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         UniProtKB/Swiss-Prot protein knowledgebase release 2013_01 statistics


1.  INTRODUCTION

Release 2013_01 of 09-Jan-13 of UniProtKB/Swiss-Prot contains 538849 sequence entries,
comprising 191337357 amino acids abstracted from 215706 references. 

272 sequences have been added since release 2012_11, the sequence data of
300 existing entries has been updated and the annotations of
163026 entries have been revised.

Number of fragments: 9045
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 32913


Protein existence (PE):           entries     %

1: Evidence at protein level        77110   14.3%
2: Evidence at transcript level     68099   12.6%
3: Inferred from homology          377455     70%
4: Predicted                        14297    2.7%
5: Uncertain                         1888    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12938

   The first twenty species represent 112892 sequences:    21 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5431
                            2x: 1883
                            3x:  983
                            4x:  641
                            5x:  466
                            6x:  382
                            7x:  284
                            8x:  218
                            9x:  199
                           10x:  123
                       11- 20x:  672
                       21- 50x:  403
                       51-100x:  212
                         >100x: 1041


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20232  Homo sapiens (Human)
       2      16580  Mus musculus (Mouse)
       3      11752  Arabidopsis thaliana (Mouse-ear cress)
       4       7839  Rattus norvegicus (Rat)
       5       6621  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5973  Bos taurus (Bovine)
       7       5089  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4188  Bacillus subtilis (strain 168)
      10       4126  Dictyostelium discoideum (Slime mold)
      11       3377  Caenorhabditis elegans
      12       3361  Xenopus laevis (African clawed frog)
      13       3179  Drosophila melanogaster (Fruit fly)
      14       2995  Oryza sativa subsp. japonica (Rice)
      15       2872  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2253  Gallus gallus (Chicken)
      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
      18       2014  Escherichia coli O157:H7
      19       2005  Mycobacterium tuberculosis
      20       1787  Methanocaldococcus jannaschii  
      21       1770  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1688  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      24       1681  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
      25       1678  Shigella flexneri
      26       1411  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1242  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      29       1242  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1036  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1018  Yersinia pestis
      33       1013  Archaeoglobus fulgidus 
      34        950  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
      35        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        904  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        886  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis (strain SC-B67)
      48        878  Shigella sonnei (strain Ss046)
      49        869  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        863  Yersinia pseudotuberculosis serotype I (strain IP32953)
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        835  Neurospora crassa 
      54        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        825  Escherichia coli (strain UTI89 / UPEC)
      57        821  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        803  Canis familiaris (Dog) (Canis lupus familiaris)
      60        791  Escherichia coli (strain SMS-3-5 / SECEC)
      61        787  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
      62        783  Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) 
      63        782  Aquifex aeolicus (strain VF5)
      64        775  Pasteurella multocida (strain Pm70)
      65        773  Emericella nidulans  
      66        771  Escherichia coli (strain K12 / DH10B)
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Staphylococcus epidermidis (strain ATCC 12228)
      75        756  Escherichia coli (strain SE11)
      76        756  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
      77        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      78        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        740  Staphylococcus aureus (strain NCTC 8325)
      82        735  Bacillus halodurans 
      83        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      84        734  Bacillus anthracis
      85        733  Vibrio vulnificus (strain CMCP6)
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      93        713  Enterobacter sp. (strain 638)
      94        713  Salmonella agona (strain SL483)
      95        713  Escherichia coli O1:K1 / APEC
      96        713  Salmonella newport (strain SL254)
      97        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      98        712  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
      99        712  Zea mays (Maize)
     100        712  Salmonella schwarzengrund (strain CVM19633)
     101        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     102        710  Salmonella heidelberg (strain SL476)
     103        702  Salmonella dublin (strain CT_02021853)
     104        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     105        696  Klebsiella pneumoniae (strain 342)
     106        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     107        693  Pseudomonas putida (strain KT2440)
     108        689  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        688  Pan troglodytes (Chimpanzee)
     110        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     111        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     112        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        670  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae (strain TN)
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        654  Bradyrhizobium japonicum (strain USDA 110)
     120        653  Debaryomyces hansenii   
     121        652  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        650  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     123        645  Escherichia coli
     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     128        634  Shewanella oneidensis (strain MR-1)
     129        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     130        632  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        617  Oryza sativa subsp. indica (Rice)
     133        616  Treponema pallidum (strain Nichols)
     134        613  Methanothermobacter thermautotrophicus  
     135        612  Staphylococcus haemolyticus (strain JCSC1435)
     136        606  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     137        605  Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
     138        602  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     139        602  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
     140        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     141        602  Staphylococcus saprophyticus subsp. saprophyticus 
     142        601  Salmonella paratyphi C (strain RKS4594)
     143        600  Yersinia pestis bv. Antiqua (strain Angola)
     144        590  Bacillus cereus (strain ATCC 10987)
     145        590  Listeria innocua serovar 6a (strain CLIP 11262)
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        580  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     149        578  Neisseria meningitidis serogroup B (strain MC58)
