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         UniProtKB/Swiss-Prot protein knowledgebase release 2013_02 statistics


1.  INTRODUCTION

Release 2013_02 of 06-Feb-13 of UniProtKB/Swiss-Prot contains 539165 sequence entries,
comprising 191456931 amino acids abstracted from 216632 references. 

321 sequences have been added since release 2013_01, the sequence data of
33 existing entries has been updated and the annotations of
112829 entries have been revised.

Number of fragments: 9056
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 33384


Protein existence (PE):           entries     %

1: Evidence at protein level        77772   14.4%
2: Evidence at transcript level     68137   12.6%
3: Inferred from homology          377073   69.9%
4: Predicted                        14290    2.7%
5: Uncertain                         1893    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12948

   The first twenty species represent 113031 sequences:    21 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5434
                            2x: 1884
                            3x:  986
                            4x:  643
                            5x:  465
                            6x:  382
                            7x:  282
                            8x:  219
                            9x:  201
                           10x:  121
                       11- 20x:  674
                       21- 50x:  403
                       51-100x:  213
                         >100x: 1041


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20247  Homo sapiens (Human)
       2      16590  Mus musculus (Mouse)
       3      11831  Arabidopsis thaliana (Mouse-ear cress)
       4       7840  Rattus norvegicus (Rat)
       5       6621  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5975  Bos taurus (Bovine)
       7       5089  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4188  Bacillus subtilis (strain 168)
      10       4126  Dictyostelium discoideum (Slime mold)
      11       3382  Caenorhabditis elegans
      12       3361  Xenopus laevis (African clawed frog)
      13       3182  Drosophila melanogaster (Fruit fly)
      14       3002  Oryza sativa subsp. japonica (Rice)
      15       2874  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2253  Gallus gallus (Chicken)
      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
      18       2020  Mycobacterium tuberculosis
      19       2014  Escherichia coli O157:H7
      20       1787  Methanocaldococcus jannaschii  
      21       1770  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1688  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      24       1683  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
      25       1678  Shigella flexneri
      26       1412  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1242  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      29       1242  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1036  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1018  Yersinia pestis
      33       1013  Archaeoglobus fulgidus 
      34        950  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
      35        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        904  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        886  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis (strain SC-B67)
      48        878  Shigella sonnei (strain Ss046)
      49        869  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        863  Yersinia pseudotuberculosis serotype I (strain IP32953)
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        835  Neurospora crassa 
      54        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        825  Escherichia coli (strain UTI89 / UPEC)
      57        821  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        803  Canis familiaris (Dog) (Canis lupus familiaris)
      60        791  Escherichia coli (strain SMS-3-5 / SECEC)
      61        787  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
      62        783  Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) 
      63        782  Aquifex aeolicus (strain VF5)
      64        775  Pasteurella multocida (strain Pm70)
      65        773  Emericella nidulans  
      66        771  Escherichia coli (strain K12 / DH10B)
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Staphylococcus epidermidis (strain ATCC 12228)
      75        756  Escherichia coli (strain SE11)
      76        756  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
      77        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      78        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        740  Staphylococcus aureus (strain NCTC 8325)
      82        735  Bacillus halodurans 
      83        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      84        734  Bacillus anthracis
      85        733  Vibrio vulnificus (strain CMCP6)
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      93        713  Enterobacter sp. (strain 638)
      94        713  Salmonella agona (strain SL483)
      95        713  Escherichia coli O1:K1 / APEC
      96        713  Salmonella newport (strain SL254)
