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         UniProtKB/Swiss-Prot protein knowledgebase release 2013_07 statistics


1.  INTRODUCTION

Release 2013_07 of 26-Jun-13 of UniProtKB/Swiss-Prot contains 540546 sequence entries,
comprising 192006283 amino acids abstracted from 220332 references. 

287 sequences have been added since release 2013_06, the sequence data of
36 existing entries has been updated and the annotations of
59264 entries have been revised.

Number of fragments: 9069
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 35070


Protein existence (PE):           entries     %

1: Evidence at protein level        79394   14.7%
2: Evidence at transcript level     64317   11.9%
3: Inferred from homology          379239   70.2%
4: Predicted                        15694    2.9%
5: Uncertain                         1902    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12994

   The first twenty species represent 113594 sequences:    21 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5434
                            2x: 1885
                            3x:  987
                            4x:  642
                            5x:  470
                            6x:  393
                            7x:  286
                            8x:  220
                            9x:  204
                           10x:  120
                       11- 20x:  695
                       21- 50x:  405
                       51-100x:  212
                         >100x: 1041


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20264  Homo sapiens (Human)
       2      16615  Mus musculus (Mouse)
       3      12182  Arabidopsis thaliana (Mouse-ear cress)
       4       7856  Rattus norvegicus (Rat)
       5       6621  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5979  Bos taurus (Bovine)
       7       5089  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4188  Bacillus subtilis (strain 168)
      10       4126  Dictyostelium discoideum (Slime mold)
      11       3431  Caenorhabditis elegans
      12       3367  Xenopus laevis (African clawed frog)
      13       3197  Drosophila melanogaster (Fruit fly)
      14       3057  Oryza sativa subsp. japonica (Rice)
      15       2891  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2255  Gallus gallus (Chicken)
      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
      18       2025  Mycobacterium tuberculosis
      19       2015  Escherichia coli O157:H7
      20       1787  Methanocaldococcus jannaschii  
      21       1771  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1694  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      24       1684  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
      25       1678  Shigella flexneri
      26       1412  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1246  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      29       1242  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1036  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1018  Yersinia pestis
      33       1015  Archaeoglobus fulgidus 
      34        950  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
      35        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        905  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      44        889  Staphylococcus aureus (strain MSSA476)
      45        889  Oryctolagus cuniculus (Rabbit)
      46        888  Staphylococcus aureus (strain MRSA252)
      47        882  Salmonella choleraesuis (strain SC-B67)
      48        878  Shigella sonnei (strain Ss046)
      49        869  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        863  Yersinia pseudotuberculosis serotype I (strain IP32953)
      51        862  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        835  Neurospora crassa 
      54        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        825  Escherichia coli (strain UTI89 / UPEC)
      57        821  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        803  Canis familiaris (Dog) (Canis lupus familiaris)
      60        791  Escherichia coli (strain SMS-3-5 / SECEC)
      61        787  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
      62        783  Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) 
      63        782  Aquifex aeolicus (strain VF5)
      64        775  Pasteurella multocida (strain Pm70)
      65        775  Emericella nidulans  
      66        771  Escherichia coli (strain K12 / DH10B)
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Staphylococcus epidermidis (strain ATCC 12228)
      75        756  Escherichia coli (strain SE11)
      76        756  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
      77        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      78        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        740  Staphylococcus aureus (strain NCTC 8325)
      82        739  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
      83        736  Bacillus anthracis
      84        736  Bacillus halodurans 
      85        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      86        733  Vibrio vulnificus (strain CMCP6)
      87        731  Escherichia coli O81 (strain ED1a)
      88        721  Salmonella enteritidis PT4 (strain P125109)
      89        718  Zea mays (Maize)
      90        717  Vibrio vulnificus (strain YJ016)
      91        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      92        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      93        714  Salmonella paratyphi A (strain AKU_12601)
