Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

         UniProtKB/Swiss-Prot protein knowledgebase release 2012_09 statistics


1.  INTRODUCTION

Release 2012_09 of 03-Oct-12 of UniProtKB/Swiss-Prot contains 538010 sequence entries,
comprising 190998508 amino acids abstracted from 213490 references. 

527 sequences have been added since release 2012_08, the sequence data of
404 existing entries has been updated and the annotations of
366127 entries have been revised.

Number of fragments: 9061
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 32533


Protein existence (PE):           entries     %

1: Evidence at protein level        76308   14.2%
2: Evidence at transcript level     68067   12.7%
3: Inferred from homology          377413   70.1%
4: Predicted                        14336    2.7%
5: Uncertain                         1886    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12909

   The first twenty species represent 112445 sequences:  20.9 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5423
                            2x: 1881
                            3x:  979
                            4x:  636
                            5x:  465
                            6x:  382
                            7x:  282
                            8x:  216
                            9x:  199
                           10x:  126
                       11- 20x:  665
                       21- 50x:  402
                       51-100x:  212
                         >100x: 1041


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20234  Homo sapiens (Human)
       2      16563  Mus musculus (Mouse)
       3      11502  Arabidopsis thaliana (Mouse-ear cress)
       4       7807  Rattus norvegicus (Rat)
       5       6621  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5962  Bos taurus (Bovine)
       7       5089  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4188  Bacillus subtilis (strain 168)
      10       4126  Dictyostelium discoideum (Slime mold)
      11       3363  Caenorhabditis elegans
      12       3354  Xenopus laevis (African clawed frog)
      13       3161  Drosophila melanogaster (Fruit fly)
      14       2957  Oryza sativa subsp. japonica (Rice)
      15       2858  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2251  Gallus gallus (Chicken)
      17       2218  Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
      18       2012  Escherichia coli O157:H7
      19       1961  Mycobacterium tuberculosis
      20       1787  Methanocaldococcus jannaschii  
      21       1770  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1678  Shigella flexneri
      24       1675  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      25       1675  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
      26       1409  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1240  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
      29       1239  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1035  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1018  Yersinia pestis
      33       1012  Archaeoglobus fulgidus 
      34        949  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
      35        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        904  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        886  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis (strain SC-B67)
      48        878  Shigella sonnei (strain Ss046)
      49        869  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        863  Yersinia pseudotuberculosis serotype I (strain IP32953)
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        834  Neurospora crassa 
      54        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        825  Escherichia coli (strain UTI89 / UPEC)
      57        821  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        803  Canis familiaris (Dog) (Canis lupus familiaris)
      60        791  Escherichia coli (strain SMS-3-5 / SECEC)
      61        787  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
      62        783  Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) 
      63        782  Aquifex aeolicus (strain VF5)
      64        775  Pasteurella multocida (strain Pm70)
      65        773  Emericella nidulans  
      66        771  Escherichia coli (strain K12 / DH10B)
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Staphylococcus epidermidis (strain ATCC 12228)
      75        756  Escherichia coli (strain SE11)
      76        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      77        754  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
      78        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        738  Staphylococcus aureus (strain NCTC 8325)
      82        735  Bacillus halodurans 
      83        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      84        734  Bacillus anthracis
      85        732  Vibrio vulnificus (strain CMCP6)
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      93        713  Enterobacter sp. (strain 638)
      94        713  Salmonella agona (strain SL483)
      95        713  Escherichia coli O1:K1 / APEC
      96        713  Salmonella newport (strain SL254)
      97        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      98        712  Salmonella schwarzengrund (strain CVM19633)