      97        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      98        712  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
      99        712  Zea mays (Maize)
     100        712  Salmonella schwarzengrund (strain CVM19633)
     101        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     102        710  Salmonella heidelberg (strain SL476)
     103        702  Salmonella dublin (strain CT_02021853)
     104        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     105        696  Klebsiella pneumoniae (strain 342)
     106        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     107        693  Pseudomonas putida (strain KT2440)
     108        689  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        688  Pan troglodytes (Chimpanzee)
     110        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     111        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     112        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        670  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae (strain TN)
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        654  Bradyrhizobium japonicum (strain USDA 110)
     120        653  Debaryomyces hansenii   
     121        652  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        650  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     123        646  Escherichia coli
     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     128        634  Shewanella oneidensis (strain MR-1)
     129        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     130        632  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        617  Oryza sativa subsp. indica (Rice)
     133        616  Treponema pallidum (strain Nichols)
     134        613  Methanothermobacter thermautotrophicus  
     135        612  Staphylococcus haemolyticus (strain JCSC1435)
     136        606  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     137        605  Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
     138        602  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     139        602  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
     140        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     141        602  Staphylococcus saprophyticus subsp. saprophyticus 
     142        601  Salmonella paratyphi C (strain RKS4594)
     143        600  Yersinia pestis bv. Antiqua (strain Angola)
     144        590  Bacillus cereus (strain ATCC 10987)
     145        590  Listeria innocua serovar 6a (strain CLIP 11262)
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        580  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     149        578  Neisseria meningitidis serogroup B (strain MC58)
     150        576  Brucella suis biovar 1 (strain 1330)
     151        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        568  Caenorhabditis briggsae
     154        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     155        566  Pseudomonas syringae pv. syringae (strain B728a)
     156        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     157        564  Vibrio fischeri (strain ATCC 700601 / ES114)
     158        564  Caulobacter crescentus (strain ATCC 19089 / CB15)
     159        564  Pseudomonas aeruginosa (strain UCBPP-PA14)
     160        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     161        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     162        561  Bacillus cereus (strain ZK / E33L)
     163        557  Clostridium acetobutylicum 
     164        556  Xanthomonas axonopodis pv. citri (strain 306)
     165        552  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     166        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     167        552  Pseudomonas fluorescens (strain Pf0-1)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        533  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     172        529  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
     173        529  Sodalis glossinidius (strain morsitans)
     174        529  Listeria monocytogenes serotype 4b (strain F2365)
     175        522  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     176        522  Xylella fastidiosa (strain 9a5c)
     177        515  Chromobacterium violaceum 
     178        515  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
     179        513  Corynebacterium glutamicum 
     180        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     181        511  Pseudomonas aeruginosa (strain PA7)
     182        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     184        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
     185        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     186        507  Geobacillus kaustophilus (strain HTA426)
     187        506  Staphylococcus aureus (strain Newman)
     188        502  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
     189        501  Deinococcus radiodurans 
     190        500  Pseudomonas entomophila (strain L48)
     191        499  Brucella abortus biovar 1 (strain 9-941)
     192        497  Streptomyces avermitilis 
     193        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     194        496  Bacillus clausii (strain KSM-K16)
