Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

         UniProtKB/Swiss-Prot protein knowledgebase release 2012_08 statistics


1.  INTRODUCTION

Release 2012_08 of 05-Sep-12 of UniProtKB/Swiss-Prot contains 537505 sequence entries,
comprising 190795142 amino acids abstracted from 212324 references. 

745 sequences have been added since release 2012_07, the sequence data of
36 existing entries has been updated and the annotations of
173689 entries have been revised.

Number of fragments: 9059
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 32358


Protein existence (PE):           entries     %

1: Evidence at protein level        75873   14.1%
2: Evidence at transcript level     68046   12.7%
3: Inferred from homology          377344   70.2%
4: Predicted                        14342    2.7%
5: Uncertain                         1900    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12897

   The first twenty species represent 112216 sequences:  20.9 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5422
                            2x: 1882
                            3x:  979
                            4x:  633
                            5x:  461
                            6x:  383
                            7x:  283
                            8x:  219
                            9x:  200
                           10x:  120
                       11- 20x:  662
                       21- 50x:  400
                       51-100x:  212
                         >100x: 1041


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20231  Homo sapiens (Human)
       2      16547  Mus musculus (Mouse)
       3      11396  Arabidopsis thaliana (Mouse-ear cress)
       4       7786  Rattus norvegicus (Rat)
       5       6619  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5950  Bos taurus (Bovine)
       7       5089  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4188  Bacillus subtilis (strain 168)
      10       4126  Dictyostelium discoideum (Slime mold)
      11       3360  Caenorhabditis elegans
      12       3350  Xenopus laevis (African clawed frog)
      13       3158  Drosophila melanogaster (Fruit fly)
      14       2936  Oryza sativa subsp. japonica (Rice)
      15       2842  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2249  Gallus gallus (Chicken)
      17       2218  Pongo abelii (Sumatran orangutan)
      18       2012  Escherichia coli O157:H7
      19       1941  Mycobacterium tuberculosis
      20       1787  Methanocaldococcus jannaschii  
      21       1769  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1678  Shigella flexneri
      24       1675  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
      25       1664  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      26       1408  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1240  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
      29       1234  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1034  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1018  Yersinia pestis
      33       1012  Archaeoglobus fulgidus 
      34        949  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
      35        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        904  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        886  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis (strain SC-B67)
      48        878  Shigella sonnei (strain Ss046)
      49        869  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        863  Yersinia pseudotuberculosis serotype I (strain IP32953)
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        834  Neurospora crassa 
      54        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        825  Escherichia coli (strain UTI89 / UPEC)
      57        821  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        802  Canis familiaris (Dog) (Canis lupus familiaris)
      60        791  Escherichia coli (strain SMS-3-5 / SECEC)
      61        786  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
      62        783  Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) 
      63        781  Aquifex aeolicus (strain VF5)
      64        775  Pasteurella multocida (strain Pm70)
      65        771  Escherichia coli (strain K12 / DH10B)
      66        771  Emericella nidulans  
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Staphylococcus epidermidis (strain ATCC 12228)
      75        756  Escherichia coli (strain SE11)
      76        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      77        754  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
      78        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        738  Staphylococcus aureus (strain NCTC 8325)
      82        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      83        734  Bacillus anthracis
      84        734  Bacillus halodurans 
      85        732  Vibrio vulnificus (strain CMCP6)
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      93        713  Enterobacter sp. (strain 638)
      94        713  Salmonella agona (strain SL483)
      95        713  Escherichia coli O1:K1 / APEC
      96        713  Salmonella newport (strain SL254)
      97        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      98        712  Salmonella schwarzengrund (strain CVM19633)