      99        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     100        710  Salmonella heidelberg (strain SL476)
     101        708  Zea mays (Maize)
     102        702  Salmonella dublin (strain CT_02021853)
     103        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     104        696  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
     105        696  Klebsiella pneumoniae (strain 342)
     106        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     107        693  Pseudomonas putida (strain KT2440)
     108        689  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        688  Pan troglodytes (Chimpanzee)
     110        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     111        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     112        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        670  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae (strain TN)
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        654  Bradyrhizobium japonicum (strain USDA 110)
     120        653  Debaryomyces hansenii   
     121        652  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        650  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     123        645  Escherichia coli
     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     128        634  Shewanella oneidensis (strain MR-1)
     129        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     130        632  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        616  Treponema pallidum (strain Nichols)
     133        614  Oryza sativa subsp. indica (Rice)
     134        613  Methanothermobacter thermautotrophicus  
     135        612  Staphylococcus haemolyticus (strain JCSC1435)
     136        606  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     137        605  Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
     138        602  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     139        602  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
     140        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     141        602  Staphylococcus saprophyticus subsp. saprophyticus 
     142        601  Salmonella paratyphi C (strain RKS4594)
     143        600  Yersinia pestis bv. Antiqua (strain Angola)
     144        590  Bacillus cereus (strain ATCC 10987)
     145        590  Listeria innocua serovar 6a (strain CLIP 11262)
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        580  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     149        576  Neisseria meningitidis serogroup B (strain MC58)
     150        576  Brucella suis biovar 1 (strain 1330)
     151        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        568  Caenorhabditis briggsae
     154        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     155        566  Pseudomonas syringae pv. syringae (strain B728a)
     156        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     157        564  Vibrio fischeri (strain ATCC 700601 / ES114)
     158        564  Caulobacter crescentus (strain ATCC 19089 / CB15)
     159        564  Pseudomonas aeruginosa (strain UCBPP-PA14)
     160        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     161        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     162        561  Bacillus cereus (strain ZK / E33L)
     163        556  Xanthomonas axonopodis pv. citri (strain 306)
     164        556  Clostridium acetobutylicum 
     165        552  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     166        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     167        552  Pseudomonas fluorescens (strain Pf0-1)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        533  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     172        529  Sodalis glossinidius (strain morsitans)
     173        529  Listeria monocytogenes serotype 4b (strain F2365)
     174        526  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
     175        522  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     176        522  Xylella fastidiosa (strain 9a5c)
     177        515  Chromobacterium violaceum 
     178        515  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
     179        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     180        511  Pseudomonas aeruginosa (strain PA7)
     181        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     182        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     183        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
     184        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     185        507  Geobacillus kaustophilus (strain HTA426)
     186        506  Staphylococcus aureus (strain Newman)
     187        502  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
     188        501  Deinococcus radiodurans 
     189        500  Pseudomonas entomophila (strain L48)
     190        499  Corynebacterium glutamicum 
     191        499  Brucella abortus biovar 1 (strain 9-941)
     192        497  Streptomyces avermitilis 
     193        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     194        496  Bacillus clausii (strain KSM-K16)