     195        495  Burkholderia pseudomallei (strain K96243)
     196        495  Haemophilus influenzae (strain 86-028NP)
     197        494  Proteus mirabilis (strain HI4320)
     198        492  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     199        492  Bacillus amyloliquefaciens (strain FZB42)
     200        491  Xanthomonas campestris pv. campestris (strain 8004)
     201        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     202        487  Shewanella sp. (strain MR-7)
     203        486  Mannheimia succiniciproducens (strain MBEL55E)
     204        484  Pseudomonas aeruginosa (strain LESB58)
     205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     206        484  Shewanella sp. (strain MR-4)
     207        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     208        481  Thermosynechococcus elongatus (strain BP-1)
     209        480  Acinetobacter sp. (strain ADP1)
     210        479  Pyrococcus horikoshii 
     211        478  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     212        478  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     213        475  Pseudomonas putida (strain F1 / ATCC 700007)
     214        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     215        474  Brucella abortus (strain 2308)
     216        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     217        472  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     218        469  Methanosarcina mazei  
     219        468  Pyrococcus abyssi (strain GE5 / Orsay)
     220        468  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 
     221        467  Clostridium perfringens (strain 13 / Type A)
     222        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     223        466  Shewanella frigidimarina (strain NCIMB 400)
     224        466  Pseudomonas putida (strain GB-1)
     225        466  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     226        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     227        463  Shewanella sp. (strain ANA-3)
     228        462  Burkholderia mallei (strain ATCC 23344)
     229        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     230        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     231        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     232        459  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     233        459  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     234        458  Enterococcus faecalis (strain ATCC 700802 / V583)
     235        457  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
     236        455  Staphylococcus aureus (strain JH1)
     237        454  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     238        454  Ovis aries (Sheep)
     239        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     240        453  Pseudomonas putida (strain W619)
     241        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     242        452  Shewanella baltica (strain OS185)
     243        451  Aeromonas salmonicida (strain A449)
     244        450  Nicotiana tabacum (Common tobacco)
     245        449  Thermoanaerobacter tengcongensis  
     246        449  Staphylococcus aureus (strain JH9)
     247        449  Hahella chejuensis (strain KCTC 2396)
     248        448  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
     249        448  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
     250        447  Vibrio fischeri (strain MJ11)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18988 (  4%)
    Bacteria         328706 ( 61%)
    Eukaryota        175157 ( 32%)
    Viruses           16314 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20248 ( 12%)           (  4%)
     Other Mammalia         45847 ( 26%)           (  9%)
     Other Vertebrata       17341 ( 10%)           (  3%)
     Viridiplantae          33519 ( 19%)           (  6%)
     Fungi                  30795 ( 18%)           (  6%)
     Insecta                 8501 (  5%)           (  2%)
     Nematoda                4257 (  2%)           (  1%)
     Other                  14649 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8853             1001-1100     3738
                 51- 100   41348             1101-1200     2587
                101- 150   57607             1201-1300     2014
                151- 200   57696             1301-1400     1876
                201- 250   56449             1401-1500     1505
                251- 300   49902             1501-1600      730
                301- 350   50069             1601-1700      562
                351- 400   43255             1701-1800      464
                401- 450   35433             1801-1900      423
                451- 500   28531             1901-2000      351
                501- 550   20294             2001-2100      212
                551- 600   14553             2101-2200      285
                601- 650   12249             2201-2300      293
                651- 700    8829             2301-2400      174
                701- 750    7274             2401-2500      136
                751- 800    5174             >2500         1087
                801- 850    4530
                851- 900    5017
                901- 950    3866
                951-1000    2743