      99        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     100        710  Salmonella heidelberg (strain SL476)
     101        708  Zea mays (Maize)
     102        702  Salmonella dublin (strain CT_02021853)
     103        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     104        696  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
     105        696  Klebsiella pneumoniae (strain 342)
     106        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     107        693  Pseudomonas putida (strain KT2440)
     108        689  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        688  Pan troglodytes (Chimpanzee)
     110        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     111        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     112        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        670  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae (strain TN)
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        654  Bradyrhizobium japonicum (strain USDA 110)
     120        653  Debaryomyces hansenii   
     121        652  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        650  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     123        645  Escherichia coli
     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     128        634  Shewanella oneidensis (strain MR-1)
     129        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     130        632  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        615  Treponema pallidum (strain Nichols)
     133        613  Methanothermobacter thermautotrophicus  
     134        612  Staphylococcus haemolyticus (strain JCSC1435)
     135        612  Oryza sativa subsp. indica (Rice)
     136        606  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     137        605  Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
     138        602  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
     139        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     140        602  Staphylococcus saprophyticus subsp. saprophyticus 
     141        601  Salmonella paratyphi C (strain RKS4594)
     142        601  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     143        600  Yersinia pestis bv. Antiqua (strain Angola)
     144        590  Bacillus cereus (strain ATCC 10987)
     145        590  Listeria innocua serovar 6a (strain CLIP 11262)
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        579  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     149        576  Neisseria meningitidis serogroup B (strain MC58)
     150        576  Brucella suis biovar 1 (strain 1330)
     151        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        568  Caenorhabditis briggsae
     154        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     155        566  Pseudomonas syringae pv. syringae (strain B728a)
     156        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     157        564  Vibrio fischeri (strain ATCC 700601 / ES114)
     158        564  Caulobacter crescentus (strain ATCC 19089 / CB15)
     159        564  Pseudomonas aeruginosa (strain UCBPP-PA14)
     160        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     161        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     162        561  Bacillus cereus (strain ZK / E33L)
     163        556  Xanthomonas axonopodis pv. citri (strain 306)
     164        556  Clostridium acetobutylicum 
     165        552  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     166        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     167        552  Pseudomonas fluorescens (strain Pf0-1)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        533  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     172        529  Sodalis glossinidius (strain morsitans)
     173        529  Listeria monocytogenes serotype 4b (strain F2365)
     174        526  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
     175        522  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     176        522  Xylella fastidiosa (strain 9a5c)
     177        515  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
     178        514  Chromobacterium violaceum 
     179        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     180        511  Pseudomonas aeruginosa (strain PA7)
     181        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     182        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     183        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
     184        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     185        507  Geobacillus kaustophilus (strain HTA426)
     186        506  Staphylococcus aureus (strain Newman)
     187        501  Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
     188        501  Deinococcus radiodurans 
     189        500  Pseudomonas entomophila (strain L48)
     190        499  Corynebacterium glutamicum 
     191        499  Brucella abortus biovar 1 (strain 9-941)
     192        497  Streptomyces avermitilis 
     193        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     194        496  Bacillus clausii (strain KSM-K16)
