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         UniProtKB/Swiss-Prot protein knowledgebase release 2013_03 statistics


1.  INTRODUCTION

Release 2013_03 of 06-Mar-13 of UniProtKB/Swiss-Prot contains 539616 sequence entries,
comprising 191569459 amino acids abstracted from 217393 references. 

462 sequences have been added since release 2013_02, the sequence data of
30 existing entries has been updated and the annotations of
400839 entries have been revised.

Number of fragments: 9055
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 33888


Protein existence (PE):           entries     %

1: Evidence at protein level        77989   14.5%
2: Evidence at transcript level     63627   11.8%
3: Inferred from homology          380347   70.5%
4: Predicted                        15761    2.9%
5: Uncertain                         1892    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12964

   The first twenty species represent 113200 sequences:    21 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5434
                            2x: 1885
                            3x:  982
                            4x:  645
                            5x:  466
                            6x:  385
                            7x:  283
                            8x:  219
                            9x:  201
                           10x:  120
                       11- 20x:  687
                       21- 50x:  404
                       51-100x:  212
                         >100x: 1041


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20254  Homo sapiens (Human)
       2      16601  Mus musculus (Mouse)
       3      11927  Arabidopsis thaliana (Mouse-ear cress)
       4       7842  Rattus norvegicus (Rat)
       5       6621  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5977  Bos taurus (Bovine)
       7       5089  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4188  Bacillus subtilis (strain 168)
      10       4126  Dictyostelium discoideum (Slime mold)
      11       3413  Caenorhabditis elegans
      12       3363  Xenopus laevis (African clawed frog)
      13       3184  Drosophila melanogaster (Fruit fly)
      14       3013  Oryza sativa subsp. japonica (Rice)
      15       2879  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2253  Gallus gallus (Chicken)
      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
      18       2020  Mycobacterium tuberculosis
      19       2014  Escherichia coli O157:H7
      20       1787  Methanocaldococcus jannaschii  
      21       1771  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1691  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      24       1683  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
      25       1678  Shigella flexneri
      26       1412  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1243  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      29       1242  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1036  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1018  Yersinia pestis
      33       1014  Archaeoglobus fulgidus 
      34        950  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
      35        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        904  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        886  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis (strain SC-B67)
      48        878  Shigella sonnei (strain Ss046)
      49        869  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        863  Yersinia pseudotuberculosis serotype I (strain IP32953)
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        835  Neurospora crassa 
      54        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        825  Escherichia coli (strain UTI89 / UPEC)
      57        821  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        803  Canis familiaris (Dog) (Canis lupus familiaris)
      60        791  Escherichia coli (strain SMS-3-5 / SECEC)
      61        787  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
      62        783  Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) 
      63        782  Aquifex aeolicus (strain VF5)
      64        775  Pasteurella multocida (strain Pm70)
      65        773  Emericella nidulans  
      66        771  Escherichia coli (strain K12 / DH10B)
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Staphylococcus epidermidis (strain ATCC 12228)
      75        756  Escherichia coli (strain SE11)
      76        756  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
      77        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      78        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        740  Staphylococcus aureus (strain NCTC 8325)
      82        735  Bacillus anthracis
      83        735  Bacillus halodurans 
      84        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      85        733  Vibrio vulnificus (strain CMCP6)
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      93        713  Enterobacter sp. (strain 638)
      94        713  Salmonella agona (strain SL483)
      95        713  Escherichia coli O1:K1 / APEC
      96        713  Salmonella newport (strain SL254)
      97        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      98        712  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
      99        712  Zea mays (Maize)
     100        712  Salmonella schwarzengrund (strain CVM19633)
     101        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     102        710  Salmonella heidelberg (strain SL476)
     103        702  Salmonella dublin (strain CT_02021853)
     104        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     105        696  Klebsiella pneumoniae (strain 342)
     106        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     107        693  Pseudomonas putida (strain KT2440)
     108        689  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        688  Pan troglodytes (Chimpanzee)
     110        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     111        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     112        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        670  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae (strain TN)
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        656  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     120        654  Bradyrhizobium japonicum (strain USDA 110)
     121        653  Debaryomyces hansenii   
     122        652  Bacillus cereus (strain ATCC 14579 / DSM 31)
     123        646  Escherichia coli
     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     128        634  Shewanella oneidensis (strain MR-1)
     129        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     130        632  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        618  Oryza sativa subsp. indica (Rice)
     133        616  Treponema pallidum (strain Nichols)
     134        613  Methanothermobacter thermautotrophicus  
     135        612  Staphylococcus haemolyticus (strain JCSC1435)
     136        606  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     137        605  Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
     138        602  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     139        602  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
     140        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     141        602  Staphylococcus saprophyticus subsp. saprophyticus 
     142        601  Salmonella paratyphi C (strain RKS4594)
     143        600  Yersinia pestis bv. Antiqua (strain Angola)
     144        591  Listeria innocua serovar 6a (strain CLIP 11262)
     145        590  Bacillus cereus (strain ATCC 10987)
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        580  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     149        578  Neisseria meningitidis serogroup B (strain MC58)