   


   The average sequence length in UniProtKB/Swiss-Prot is 355 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2301


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  753
                       2x:  294
                       3x:  159
                       4x:  116
                       5x:   87
                       6x:   71
                       7x:   57
                       8x:   41
                       9x:   37
                      10x:   28
                  11- 20x:  184
                  21- 50x:  193
                  51-100x:   99
                    >100x:  182


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        20838   Journal of Biological Chemistry
    2         9404   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5650   Journal of Bacteriology
    4         5002   Biochemical and Biophysical Research Communications
    5         4594   Gene
    6         4529   Nucleic Acids Research
    7         4394   Biochemistry
    8         4332   FEBS Letters
    9         4184   The EMBO Journal
   10         3898   Molecular and Cellular Biology
   11         3666   Nature
   12         3521   Journal of Molecular Biology
   13         3237   European Journal of Biochemistry
   14         3201   Biochimica et Biophysica Acta
   15         3004   Cell
   16         2506   Journal of Virology
   17         2505   Genomics
   18         2471   Biochemical Journal
   19         2425   Science
   20         2028   Molecular Microbiology
   21         1840   Journal of Cell Biology
   22         1815   Plant Physiology
   23         1630   Plant Molecular Biology
   24         1579   The American Journal of Human Genetics
   25         1570   Genes and Development
   26         1524   Virology
   27         1491   Nature Genetics
   28         1445   Human Molecular Genetics
   29         1418   Oncogene
   30         1338   Molecular and General Genetics
   31         1322   Development
   32         1292   Human Mutation
   33         1278   Molecular Biology of the Cell
   34         1263   The Plant Cell
   35         1229   Journal of Biochemistry
   36         1181   Journal of Immunology
   37         1131   The Plant Journal
   38         1124   Molecular Cell
   39         1098   Genetics
   40         1061   Structure
   41         1022   Journal of General Virology
   42          967   Blood
   43          946   Infection and Immunity
   44          923   Archives of Biochemistry and Biophysics
   45          921   Journal of Cell Science
   46          852   Microbiology
   47          824   Developmental Biology
   48          800   Cancer Research
   49          786   Yeast
   50          782   Current Biology
   51          726   FEMS Microbiology Letters
   52          660   Acta Crystallographica, Section D
   53          647   Protein Science
   54          637   Journal of Neuroscience
   55          637   Toxicon
   56          626   Applied and Environmental Microbiology
   57          624   Human Genetics
   58          623   Nature Structural Biology
   59          622   Mechanisms of Development
   60          587   Neuron
   61          568   Journal of Clinical Investigation
   62          543   American Journal of Physiology
   63          537   Current Genetics
   64          527   The Journal of Experimental Medicine
   65          506   PLoS ONE
   66          486   Proteins
   67          482   Molecular Endocrinology
   68          479   Mammalian Genome
   69          461   Journal of Neurochemistry
   70          457   Plant and Cell Physiology
   71          456   Immunogenetics
   72          442   The Journal of Clinical Endocrinology and Metabolism
   73          437   Bioscience, Biotechnology, and Biochemistry
   74          436   Nature Cell Biology
   75          434   Endocrinology
   76          428   Molecular and Biochemical Parasitology
   77          408   Journal of Medical Genetics
   78          397   Journal of Molecular Evolution
   79          379   Molecular Biology and Evolution
   80          377   DNA and Cell Biology
   81          371   Experimental Cell Research
   82          365   DNA Sequence
   83          347   Peptides
   84          328   Brain Research. Molecular Brain Research
   85          324   Tissue Antigens
   86          319   Comparative Biochemistry and Physiology
   87          318   Developmental Cell
   88          316   RNA
   89          314   Antimicrobial Agents and Chemotherapy
   90          308   Journal of Investigative Dermatology
   91          308   Nature Structural and Molecular Biology
   92          302   Molecular Pharmacology
   93          302   The FEBS Journal
   94          294   Biological Chemistry Hoppe-Seyler
   95          292   Planta
   96          284   Biology of Reproduction
   97          279   Cytogenetics and Cell Genetics
   98          278   Neurology
   99          267   Developmental Dynamics
  100          266   Genome Research
  101          266   Virus Research
  102          256   Journal of General Microbiology
  103          251   EMBO Reports
  104          250   Biochimie
  105          250   Immunity
  106          248   Eukaryotic Cell
  107          244   Molecular Plant-Microbe Interactions
  108          238   Genes to Cells
  109          236   The FASEB Journal
  110          235   The New England Journal of Medicine
  111          230   European Journal of Immunology
  112          222   Annals of Neurology
  113          220   European Journal of Human Genetics
  114          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  115          212   DNA Research
  116          210   Journal of Human Genetics
  117          204   Journal of the American Chemical Society
  118          202   Investigative Ophthalmology and Visual Science
  119          198   Archives of Microbiology
  120          193   Nature Immunology
  121          190   Archives of Virology
  122          188   Journal of Cellular Biochemistry
  123          186   BMC Genomics
  124          185   American Journal of Medical Genetics. Part A
  125          184   Molecular and Cellular Endocrinology
  126          182   Molecular Immunology
  127          181   Acta Crystallographica, Section F
  128          179   Glycobiology
  129          176   Clinical Genetics
  130          176   Journal of Experimental Botany
  131          175   Journal of Medicinal Chemistry
  132          172   Diabetes
  133          172   Insect Biochemistry and Molecular Biology
  134          168   American Journal of Medical Genetics
  135          168   Molecular Phylogenetics and Evolution
  136          165   Circulation Research
  137          162   International Journal of Cancer
  138          159   Molecular Reproduction and Development
  139          159   DNA
  140          156   PLoS Genetics
  141          156   Molecular Genetics and Metabolism
  142          155   Hemoglobin
  143          154   Bioorganicheskaia Khimiia
  144          153   Phytochemistry
  145          152   Traffic
  146          151   Molecular Genetics and Genomics
  147          151   Molecular and Cellular Neuroscience
  148          151   Biological Chemistry
  149          150   Protein Expression and Purification
  150          146   Journal of Lipid Research