     195        495  Burkholderia pseudomallei (strain K96243)
     196        495  Haemophilus influenzae (strain 86-028NP)
     197        494  Proteus mirabilis (strain HI4320)
     198        492  Bacillus amyloliquefaciens (strain FZB42)
     199        491  Xanthomonas campestris pv. campestris (strain 8004)
     200        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     201        489  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     202        487  Shewanella sp. (strain MR-7)
     203        486  Mannheimia succiniciproducens (strain MBEL55E)
     204        484  Pseudomonas aeruginosa (strain LESB58)
     205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     206        484  Shewanella sp. (strain MR-4)
     207        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     208        481  Thermosynechococcus elongatus (strain BP-1)
     209        480  Acinetobacter sp. (strain ADP1)
     210        479  Pyrococcus horikoshii 
     211        478  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     212        475  Pseudomonas putida (strain F1 / ATCC 700007)
     213        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     214        474  Brucella abortus (strain 2308)
     215        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     216        472  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     217        467  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 
     218        467  Clostridium perfringens (strain 13 / Type A)
     219        467  Methanosarcina mazei  
     220        466  Pyrococcus abyssi (strain GE5 / Orsay)
     221        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     222        466  Shewanella frigidimarina (strain NCIMB 400)
     223        466  Pseudomonas putida (strain GB-1)
     224        466  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     225        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     226        463  Shewanella sp. (strain ANA-3)
     227        462  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     228        462  Burkholderia mallei (strain ATCC 23344)
     229        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     230        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     231        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     232        459  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     233        458  Enterococcus faecalis (strain ATCC 700802 / V583)
     234        455  Staphylococcus aureus (strain JH1)
     235        455  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     236        454  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     237        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     238        453  Ovis aries (Sheep)
     239        453  Pseudomonas putida (strain W619)
     240        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     241        452  Shewanella baltica (strain OS185)
     242        451  Aeromonas salmonicida (strain A449)
     243        449  Thermoanaerobacter tengcongensis  
     244        449  Staphylococcus aureus (strain JH9)
     245        449  Hahella chejuensis (strain KCTC 2396)
     246        448  Nicotiana tabacum (Common tobacco)
     247        447  Vibrio fischeri (strain MJ11)
     248        447  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
     249        446  Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
     250        445  Pseudomonas mendocina (strain ymp)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18942 (  4%)
    Bacteria         328442 ( 61%)
    Eukaryota        173917 ( 32%)
    Viruses           16204 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20232 ( 12%)           (  4%)
     Other Mammalia         45697 ( 26%)           (  9%)
     Other Vertebrata       17184 ( 10%)           (  3%)
     Viridiplantae          32907 ( 19%)           (  6%)
     Fungi                  30761 ( 18%)           (  6%)
     Insecta                 8385 (  5%)           (  2%)
     Nematoda                4234 (  2%)           (  1%)
     Other                  14517 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8674             1001-1100     3708
                 51- 100   41236             1101-1200     2575
                101- 150   57444             1201-1300     2005
                151- 200   57606             1301-1400     1867
                201- 250   56355             1401-1500     1500
                251- 300   49713             1501-1600      724
                301- 350   49934             1601-1700      560
                351- 400   43153             1701-1800      456
                401- 450   35353             1801-1900      419
                451- 500   28448             1901-2000      344
                501- 550   20210             2001-2100      208
                551- 600   14496             2101-2200      282
                601- 650   12197             2201-2300      293
                651- 700    8805             2301-2400      171
                701- 750    7256             2401-2500      136
                751- 800    5153             >2500         1080
                801- 850    4508
                851- 900    5007
                901- 950    3849
                951-1000    2721