     195        495  Burkholderia pseudomallei (strain K96243)
     196        495  Haemophilus influenzae (strain 86-028NP)
     197        494  Proteus mirabilis (strain HI4320)
     198        492  Bacillus amyloliquefaciens (strain FZB42)
     199        491  Xanthomonas campestris pv. campestris (strain 8004)
     200        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     201        489  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     202        487  Shewanella sp. (strain MR-7)
     203        486  Mannheimia succiniciproducens (strain MBEL55E)
     204        484  Pseudomonas aeruginosa (strain LESB58)
     205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     206        484  Shewanella sp. (strain MR-4)
     207        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     208        481  Thermosynechococcus elongatus (strain BP-1)
     209        480  Acinetobacter sp. (strain ADP1)
     210        479  Pyrococcus horikoshii 
     211        478  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     212        475  Pseudomonas putida (strain F1 / ATCC 700007)
     213        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     214        474  Brucella abortus (strain 2308)
     215        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     216        472  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     217        469  Methanosarcina mazei  
     218        467  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 
     219        467  Clostridium perfringens (strain 13 / Type A)
     220        466  Pyrococcus abyssi (strain GE5 / Orsay)
     221        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     222        466  Shewanella frigidimarina (strain NCIMB 400)
     223        466  Pseudomonas putida (strain GB-1)
     224        466  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     225        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     226        463  Shewanella sp. (strain ANA-3)
     227        462  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     228        462  Burkholderia mallei (strain ATCC 23344)
     229        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     230        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     231        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     232        459  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     233        458  Enterococcus faecalis (strain ATCC 700802 / V583)
     234        455  Staphylococcus aureus (strain JH1)
     235        455  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     236        454  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     237        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     238        453  Ovis aries (Sheep)
     239        453  Pseudomonas putida (strain W619)
     240        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     241        452  Shewanella baltica (strain OS185)
     242        451  Aeromonas salmonicida (strain A449)
     243        449  Thermoanaerobacter tengcongensis  
     244        449  Staphylococcus aureus (strain JH9)
     245        449  Hahella chejuensis (strain KCTC 2396)
     246        448  Nicotiana tabacum (Common tobacco)
     247        447  Vibrio fischeri (strain MJ11)
     248        447  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
     249        446  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
     250        446  Streptococcus mutans serotype c (strain ATCC 700610 / UA159)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18950 (  4%)
    Bacteria         328507 ( 61%)
    Eukaryota        174260 ( 32%)
    Viruses           16293 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20235 ( 12%)           (  4%)
     Other Mammalia         45748 ( 26%)           (  9%)
     Other Vertebrata       17251 ( 10%)           (  3%)
     Viridiplantae          33063 ( 19%)           (  6%)
     Fungi                  30775 ( 18%)           (  6%)
     Insecta                 8421 (  5%)           (  2%)
     Nematoda                4237 (  2%)           (  1%)
     Other                  14530 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8714             1001-1100     3717
                 51- 100   41259             1101-1200     2584
                101- 150   57493             1201-1300     2007
                151- 200   57622             1301-1400     1870
                201- 250   56388             1401-1500     1502
                251- 300   49825             1501-1600      725
                301- 350   49971             1601-1700      561
                351- 400   43178             1701-1800      459
                401- 450   35375             1801-1900      423
                451- 500   28475             1901-2000      346
                501- 550   20230             2001-2100      212
                551- 600   14515             2101-2200      283
                601- 650   12210             2201-2300      292
                651- 700    8815             2301-2400      172
                701- 750    7261             2401-2500      136
                751- 800    5155             >2500         1081
                801- 850    4515
                851- 900    5009
                901- 950    3849
                951-1000    2720