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1037380                 1.92                                         
   Journal                            830271     415160      1.54       1                                 
   Submitted to EMBL/GenBank/DDBJ     198015     177263      0.37       2                                 
   Submitted to other databases         6877       6412      0.01       3                                 
   Book citation                         720        706     <0.01       4                                 
   Plant Gene Register                   578        566     <0.01       5                                 
   Thesis                                419        416     <0.01       6                                 
   Unpublished observations              304        300     <0.01       7                                 
   Patent                                190        187     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 332145

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2414263                 4.48                                         
   ALLERGEN                              529        529     <0.01      27                                 
   ALTERNATIVE PRODUCTS                21656      21656      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        4771       4771      0.01      23                                 
   BIOTECHNOLOGY                         339        337     <0.01      28                                 
   CATALYTIC ACTIVITY                 242976     220294      0.45       4                                 
   CAUTION                              9249       9078      0.02      18                                 
   COFACTOR                           106973      97807      0.20       7                                 
   DEVELOPMENTAL STAGE                  9783       9783      0.02      17                                 
   DISEASE                              5181       3472      0.01      22                                 
   DISRUPTION PHENOTYPE                 5381       5381      0.01      21                                 
   DOMAIN                              38797      34243      0.07      10                                 
   ENZYME REGULATION                   10994      10994      0.02      15                                 
   FUNCTION                           419495     402327      0.78       2                                 
   INDUCTION                           14878      14878      0.03      14                                 
   INTERACTION                          9793       9793      0.02      16                                 
   MASS SPECTROMETRY                    5468       4174      0.01      20                                 
   MISCELLANEOUS                       32495      30037      0.06      12                                 
   PATHWAY                            131707     119532      0.24       6                                 
   PHARMACEUTICAL                         90         90     <0.01      29                                 
   POLYMORPHISM                          889        836     <0.01      24                                 
   PTM                                 45348      35600      0.08       8                                 
   RNA EDITING                           627        627     <0.01      25                                 
   SEQUENCE CAUTION                    40933      40933      0.08       9                                 
   SIMILARITY                         639577     514428      1.19       1                                 
   SUBCELLULAR LOCATION               325957     320118      0.60       3                                 
   SUBUNIT                            242575     242575      0.45       5                                 
   TISSUE SPECIFICITY                  38341      38341      0.07      11                                 
   TOXIC DOSE                            545        510     <0.01      26                                 
   WEB RESOURCE                         8916       7122      0.02      19                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3701860                 6.87                                         
   ACT_SITE                           140351      85691      0.26       9                                 
   BINDING                            280740      74805      0.52       4                                 
   CA_BIND                              3880       1601      0.01      35                                 
   CARBOHYD                           107252      27469      0.20      15                                 
   CHAIN                              545976     533132      1.01       1                                 
   COILED                              20137      13833      0.04      26                                 
   COMPBIAS                            54229      28741      0.10      18                                 
   CONFLICT                           126972      44515      0.24      12                                 
   CROSSLNK                             6663       3889      0.01      34                                 
   DISULFID                           108791      29867      0.20      14                                 
   DNA_BIND                            10327       9430      0.02      31                                 
   DOMAIN                             160409      95320      0.30       8                                 
   HELIX                              175434      17151      0.33       7                                 
   INIT_MET                            15326      15326      0.03      27                                 
   INTRAMEM                             2139        919     <0.01      37                                 
   LIPID                               11890       7547      0.02      30                                 
   METAL                              313589      77234      0.58       3                                 
   MOD_RES                            195707      63750      0.36       5                                 
   MOTIF                               35584      22999      0.07      24                                 