   


   The average sequence length in UniProtKB/Swiss-Prot is 354 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2258


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  741
                       2x:  288
                       3x:  149
                       4x:  117
                       5x:   84
                       6x:   73
                       7x:   54
                       8x:   46
                       9x:   28
                      10x:   27
                  11- 20x:  182
                  21- 50x:  190
                  51-100x:  101
                    >100x:  178


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        20361   Journal of Biological Chemistry
    2         9241   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5560   Journal of Bacteriology
    4         4941   Biochemical and Biophysical Research Communications
    5         4575   Gene
    6         4472   Nucleic Acids Research
    7         4317   Biochemistry
    8         4269   FEBS Letters
    9         4131   The EMBO Journal
   10         3846   Molecular and Cellular Biology
   11         3600   Nature
   12         3443   Journal of Molecular Biology
   13         3212   European Journal of Biochemistry
   14         3158   Biochimica et Biophysica Acta
   15         2953   Cell
   16         2499   Genomics
   17         2448   Journal of Virology
   18         2393   Biochemical Journal
   19         2376   Science
   20         1972   Molecular Microbiology
   21         1801   Journal of Cell Biology
   22         1719   Plant Physiology
   23         1605   Plant Molecular Biology
   24         1545   Genes and Development
   25         1535   The American Journal of Human Genetics
   26         1509   Virology
   27         1463   Nature Genetics
   28         1425   Human Molecular Genetics
   29         1385   Oncogene
   30         1328   Molecular and General Genetics
   31         1293   Development
   32         1265   Human Mutation
   33         1231   Molecular Biology of the Cell
   34         1223   Journal of Biochemistry
   35         1197   The Plant Cell
   36         1142   Journal of Immunology
   37         1086   Genetics
   38         1076   Molecular Cell
   39         1065   The Plant Journal
   40         1036   Structure
   41         1011   Journal of General Virology
   42          947   Blood
   43          919   Infection and Immunity
   44          914   Archives of Biochemistry and Biophysics
   45          895   Journal of Cell Science
   46          820   Microbiology
   47          808   Developmental Biology
   48          787   Cancer Research
   49          783   Yeast
   50          763   Current Biology
   51          706   FEMS Microbiology Letters
   52          639   Acta Crystallographica, Section D
   53          627   Protein Science
   54          626   Journal of Neuroscience
   55          622   Human Genetics
   56          620   Applied and Environmental Microbiology
   57          617   Nature Structural Biology
   58          614   Mechanisms of Development
   59          608   Toxicon
   60          576   Neuron
   61          560   Journal of Clinical Investigation
   62          536   Current Genetics
   63          522   American Journal of Physiology
   64          514   The Journal of Experimental Medicine
   65          479   Molecular Endocrinology
   66          478   Mammalian Genome
   67          467   Proteins
   68          454   Immunogenetics
   69          454   Journal of Neurochemistry
   70          441   The Journal of Clinical Endocrinology and Metabolism
   71          428   Endocrinology
   72          428   Molecular and Biochemical Parasitology
   73          427   Bioscience, Biotechnology, and Biochemistry
   74          422   Plant and Cell Physiology
   75          419   Nature Cell Biology
   76          396   Journal of Medical Genetics
   77          394   PLoS ONE
   78          393   Journal of Molecular Evolution
   79          374   Molecular Biology and Evolution
   80          373   DNA and Cell Biology
   81          366   Experimental Cell Research
   82          364   DNA Sequence
   83          338   Peptides
   84          325   Brain Research. Molecular Brain Research
   85          323   Tissue Antigens
   86          318   Comparative Biochemistry and Physiology
   87          308   Antimicrobial Agents and Chemotherapy
   88          307   Developmental Cell
   89          304   RNA
   90          302   Molecular Pharmacology
   91          301   Journal of Investigative Dermatology
   92          294   Biological Chemistry Hoppe-Seyler
   93          284   Planta
   94          281   The FEBS Journal
   95          280   Nature Structural and Molecular Biology
   96          279   Cytogenetics and Cell Genetics
   97          277   Neurology
   98          274   Biology of Reproduction
   99          265   Developmental Dynamics
  100          262   Virus Research
  101          260   Genome Research
  102          254   Journal of General Microbiology
  103          243   Immunity
  104          242   Molecular Plant-Microbe Interactions
  105          241   EMBO Reports
  106          238   Biochimie
  107          230   The New England Journal of Medicine
  108          230   Genes to Cells
  109          228   Eukaryotic Cell
  110          226   European Journal of Immunology
  111          226   The FASEB Journal
  112          221   Annals of Neurology
  113          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  114          217   European Journal of Human Genetics
  115          212   DNA Research
  116          205   Journal of Human Genetics
  117          196   Investigative Ophthalmology and Visual Science
  118          194   Archives of Microbiology
  119          192   Journal of the American Chemical Society
  120          188   Archives of Virology
  121          183   Molecular and Cellular Endocrinology
  122          183   American Journal of Medical Genetics. Part A
  123          181   Journal of Cellular Biochemistry
  124          178   BMC Genomics
  125          177   Molecular Immunology
  126          175   Glycobiology
  127          175   Nature Immunology
  128          174   Clinical Genetics
  129          172   Insect Biochemistry and Molecular Biology
  130          169   Diabetes
  131          168   American Journal of Medical Genetics
  132          167   Molecular Phylogenetics and Evolution
  133          166   Journal of Medicinal Chemistry
  134          159   International Journal of Cancer
  135          159   DNA
  136          158   Molecular Reproduction and Development
  137          158   Circulation Research
  138          155   Hemoglobin
  139          154   Journal of Experimental Botany
  140          154   Bioorganicheskaia Khimiia
  141          153   Acta Crystallographica, Section F
  142          151   Molecular Genetics and Metabolism
  143          149   Biological Chemistry
  144          148   Molecular Genetics and Genomics
  145          148   Molecular and Cellular Neuroscience
  146          145   PLoS Genetics
  147          145   Phytochemistry
  148          140   British Journal of Haematology
  149          140   Protein Expression and Purification
  150          139   Traffic