     150        576  Brucella suis biovar 1 (strain 1330)
     151        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        568  Caenorhabditis briggsae
     154        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     155        566  Pseudomonas syringae pv. syringae (strain B728a)
     156        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     157        564  Vibrio fischeri (strain ATCC 700601 / ES114)
     158        564  Caulobacter crescentus (strain ATCC 19089 / CB15)
     159        564  Pseudomonas aeruginosa (strain UCBPP-PA14)
     160        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     161        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     162        561  Bacillus cereus (strain ZK / E33L)
     163        556  Xanthomonas axonopodis pv. citri (strain 306)
     164        556  Clostridium acetobutylicum 
     165        552  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     166        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     167        552  Pseudomonas fluorescens (strain Pf0-1)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        533  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     172        529  Sodalis glossinidius (strain morsitans)
     173        529  Listeria monocytogenes serotype 4b (strain F2365)
     174        528  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
     175        522  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     176        522  Xylella fastidiosa (strain 9a5c)
     177        515  Chromobacterium violaceum 
     178        515  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
     179        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     180        511  Pseudomonas aeruginosa (strain PA7)
     181        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     182        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     183        508  Corynebacterium glutamicum 
     184        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
     185        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     186        507  Geobacillus kaustophilus (strain HTA426)
     187        506  Staphylococcus aureus (strain Newman)
     188        502  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
     189        501  Deinococcus radiodurans 
     190        500  Pseudomonas entomophila (strain L48)
     191        499  Brucella abortus biovar 1 (strain 9-941)
     192        497  Streptomyces avermitilis 
     193        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     194        496  Bacillus clausii (strain KSM-K16)
     195        495  Burkholderia pseudomallei (strain K96243)
     196        495  Haemophilus influenzae (strain 86-028NP)
     197        494  Proteus mirabilis (strain HI4320)
     198        492  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     199        492  Bacillus amyloliquefaciens (strain FZB42)
     200        491  Xanthomonas campestris pv. campestris (strain 8004)
     201        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     202        487  Shewanella sp. (strain MR-7)
     203        486  Mannheimia succiniciproducens (strain MBEL55E)
     204        484  Pseudomonas aeruginosa (strain LESB58)
     205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     206        484  Shewanella sp. (strain MR-4)
     207        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     208        481  Thermosynechococcus elongatus (strain BP-1)
     209        480  Acinetobacter sp. (strain ADP1)
     210        479  Pyrococcus horikoshii 
     211        478  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     212        478  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     213        475  Pseudomonas putida (strain F1 / ATCC 700007)
     214        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     215        474  Brucella abortus (strain 2308)
     216        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     217        472  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     218        469  Methanosarcina mazei  
     219        468  Pyrococcus abyssi (strain GE5 / Orsay)
     220        467  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 
     221        467  Clostridium perfringens (strain 13 / Type A)
     222        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     223        466  Shewanella frigidimarina (strain NCIMB 400)
     224        466  Pseudomonas putida (strain GB-1)
     225        466  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     226        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     227        463  Shewanella sp. (strain ANA-3)
     228        462  Burkholderia mallei (strain ATCC 23344)
     229        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     230        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     231        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     232        459  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     233        459  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     234        458  Enterococcus faecalis (strain ATCC 700802 / V583)
     235        455  Staphylococcus aureus (strain JH1)
     236        454  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     237        454  Ovis aries (Sheep)
     238        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     239        453  Pseudomonas putida (strain W619)
     240        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     241        452  Shewanella baltica (strain OS185)
     242        451  Aeromonas salmonicida (strain A449)
     243        449  Thermoanaerobacter tengcongensis  
     244        449  Staphylococcus aureus (strain JH9)
     245        449  Nicotiana tabacum (Common tobacco)
     246        449  Hahella chejuensis (strain KCTC 2396)
     247        449  Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
     248        448  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
     249        448  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
     250        447  Vibrio fischeri (strain MJ11)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18977 (  4%)
    Bacteria         328667 ( 61%)
    Eukaryota        174906 ( 32%)
    Viruses           16299 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20233 ( 12%)           (  4%)
     Other Mammalia         45812 ( 26%)           (  9%)
     Other Vertebrata       17325 ( 10%)           (  3%)
     Viridiplantae          33401 ( 19%)           (  6%)
     Fungi                  30792 ( 18%)           (  6%)
     Insecta                 8498 (  5%)           (  2%)
     Nematoda                4252 (  2%)           (  1%)
     Other                  14593 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8805             1001-1100     3738
                 51- 100   41334             1101-1200     2586
                101- 150   57571             1201-1300     2011
                151- 200   57664             1301-1400     1873
                201- 250   56430             1401-1500     1503
                251- 300   49870             1501-1600      730
                301- 350   50051             1601-1700      561
                351- 400   43231             1701-1800      459
                401- 450   35430             1801-1900      424
                451- 500   28518             1901-2000      351
                501- 550   20272             2001-2100      212
                551- 600   14547             2101-2200      285
                601- 650   12246             2201-2300      292
                651- 700    8828             2301-2400      172
                701- 750    7274             2401-2500      136
                751- 800    5171             >2500         1082
                801- 850    4528
                851- 900    5015
                901- 950    3861
                951-1000    2743