   MUTAGEN                             42245       9852      0.08      22                                 
   NON_CONS                             2034        749     <0.01      38                                 
   NON_STD                               354        279     <0.01      39                                 
   NON_TER                             12199       9321      0.02      29                                 
   NP_BIND                            116551      72619      0.22      13                                 
   PEPTIDE                             10089       6820      0.02      32                                 
   PROPEP                              12637      10870      0.02      28                                 
   REGION                             129641      65792      0.24      11                                 
   REPEAT                              94649      13989      0.18      16                                 
   SIGNAL                              38167      38157      0.07      23                                 
   SITE                                45533      25463      0.08      19                                 
   STRAND                             184116      16223      0.34       6                                 
   TOPO_DOM                           130061      26992      0.24      10                                 
   TRANSIT                              8264       8161      0.02      33                                 
   TRANSMEM                           355398      73357      0.66       2                                 
   TURN                                42827      13901      0.08      21                                 
   UNSURE                               3141        607      0.01      36                                 
   VAR_SEQ                             43974      18817      0.08      20                                 
   VARIANT                             85244      16722      0.16      17                                 
   ZN_FING                             29340      12895      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15726439                29.17                                                           
   2DBase-Ecoli                           85         85     <0.01     129      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     126      2D gel databases                             
   AGD                                   932        926     <0.01     104      Organism-specific databases                  
   Allergome                            1483        929     <0.01      99      Protein family/group databases               
   ANU-2DPAGE                             27         27     <0.01     135      2D gel databases                             
   ArachnoServer                         763        755     <0.01     109      Organism-specific databases                  
   ArrayExpress                        60032      60032      0.11      43      Gene expression databases                    
   Bgee                                38759      38759      0.07      46      Gene expression databases                    
   BindingDB                             295        295     <0.01     121      Other                                        
   BioCyc                             229558     220520      0.43      22      Enzyme and pathway databases                 
   BRENDA                               4308       4298      0.01      91      Enzyme and pathway databases                 
   CAZy                                 7601       6841      0.01      75      Protein family/group databases               
   CGD                                   692        670     <0.01     110      Organism-specific databases                  
   ChEMBL                               5222       5222      0.01      82      Other                                        
   CleanEx                             30091      29450      0.06      52      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     128      2D gel databases                             
   ConoServer                            916        834     <0.01     106      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     130      2D gel databases                             
   CTD                                 69568      68904      0.13      41      Organism-specific databases                  
   CYGD                                 5596       5593      0.01      79      Organism-specific databases                  
   dictyBase                            4203       4086      0.01      93      Organism-specific databases                  
   DIP                                 14128      14037      0.03      69      Protein-protein interaction databases        
   DisProt                               398        395     <0.01     119      3D structure databases                       
   DMDM                                16762      16759      0.03      65      Polymorphism databases                       
   DNASU                               18677      18606      0.03      59      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     125      2D gel databases                             
   DrugBank                             5319       1628      0.01      81      Other                                        
   EchoBASE                             4161       4161      0.01      94      Organism-specific databases                  
   EcoGene                              4292       4290      0.01      92      Organism-specific databases                  
   eggNOG                             430419     430419      0.80       9      Phylogenomic databases                       
   EMBL                               934602     528152      1.73       3      Sequence databases                           
   Ensembl                             80691      48037      0.15      36      Genome annotation databases                  
   EnsemblBacteria                     98130      85125      0.18      31      Genome annotation databases                  
   EnsemblFungi                        17423      17131      0.03      64      Genome annotation databases                  