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1022236                 1.90                                         
   Journal                            816041     412765      1.52       1                                 
   Submitted to EMBL/GenBank/DDBJ     197176     177036      0.37       2                                 
   Submitted to other databases         6852       6389      0.01       3                                 
   Book citation                         699        685     <0.01       4                                 
   Plant Gene Register                   578        566     <0.01       5                                 
   Thesis                                412        409     <0.01       6                                 
   Unpublished observations              283        279     <0.01       7                                 
   Patent                                189        186     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 325426

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2387556                 4.44                                         
   ALLERGEN                              516        516     <0.01      26                                 
   ALTERNATIVE PRODUCTS                20984      20984      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        4478       4478      0.01      23                                 
   BIOTECHNOLOGY                         331        329     <0.01      28                                 
   CATALYTIC ACTIVITY                 241259     218726      0.45       4                                 
   CAUTION                              8010       7850      0.01      19                                 
   COFACTOR                           106073      96993      0.20       7                                 
   DEVELOPMENTAL STAGE                  9567       9567      0.02      16                                 
   DISEASE                              5081       3402      0.01      21                                 
   DISRUPTION PHENOTYPE                 4861       4861      0.01      22                                 
   DOMAIN                              37803      33480      0.07      10                                 
   ENZYME REGULATION                   10728      10728      0.02      15                                 
   FUNCTION                           413943     396922      0.77       2                                 
   INDUCTION                           14452      14452      0.03      14                                 
   INTERACTION                          9408       9408      0.02      17                                 
   MASS SPECTROMETRY                    5192       3968      0.01      20                                 
   MISCELLANEOUS                       31553      29116      0.06      12                                 
   PATHWAY                            131344     119173      0.24       6                                 
   PHARMACEUTICAL                         85         85     <0.01      29                                 
   POLYMORPHISM                          869        817     <0.01      24                                 
   PTM                                 43865      34653      0.08       8                                 
   RNA EDITING                           623        623     <0.01      25                                 
   SEQUENCE CAUTION                    40598      40598      0.08       9                                 
   SIMILARITY                         635908     512786      1.18       1                                 
   SUBCELLULAR LOCATION               323418     317658      0.60       3                                 
   SUBUNIT                            239793     239793      0.45       5                                 
   TISSUE SPECIFICITY                  37546      37546      0.07      11                                 
   TOXIC DOSE                            499        485     <0.01      27                                 
   WEB RESOURCE                         8769       7028      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3626172                 6.75                                         
   ACT_SITE                           136720      83897      0.25       9                                 
   BINDING                            262021      71290      0.49       4                                 
   CA_BIND                              3829       1582      0.01      35                                 
   CARBOHYD                           106600      27251      0.20      14                                 
   CHAIN                              544277     531668      1.01       1                                 
   COILED                              19912      13681      0.04      26                                 
   COMPBIAS                            53796      28468      0.10      18                                 
   CONFLICT                           125497      43999      0.23      11                                 
   CROSSLNK                             6466       3830      0.01      34                                 
   DISULFID                           106129      28398      0.20      15                                 
   DNA_BIND                            10965      10066      0.02      31                                 
   DOMAIN                             159206      94619      0.30       8                                 
   HELIX                              169842      16684      0.32       7                                 
   INIT_MET                            15276      15276      0.03      27                                 
   INTRAMEM                             2005        911     <0.01      38                                 
   LIPID                               11564       7339      0.02      30                                 
   METAL                              308670      76059      0.57       3                                 
   MOD_RES                            193400      63325      0.36       5                                 