   


   The average sequence length in UniProtKB/Swiss-Prot is 355 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2288


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  749
                       2x:  292
                       3x:  156
                       4x:  117
                       5x:   84
                       6x:   72
                       7x:   56
                       8x:   45
                       9x:   34
                      10x:   26
                  11- 20x:  185
                  21- 50x:  191
                  51-100x:   99
                    >100x:  182


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        20733   Journal of Biological Chemistry
    2         9366   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5632   Journal of Bacteriology
    4         4989   Biochemical and Biophysical Research Communications
    5         4589   Gene
    6         4514   Nucleic Acids Research
    7         4367   Biochemistry
    8         4321   FEBS Letters
    9         4171   The EMBO Journal
   10         3895   Molecular and Cellular Biology
   11         3648   Nature
   12         3496   Journal of Molecular Biology
   13         3235   European Journal of Biochemistry
   14         3195   Biochimica et Biophysica Acta
   15         2992   Cell
   16         2505   Genomics
   17         2476   Journal of Virology
   18         2454   Biochemical Journal
   19         2411   Science
   20         2018   Molecular Microbiology
   21         1833   Journal of Cell Biology
   22         1805   Plant Physiology
   23         1628   Plant Molecular Biology
   24         1575   The American Journal of Human Genetics
   25         1565   Genes and Development
   26         1514   Virology
   27         1489   Nature Genetics
   28         1443   Human Molecular Genetics
   29         1412   Oncogene
   30         1336   Molecular and General Genetics
   31         1314   Development
   32         1290   Human Mutation
   33         1275   Molecular Biology of the Cell
   34         1245   The Plant Cell
   35         1228   Journal of Biochemistry
   36         1171   Journal of Immunology
   37         1125   The Plant Journal
   38         1114   Molecular Cell
   39         1096   Genetics
   40         1051   Structure
   41         1015   Journal of General Virology
   42          963   Blood
   43          943   Infection and Immunity
   44          921   Archives of Biochemistry and Biophysics
   45          916   Journal of Cell Science
   46          846   Microbiology
   47          822   Developmental Biology
   48          796   Cancer Research
   49          785   Yeast
   50          778   Current Biology
   51          719   FEMS Microbiology Letters
   52          654   Acta Crystallographica, Section D
   53          642   Protein Science
   54          635   Journal of Neuroscience
   55          630   Toxicon
   56          624   Applied and Environmental Microbiology
   57          624   Human Genetics
   58          620   Mechanisms of Development
   59          620   Nature Structural Biology
   60          586   Neuron
   61          568   Journal of Clinical Investigation
   62          537   Current Genetics
   63          535   American Journal of Physiology
   64          525   The Journal of Experimental Medicine
   65          487   PLoS ONE
   66          484   Proteins
   67          482   Molecular Endocrinology
   68          479   Mammalian Genome
   69          460   Journal of Neurochemistry
   70          456   Immunogenetics
   71          453   Plant and Cell Physiology
   72          442   The Journal of Clinical Endocrinology and Metabolism
   73          435   Bioscience, Biotechnology, and Biochemistry
   74          433   Endocrinology
   75          432   Nature Cell Biology
   76          428   Molecular and Biochemical Parasitology
   77          406   Journal of Medical Genetics
   78          396   Journal of Molecular Evolution
   79          379   Molecular Biology and Evolution
   80          377   DNA and Cell Biology
   81          369   Experimental Cell Research