   EnsemblMetazoa                      11917       8849      0.02      71      Genome annotation databases                  
   EnsemblPlants                       15649      13858      0.03      68      Genome annotation databases                  
   EnsemblProtists                      4461       4336      0.01      90      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     131      Organism-specific databases                  
   EuPathDB                              571        501     <0.01     114      Organism-specific databases                  
   EvolutionaryTrace                   16530      16530      0.03      66      Other                                        
   FlyBase                              5881       5507      0.01      78      Organism-specific databases                  
   Gene3D                             330774     253802      0.61      17      Family and domain databases                  
   GeneCards                           20052      19764      0.04      57      Organism-specific databases                  
   GeneFarm                             3135       3124      0.01      96      Organism-specific databases                  
   GeneID                             501305     470967      0.93       6      Genome annotation databases                  
   GeneTree                            37501      37483      0.07      47      Phylogenomic databases                       
   Genevestigator                      67151      67151      0.12      42      Gene expression databases                    
   GenoList                             7069       7057      0.01      76      Organism-specific databases                  
   GenomeReviews                      377544     357887      0.70      13      Genome annotation databases                  
   GenomeRNAi                          21232      21232      0.04      55      Other                                        
   GermOnline                          41897      41323      0.08      45      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     122      PTM databases                                
   GO                                2394044     509051      4.44       1      Ontologies                                   
   Gramene                              4880       4880      0.01      85      Organism-specific databases                  
   H-InvDB                              5593       4772      0.01      80      Organism-specific databases                  
   HAMAP                              314843     314599      0.58      18      Family and domain databases                  
   HGNC                                19842      19676      0.04      58      Organism-specific databases                  
   HOGENOM                            385061     385061      0.71      12      Phylogenomic databases                       
   HOVERGEN                            75528      75528      0.14      38      Phylogenomic databases                       
   HPA                                 17641      13725      0.03      62      Organism-specific databases                  
   HSSP                                30572      30572      0.06      51      3D structure databases                       
   InParanoid                          69729      69729      0.13      40      Phylogenomic databases                       
   IntAct                              34202      34202      0.06      49      Protein-protein interaction databases        
   InterPro                          1772888     516246      3.29       2      Family and domain databases                  
   IPI                                 96313      67517      0.18      33      Sequence databases                           
   KEGG                               478924     449333      0.89       8      Genome annotation databases                  
   KO                                 373616     373195      0.69      14      Phylogenomic databases                       
   LegioList                             765        763     <0.01     108      Organism-specific databases                  
   Leproma                               671        668     <0.01     111      Organism-specific databases                  
   MaizeGDB                              497        492     <0.01     117      Organism-specific databases                  
   MEROPS                              10500      10500      0.02      73      Protein family/group databases               
   MGI                                 16501      16455      0.03      67      Organism-specific databases                  
   MIM                                 17908      13595      0.03      61      Organism-specific databases                  
   MINT                                17630      17630      0.03      63      Protein-protein interaction databases        
   mycoCLAP                              268        263     <0.01     123      Protein family/group databases               
   NextBio                             70058      70058      0.13      39      Other                                        
   neXtProt                            20086      20086      0.04      56      Organism-specific databases                  
   OGP                                   377        377     <0.01     120      2D gel databases                             
   OMA                                391125     391125      0.73      11      Phylogenomic databases                       
   Orphanet                             4682       2650      0.01      88      Organism-specific databases                  
   OrthoDB                             78192      78192      0.15      37      Phylogenomic databases                       
   PANTHER                            195995     182914      0.36      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      89      Enzyme and pathway databases                 
   PATRIC                             308862     308834      0.57      20      Genome annotation databases                  
   PaxDb                               37188      37188      0.07      48      Proteomic databases                          
   PDB                                 90602      18896      0.17      35      3D structure databases                       