   MOTIF                               35085      22702      0.07      24                                 
   MUTAGEN                             40261       9410      0.07      22                                 
   NON_CONS                             2029        744     <0.01      37                                 
   NON_STD                               354        279     <0.01      39                                 
   NON_TER                             12204       9327      0.02      29                                 
   NP_BIND                            115044      71831      0.21      13                                 
   PEPTIDE                              9814       6617      0.02      32                                 
   PROPEP                              12544      10787      0.02      28                                 
   REGION                             117614      62514      0.22      12                                 
   REPEAT                              93528      13856      0.17      16                                 
   SIGNAL                              37847      37837      0.07      23                                 
   SITE                                41832      24497      0.08      20                                 
   STRAND                             178651      15787      0.33       6                                 
   TOPO_DOM                           129765      26787      0.24      10                                 
   TRANSIT                              8129       8034      0.02      33                                 
   TRANSMEM                           354091      73012      0.66       2                                 
   TURN                                41522      13510      0.08      21                                 
   UNSURE                               3000        525      0.01      36                                 
   VAR_SEQ                             42788      18389      0.08      19                                 
   VARIANT                             84621      16682      0.16      17                                 
   ZN_FING                             29274      12846      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15544942                28.92                                                           
   2DBase-Ecoli                           85         85     <0.01     127      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     124      2D gel databases                             
   AGD                                   932        926     <0.01     102      Organism-specific databases                  
   Allergome                            1442        893     <0.01      98      Protein family/group databases               
   ANU-2DPAGE                             27         27     <0.01     133      2D gel databases                             
   ArachnoServer                         763        755     <0.01     108      Organism-specific databases                  
   ArrayExpress                        59851      59851      0.11      43      Gene expression databases                    
   Bgee                                39434      39432      0.07      47      Gene expression databases                    
   BindingDB                             295        295     <0.01     120      Other                                        
   BioCyc                             248580     240127      0.46      22      Enzyme and pathway databases                 
   BRENDA                               4283       4276      0.01      90      Enzyme and pathway databases                 
   CAZy                                 7573       6814      0.01      74      Protein family/group databases               
   CGD                                   677        655     <0.01     109      Organism-specific databases                  
   CleanEx                             30097      29456      0.06      50      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     126      2D gel databases                             
   ConoServer                            915        833     <0.01     104      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     128      2D gel databases                             
   CTD                                 68657      68038      0.13      41      Organism-specific databases                  
   CYGD                                 5594       5591      0.01      79      Organism-specific databases                  
   dictyBase                            4203       4087      0.01      91      Organism-specific databases                  
   DIP                                 13570      13464      0.03      67      Protein-protein interaction databases        
   DisProt                               398        395     <0.01     117      3D structure databases                       
   DMDM                                16766      16764      0.03      63      Polymorphism databases                       
   DNASU                               18640      18569      0.03      59      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     123      2D gel databases                             
   DrugBank                             5319       1628      0.01      80      Other                                        
   EchoBASE                             4167       4163      0.01      92      Organism-specific databases                  
   ECO2DBASE                             352        300     <0.01     119      2D gel databases                             
   EcoGene                              4292       4290      0.01      89      Organism-specific databases                  
   eggNOG                             429850     429850      0.80       9      Phylogenomic databases                       
   EMBL                               926081     526924      1.72       3      Sequence databases                           
   Ensembl                             80722      47901      0.15      35      Genome annotation databases                  
   EnsemblBacteria                     97931      84972      0.18      29      Genome annotation databases                  