   


   The average sequence length in UniProtKB/Swiss-Prot is 355 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2270


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  746
                       2x:  292
                       3x:  146
                       4x:  118
                       5x:   84
                       6x:   71
                       7x:   55
                       8x:   50
                       9x:   29
                      10x:   28
                  11- 20x:  181
                  21- 50x:  190
                  51-100x:  101
                    >100x:  179


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        20493   Journal of Biological Chemistry
    2         9303   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5586   Journal of Bacteriology
    4         4959   Biochemical and Biophysical Research Communications
    5         4582   Gene
    6         4489   Nucleic Acids Research
    7         4333   Biochemistry
    8         4285   FEBS Letters
    9         4141   The EMBO Journal
   10         3861   Molecular and Cellular Biology
   11         3617   Nature
   12         3459   Journal of Molecular Biology
   13         3219   European Journal of Biochemistry
   14         3167   Biochimica et Biophysica Acta
   15         2969   Cell
   16         2502   Genomics
   17         2462   Journal of Virology
   18         2409   Biochemical Journal
   19         2388   Science
   20         1983   Molecular Microbiology
   21         1813   Journal of Cell Biology
   22         1742   Plant Physiology
   23         1609   Plant Molecular Biology
   24         1552   Genes and Development
   25         1548   The American Journal of Human Genetics
   26         1513   Virology
   27         1474   Nature Genetics
   28         1430   Human Molecular Genetics
   29         1400   Oncogene
   30         1328   Molecular and General Genetics
   31         1300   Development
   32         1282   Human Mutation
   33         1244   Molecular Biology of the Cell
   34         1223   Journal of Biochemistry
   35         1211   The Plant Cell
   36         1150   Journal of Immunology
   37         1095   Molecular Cell
   38         1087   The Plant Journal
   39         1086   Genetics
   40         1044   Structure
   41         1013   Journal of General Virology
   42          954   Blood
   43          922   Infection and Immunity
   44          918   Archives of Biochemistry and Biophysics
   45          899   Journal of Cell Science
   46          826   Microbiology
   47          813   Developmental Biology
   48          792   Cancer Research
   49          783   Yeast
   50          767   Current Biology
   51          709   FEMS Microbiology Letters
   52          644   Acta Crystallographica, Section D
   53          632   Protein Science
   54          629   Journal of Neuroscience
   55          622   Applied and Environmental Microbiology
   56          622   Human Genetics
   57          618   Toxicon
   58          617   Nature Structural Biology
   59          616   Mechanisms of Development
   60          578   Neuron
   61          564   Journal of Clinical Investigation
   62          537   Current Genetics
   63          529   American Journal of Physiology
   64          517   The Journal of Experimental Medicine
   65          480   Molecular Endocrinology
   66          479   Mammalian Genome
   67          477   Proteins
   68          457   Journal of Neurochemistry
   69          455   Immunogenetics
   70          441   The Journal of Clinical Endocrinology and Metabolism
   71          432   Plant and Cell Physiology
   72          432   PLoS ONE
   73          430   Bioscience, Biotechnology, and Biochemistry
   74          429   Endocrinology
   75          428   Molecular and Biochemical Parasitology
   76          422   Nature Cell Biology
   77          398   Journal of Medical Genetics
   78          393   Journal of Molecular Evolution
   79          375   Molecular Biology and Evolution
   80          375   DNA and Cell Biology
   81          367   Experimental Cell Research
   82          364   DNA Sequence
   83          341   Peptides
   84          325   Brain Research. Molecular Brain Research
   85          323   Tissue Antigens
   86          318   Comparative Biochemistry and Physiology
   87          311   Developmental Cell
   88          309   Antimicrobial Agents and Chemotherapy
   89          308   RNA
   90          302   Journal of Investigative Dermatology
   91          302   Molecular Pharmacology
   92          294   Biological Chemistry Hoppe-Seyler
   93          292   Nature Structural and Molecular Biology
   94          288   Planta
   95          283   The FEBS Journal
   96          279   Cytogenetics and Cell Genetics
   97          277   Neurology
   98          274   Biology of Reproduction
   99          266   Developmental Dynamics
  100          262   Genome Research
  101          262   Virus Research
  102          254   Journal of General Microbiology
  103          246   EMBO Reports
  104          245   Immunity
  105          242   Molecular Plant-Microbe Interactions
  106          239   Biochimie
  107          232   Genes to Cells
  108          230   The New England Journal of Medicine
  109          230   Eukaryotic Cell
  110          229   The FASEB Journal
  111          227   European Journal of Immunology
  112          222   Annals of Neurology
  113          219   European Journal of Human Genetics
  114          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  115          212   DNA Research
  116          208   Journal of Human Genetics
  117          196   Investigative Ophthalmology and Visual Science
  118          194   Archives of Microbiology
  119          193   Journal of the American Chemical Society
  120          188   Archives of Virology
  121          184   Nature Immunology
  122          183   Molecular and Cellular Endocrinology
  123          183   American Journal of Medical Genetics. Part A
  124          183   Journal of Cellular Biochemistry
  125          181   BMC Genomics
  126          178   Molecular Immunology
  127          176   Glycobiology
  128          175   Clinical Genetics
  129          172   Insect Biochemistry and Molecular Biology
  130          171   Diabetes
  131          168   American Journal of Medical Genetics
  132          167   Journal of Medicinal Chemistry
  133          167   Molecular Phylogenetics and Evolution
  134          161   Journal of Experimental Botany
  135          160   Acta Crystallographica, Section F
  136          160   Circulation Research
  137          159   International Journal of Cancer
  138          159   DNA
  139          158   Molecular Reproduction and Development
  140          155   Hemoglobin
  141          154   Bioorganicheskaia Khimiia
  142          153   Molecular Genetics and Metabolism
  143          149   Biological Chemistry
  144          148   PLoS Genetics
  145          148   Molecular Genetics and Genomics
  146          148   Molecular and Cellular Neuroscience
  147          147   Phytochemistry
  148          143   Protein Expression and Purification
  149          141   British Journal of Haematology
  150          141   Journal of Lipid Research