     150        576  Brucella suis biovar 1 (strain 1330)
     151        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        568  Caenorhabditis briggsae
     154        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     155        566  Pseudomonas syringae pv. syringae (strain B728a)
     156        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     157        564  Vibrio fischeri (strain ATCC 700601 / ES114)
     158        564  Caulobacter crescentus (strain ATCC 19089 / CB15)
     159        564  Pseudomonas aeruginosa (strain UCBPP-PA14)
     160        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     161        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     162        561  Bacillus cereus (strain ZK / E33L)
     163        557  Clostridium acetobutylicum 
     164        556  Xanthomonas axonopodis pv. citri (strain 306)
     165        552  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     166        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     167        552  Pseudomonas fluorescens (strain Pf0-1)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        533  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     172        529  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
     173        529  Sodalis glossinidius (strain morsitans)
     174        529  Listeria monocytogenes serotype 4b (strain F2365)
     175        522  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     176        522  Xylella fastidiosa (strain 9a5c)
     177        515  Chromobacterium violaceum 
     178        515  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
     179        513  Corynebacterium glutamicum 
     180        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     181        511  Pseudomonas aeruginosa (strain PA7)
     182        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     184        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
     185        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     186        507  Geobacillus kaustophilus (strain HTA426)
     187        506  Staphylococcus aureus (strain Newman)
     188        502  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
     189        501  Deinococcus radiodurans 
     190        500  Pseudomonas entomophila (strain L48)
     191        499  Brucella abortus biovar 1 (strain 9-941)
     192        497  Streptomyces avermitilis 
     193        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     194        496  Bacillus clausii (strain KSM-K16)
     195        495  Burkholderia pseudomallei (strain K96243)
     196        495  Haemophilus influenzae (strain 86-028NP)
     197        494  Proteus mirabilis (strain HI4320)
     198        492  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     199        492  Bacillus amyloliquefaciens (strain FZB42)
     200        491  Xanthomonas campestris pv. campestris (strain 8004)
     201        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     202        487  Shewanella sp. (strain MR-7)
     203        486  Mannheimia succiniciproducens (strain MBEL55E)
     204        484  Pseudomonas aeruginosa (strain LESB58)
     205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     206        484  Shewanella sp. (strain MR-4)
     207        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     208        481  Thermosynechococcus elongatus (strain BP-1)
     209        480  Acinetobacter sp. (strain ADP1)
     210        479  Pyrococcus horikoshii 
     211        478  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     212        478  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     213        475  Pseudomonas putida (strain F1 / ATCC 700007)
     214        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     215        474  Brucella abortus (strain 2308)
     216        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     217        472  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     218        469  Methanosarcina mazei  
     219        468  Pyrococcus abyssi (strain GE5 / Orsay)
     220        468  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 
     221        467  Clostridium perfringens (strain 13 / Type A)
     222        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     223        466  Shewanella frigidimarina (strain NCIMB 400)
     224        466  Pseudomonas putida (strain GB-1)
     225        466  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     226        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     227        463  Shewanella sp. (strain ANA-3)
     228        462  Burkholderia mallei (strain ATCC 23344)
     229        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     230        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     231        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     232        459  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     233        459  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     234        459  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
     235        458  Enterococcus faecalis (strain ATCC 700802 / V583)
     236        455  Staphylococcus aureus (strain JH1)
     237        454  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     238        454  Ovis aries (Sheep)
     239        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     240        453  Pseudomonas putida (strain W619)
     241        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     242        452  Shewanella baltica (strain OS185)
     243        451  Aeromonas salmonicida (strain A449)
     244        450  Nicotiana tabacum (Common tobacco)
     245        449  Thermoanaerobacter tengcongensis  
     246        449  Staphylococcus aureus (strain JH9)
     247        449  Hahella chejuensis (strain KCTC 2396)
     248        448  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
     249        448  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
     250        447  Vibrio fischeri (strain MJ11)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18993 (  4%)
    Bacteria         328774 ( 61%)
    Eukaryota        175533 ( 33%)
    Viruses           16316 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20255 ( 12%)           (  4%)
     Other Mammalia         45865 ( 26%)           (  8%)
     Other Vertebrata       17353 ( 10%)           (  3%)
     Viridiplantae          33643 ( 19%)           (  6%)
     Fungi                  30804 ( 18%)           (  6%)
     Insecta                 8674 (  5%)           (  2%)
     Nematoda                4288 (  2%)           (  1%)
     Other                  14651 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    9026             1001-1100     3738
                 51- 100   41355             1101-1200     2588
                101- 150   57624             1201-1300     2016
                151- 200   57703             1301-1400     1878
                201- 250   56464             1401-1500     1506
                251- 300   49927             1501-1600      730
                301- 350   50094             1601-1700      562
                351- 400   43345             1701-1800      465
                401- 450   35466             1801-1900      423
                451- 500   28550             1901-2000      351
                501- 550   20306             2001-2100      212
                551- 600   14560             2101-2200      285
                601- 650   12252             2201-2300      293
                651- 700    8829             2301-2400      174
                701- 750    7279             2401-2500      136
                751- 800    5175             >2500         1087
                801- 850    4530
                851- 900    5021
                901- 950    3868
                951-1000    2743