      94        713  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      95        713  Enterobacter sp. (strain 638)
      96        713  Salmonella agona (strain SL483)
      97        713  Escherichia coli O1:K1 / APEC
      98        713  Salmonella newport (strain SL254)
      99        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
     100        712  Salmonella schwarzengrund (strain CVM19633)
     101        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     102        710  Salmonella heidelberg (strain SL476)
     103        702  Salmonella dublin (strain CT_02021853)
     104        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     105        696  Klebsiella pneumoniae (strain 342)
     106        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     107        693  Pseudomonas putida (strain KT2440)
     108        689  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        688  Pan troglodytes (Chimpanzee)
     110        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     111        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     112        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        670  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae (strain TN)
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        658  Bradyrhizobium japonicum (strain USDA 110)
     120        656  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     121        653  Debaryomyces hansenii   
     122        652  Bacillus cereus (strain ATCC 14579 / DSM 31)
     123        646  Escherichia coli
     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     128        635  Shewanella oneidensis (strain MR-1)
     129        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     130        632  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     131        623  Oryza sativa subsp. indica (Rice)
     132        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     133        616  Treponema pallidum (strain Nichols)
     134        613  Methanothermobacter thermautotrophicus  
     135        612  Staphylococcus haemolyticus (strain JCSC1435)
     136        606  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     137        605  Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
     138        602  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     139        602  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
     140        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     141        602  Staphylococcus saprophyticus subsp. saprophyticus 
     142        601  Salmonella paratyphi C (strain RKS4594)
     143        600  Yersinia pestis bv. Antiqua (strain Angola)
     144        591  Listeria innocua serovar 6a (strain CLIP 11262)
     145        590  Bacillus cereus (strain ATCC 10987)
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        581  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     149        579  Neisseria meningitidis serogroup B (strain MC58)
     150        576  Brucella suis biovar 1 (strain 1330)
     151        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        568  Caenorhabditis briggsae
     154        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     155        566  Pseudomonas syringae pv. syringae (strain B728a)
     156        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     157        565  Caulobacter crescentus (strain ATCC 19089 / CB15)
     158        564  Vibrio fischeri (strain ATCC 700601 / ES114)
     159        564  Pseudomonas aeruginosa (strain UCBPP-PA14)
     160        563  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     161        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     162        561  Bacillus cereus (strain ZK / E33L)
     163        557  Clostridium acetobutylicum 
     164        556  Xanthomonas axonopodis pv. citri (strain 306)
     165        552  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     166        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     167        552  Pseudomonas fluorescens (strain Pf0-1)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        533  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        532  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
     172        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     173        529  Sodalis glossinidius (strain morsitans)
     174        529  Listeria monocytogenes serotype 4b (strain F2365)
     175        523  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     176        522  Xylella fastidiosa (strain 9a5c)
     177        515  Chromobacterium violaceum 
     178        515  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
     179        513  Corynebacterium glutamicum 
     180        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     181        511  Pseudomonas aeruginosa (strain PA7)
     182        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     184        508  Staphylococcus aureus (strain Newman)
     185        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
     186        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     187        507  Geobacillus kaustophilus (strain HTA426)
     188        505  Streptomyces avermitilis 
     189        502  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
     190        502  Deinococcus radiodurans 
