      11                                 

   TRANSIT                              8540       8434      0.02      33                                 

   TRANSMEM                           357582      73883      0.66       2                                 

   TURN                                46304      14859      0.09      22                                 

   UNSURE                               3404        726      0.01      36                                 

   VAR_SEQ                             46727      19596      0.09      21                                 

   VARIANT                             86822      16848      0.16      17                                 

   ZN_FING                             29465      12976      0.05      25                                 



Total number of feature keys: 39







                                      Total    Number of  Average

   Line type / subtype                number   entries    per entry  Rank      Category

------------------------------------  -------- ---------  ---------  ----      -------------------------------------------

Cross-references (DR)               16346888                30.15                                                           

   Allergome                            1617       1054     <0.01     101      Protein family/group databases               

   ArachnoServer                         763        755     <0.01     113      Organism-specific databases                  

   ArrayExpress                        33212      33212      0.06      48      Gene expression databases                    

   Bgee                                38815      38815      0.07      45      Gene expression databases                    

   BindingDB                            5033       5033      0.01      86      Chemistry                                    

   BioCyc                             323118     307224      0.60      20      Enzyme and pathway databases                 

   BRENDA                               4344       4333      0.01      91      Enzyme and pathway databases                 

   CAZy                                 7672       6907      0.01      74      Protein family/group databases               

   CGD                                   830        808     <0.01     109      Organism-specific databases                  

   ChEMBL                               5709       5709      0.01      79      Chemistry                                    

   ChiTaRS                             12547      12542      0.02      69      Other                                        

   CleanEx                             30072      29432      0.06      50      Gene expression databases                    

   COMPLUYEAST-2DPAGE                     99         98     <0.01     125      2D gel databases                             

   ConoServer                            926        844     <0.01     106      Organism-specific databases                  

   CTD                                 70709      69994      0.13      38      Organism-specific databases                  

   CYGD                                 5596       5593      0.01      80      Organism-specific databases                  

   dictyBase                            4201       4086      0.01      93      Organism-specific databases                  

   DIP                                 14903      14825      0.03      66      Protein-protein interaction databases        

   DisProt                               608        605     <0.01     116      3D structure databases                       

   DMDM                                16753      16750      0.03      62      Polymorphism databases                       

   DNASU                               18742      18671      0.03      58      Protocols and materials databases            

   DOSAC-COBS-2DPAGE                     149        147     <0.01     124      2D gel databases                             

   DrugBank                             5319       1628      0.01      83      Chemistry                                    

   EchoBASE                             4161       4161      0.01      94      Organism-specific databases                  

   EcoGene                              4292       4290      0.01      92      Organism-specific databases                  

   eggNOG                             431485     431485      0.80      10      Phylogenomic databases                       

   EMBL                               946956     530931      1.75       3      Sequence databases                           

   Ensembl                             84865      48973      0.16      35      Genome annotation databases                  

   EnsemblBacteria                    348420     327981      0.64      18      Genome annotation databases                  

   EnsemblFungi                        17962      17662      0.03      61      Genome annotation databases                  

   EnsemblMetazoa                      12465       9346      0.02      71      Genome annotation databases                  

   EnsemblPlants                       16495      14753      0.03      65      Genome annotation databases                  

   EnsemblProtists                      4576       4449      0.01      90      Genome annotation databases                  

   euHCVdb                                55         44     <0.01     126      Organism-specific databases                  

   EuPathDB                              776        776     <0.01     110      Organism-specific databases                  

   EvolutionaryTrace                   16657      16657      0.03      63      Other                                        

   FlyBase                              5920       5546      0.01      78      Organism-specific databases                  

   Gene3D                             357596     272822      0.66      17      Family and domain databases                  

   GeneCards                           20903      19802      0.04      54      Organism-specific databases                  

   GeneFarm                             3229       3218      0.01      95      Organism-specific databases                  