   82          364   DNA Sequence
   83          344   Peptides
   84          326   Brain Research. Molecular Brain Research
   85          324   Tissue Antigens
   86          318   Comparative Biochemistry and Physiology
   87          317   Developmental Cell
   88          314   RNA
   89          312   Antimicrobial Agents and Chemotherapy
   90          308   Journal of Investigative Dermatology
   91          302   Molecular Pharmacology
   92          301   Nature Structural and Molecular Biology
   93          297   The FEBS Journal
   94          294   Biological Chemistry Hoppe-Seyler
   95          291   Planta
   96          282   Biology of Reproduction
   97          279   Cytogenetics and Cell Genetics
   98          278   Neurology
   99          267   Developmental Dynamics
  100          265   Genome Research
  101          263   Virus Research
  102          256   Journal of General Microbiology
  103          251   EMBO Reports
  104          248   Immunity
  105          247   Biochimie
  106          246   Eukaryotic Cell
  107          244   Molecular Plant-Microbe Interactions
  108          237   Genes to Cells
  109          236   The FASEB Journal
  110          234   The New England Journal of Medicine
  111          228   European Journal of Immunology
  112          222   Annals of Neurology
  113          220   European Journal of Human Genetics
  114          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  115          212   DNA Research
  116          210   Journal of Human Genetics
  117          201   Journal of the American Chemical Society
  118          198   Investigative Ophthalmology and Visual Science
  119          196   Archives of Microbiology
  120          193   Nature Immunology
  121          190   Archives of Virology
  122          188   Journal of Cellular Biochemistry
  123          183   Molecular and Cellular Endocrinology
  124          183   BMC Genomics
  125          183   American Journal of Medical Genetics. Part A
  126          181   Molecular Immunology
  127          179   Glycobiology
  128          176   Clinical Genetics
  129          172   Diabetes
  130          172   Insect Biochemistry and Molecular Biology
  131          172   Journal of Experimental Botany
  132          170   Acta Crystallographica, Section F
  133          168   Journal of Medicinal Chemistry
  134          168   American Journal of Medical Genetics
  135          168   Molecular Phylogenetics and Evolution
  136          164   Circulation Research
  137          161   International Journal of Cancer
  138          159   DNA
  139          158   Molecular Reproduction and Development
  140          155   PLoS Genetics
  141          155   Hemoglobin
  142          154   Bioorganicheskaia Khimiia
  143          154   Molecular Genetics and Metabolism
  144          153   Phytochemistry
  145          150   Molecular Genetics and Genomics
  146          150   Traffic
  147          150   Molecular and Cellular Neuroscience
  148          149   Biological Chemistry
  149          147   Protein Expression and Purification
  150          146   Journal of Lipid Research


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1034610                 1.92                                         
   Journal                            827199     414711      1.54       1                                 
   Submitted to EMBL/GenBank/DDBJ     198343     177678      0.37       2                                 
   Submitted to other databases         6872       6408      0.01       3                                 
   Book citation                         720        706     <0.01       4                                 
   Plant Gene Register                   578        566     <0.01       5                                 
   Thesis                                419        416     <0.01       6                                 
   Unpublished observations              283        279     <0.01       7                                 
   Patent                                190        187     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 330815