     191        500  Pseudomonas entomophila (strain L48)
     192        499  Brucella abortus biovar 1 (strain 9-941)
     193        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     194        496  Bacillus clausii (strain KSM-K16)
     195        495  Burkholderia pseudomallei (strain K96243)
     196        495  Haemophilus influenzae (strain 86-028NP)
     197        494  Proteus mirabilis (strain HI4320)
     198        492  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     199        492  Bacillus amyloliquefaciens (strain FZB42)
     200        491  Xanthomonas campestris pv. campestris (strain 8004)
     201        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     202        487  Shewanella sp. (strain MR-7)
     203        486  Mannheimia succiniciproducens (strain MBEL55E)
     204        484  Pseudomonas aeruginosa (strain LESB58)
     205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     206        484  Shewanella sp. (strain MR-4)
     207        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     208        481  Thermosynechococcus elongatus (strain BP-1)
     209        480  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     210        480  Acinetobacter sp. (strain ADP1)
     211        479  Pyrococcus horikoshii 
     212        478  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     213        475  Pseudomonas putida (strain F1 / ATCC 700007)
     214        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     215        474  Brucella abortus (strain 2308)
     216        473  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     217        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     218        469  Methanosarcina mazei  
     219        468  Pyrococcus abyssi (strain GE5 / Orsay)
     220        468  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 
     221        468  Clostridium perfringens (strain 13 / Type A)
     222        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     223        466  Shewanella frigidimarina (strain NCIMB 400)
     224        466  Pseudomonas putida (strain GB-1)
     225        466  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     226        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     227        464  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
     228        463  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     229        463  Shewanella sp. (strain ANA-3)
     230        462  Burkholderia mallei (strain ATCC 23344)
     231        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     232        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     233        460  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     234        459  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     235        458  Enterococcus faecalis (strain ATCC 700802 / V583)
     236        455  Staphylococcus aureus (strain JH1)
     237        454  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     238        454  Ovis aries (Sheep)
     239        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     240        453  Nicotiana tabacum (Common tobacco)
     241        453  Pseudomonas putida (strain W619)
     242        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     243        452  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
     244        452  Shewanella baltica (strain OS185)
     245        451  Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
     246        451  Aeromonas salmonicida (strain A449)
     247        449  Thermoanaerobacter tengcongensis  
     248        449  Staphylococcus aureus (strain JH9)
     249        449  Hahella chejuensis (strain KCTC 2396)
     250        449  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           19029 (  4%)
    Bacteria         328977 ( 61%)
    Eukaryota        176209 ( 33%)
    Viruses           16331 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20265 ( 12%)           (  4%)
     Other Mammalia         45900 ( 26%)           (  8%)
     Other Vertebrata       17462 ( 10%)           (  3%)
     Viridiplantae          34039 ( 19%)           (  6%)
     Fungi                  30855 ( 18%)           (  6%)
     Insecta                 8688 (  5%)           (  2%)
     Nematoda                4306 (  2%)           (  1%)
     Other                  14694 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    9060             1001-1100     3747
                 51- 100   41411             1101-1200     2597
                101- 150   57674             1201-1300     2023
                151- 200   57791             1301-1400     1883
                201- 250   56506             1401-1500     1511
                251- 300   49997             1501-1600      737
                301- 350   50180             1601-1700      567
                351- 400   43435             1701-1800      470
                401- 450   35520             1801-1900      427
                451- 500   28597             1901-2000      351
                501- 550   20358             2001-2100      213
                551- 600   14620             2101-2200      287
                601- 650   12271             2201-2300      295
                651- 700    8853             2301-2400      181
                701- 750    7298             2401-2500      138
                751- 800    5187             >2500         1090
                801- 850    4536
                851- 900    5030
                901- 950    3880
                951-1000    2756