   GeneID                             496170     464119      0.92       6      Genome annotation databases                  

   GeneTree                            38063      38050      0.07      46      Phylogenomic databases                       

   Genevestigator                      67779      67779      0.12      40      Gene expression databases                    

   GeneWiki                            10373      10286      0.02      72      Other                                        

   GenoList                             7071       7059      0.01      75      Organism-specific databases                  

   GenomeRNAi                          21328      21328      0.04      53      Other                                        

   GO                                2440172     512765      4.50       1      Ontologies                                   

   Gramene                              6081       6081      0.01      77      Organism-specific databases                  

   GuidetoPHARMACOLOGY                  1748       1748     <0.01     100      Chemistry                                    

   H-InvDB                              5590       4770      0.01      81      Organism-specific databases                  

   HAMAP                              317495     317070      0.59      21      Family and domain databases                  

   HGNC                                19895      19730      0.04      56      Organism-specific databases                  

   HOGENOM                            386214     386214      0.71      14      Phylogenomic databases                       

   HOVERGEN                            75624      75624      0.14      36      Phylogenomic databases                       

   HPA                                 19098      14746      0.04      57      Organism-specific databases                  

   InParanoid                          70470      70470      0.13      39      Phylogenomic databases                       

   IntAct                              41177      41177      0.08      44      Protein-protein interaction databases        

   InterPro                          1830774     520259      3.38       2      Family and domain databases                  

   KEGG                               481989     450929      0.89       8      Genome annotation databases                  

   KO                                 378295     377861      0.70      15      Phylogenomic databases                       

   LegioList                             765        763     <0.01     112      Organism-specific databases                  

   Leproma                               671        668     <0.01     115      Organism-specific databases                  

   MaizeGDB                              502        497     <0.01     119      Organism-specific databases                  

   MEROPS                              12528      12528      0.02      70      Protein family/group databases               

   MGI                                 16562      16517      0.03      64      Organism-specific databases                  

   MIM                                 18443      13856      0.03      59      Organism-specific databases                  

   MINT                                31569      31569      0.06      49      Protein-protein interaction databases        

   mycoCLAP                              285        279     <0.01     122      Protein family/group databases               

   NextBio                             71095      71095      0.13      37      Other                                        

   neXtProt                            20108      20108      0.04      55      Organism-specific databases                  

   OGP                                   377        377     <0.01     121      2D gel databases                             

   OMA                                400883     400883      0.74      11      Phylogenomic databases                       

   Orphanet                             5588       2980      0.01      82      Organism-specific databases                  

   OrthoDB                            390469     390469      0.72      13      Phylogenomic databases                       

   PANTHER                            190857     179511      0.35      25      Family and domain databases                  

   PATRIC                             309154     309123      0.57      22      Genome annotation databases                  

   PaxDb                               66729      66729      0.12      41      Proteomic databases                          

   PDB                                103080      20378      0.19      32      3D structure databases                       

   PDBsum                             103080      20378      0.19      31      3D structure databases                       

   PeptideAtlas                         5162       5162      0.01      84      Proteomic databases                          

   PeroxiBase                            772        756     <0.01     111      Protein family/group databases               

   Pfam                               725611     499703      1.34       4      Family and domain databases                  

   PharmGKB                            18387      18359      0.03      60      Organism-specific databases                  

   PhosphoSite                         33567      33567      0.06      47      PTM databases                                

   PhosSite                              699        687     <0.01     114      PTM databases                                

   PhylomeDB                           27775      27775      0.05      52      Phylogenomic databases                       

   PIR                                119193     109015      0.22      30      Sequence databases                           

   PIRSF                              101651     100691      0.19      33      Family and domain databases                  

   PMAP-CutDB                           1462       1462     <0.01     102      Other                                        

   PomBase                              5015       4968      0.01      87      Organism-specific databases                  

   PptaseDB                               40         40     <0.01     127      Protein family/group databases               