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1026354                 1.91                                         
   Journal                            819803     413495      1.52       1                                 
   Submitted to EMBL/GenBank/DDBJ     197535     177194      0.37       2                                 
   Submitted to other databases         6837       6374      0.01       3                                 
   Book citation                         710        696     <0.01       4                                 
   Plant Gene Register                   578        566     <0.01       5                                 
   Thesis                                413        410     <0.01       6                                 
   Unpublished observations              283        279     <0.01       7                                 
   Patent                                189        186     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 327313

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2395309                 4.45                                         
   ALLERGEN                              519        519     <0.01      26                                 
   ALTERNATIVE PRODUCTS                21242      21242      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        4563       4563      0.01      23                                 
   BIOTECHNOLOGY                         332        330     <0.01      28                                 
   CATALYTIC ACTIVITY                 241387     218816      0.45       4                                 
   CAUTION                              8062       7898      0.01      19                                 
   COFACTOR                           106326      97217      0.20       7                                 
   DEVELOPMENTAL STAGE                  9657       9657      0.02      16                                 
   DISEASE                              5111       3425      0.01      21                                 
   DISRUPTION PHENOTYPE                 4979       4979      0.01      22                                 
   DOMAIN                              38076      33706      0.07      10                                 
   ENZYME REGULATION                   10784      10784      0.02      15                                 
   FUNCTION                           415620     398547      0.77       2                                 
   INDUCTION                           14552      14552      0.03      14                                 
   INTERACTION                          9601       9601      0.02      17                                 
   MASS SPECTROMETRY                    5288       4042      0.01      20                                 
   MISCELLANEOUS                       31611      29176      0.06      12                                 
   PATHWAY                            131381     119240      0.24       6                                 
   PHARMACEUTICAL                         85         85     <0.01      29                                 
   POLYMORPHISM                          872        820     <0.01      24                                 
   PTM                                 44325      34990      0.08       8                                 
   RNA EDITING                           623        623     <0.01      25                                 
   SEQUENCE CAUTION                    40685      40685      0.08       9                                 
   SIMILARITY                         637470     513331      1.18       1                                 
   SUBCELLULAR LOCATION               324565     318788      0.60       3                                 
   SUBUNIT                            240495     240495      0.45       5                                 
   TISSUE SPECIFICITY                  37778      37778      0.07      11                                 
   TOXIC DOSE                            508        493     <0.01      27                                 
   WEB RESOURCE                         8812       7042      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3642496                 6.77                                         
   ACT_SITE                           137193      84135      0.26       9                                 
   BINDING                            265200      72171      0.49       4                                 
   CA_BIND                              3834       1587      0.01      35                                 
   CARBOHYD                           106644      27266      0.20      14                                 
   CHAIN                              544797     532128      1.01       1                                 
   COILED                              19973      13709      0.04      26                                 
   COMPBIAS                            53912      28539      0.10      18                                 
   CONFLICT                           126112      44235      0.23      11                                 
   CROSSLNK                             6603       3851      0.01      34                                 
   DISULFID                           106599      28471      0.20      15                                 
   DNA_BIND                            10279       9391      0.02      31                                 
   DOMAIN                             159304      94682      0.30       8                                 
   HELIX                              170742      16787      0.32       7                                 
   INIT_MET                            15289      15289      0.03      27                                 
   INTRAMEM                             2139        919     <0.01      37                                 
   LIPID                               11816       7488      0.02      30                                 
   METAL                              310325      76568      0.58       3                                 
   MOD_RES                            193851      63428      0.36       5                                 