   


   The average sequence length in UniProtKB/Swiss-Prot is 355 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2329


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  753
                       2x:  311
                       3x:  155
                       4x:  115
                       5x:   89
                       6x:   73
                       7x:   59
                       8x:   43
                       9x:   39
                      10x:   29
                  11- 20x:  183
                  21- 50x:  192
                  51-100x:   99
                    >100x:  189


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        21201   Journal of Biological Chemistry
    2         9570   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5734   Journal of Bacteriology
    4         5056   Biochemical and Biophysical Research Communications
    5         4602   Gene
    6         4575   Nucleic Acids Research
    7         4470   Biochemistry
    8         4375   FEBS Letters
    9         4235   The EMBO Journal
   10         3930   Molecular and Cellular Biology
   11         3730   Nature
   12         3585   Journal of Molecular Biology
   13         3245   European Journal of Biochemistry
   14         3227   Biochimica et Biophysica Acta
   15         3047   Cell
   16         2584   Journal of Virology
   17         2513   Biochemical Journal
   18         2509   Genomics
   19         2475   Science
   20         2068   Molecular Microbiology
   21         1886   Journal of Cell Biology
   22         1883   Plant Physiology
   23         1654   Plant Molecular Biology
   24         1604   Genes and Development
   25         1599   The American Journal of Human Genetics
   26         1539   Virology
   27         1518   Nature Genetics
   28         1458   Human Molecular Genetics
   29         1443   Oncogene
   30         1349   Development
   31         1345   Molecular and General Genetics
   32         1343   Molecular Biology of the Cell
   33         1313   Human Mutation
   34         1302   The Plant Cell
   35         1242   Journal of Biochemistry
   36         1196   The Plant Journal
   37         1191   Journal of Immunology
   38         1168   Molecular Cell
   39         1111   Genetics
   40         1093   Structure
   41         1031   Journal of General Virology
   42          983   Blood
   43          958   Journal of Cell Science
   44          955   Infection and Immunity
   45          928   Archives of Biochemistry and Biophysics
   46          871   Microbiology
   47          843   Developmental Biology
   48          812   Cancer Research
   49          801   Current Biology
   50          788   Yeast
   51          735   FEMS Microbiology Letters
   52          689   Acta Crystallographica, Section D
   53          660   Protein Science
   54          652   Journal of Neuroscience
   55          650   Toxicon
   56          644   Applied and Environmental Microbiology
   57          628   Human Genetics
   58          627   Nature Structural Biology
   59          626   Mechanisms of Development
   60          601   PLoS ONE
   61          594   Neuron
   62          577   Journal of Clinical Investigation
   63          547   American Journal of Physiology
   64          541   Current Genetics
   65          531   The Journal of Experimental Medicine
   66          501   Proteins
   67          486   Molecular Endocrinology
   68          482   Plant and Cell Physiology
   69          479   Mammalian Genome
   70          467   Journal of Neurochemistry
   71          459   Immunogenetics
   72          452   Nature Cell Biology
   73          450   Bioscience, Biotechnology, and Biochemistry
   74          444   The Journal of Clinical Endocrinology and Metabolism
   75          437   Endocrinology
   76          429   Molecular and Biochemical Parasitology
   77          420   Journal of Medical Genetics
   78          399   Journal of Molecular Evolution
   79          381   Experimental Cell Research
   80          379   Molecular Biology and Evolution
   81          377   DNA and Cell Biology
   82          366   DNA Sequence
   83          353   Peptides
   84          342   Nature Structural and Molecular Biology
   85          333   RNA
   86          329   Brain Research. Molecular Brain Research
   87          328   Developmental Cell
   88          325   Tissue Antigens
   89          323   The FEBS Journal
   90          320   Comparative Biochemistry and Physiology
   91          319   Antimicrobial Agents and Chemotherapy
   92          308   Journal of Investigative Dermatology
   93          305   Molecular Pharmacology
   94          304   Planta
   95          294   Biological Chemistry Hoppe-Seyler
   96          287   Biology of Reproduction
   97          281   Neurology
   98          279   Cytogenetics and Cell Genetics
   99          273   Eukaryotic Cell
  100          271   Developmental Dynamics
  101          269   Virus Research
  102          267   Genome Research
  103          260   EMBO Reports
  104          260   Immunity
  105          257   Journal of General Microbiology
  106          257   Biochimie
  107          252   Genes to Cells
  108          245   Molecular Plant-Microbe Interactions
  109          244   The FASEB Journal
  110          238   The New England Journal of Medicine
  111          234   European Journal of Immunology
  112          225   Annals of Neurology
  113          223   European Journal of Human Genetics
  114          219   Journal of the American Chemical Society
  115          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  116          215   DNA Research
  117          211   Journal of Human Genetics
  118          203   Investigative Ophthalmology and Visual Science
  119          201   Archives of Microbiology
  120          200   Acta Crystallographica, Section F
  121          197   Journal of Experimental Botany
  122          196   Nature Immunology
  123          190   BMC Genomics
  124          190   Journal of Cellular Biochemistry
  125          190   Archives of Virology
  126          188   American Journal of Medical Genetics. Part A
  127          186   Molecular and Cellular Endocrinology
  128          183   Molecular Immunology
  129          181   Glycobiology
  130          179   Clinical Genetics
  131          176   Journal of Medicinal Chemistry
  132          173   Diabetes
  133          173   PLoS Genetics
  134          172   Insect Biochemistry and Molecular Biology
  135          169   Circulation Research
  136          168   American Journal of Medical Genetics
  137          168   Molecular Phylogenetics and Evolution
  138          166   International Journal of Cancer
  139          165   Traffic
  140          160   Phytochemistry
  141          160   Molecular Genetics and Metabolism
  142          159   Molecular Reproduction and Development
  143          159   DNA
  144          157   Protein Expression and Purification
  145          156   Molecular Genetics and Genomics
  146          155   Hemoglobin
  147          154   Bioorganicheskaia Khimiia
  148          154   Biological Chemistry
  149          153   Cell Cycle
  150          153   Molecular and Cellular Neuroscience