   EnsemblFungi                        17300      17015      0.03      62      Genome annotation databases                  
   EnsemblMetazoa                      10346       8843      0.02      72      Genome annotation databases                  
   EnsemblPlants                       13476      13197      0.03      68      Genome annotation databases                  
   EnsemblProtists                      4452       4336      0.01      88      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     129      Organism-specific databases                  
   EuPathDB                              805        804     <0.01     105      Organism-specific databases                  
   EvolutionaryTrace                   16488      16488      0.03      64      Other                                        
   FlyBase                              5857       5483      0.01      77      Organism-specific databases                  
   Gene3D                             328405     253067      0.61      17      Family and domain databases                  
   GeneCards                           20038      19730      0.04      56      Organism-specific databases                  
   GeneFarm                             3064       3053      0.01      94      Organism-specific databases                  
   GeneID                             494807     468784      0.92       6      Genome annotation databases                  
   GeneTree                            52521      52493      0.10      44      Phylogenomic databases                       
   Genevestigator                      66748      66748      0.12      42      Gene expression databases                    
   GenoList                             7069       7057      0.01      75      Organism-specific databases                  
   GenomeReviews                      376951     357346      0.70      13      Genome annotation databases                  
   GenomeRNAi                          21199      21199      0.04      54      Other                                        
   GermOnline                          41902      41328      0.08      46      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     121      PTM databases                                
   GO                                2344354     506259      4.36       1      Ontologies                                   
   Gramene                              4822       4822      0.01      83      Organism-specific databases                  
   H-InvDB                              5596       4774      0.01      78      Organism-specific databases                  
   HAMAP                              312209     312005      0.58      18      Family and domain databases                  
   HGNC                                19779      19622      0.04      57      Organism-specific databases                  
   HOGENOM                            384358     384358      0.72      12      Phylogenomic databases                       
   HOVERGEN                            75428      75428      0.14      38      Phylogenomic databases                       
   HPA                                 15757      12090      0.03      66      Organism-specific databases                  
   HSSP                                30400      30400      0.06      49      3D structure databases                       
   InParanoid                          69305      69305      0.13      40      Phylogenomic databases                       
   IntAct                              33486      33486      0.06      48      Protein-protein interaction databases        
   InterPro                          1769829     512827      3.29       2      Family and domain databases                  
   IPI                                 94926      66929      0.18      32      Sequence databases                           
   KEGG                               466404     446347      0.87       8      Genome annotation databases                  
   KO                                 369930     369537      0.69      14      Phylogenomic databases                       
   LegioList                             765        763     <0.01     107      Organism-specific databases                  
   Leproma                               671        668     <0.01     110      Organism-specific databases                  
   MaizeGDB                              494        489     <0.01     115      Organism-specific databases                  
   MEROPS                              10659      10659      0.02      71      Protein family/group databases               
   MGI                                 16457      16412      0.03      65      Organism-specific databases                  
   MIM                                 17639      13401      0.03      60      Organism-specific databases                  
   MINT                                17615      17615      0.03      61      Protein-protein interaction databases        
   NextBio                             69638      69638      0.13      39      Other                                        
   neXtProt                            20086      20086      0.04      55      Organism-specific databases                  
   OGP                                   377        377     <0.01     118      2D gel databases                             
   OMA                                390308     390308      0.73      11      Phylogenomic databases                       
   Orphanet                             4478       2566      0.01      87      Organism-specific databases                  
   OrthoDB                             78087      78087      0.15      36      Phylogenomic databases                       
   PANTHER                            200633     186407      0.37      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      86      Enzyme and pathway databases                 
   PATRIC                             308645     308621      0.57      20      Genome annotation databases                  
   PDB                                 87491      18406      0.16      34      3D structure databases                       
   PDBsum                              87491      18406      0.16      33      3D structure databases                       