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2407401                 4.47                                         
   ALLERGEN                              522        522     <0.01      27                                 
   ALTERNATIVE PRODUCTS                21483      21483      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        4730       4730      0.01      23                                 
   BIOTECHNOLOGY                         332        330     <0.01      28                                 
   CATALYTIC ACTIVITY                 242293     219835      0.45       4                                 
   CAUTION                              8146       7979      0.02      19                                 
   COFACTOR                           106756      97593      0.20       7                                 
   DEVELOPMENTAL STAGE                  9749       9749      0.02      17                                 
   DISEASE                              5169       3464      0.01      22                                 
   DISRUPTION PHENOTYPE                 5271       5271      0.01      21                                 
   DOMAIN                              38493      34049      0.07      10                                 
   ENZYME REGULATION                   10937      10937      0.02      15                                 
   FUNCTION                           417519     400383      0.77       2                                 
   INDUCTION                           14754      14754      0.03      14                                 
   INTERACTION                          9794       9794      0.02      16                                 
   MASS SPECTROMETRY                    5384       4104      0.01      20                                 
   MISCELLANEOUS                       32403      29950      0.06      12                                 
   PATHWAY                            131616     119442      0.24       6                                 
   PHARMACEUTICAL                         89         89     <0.01      29                                 
   POLYMORPHISM                          876        823     <0.01      24                                 
   PTM                                 45049      35418      0.08       8                                 
   RNA EDITING                           625        625     <0.01      25                                 
   SEQUENCE CAUTION                    40862      40862      0.08       9                                 
   SIMILARITY                         639212     514135      1.19       1                                 
   SUBCELLULAR LOCATION               325527     319723      0.60       3                                 
   SUBUNIT                            242221     242221      0.45       5                                 
   TISSUE SPECIFICITY                  38141      38141      0.07      11                                 
   TOXIC DOSE                            539        506     <0.01      26                                 
   WEB RESOURCE                         8909       7115      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3688013                 6.84                                         
   ACT_SITE                           139423      85447      0.26       9                                 
   BINDING                            277669      74190      0.52       4                                 
   CA_BIND                              3871       1596      0.01      35                                 
   CARBOHYD                           107061      27415      0.20      15                                 
   CHAIN                              545694     532871      1.01       1                                 
   COILED                              20112      13813      0.04      26                                 
   COMPBIAS                            54122      28678      0.10      18                                 
   CONFLICT                           126695      44444      0.24      12                                 
   CROSSLNK                             6663       3889      0.01      34                                 
   DISULFID                           108050      29356      0.20      14                                 
   DNA_BIND                            10323       9427      0.02      31                                 
   DOMAIN                             160287      95247      0.30       8                                 
   HELIX                              175447      17152      0.33       7                                 
   INIT_MET                            15317      15317      0.03      27                                 
   INTRAMEM                             2139        919     <0.01      37                                 
   LIPID                               11863       7529      0.02      30                                 
   METAL                              312601      76996      0.58       3                                 
   MOD_RES                            195386      63649      0.36       5                                 
   MOTIF                               35532      22966      0.07      24                                 
   MUTAGEN                             41898       9752      0.08      22                                 
   NON_CONS                             2029        744     <0.01      38                                 
   NON_STD                               354        279     <0.01      39                                 
   NON_TER                             12193       9315      0.02      29                                 
   NP_BIND                            116341      72530      0.22      13                                 
   PEPTIDE                             10020       6758      0.02      32                                 
   PROPEP                              12619      10853      0.02      28                                 
   REGION                             127845      65508      0.24      11                                 
   REPEAT                              94439      13969      0.18      16                                 
   SIGNAL                              38100      38090      0.07      23                                 
   SITE                                42720      24694      0.08      21                                 
   STRAND                             184128      16224      0.34       6                                 
   TOPO_DOM                           129782      26951      0.24      10                                 
   TRANSIT                              8240       8137      0.02      33                                 
   TRANSMEM                           355191      73302      0.66       2                                 
   TURN                                42832      13902      0.08      20                                 
   UNSURE                               3138        604      0.01      36                                 
   VAR_SEQ                             43421      18650      0.08      19                                 
   VARIANT                             85160      16714      0.16      17                                 
   ZN_FING                             29308      12893      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15729659                29.19                                                           
   2DBase-Ecoli                           85         85     <0.01     128      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     125      2D gel databases                             
   AGD                                   932        926     <0.01     104      Organism-specific databases                  
   Allergome                            1463        913     <0.01      99      Protein family/group databases               