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1045165                 1.93                                         
   Journal                            838798     418429      1.55       1                                 
   Submitted to EMBL/GenBank/DDBJ     197291     176084      0.36       2                                 
   Submitted to other databases         6846       6371      0.01       3                                 
   Book citation                         724        710     <0.01       4                                 
   Plant Gene Register                   586        574     <0.01       5                                 
   Thesis                                419        416     <0.01       6                                 
   Unpublished observations              305        301     <0.01       7                                 
   Patent                                190        187     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 337426

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2431720                 4.50                                         
   ALLERGEN                              530        530     <0.01      27                                 
   ALTERNATIVE PRODUCTS                22233      22233      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        5024       5024      0.01      23                                 
   BIOTECHNOLOGY                         349        347     <0.01      28                                 
   CATALYTIC ACTIVITY                 244149     221228      0.45       5                                 
   CAUTION                              9385       9211      0.02      19                                 
   COFACTOR                           108570      98939      0.20       7                                 
   DEVELOPMENTAL STAGE                  9915       9915      0.02      17                                 
   DISEASE                              5276       3541      0.01      22                                 
   DISRUPTION PHENOTYPE                 5835       5835      0.01      20                                 
   DOMAIN                              39712      34968      0.07      10                                 
   ENZYME REGULATION                   11215      11215      0.02      15                                 
   FUNCTION                           422276     404979      0.78       2                                 
   INDUCTION                           15352      15352      0.03      14                                 
   INTERACTION                         10211      10211      0.02      16                                 
   MASS SPECTROMETRY                    5546       4243      0.01      21                                 
   MISCELLANEOUS                       32739      30260      0.06      12                                 
   PATHWAY                            131776     119911      0.24       6                                 
   PHARMACEUTICAL                         93         93     <0.01      29                                 
   POLYMORPHISM                          896        843     <0.01      24                                 
   PTM                                 44538      34814      0.08       8                                 
   RNA EDITING                           627        627     <0.01      25                                 
   SEQUENCE CAUTION                    41222      41222      0.08       9                                 
   SIMILARITY                         642485     515926      1.19       1                                 
   SUBCELLULAR LOCATION               327753     321755      0.61       3                                 
   SUBUNIT                            245102     245102      0.45       4                                 
   TISSUE SPECIFICITY                  38908      38908      0.07      11                                 
   TOXIC DOSE                            551        515     <0.01      26                                 
   WEB RESOURCE                         9452       7520      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3732820                 6.91                                         
   ACT_SITE                           142778      87256      0.26       9                                 
   BINDING                            293456      78286      0.54       4                                 
   CA_BIND                              3920       1641      0.01      35                                 
   CARBOHYD                           107445      27552      0.20      15                                 
   CHAIN                              547352     534324      1.01       1                                 
   COILED                              20294      13942      0.04      26                                 
   COMPBIAS                            54469      28902      0.10      18                                 
   CONFLICT                           128160      44869      0.24      12                                 
   CROSSLNK                             6804       3928      0.01      34                                 
   DISULFID                           109650      30129      0.20      14                                 
   DNA_BIND                            10391       9466      0.02      31                                 
   DOMAIN                             161764      96291      0.30       8                                 
   HELIX                              182105      17734      0.34       6                                 
   INIT_MET                            14606      14606      0.03      27                                 
   INTRAMEM                             2173        937     <0.01      37                                 
   LIPID                               11927       7567      0.02      30                                 
   METAL                              319691      78457      0.59       3                                 