   PeptideAtlas                         5163       5163      0.01      81      Proteomic databases                          
   PeroxiBase                            768        752     <0.01     106      Protein family/group databases               
   Pfam                               710628     494989      1.32       4      Family and domain databases                  
   PharmGKB                            18759      18342      0.03      58      Organism-specific databases                  
   PHCI-2DPAGE                           250        250     <0.01     122      2D gel databases                             
   PhosphoSite                         25554      25554      0.05      53      PTM databases                                
   PhosSite                              537        529     <0.01     112      PTM databases                                
   PhylomeDB                           26767      26767      0.05      52      Phylogenomic databases                       
   PIR                                118058     107947      0.22      28      Sequence databases                           
   PIRSF                               97260      97245      0.18      31      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01      97      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     130      2D gel databases                             
   PomBase                              5014       4956      0.01      82      Organism-specific databases                  
   PptaseDB                               38         38     <0.01     131      Protein family/group databases               
   PRIDE                               75746      75746      0.14      37      Proteomic databases                          
   PRINTS                             137738     120619      0.26      26      Family and domain databases                  
   ProDom                              29282      29103      0.05      51      Family and domain databases                  
   ProMEX                                511        511     <0.01     113      Proteomic databases                          
   PROSITE                            478912     302950      0.89       7      Family and domain databases                  
   ProtClustDB                        342971     342971      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 428239     428239      0.80      10      3D structure databases                       
   PseudoCAP                            1242       1233     <0.01     100      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     132      2D gel databases                             
   Reactome                            12219       7549      0.02      69      Enzyme and pathway databases                 
   REBASE                                402        402     <0.01     116      Protein family/group databases               
   RefSeq                             517573     469061      0.96       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01      99      2D gel databases                             
   RGD                                  7694       7690      0.01      73      Organism-specific databases                  
   SGD                                  6638       6633      0.01      76      Organism-specific databases                  
   Siena-2DPAGE                          103        103     <0.01     125      2D gel databases                             
   SMART                              166986     124992      0.31      25      Family and domain databases                  
   SMR                                217837     217837      0.41      23      3D structure databases                       
   STRING                             309173     309171      0.58      19      Protein-protein interaction databases        
   SUPFAM                             331255     262443      0.62      16      Family and domain databases                  
   SWISS-2DPAGE                         1182       1181     <0.01     101      2D gel databases                             
   TAIR                                11423      11360      0.02      70      Organism-specific databases                  
   TCDB                                 3639       3624      0.01      93      Protein family/group databases               
   TIGR                                   18         16     <0.01     134      Genome annotation databases                  
   TIGRFAMs                           289014     268618      0.54      21      Family and domain databases                  
   TubercuList                          1957       1921     <0.01      96      Organism-specific databases                  
   UCD-2DPAGE                            509        500     <0.01     114      2D gel databases                             
   UCSC                                51894      39759      0.10      45      Genome annotation databases                  
   UniGene                             97836      89380      0.18      30      Sequence databases                           
   UniPathway                         131231     119062      0.24      27      Enzyme and pathway databases                 
   VectorBase                            606        588     <0.01     111      Genome annotation databases                  
   World-2DPAGE                          919        908     <0.01     103      2D gel databases                             
   WormBase                             4774       3875      0.01      84      Organism-specific databases                  
   Xenbase                              4699       4694      0.01      85      Organism-specific databases                  
   ZFIN                                 2754       2754      0.01      95      Organism-specific databases                  

Total number of cross-referenced databases: 134

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.56
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.37   Ile (I) 5.96   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4460 entries are encoded on a mitochondrion, and 3687 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 73720