   PDBsum                              90602      18896      0.17      34      3D structure databases                       
   PeptideAtlas                         5163       5163      0.01      83      Proteomic databases                          
   PeroxiBase                            770        754     <0.01     107      Protein family/group databases               
   Pfam                               717357     496903      1.33       4      Family and domain databases                  
   PharmGKB                            18375      18351      0.03      60      Organism-specific databases                  
   PHCI-2DPAGE                           250        250     <0.01     124      2D gel databases                             
   PhosphoSite                         33569      33569      0.06      50      PTM databases                                
   PhosSite                              631        619     <0.01     112      PTM databases                                
   PhylomeDB                           27470      27470      0.05      54      Phylogenomic databases                       
   PIR                                118472     108341      0.22      28      Sequence databases                           
   PIRSF                               98670      98655      0.18      30      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01     100      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     132      2D gel databases                             
   PomBase                              5016       4959      0.01      84      Organism-specific databases                  
   PptaseDB                               38         38     <0.01     133      Protein family/group databases               
   PRIDE                              110533     110533      0.21      29      Proteomic databases                          
   PRINTS                             137392     120190      0.25      26      Family and domain databases                  
   ProDom                              29300      29121      0.05      53      Family and domain databases                  
   ProMEX                                524        524     <0.01     115      Proteomic databases                          
   PROSITE                            481877     303955      0.89       7      Family and domain databases                  
   ProtClustDB                        343656     343656      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 430232     430232      0.80      10      3D structure databases                       
   PseudoCAP                            1250       1241     <0.01     102      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     134      2D gel databases                             
   Reactome                            12772       7726      0.02      70      Enzyme and pathway databases                 
   REBASE                                403        403     <0.01     118      Protein family/group databases               
   RefSeq                             525614     471415      0.97       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01     101      2D gel databases                             
   RGD                                  7749       7745      0.01      74      Organism-specific databases                  
   SGD                                  6640       6635      0.01      77      Organism-specific databases                  
   Siena-2DPAGE                          103        103     <0.01     127      2D gel databases                             
   SMART                              167429     125335      0.31      25      Family and domain databases                  
   SMR                                218970     218970      0.41      23      3D structure databases                       
   STRING                             309544     309541      0.57      19      Protein-protein interaction databases        
   SUPFAM                             331089     262664      0.61      16      Family and domain databases                  
   SWISS-2DPAGE                         1182       1181     <0.01     103      2D gel databases                             
   TAIR                                11848      11795      0.02      72      Organism-specific databases                  
   TCDB                                 3658       3643      0.01      95      Protein family/group databases               
   TIGRFAMs                           289980     269409      0.54      21      Family and domain databases                  
   TubercuList                          2033       1997     <0.01      98      Organism-specific databases                  
   UCD-2DPAGE                            509        500     <0.01     116      2D gel databases                             
   UCSC                                51989      39854      0.10      44      Genome annotation databases                  
   UniGene                             96808      87922      0.18      32      Sequence databases                           
   UniPathway                         131594     119421      0.24      27      Enzyme and pathway databases                 
   VectorBase                            606        588     <0.01     113      Genome annotation databases                  
   World-2DPAGE                          920        909     <0.01     105      2D gel databases                             
   WormBase                             4823       3899      0.01      86      Organism-specific databases                  
   Xenbase                              4728       4723      0.01      87      Organism-specific databases                  
   ZFIN                                 2787       2787      0.01      97      Organism-specific databases                  

Total number of cross-referenced databases: 135

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.56
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.07   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.37   Ile (I) 5.96   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4460 entries are encoded on a mitochondrion, and 3703 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 74396