   MOD_RES                            166754      60860      0.31       7                                 
   MOTIF                               35973      23318      0.07      24                                 
   MUTAGEN                             43989      10206      0.08      22                                 
   NON_CONS                             2043        751     <0.01      38                                 
   NON_STD                               354        279     <0.01      39                                 
   NON_TER                             12215       9334      0.02      29                                 
   NP_BIND                            121341      73875      0.22      13                                 
   PEPTIDE                             10313       7034      0.02      32                                 
   PROPEP                              12683      10914      0.02      28                                 
   REGION                             134012      68189      0.25      10                                 
   REPEAT                              95866      14180      0.18      16                                 
   SIGNAL                              38354      38344      0.07      23                                 
   SITE                                47173      26335      0.09      19                                 
   STRAND                             190535      16746      0.35       5                                 
   TOPO_DOM                           130690      27133      0.24      11                                 
   TRANSIT                              8396       8292      0.02      33                                 
   TRANSMEM                           356536      73611      0.66       2                                 
   TURN                                44307      14357      0.08      21                                 
   UNSURE                               3360        716      0.01      36                                 
   VAR_SEQ                             45898      19359      0.08      20                                 
   VARIANT                             85632      16762      0.16      17                                 
   ZN_FING                             29411      12929      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               16003301                29.61                                                           
   Allergome                            1501        942     <0.01     101      Protein family/group databases               
   ArachnoServer                         763        755     <0.01     112      Organism-specific databases                  
   ArrayExpress                        36266      36266      0.07      47      Gene expression databases                    
   Bgee                                38780      38780      0.07      45      Gene expression databases                    
   BindingDB                            5033       5033      0.01      85      Other                                        
   BioCyc                             311782     301097      0.58      20      Enzyme and pathway databases                 
   BRENDA                               4324       4314      0.01      92      Enzyme and pathway databases                 
   CAZy                                 7635       6875      0.01      74      Protein family/group databases               
   CGD                                   719        697     <0.01     113      Organism-specific databases                  
   ChEMBL                               5222       5222      0.01      82      Other                                        
   ChiTaRS                             12535      12530      0.02      69      Other                                        
   CleanEx                             30084      29443      0.06      51      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     125      2D gel databases                             
   ConoServer                            921        839     <0.01     106      Organism-specific databases                  
   CTD                                 70241      69575      0.13      39      Organism-specific databases                  
   CYGD                                 5596       5593      0.01      79      Organism-specific databases                  
   dictyBase                            4203       4087      0.01      94      Organism-specific databases                  
   DIP                                 14224      14133      0.03      67      Protein-protein interaction databases        
   DisProt                               605        602     <0.01     117      3D structure databases                       
   DMDM                                16758      16755      0.03      63      Polymorphism databases                       
   DNASU                               18708      18637      0.03      59      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     124      2D gel databases                             
   DrugBank                             5319       1628      0.01      81      Other                                        
   EchoBASE                             4161       4161      0.01      95      Organism-specific databases                  
   EcoGene                              4292       4290      0.01      93      Organism-specific databases                  
   eggNOG                             430882     430882      0.80      10      Phylogenomic databases                       
   EMBL                               940548     529282      1.74       3      Sequence databases                           
   Ensembl                             84367      48693      0.16      35      Genome annotation databases                  
   EnsemblBacteria                    342867     324699      0.63      18      Genome annotation databases                  
   EnsemblFungi                        17645      17353      0.03      62      Genome annotation databases                  