   PRIDE                              123298     123298      0.23      29      Proteomic databases                          

   PRINTS                             136620     120391      0.25      27      Family and domain databases                  

   PRO                                 57887      57887      0.11      42      Other                                        

   ProDom                              29300      29121      0.05      51      Family and domain databases                  

   ProMEX                                867        867     <0.01     108      Proteomic databases                          

   PROSITE                            490221     308067      0.90       7      Family and domain databases                  

   ProtClustDB                        344691     344691      0.64      19      Phylogenomic databases                       

   ProteinModelPortal                 435873     435873      0.80       9      3D structure databases                       

   PseudoCAP                            1266       1257     <0.01     103      Organism-specific databases                  

   Reactome                            14504       8313      0.03      67      Enzyme and pathway databases                 

   REBASE                                403        403     <0.01     120      Protein family/group databases               

   RefSeq                             547613     474533      1.01       5      Sequence databases                           

   REPRODUCTION-2DPAGE                  1258       1037     <0.01     104      2D gel databases                             

   RGD                                  7800       7796      0.01      73      Organism-specific databases                  

   SABIO-RK                             2782       2782      0.01      97      Enzyme and pathway databases                 

   SGD                                  6640       6635      0.01      76      Organism-specific databases                  

   SignaLink                            2959       2959      0.01      96      Enzyme and pathway databases                 

   SMART                              168358     126111      0.31      26      Family and domain databases                  

   SMR                                220858     220858      0.41      24      3D structure databases                       

   STRING                             397175     397174      0.73      12      Protein-protein interaction databases        

   SUPFAM                             378013     292548      0.70      16      Family and domain databases                  

   SWISS-2DPAGE                         1182       1181     <0.01     105      2D gel databases                             

   TAIR                                12590      12534      0.02      68      Organism-specific databases                  

   TCDB                                 5146       5121      0.01      85      Protein family/group databases               

   TIGRFAMs                           290121     270071      0.54      23      Family and domain databases                  

   TubercuList                          2055       2019     <0.01      99      Organism-specific databases                  

   UCD-2DPAGE                            509        500     <0.01     118      2D gel databases                             

   UCSC                                44331      44331      0.08      43      Genome annotation databases                  

   UniCarbKB                             272        272     <0.01     123      PTM databases                                

   UniGene                             99928      90670      0.18      34      Sequence databases                           

   UniPathway                         132312     120425      0.24      28      Enzyme and pathway databases                 

   VectorBase                            606        588     <0.01     117      Genome annotation databases                  

   World-2DPAGE                          921        910     <0.01     107      2D gel databases                             

   WormBase                             4985       3991      0.01      88      Organism-specific databases                  

   Xenbase                              4755       4749      0.01      89      Organism-specific databases                  

   ZFIN                                 2754       2754      0.01      98      Organism-specific databases                  



Total number of cross-referenced databases: 127



6.  AMINO ACID COMPOSITION



   6.1  Composition in percent for the complete database



   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.57

   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34

   Asn (N) 4.06   Gly (G) 7.07   Met (M) 2.42   Trp (W) 1.08

   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92

   Cys (C) 1.37   Ile (I) 5.95   Pro (P) 4.70   Val (V) 6.86



   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00



   



   Legend: gray = aliphatic, red = acidic, green = small hydroxy,

           blue = basic, black = aromatic, white = amide, yellow = sulfur





   6.2  Classification of the amino acids by their frequency



   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,

   Phe, Tyr, Met, His, Cys, Trp





7.  MISCELLANEOUS STATISTICS



4464 entries are encoded on a mitochondrion, and 3733 are encoded on a plasmid.



12188 entries are encoded on a plastid, 

of which 21 are encoded on apicoplasts, 

11623 on chloroplasts, 

51 on organellar chromatophores,

145 on cyanelles, 

149 on non-photosynthetic plastids and 

199 on unspecified types of plastid.



Number of entries with at least one sequence correction: 75407