   ANU-2DPAGE                             27         27     <0.01     134      2D gel databases                             
   ArachnoServer                         763        755     <0.01     110      Organism-specific databases                  
   ArrayExpress                        60006      60006      0.11      43      Gene expression databases                    
   Bgee                                39220      39220      0.07      46      Gene expression databases                    
   BindingDB                             295        295     <0.01     121      Other                                        
   BioCyc                             250066     240724      0.46      22      Enzyme and pathway databases                 
   BRENDA                               4303       4293      0.01      91      Enzyme and pathway databases                 
   CAZy                                 7594       6835      0.01      75      Protein family/group databases               
   CGD                                   692        670     <0.01     111      Organism-specific databases                  
   ChEMBL                               5222       5222      0.01      82      Other                                        
   CleanEx                             30093      29452      0.06      52      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     127      2D gel databases                             
   ConoServer                            915        833     <0.01     106      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     129      2D gel databases                             
   CTD                                 69548      68884      0.13      41      Organism-specific databases                  
   CYGD                                 5596       5593      0.01      79      Organism-specific databases                  
   dictyBase                            4203       4086      0.01      93      Organism-specific databases                  
   DIP                                 13942      13848      0.03      69      Protein-protein interaction databases        
   DisProt                               398        395     <0.01     119      3D structure databases                       
   DMDM                                16762      16759      0.03      65      Polymorphism databases                       
   DNASU                               18668      18597      0.03      59      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     124      2D gel databases                             
   DrugBank                             5319       1628      0.01      81      Other                                        
   EchoBASE                             4161       4161      0.01      94      Organism-specific databases                  
   EcoGene                              4292       4290      0.01      92      Organism-specific databases                  
   eggNOG                             430338     430338      0.80       9      Phylogenomic databases                       
   EMBL                               932778     527902      1.73       3      Sequence databases                           
   Ensembl                             80175      47998      0.15      36      Genome annotation databases                  
   EnsemblBacteria                     98095      85100      0.18      31      Genome annotation databases                  
   EnsemblFungi                        17423      17131      0.03      64      Genome annotation databases                  
   EnsemblMetazoa                      11906       8842      0.02      71      Genome annotation databases                  
   EnsemblPlants                       15549      13774      0.03      68      Genome annotation databases                  
   EnsemblProtists                      4461       4336      0.01      90      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     130      Organism-specific databases                  
   EuPathDB                              808        807     <0.01     107      Organism-specific databases                  
   EvolutionaryTrace                   16522      16522      0.03      66      Other                                        
   FlyBase                              5878       5504      0.01      78      Organism-specific databases                  
   Gene3D                             330668     253728      0.61      17      Family and domain databases                  
   GeneCards                           20032      19724      0.04      57      Organism-specific databases                  
   GeneFarm                             3095       3084      0.01      96      Organism-specific databases                  
   GeneID                             502238     470734      0.93       6      Genome annotation databases                  
   GeneTree                            37472      37454      0.07      47      Phylogenomic databases                       
   Genevestigator                      67077      67077      0.12      42      Gene expression databases                    
   GenoList                             7069       7057      0.01      76      Organism-specific databases                  
   GenomeReviews                      377431     357786      0.70      13      Genome annotation databases                  
   GenomeRNAi                          21218      21218      0.04      55      Other                                        
   GermOnline                          41899      41325      0.08      45      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     122      PTM databases                                
   GO                                2384689     508755      4.43       1      Ontologies                                   
   Gramene                              4874       4874      0.01      85      Organism-specific databases                  
   H-InvDB                              5596       4774      0.01      80      Organism-specific databases                  
   HAMAP                              314607     314363      0.58      18      Family and domain databases                  
   HGNC                                19820      19660      0.04      58      Organism-specific databases                  
   HOGENOM                            384939     384939      0.71      12      Phylogenomic databases                       
   HOVERGEN                            75521      75521      0.14      38      Phylogenomic databases                       
   HPA                                 17641      13725      0.03      62      Organism-specific databases                  
   HSSP                                30541      30541      0.06      51      3D structure databases                       
   InParanoid                          69654      69654      0.13      40      Phylogenomic databases                       
   IntAct                              34190      34190      0.06      49      Protein-protein interaction databases        
   InterPro                          1772273     516025      3.29       2      Family and domain databases                  
   IPI                                 95897      67412      0.18      33      Sequence databases                           
   KEGG                               477109     448500      0.89       8      Genome annotation databases                  
   KO                                 372577     372190      0.69      14      Phylogenomic databases                       
   LegioList                             765        763     <0.01     109      Organism-specific databases                  
   Leproma                               671        668     <0.01     112      Organism-specific databases                  
   MaizeGDB                              497        492     <0.01     117      Organism-specific databases                  