   EnsemblMetazoa                      12379       9277      0.02      70      Genome annotation databases                  
   EnsemblPlants                       16611      14651      0.03      64      Genome annotation databases                  
   EnsemblProtists                      4499       4372      0.01      91      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     126      Organism-specific databases                  
   EuPathDB                              810        798     <0.01     109      Organism-specific databases                  
   EvolutionaryTrace                   16605      16605      0.03      65      Other                                        
   FlyBase                              5899       5525      0.01      78      Organism-specific databases                  
   Gene3D                             358968     274195      0.66      16      Family and domain databases                  
   GeneCards                           20041      19753      0.04      56      Organism-specific databases                  
   GeneFarm                             3198       3187      0.01      96      Organism-specific databases                  
   GeneID                             502070     470978      0.93       6      Genome annotation databases                  
   GeneTree                            38215      38196      0.07      46      Phylogenomic databases                       
   Genevestigator                      67450      67450      0.12      41      Gene expression databases                    
   GenoList                             7071       7059      0.01      75      Organism-specific databases                  
   GenomeRNAi                          21300      21298      0.04      54      Other                                        
   GermOnline                          41895      41321      0.08      44      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     123      PTM databases                                
   GO                                2436004     510832      4.51       1      Ontologies                                   
   Gramene                              6026       6026      0.01      77      Organism-specific databases                  
   H-InvDB                              5593       4772      0.01      80      Organism-specific databases                  
   HAMAP                              315832     315423      0.58      19      Family and domain databases                  
   HGNC                                19857      19690      0.04      57      Organism-specific databases                  
   HOGENOM                            385558     385558      0.71      13      Phylogenomic databases                       
   HOVERGEN                            75565      75565      0.14      37      Phylogenomic databases                       
   HPA                                 19101      14749      0.04      58      Organism-specific databases                  
   InParanoid                          70081      70081      0.13      40      Phylogenomic databases                       
   IntAct                              35068      35068      0.06      48      Protein-protein interaction databases        
   InterPro                          1824629     517546      3.38       2      Family and domain databases                  
   IPI                                 97815      67931      0.18      32      Sequence databases                           
   KEGG                               477721     451029      0.88       8      Genome annotation databases                  
   KO                                 376153     375721      0.70      14      Phylogenomic databases                       
   LegioList                             765        763     <0.01     111      Organism-specific databases                  
   Leproma                               671        668     <0.01     114      Organism-specific databases                  
   MaizeGDB                              499        494     <0.01     119      Organism-specific databases                  
   MEROPS                              11876      11876      0.02      72      Protein family/group databases               
   MGI                                 16529      16483      0.03      66      Organism-specific databases                  
   MIM                                 18089      13686      0.03      61      Organism-specific databases                  
   MINT                                31526      31526      0.06      50      Protein-protein interaction databases        
   mycoCLAP                              282        277     <0.01     122      Protein family/group databases               
   NextBio                             70871      70871      0.13      38      Other                                        
   neXtProt                            20098      20098      0.04      55      Organism-specific databases                  
   OGP                                   377        377     <0.01     121      2D gel databases                             
   OMA                                394881     394881      0.73      12      Phylogenomic databases                       
   Orphanet                             5193       2816      0.01      83      Organism-specific databases                  
   OrthoDB                             78238      78238      0.14      36      Phylogenomic databases                       
   PANTHER                            203615     189782      0.38      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      90      Enzyme and pathway databases                 
   PATRIC                             308979     308948      0.57      21      Genome annotation databases                  
   PaxDb                               66685      66685      0.12      42      Proteomic databases                          
   PDB                                 96097      19654      0.18      33      3D structure databases                       
   PDBsum                              96096      19654      0.18      34      3D structure databases                       