   


   The average sequence length in UniProtKB/Swiss-Prot is 355 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2306


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  754
                       2x:  296
                       3x:  159
                       4x:  115
                       5x:   88
                       6x:   72
                       7x:   54
                       8x:   44
                       9x:   37
                      10x:   29
                  11- 20x:  183
                  21- 50x:  193
                  51-100x:   98
                    >100x:  184


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        20926   Journal of Biological Chemistry
    2         9440   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5662   Journal of Bacteriology
    4         5012   Biochemical and Biophysical Research Communications
    5         4595   Gene
    6         4538   Nucleic Acids Research
    7         4406   Biochemistry
    8         4339   FEBS Letters
    9         4191   The EMBO Journal
   10         3903   Molecular and Cellular Biology
   11         3682   Nature
   12         3532   Journal of Molecular Biology
   13         3240   European Journal of Biochemistry
   14         3206   Biochimica et Biophysica Acta
   15         3011   Cell
   16         2541   Journal of Virology
   17         2507   Genomics
   18         2477   Biochemical Journal
   19         2440   Science
   20         2030   Molecular Microbiology
   21         1854   Journal of Cell Biology
   22         1824   Plant Physiology
   23         1634   Plant Molecular Biology
   24         1586   The American Journal of Human Genetics
   25         1577   Genes and Development
   26         1532   Virology
   27         1495   Nature Genetics
   28         1446   Human Molecular Genetics
   29         1426   Oncogene
   30         1341   Molecular and General Genetics
   31         1328   Development
   32         1301   Human Mutation
   33         1285   Molecular Biology of the Cell
   34         1268   The Plant Cell
   35         1231   Journal of Biochemistry
   36         1182   Journal of Immunology
   37         1140   The Plant Journal
   38         1137   Molecular Cell
   39         1099   Genetics
   40         1064   Structure
   41         1025   Journal of General Virology
   42          967   Blood
   43          946   Infection and Immunity
   44          929   Journal of Cell Science
   45          924   Archives of Biochemistry and Biophysics
   46          855   Microbiology
   47          826   Developmental Biology
   48          802   Cancer Research
   49          786   Yeast
   50          782   Current Biology
   51          728   FEMS Microbiology Letters
   52          664   Acta Crystallographica, Section D
   53          649   Protein Science
   54          641   Journal of Neuroscience
   55          638   Toxicon
   56          628   Applied and Environmental Microbiology
   57          626   Human Genetics
   58          624   Nature Structural Biology
   59          622   Mechanisms of Development
   60          591   Neuron
   61          570   Journal of Clinical Investigation
   62          545   American Journal of Physiology
   63          538   Current Genetics
   64          527   The Journal of Experimental Medicine
   65          523   PLoS ONE
   66          490   Proteins
   67          482   Molecular Endocrinology
   68          479   Mammalian Genome
   69          464   Journal of Neurochemistry
   70          459   Plant and Cell Physiology
   71          456   Immunogenetics
   72          443   The Journal of Clinical Endocrinology and Metabolism
   73          441   Nature Cell Biology
   74          441   Bioscience, Biotechnology, and Biochemistry
   75          434   Endocrinology
   76          428   Molecular and Biochemical Parasitology
   77          408   Journal of Medical Genetics
   78          398   Journal of Molecular Evolution
   79          379   Molecular Biology and Evolution
   80          377   DNA and Cell Biology
   81          374   Experimental Cell Research