   MOTIF                               35340      22862      0.07      24                                 
   MUTAGEN                             40846       9531      0.08      22                                 
   NON_CONS                             2028        743     <0.01      38                                 
   NON_STD                               354        279     <0.01      39                                 
   NON_TER                             12206       9330      0.02      29                                 
   NP_BIND                            115351      71975      0.21      13                                 
   PEPTIDE                              9862       6660      0.02      32                                 
   PROPEP                              12553      10791      0.02      28                                 
   REGION                             122368      63793      0.23      12                                 
   REPEAT                              93858      13893      0.17      16                                 
   SIGNAL                              37919      37909      0.07      23                                 
   SITE                                42011      24571      0.08      20                                 
   STRAND                             179602      15871      0.33       6                                 
   TOPO_DOM                           129195      26767      0.24      10                                 
   TRANSIT                              8160       8062      0.02      33                                 
   TRANSMEM                           354409      73096      0.66       2                                 
   TURN                                41718      13578      0.08      21                                 
   UNSURE                               3029        543      0.01      36                                 
   VAR_SEQ                             42979      18467      0.08      19                                 
   VARIANT                             84835      16683      0.16      17                                 
   ZN_FING                             29261      12870      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15563342                28.93                                                           
   2DBase-Ecoli                           85         85     <0.01     127      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     124      2D gel databases                             
   AGD                                   932        926     <0.01     102      Organism-specific databases                  
   Allergome                            1446        896     <0.01      98      Protein family/group databases               
   ANU-2DPAGE                             27         27     <0.01     134      2D gel databases                             
   ArachnoServer                         763        755     <0.01     108      Organism-specific databases                  
   ArrayExpress                        59896      59896      0.11      43      Gene expression databases                    
   Bgee                                39192      39192      0.07      47      Gene expression databases                    
   BindingDB                             295        295     <0.01     120      Other                                        
   BioCyc                             248595     240142      0.46      22      Enzyme and pathway databases                 
   BRENDA                               4293       4284      0.01      89      Enzyme and pathway databases                 
   CAZy                                 7577       6818      0.01      74      Protein family/group databases               
   CGD                                   677        655     <0.01     109      Organism-specific databases                  
   CleanEx                             30094      29453      0.06      51      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     126      2D gel databases                             
   ConoServer                            915        833     <0.01     104      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     128      2D gel databases                             
   CTD                                 68838      68189      0.13      41      Organism-specific databases                  
   CYGD                                 5596       5593      0.01      78      Organism-specific databases                  
   dictyBase                            4203       4086      0.01      91      Organism-specific databases                  
   DIP                                 13562      13467      0.03      68      Protein-protein interaction databases        
   DisProt                               398        395     <0.01     117      3D structure databases                       
   DMDM                                16765      16762      0.03      63      Polymorphism databases                       
   DNASU                               18653      18582      0.03      59      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     123      2D gel databases                             
   DrugBank                             5319       1628      0.01      80      Other                                        
   EchoBASE                             4167       4163      0.01      92      Organism-specific databases                  
   ECO2DBASE                             352        300     <0.01     119      2D gel databases                             
   EcoGene                              4292       4290      0.01      90      Organism-specific databases                  
   eggNOG                             429996     429996      0.80       9      Phylogenomic databases                       
   EMBL                               928928     527385      1.73       3      Sequence databases                           
   Ensembl                             81153      48186      0.15      35      Genome annotation databases                  
   EnsemblBacteria                     97966      84996      0.18      31      Genome annotation databases                  