   PeptideAtlas                         5162       5162      0.01      84      Proteomic databases                          
   PeroxiBase                            772        756     <0.01     110      Protein family/group databases               
   Pfam                               722655     499158      1.34       4      Family and domain databases                  
   PharmGKB                            18375      18351      0.03      60      Organism-specific databases                  
   PhosphoSite                         33567      33567      0.06      49      PTM databases                                
   PhosSite                              659        647     <0.01     115      PTM databases                                
   PhylomeDB                           27570      27570      0.05      53      Phylogenomic databases                       
   PIR                                118816     108655      0.22      28      Sequence databases                           
   PIRSF                               99517      99323      0.18      30      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01     102      Other                                        
   PomBase                              5010       4959      0.01      86      Organism-specific databases                  
   PptaseDB                               40         40     <0.01     127      Protein family/group databases               
   PRIDE                              111595     111595      0.21      29      Proteomic databases                          
   PRINTS                             137348     120342      0.25      26      Family and domain databases                  
   ProDom                              29306      29127      0.05      52      Family and domain databases                  
   ProMEX                                822        822     <0.01     108      Proteomic databases                          
   PROSITE                            484176     305148      0.90       7      Family and domain databases                  
   ProtClustDB                        344110     344110      0.64      17      Phylogenomic databases                       
   ProteinModelPortal                 433028     433028      0.80       9      3D structure databases                       
   PseudoCAP                            1254       1245     <0.01     104      Organism-specific databases                  
   Reactome                            13102       7882      0.02      68      Enzyme and pathway databases                 
   REBASE                                403        403     <0.01     120      Protein family/group databases               
   RefSeq                             527722     471328      0.98       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1257       1036     <0.01     103      2D gel databases                             
   RGD                                  7771       7767      0.01      73      Organism-specific databases                  
   SABIO-RK                             2543       2543     <0.01      99      Enzyme and pathway databases                 
   SGD                                  6640       6635      0.01      76      Organism-specific databases                  
   SignaLink                            2960       2960      0.01      97      Enzyme and pathway databases                 
   SMART                              167874     125663      0.31      25      Family and domain databases                  
   SMR                                207693     207693      0.38      23      3D structure databases                       
   STRING                             396659     396659      0.73      11      Protein-protein interaction databases        
   SUPFAM                             373905     288976      0.69      15      Family and domain databases                  
   SWISS-2DPAGE                         1182       1181     <0.01     105      2D gel databases                             
   TAIR                                12164      12109      0.02      71      Organism-specific databases                  
   TCDB                                 4951       4930      0.01      87      Protein family/group databases               
   TIGRFAMs                           290448     269852      0.54      22      Family and domain databases                  
   TubercuList                          2038       2002     <0.01     100      Organism-specific databases                  
   UCD-2DPAGE                            509        500     <0.01     118      2D gel databases                             
   UCSC                                59075      44644      0.11      43      Genome annotation databases                  
   UniGene                             99025      89958      0.18      31      Sequence databases                           
   UniPathway                         131650     119790      0.24      27      Enzyme and pathway databases                 
   VectorBase                            606        588     <0.01     116      Genome annotation databases                  
   World-2DPAGE                          920        909     <0.01     107      2D gel databases                             
   WormBase                             4917       3959      0.01      88      Organism-specific databases                  
   Xenbase                              4739       4734      0.01      89      Organism-specific databases                  
   ZFIN                                 2804       2804      0.01      98      Organism-specific databases                  

Total number of cross-referenced databases: 127

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.57
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.07   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.37   Ile (I) 5.96   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4461 entries are encoded on a mitochondrion, and 3722 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 74863