   MEROPS                              10495      10495      0.02      73      Protein family/group databases               
   MGI                                 16491      16446      0.03      67      Organism-specific databases                  
   MIM                                 17881      13564      0.03      61      Organism-specific databases                  
   MINT                                17628      17628      0.03      63      Protein-protein interaction databases        
   NextBio                             70028      70028      0.13      39      Other                                        
   neXtProt                            20088      20088      0.04      56      Organism-specific databases                  
   OGP                                   377        377     <0.01     120      2D gel databases                             
   OMA                                390983     390983      0.73      11      Phylogenomic databases                       
   Orphanet                             4478       2566      0.01      89      Organism-specific databases                  
   OrthoDB                             78177      78177      0.15      37      Phylogenomic databases                       
   PANTHER                            195971     182890      0.36      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      88      Enzyme and pathway databases                 
   PATRIC                             308825     308800      0.57      20      Genome annotation databases                  
   PaxDb                               37152      37152      0.07      48      Proteomic databases                          
   PDB                                 90575      18883      0.17      35      3D structure databases                       
   PDBsum                              90575      18883      0.17      34      3D structure databases                       
   PeptideAtlas                         5163       5163      0.01      83      Proteomic databases                          
   PeroxiBase                            770        754     <0.01     108      Protein family/group databases               
   Pfam                               717075     496698      1.33       4      Family and domain databases                  
   PharmGKB                            18375      18351      0.03      60      Organism-specific databases                  
   PHCI-2DPAGE                           250        250     <0.01     123      2D gel databases                             
   PhosphoSite                         33567      33567      0.06      50      PTM databases                                
   PhosSite                              630        618     <0.01     113      PTM databases                                
   PhylomeDB                           27408      27408      0.05      54      Phylogenomic databases                       
   PIR                                118394     108268      0.22      28      Sequence databases                           
   PIRSF                               98641      98626      0.18      30      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01     100      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     131      2D gel databases                             
   PomBase                              5015       4958      0.01      84      Organism-specific databases                  
   PptaseDB                               38         38     <0.01     132      Protein family/group databases               
   PRIDE                              110438     110438      0.20      29      Proteomic databases                          
   PRINTS                             137351     120152      0.25      26      Family and domain databases                  
   ProDom                              29297      29118      0.05      53      Family and domain databases                  
   ProMEX                                522        522     <0.01     115      Proteomic databases                          
   PROSITE                            481632     303794      0.89       7      Family and domain databases                  
   ProtClustDB                        343546     343546      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 430131     430131      0.80      10      3D structure databases                       
   PseudoCAP                            1250       1241     <0.01     102      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     133      2D gel databases                             
   Reactome                            12772       7726      0.02      70      Enzyme and pathway databases                 
   REBASE                                403        403     <0.01     118      Protein family/group databases               
   RefSeq                             526275     471064      0.98       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01     101      2D gel databases                             
   RGD                                  7748       7744      0.01      74      Organism-specific databases                  
   SGD                                  6640       6635      0.01      77      Organism-specific databases                  
   Siena-2DPAGE                          103        103     <0.01     126      2D gel databases                             
   SMART                              167370     125293      0.31      25      Family and domain databases                  
   SMR                                218885     218885      0.41      23      3D structure databases                       
   STRING                             309486     309483      0.57      19      Protein-protein interaction databases        
   SUPFAM                             330991     262581      0.61      16      Family and domain databases                  
   SWISS-2DPAGE                         1182       1181     <0.01     103      2D gel databases                             
   TAIR                                11769      11716      0.02      72      Organism-specific databases                  
   TCDB                                 3658       3643      0.01      95      Protein family/group databases               
   TIGRFAMs                           289954     269383      0.54      21      Family and domain databases                  
   TubercuList                          2018       1982     <0.01      98      Organism-specific databases                  
   UCD-2DPAGE                            509        500     <0.01     116      2D gel databases                             
   UCSC                                51977      39842      0.10      44      Genome annotation databases                  
   UniGene                             96657      87808      0.18      32      Sequence databases                           
   UniPathway                         131503     119331      0.24      27      Enzyme and pathway databases                 
   VectorBase                            606        588     <0.01     114      Genome annotation databases                  
   World-2DPAGE                          920        909     <0.01     105      2D gel databases                             
   WormBase                             4818       3894      0.01      86      Organism-specific databases                  
   Xenbase                              4728       4723      0.01      87      Organism-specific databases                  
   ZFIN                                 2783       2783      0.01      97      Organism-specific databases                  

Total number of cross-referenced databases: 134

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.56
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.07   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.37   Ile (I) 5.96   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4460 entries are encoded on a mitochondrion, and 3697 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 74284