   EnsemblFungi                        17304      17019      0.03      62      Genome annotation databases                  
   EnsemblMetazoa                      10352       8849      0.02      72      Genome annotation databases                  
   EnsemblPlants                       13592      13321      0.03      67      Genome annotation databases                  
   EnsemblProtists                      4453       4337      0.01      88      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     129      Organism-specific databases                  
   EuPathDB                              808        807     <0.01     105      Organism-specific databases                  
   EvolutionaryTrace                   16505      16505      0.03      64      Other                                        
   FlyBase                              5860       5486      0.01      77      Organism-specific databases                  
   Gene3D                             330118     253262      0.61      17      Family and domain databases                  
   GeneCards                           20037      19729      0.04      56      Organism-specific databases                  
   GeneFarm                             3078       3067      0.01      94      Organism-specific databases                  
   GeneID                             495323     469193      0.92       6      Genome annotation databases                  
   GeneTree                            52597      52568      0.10      44      Phylogenomic databases                       
   Genevestigator                      66836      66836      0.12      42      Gene expression databases                    
   GenoList                             7069       7057      0.01      75      Organism-specific databases                  
   GenomeReviews                      377072     357461      0.70      13      Genome annotation databases                  
   GenomeRNAi                          21198      21198      0.04      54      Other                                        
   GermOnline                          41901      41327      0.08      46      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     121      PTM databases                                
   GO                                2343866     506757      4.36       1      Ontologies                                   
   Gramene                              4843       4843      0.01      83      Organism-specific databases                  
   H-InvDB                              5596       4774      0.01      79      Organism-specific databases                  
   HAMAP                              312211     312005      0.58      18      Family and domain databases                  
   HGNC                                19806      19649      0.04      57      Organism-specific databases                  
   HOGENOM                            384519     384519      0.71      12      Phylogenomic databases                       
   HOVERGEN                            75471      75471      0.14      38      Phylogenomic databases                       
   HPA                                 15754      12087      0.03      66      Organism-specific databases                  
   HSSP                                30454      30454      0.06      50      3D structure databases                       
   InParanoid                          69401      69401      0.13      40      Phylogenomic databases                       
   IntAct                              33910      33910      0.06      48      Protein-protein interaction databases        
   InterPro                          1768354     514335      3.29       2      Family and domain databases                  
   IPI                                 95258      67090      0.18      32      Sequence databases                           
   KEGG                               468982     447292      0.87       8      Genome annotation databases                  
   KO                                 370522     370137      0.69      14      Phylogenomic databases                       
   LegioList                             765        763     <0.01     107      Organism-specific databases                  
   Leproma                               671        668     <0.01     110      Organism-specific databases                  
   MaizeGDB                              494        489     <0.01     115      Organism-specific databases                  
   MEROPS                              10482      10482      0.02      71      Protein family/group databases               
   MGI                                 16474      16429      0.03      65      Organism-specific databases                  
   MIM                                 17770      13511      0.03      60      Organism-specific databases                  
   MINT                                17618      17618      0.03      61      Protein-protein interaction databases        
   NextBio                             69685      69685      0.13      39      Other                                        
   neXtProt                            20086      20086      0.04      55      Organism-specific databases                  
   OGP                                   377        377     <0.01     118      2D gel databases                             
   OMA                                390510     390510      0.73      11      Phylogenomic databases                       
   Orphanet                             4478       2566      0.01      87      Organism-specific databases                  
   OrthoDB                             78124      78124      0.15      37      Phylogenomic databases                       
   PANTHER                            189654     177339      0.35      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      86      Enzyme and pathway databases                 
   PATRIC                             308689     308664      0.57      20      Genome annotation databases                  
   PDB                                 88513      18582      0.16      34      3D structure databases                       
   PDBsum                              88513      18582      0.16      33      3D structure databases                       