   82          365   DNA Sequence
   83          347   Peptides
   84          328   Brain Research. Molecular Brain Research
   85          324   Tissue Antigens
   86          321   Developmental Cell
   87          319   Comparative Biochemistry and Physiology
   88          318   RNA
   89          314   Antimicrobial Agents and Chemotherapy
   90          314   Nature Structural and Molecular Biology
   91          308   Journal of Investigative Dermatology
   92          306   The FEBS Journal
   93          302   Molecular Pharmacology
   94          296   Planta
   95          294   Biological Chemistry Hoppe-Seyler
   96          284   Biology of Reproduction
   97          280   Neurology
   98          279   Cytogenetics and Cell Genetics
   99          267   Developmental Dynamics
  100          266   Genome Research
  101          266   Virus Research
  102          256   Journal of General Microbiology
  103          254   Immunity
  104          252   EMBO Reports
  105          250   Biochimie
  106          248   Eukaryotic Cell
  107          244   Molecular Plant-Microbe Interactions
  108          239   The FASEB Journal
  109          239   Genes to Cells
  110          235   The New England Journal of Medicine
  111          231   European Journal of Immunology
  112          222   Annals of Neurology
  113          221   European Journal of Human Genetics
  114          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  115          213   DNA Research
  116          211   Journal of Human Genetics
  117          207   Journal of the American Chemical Society
  118          202   Investigative Ophthalmology and Visual Science
  119          200   Archives of Microbiology
  120          196   Nature Immunology
  121          190   Archives of Virology
  122          189   Journal of Cellular Biochemistry
  123          187   BMC Genomics
  124          187   Acta Crystallographica, Section F
  125          185   Journal of Experimental Botany
  126          185   American Journal of Medical Genetics. Part A
  127          184   Molecular and Cellular Endocrinology
  128          182   Molecular Immunology
  129          181   Glycobiology
  130          177   Clinical Genetics
  131          176   Journal of Medicinal Chemistry
  132          173   Diabetes
  133          172   Insect Biochemistry and Molecular Biology
  134          168   American Journal of Medical Genetics
  135          168   Molecular Phylogenetics and Evolution
  136          165   Circulation Research
  137          163   International Journal of Cancer
  138          159   Molecular Reproduction and Development
  139          159   DNA
  140          159   Molecular Genetics and Metabolism
  141          157   PLoS Genetics
  142          156   Traffic
  143          155   Hemoglobin
  144          154   Bioorganicheskaia Khimiia
  145          153   Phytochemistry
  146          152   Molecular Genetics and Genomics
  147          152   Molecular and Cellular Neuroscience
  148          152   Biological Chemistry
  149          150   Protein Expression and Purification
  150          147   Journal of Lipid Research


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1037168                 1.92                                         
   Journal                            829697     415605      1.54       1                                 
   Submitted to EMBL/GenBank/DDBJ     198359     177448      0.37       2                                 
   Submitted to other databases         6893       6429      0.01       3                                 
   Book citation                         722        708     <0.01       4                                 
   Plant Gene Register                   579        567     <0.01       5                                 
   Thesis                                419        416     <0.01       6                                 
   Unpublished observations              303        299     <0.01       7                                 
   Patent                                190        187     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 333257