   PeptideAtlas                         5163       5163      0.01      81      Proteomic databases                          
   PeroxiBase                            768        752     <0.01     106      Protein family/group databases               
   Pfam                               711372     494957      1.32       4      Family and domain databases                  
   PharmGKB                            18758      18341      0.03      58      Organism-specific databases                  
   PHCI-2DPAGE                           250        250     <0.01     122      2D gel databases                             
   PhosphoSite                         33567      33567      0.06      49      PTM databases                                
   PhosSite                              625        613     <0.01     111      PTM databases                                
   PhylomeDB                           26786      26786      0.05      53      Phylogenomic databases                       
   PIR                                118166     108050      0.22      28      Sequence databases                           
   PIRSF                               98469      98454      0.18      29      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01      97      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     130      2D gel databases                             
   PomBase                              5016       4958      0.01      82      Organism-specific databases                  
   PptaseDB                               38         38     <0.01     131      Protein family/group databases               
   PRIDE                               79203      79203      0.15      36      Proteomic databases                          
   PRINTS                             137627     120428      0.26      26      Family and domain databases                  
   ProDom                              29289      29110      0.05      52      Family and domain databases                  
   ProMEX                                511        511     <0.01     113      Proteomic databases                          
   PROSITE                            479735     303215      0.89       7      Family and domain databases                  
   ProtClustDB                        343132     343132      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 429026     429026      0.80      10      3D structure databases                       
   PseudoCAP                            1247       1238     <0.01     100      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     133      2D gel databases                             
   Reactome                            12220       7550      0.02      69      Enzyme and pathway databases                 
   REBASE                                402        402     <0.01     116      Protein family/group databases               
   RefSeq                             518522     469485      0.96       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01      99      2D gel databases                             
   RGD                                  7715       7711      0.01      73      Organism-specific databases                  
   SGD                                  6640       6635      0.01      76      Organism-specific databases                  
   Siena-2DPAGE                          103        103     <0.01     125      2D gel databases                             
   SMART                              167116     125117      0.31      25      Family and domain databases                  
   SMR                                218803     218803      0.41      23      3D structure databases                       
   STRING                             309240     309237      0.57      19      Protein-protein interaction databases        
   SUPFAM                             330744     261891      0.61      16      Family and domain databases                  
   SWISS-2DPAGE                         1182       1181     <0.01     101      2D gel databases                             
   TAIR                                11519      11466      0.02      70      Organism-specific databases                  
   TCDB                                 3640       3625      0.01      93      Protein family/group databases               
   TIGR                                   33         31     <0.01     132      Genome annotation databases                  
   TIGRFAMs                           289840     269276      0.54      21      Family and domain databases                  
   TubercuList                          1977       1941     <0.01      96      Organism-specific databases                  
   UCD-2DPAGE                            509        500     <0.01     114      2D gel databases                             
   UCSC                                51918      39783      0.10      45      Genome annotation databases                  
   UniGene                             98332      89575      0.18      30      Sequence databases                           
   UniPathway                         131268     119129      0.24      27      Enzyme and pathway databases                 
   VectorBase                            606        588     <0.01     112      Genome annotation databases                  
   World-2DPAGE                          919        908     <0.01     103      2D gel databases                             
   WormBase                             4797       3879      0.01      84      Organism-specific databases                  
   Xenbase                              4712       4707      0.01      85      Organism-specific databases                  
   ZFIN                                 2780       2780      0.01      95      Organism-specific databases                  

Total number of cross-referenced databases: 134

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.56
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.37   Ile (I) 5.96   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4460 entries are encoded on a mitochondrion, and 3687 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 73999