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2417823                 4.48                                         
   ALLERGEN                              529        529     <0.01      27                                 
   ALTERNATIVE PRODUCTS                21849      21849      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        4827       4827      0.01      23                                 
   BIOTECHNOLOGY                         343        341     <0.01      28                                 
   CATALYTIC ACTIVITY                 243232     220511      0.45       4                                 
   CAUTION                              9279       9107      0.02      18                                 
   COFACTOR                           107379      98182      0.20       7                                 
   DEVELOPMENTAL STAGE                  9791       9791      0.02      17                                 
   DISEASE                              5203       3486      0.01      22                                 
   DISRUPTION PHENOTYPE                 5454       5454      0.01      21                                 
   DOMAIN                              38937      34368      0.07      10                                 
   ENZYME REGULATION                   11057      11057      0.02      15                                 
   FUNCTION                           420362     403162      0.78       2                                 
   INDUCTION                           15100      15100      0.03      14                                 
   INTERACTION                          9940       9940      0.02      16                                 
   MASS SPECTROMETRY                    5470       4176      0.01      20                                 
   MISCELLANEOUS                       32686      30221      0.06      12                                 
   PATHWAY                            131828     119652      0.24       6                                 
   PHARMACEUTICAL                         92         92     <0.01      29                                 
   POLYMORPHISM                          889        836     <0.01      24                                 
   PTM                                 44217      34571      0.08       8                                 
   RNA EDITING                           627        627     <0.01      25                                 
   SEQUENCE CAUTION                    41025      41025      0.08       9                                 
   SIMILARITY                         640284     514937      1.19       1                                 
   SUBCELLULAR LOCATION               326580     320688      0.61       3                                 
   SUBUNIT                            242958     242958      0.45       5                                 
   TISSUE SPECIFICITY                  38421      38421      0.07      11                                 
   TOXIC DOSE                            545        510     <0.01      26                                 
   WEB RESOURCE                         8919       7124      0.02      19                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3685460                 6.83                                         
   ACT_SITE                           141706      86474      0.26       9                                 
   BINDING                            282593      75587      0.52       4                                 
   CA_BIND                              3920       1636      0.01      35                                 
   CARBOHYD                           107254      27473      0.20      15                                 
   CHAIN                              546357     533440      1.01       1                                 
   COILED                              20175      13859      0.04      26                                 
   COMPBIAS                            54277      28777      0.10      18                                 
   CONFLICT                           127384      44638      0.24      12                                 
   CROSSLNK                             6713       3895      0.01      34                                 
   DISULFID                           109037      29981      0.20      14                                 
   DNA_BIND                            10327       9430      0.02      31                                 
   DOMAIN                             160631      95469      0.30       8                                 
   HELIX                              176617      17262      0.33       6                                 
   INIT_MET                            14239      14239      0.03      27                                 
   INTRAMEM                             2139        919     <0.01      37                                 
   LIPID                               11899       7553      0.02      30                                 
   METAL                              314875      77604      0.58       3                                 
   MOD_RES                            165917      60608      0.31       7                                 
   MOTIF                               35627      23029      0.07      24                                 
   MUTAGEN                             42682       9920      0.08      22                                 
   NON_CONS                             2042        750     <0.01      38                                 
   NON_STD                               354        279     <0.01      39                                 
   NON_TER                             12199       9321      0.02      29                                 
   NP_BIND                            118292      73233      0.22      13                                 
   PEPTIDE                             10259       6988      0.02      32                                 
   PROPEP                              12647      10880      0.02      28                                 
   REGION                             130708      66636      0.24      10                                 
   REPEAT                              94864      14006      0.18      16                                 
   SIGNAL                              38171      38161      0.07      23                                 
   SITE                                46072      25785      0.09      19                                 
   STRAND                             185338      16320      0.34       5                                 
   TOPO_DOM                           130194      27023      0.24      11                                 
   TRANSIT                              8329       8225      0.02      33                                 
   TRANSMEM                           356013      73450      0.66       2                                 
   TURN                                43087      13986      0.08      21                                 
   UNSURE                               3277        691      0.01      36                                 
   VAR_SEQ                             44605      19004      0.08      20                                 
   VARIANT                             85296      16732      0.16      17                                 
   ZN_FING                             29344      12895      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15727190                29.15                                                           
   Allergome                            1492        936     <0.01     102      Protein family/group databases               
   ArachnoServer                         763        755     <0.01     111      Organism-specific databases                  
   ArrayExpress                        21032      21032      0.04      55      Gene expression databases                    
   Bgee                                38764      38764      0.07      45      Gene expression databases                    
   BindingDB                            5034       5034      0.01      86      Other                                        
   BioCyc                             229610     220569      0.43      22      Enzyme and pathway databases                 
   BRENDA                               4313       4303      0.01      93      Enzyme and pathway databases                 
   CAZy                                 7610       6850      0.01      76      Protein family/group databases               
   CGD                                   692        670     <0.01     112      Organism-specific databases                  
   ChEMBL                               5222       5222      0.01      84      Other                                        
   ChiTaRS                             12531      12526      0.02      71      Other                                        
   CleanEx                             30089      29448      0.06      51      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     126      2D gel databases                             
   ConoServer                            916        834     <0.01     108      Organism-specific databases                  
   CTD                                 69940      69264      0.13      40      Organism-specific databases                  
   CYGD                                 5596       5593      0.01      81      Organism-specific databases                  
   dictyBase                            4203       4087      0.01      95      Organism-specific databases                  
   DIP                                 14208      14117      0.03      69      Protein-protein interaction databases        
   DisProt                               398        395     <0.01     121      3D structure databases                       
   DMDM                                16760      16757      0.03      65      Polymorphism databases                       
   DNASU                               18682      18611      0.03      59      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     125      2D gel databases                             
   DrugBank                             5319       1628      0.01      83      Other                                        
   EchoBASE                             4161       4161      0.01      96      Organism-specific databases                  
   EcoGene                              4292       4290      0.01      94      Organism-specific databases                  
   eggNOG                             430545     430545      0.80      10      Phylogenomic databases                       
   EMBL                               936444     528428      1.74       3      Sequence databases                           
   Ensembl                             81180      48075      0.15      36      Genome annotation databases                  
   EnsemblBacteria                     98138      85131      0.18      31      Genome annotation databases                  
   EnsemblFungi                        17429      17137      0.03      64      Genome annotation databases                  
   EnsemblMetazoa                      11971       8882      0.02      72      Genome annotation databases                  
   EnsemblPlants                       15749      13956      0.03      68      Genome annotation databases                  
   EnsemblProtists                      4461       4336      0.01      92      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     127      Organism-specific databases                  
   EuPathDB                              571        501     <0.01     116      Organism-specific databases                  
   EvolutionaryTrace                   16536      16536      0.03      66      Other                                        
   FlyBase                              5882       5508      0.01      80      Organism-specific databases                  
   Gene3D                             331054     255824      0.61      16      Family and domain databases                  
   GeneCards                           20049      19761      0.04      57      Organism-specific databases                  
   GeneFarm                             3163       3152      0.01      98      Organism-specific databases                  
   GeneID                             502250     471861      0.93       6      Genome annotation databases                  
   GeneTree                            37487      37469      0.07      46      Phylogenomic databases                       
   Genevestigator                      67235      67235      0.12      42      Gene expression databases                    
   GenoList                             7070       7058      0.01      77      Organism-specific databases                  
   GenomeReviews                      377618     357959      0.70      13      Genome annotation databases                  
   GenomeRNAi                          21239      21239      0.04      54      Other                                        
   GermOnline                          41896      41322      0.08      44      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     124      PTM databases                                
   GO                                2399431     509300      4.45       1      Ontologies                                   
   Gramene                              5990       5990      0.01      79      Organism-specific databases                  
   H-InvDB                              5593       4772      0.01      82      Organism-specific databases                  
   HAMAP                              315037     314745      0.58      18      Family and domain databases                  
   HGNC                                19851      19684      0.04      58      Organism-specific databases                  
   HOGENOM                            385197     385197      0.71      12      Phylogenomic databases                       
   HOVERGEN                            75540      75540      0.14      38      Phylogenomic databases                       
   HPA                                 17640      13724      0.03      63      Organism-specific databases                  
   HSSP                                30609      30609      0.06      50      3D structure databases                       
   InParanoid                          69838      69838      0.13      41      Phylogenomic databases                       
   IntAct                              34534      34534      0.06      48      Protein-protein interaction databases        
   InterPro                          1762677     516376      3.27       2      Family and domain databases                  
   IPI                                 96822      67631      0.18      33      Sequence databases                           
   KEGG                               480993     449819      0.89       8      Genome annotation databases                  
   KO                                 374473     373771      0.69      14      Phylogenomic databases                       
   LegioList                             765        763     <0.01     110      Organism-specific databases                  
   Leproma                               671        668     <0.01     113      Organism-specific databases                  
   MaizeGDB                              497        492     <0.01     119      Organism-specific databases                  
   MEROPS                              11867      11867      0.02      74      Protein family/group databases               
   MGI                                 16512      16466      0.03      67      Organism-specific databases                  
   MIM                                 17957      13624      0.03      61      Organism-specific databases                  
   MINT                                17645      17645      0.03      62      Protein-protein interaction databases        
   mycoCLAP                              282        277     <0.01     123      Protein family/group databases               
   NextBio                             70103      70103      0.13      39      Other                                        
   neXtProt                            20089      20089      0.04      56      Organism-specific databases                  
   OGP                                   377        377     <0.01     122      2D gel databases                             
   OMA                                394441     394441      0.73      11      Phylogenomic databases                       
   Orphanet                             4682       2650      0.01      90      Organism-specific databases                  
   OrthoDB                             78207      78207      0.14      37      Phylogenomic databases                       
   PANTHER                            199967     186501      0.37      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      91      Enzyme and pathway databases                 
   PATRIC                             308877     308848      0.57      20      Genome annotation databases                  
   PaxDb                               37233      37232      0.07      47      Proteomic databases                          
   PDB                                 92042      19121      0.17      35      3D structure databases                       
   PDBsum                              92042      19121      0.17      34      3D structure databases                       
   PeptideAtlas                         5163       5163      0.01      85      Proteomic databases                          
   PeroxiBase                            770        754     <0.01     109      Protein family/group databases               
   Pfam                               718283     498109      1.33       4      Family and domain databases                  
   PharmGKB                            18375      18351      0.03      60      Organism-specific databases                  
   PhosphoSite                         33569      33569      0.06      49      PTM databases                                
   PhosSite                              631        619     <0.01     114      PTM databases                                
   PhylomeDB                           27358      27358      0.05      53      Phylogenomic databases                       
   PIR                                118569     108429      0.22      28      Sequence databases                           
   PIRSF                               99197      99071      0.18      30      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01     103      Other                                        
   PomBase                              5016       4959      0.01      87      Organism-specific databases                  
   PptaseDB                               38         38     <0.01     128      Protein family/group databases               
   PRIDE                              110654     110654      0.21      29      Proteomic databases                          
   PRINTS                             137173     120173      0.25      26      Family and domain databases                  
   ProDom                              29300      29121      0.05      52      Family and domain databases                  
   ProMEX                                530        530     <0.01     117      Proteomic databases                          
   PROSITE                            482163     304139      0.89       7      Family and domain databases                  
   ProtClustDB                        343749     343749      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 431338     431338      0.80       9      3D structure databases                       
   PseudoCAP                            1251       1242     <0.01     105      Organism-specific databases                  
   Reactome                            13102       7882      0.02      70      Enzyme and pathway databases                 
   REBASE                                404        404     <0.01     120      Protein family/group databases               
   RefSeq                             526743     472148      0.98       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1257       1036     <0.01     104      2D gel databases                             
   RGD                                  7751       7747      0.01      75      Organism-specific databases                  
   SABIO-RK                             2465       2465     <0.01     100      Enzyme and pathway databases                 
   SGD                                  6640       6635      0.01      78      Organism-specific databases                  
   SMART                              167506     125398      0.31      25      Family and domain databases                  
   SMR                                219049     219049      0.41      23      3D structure databases                       
   STRING                             309634     309631      0.57      19      Protein-protein interaction databases        
   SUPFAM                             331046     262685      0.61      17      Family and domain databases                  
   SWISS-2DPAGE                         1182       1181     <0.01     106      2D gel databases                             
   TAIR                                11944      11891      0.02      73      Organism-specific databases                  
   TCDB                                 3664       3649      0.01      97      Protein family/group databases               
   TIGRFAMs                           289822     269448      0.54      21      Family and domain databases                  
   TubercuList                          2033       1997     <0.01     101      Organism-specific databases                  
   UCD-2DPAGE                            509        500     <0.01     118      2D gel databases                             
   UCSC                                52025      39890      0.10      43      Genome annotation databases                  
   UniGene                             96974      88064      0.18      32      Sequence databases                           
   UniPathway                         131715     119541      0.24      27      Enzyme and pathway databases                 
   VectorBase                            606        588     <0.01     115      Genome annotation databases                  
   World-2DPAGE                          921        910     <0.01     107      2D gel databases                             
   WormBase                             4871       3930      0.01      88      Organism-specific databases                  
   Xenbase                              4731       4726      0.01      89      Organism-specific databases                  
   ZFIN                                 2794       2794      0.01      99      Organism-specific databases                  

Total number of cross-referenced databases: 128

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.56
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.37   Ile (I) 5.96   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4460 entries are encoded on a mitochondrion, and 3713 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 74552