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         UniProtKB/Swiss-Prot protein knowledgebase release 2012_07 statistics


1.  INTRODUCTION

Release 2012_07 of 11-Jul-12 of UniProtKB/Swiss-Prot contains 536789 sequence entries,
comprising 190518892 amino acids abstracted from 211308 references. 

324 sequences have been added since release 2012_06, the sequence data of
111 existing entries has been updated and the annotations of
332753 entries have been revised.

Number of fragments: 9025
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 32329


Protein existence (PE):           entries     %

1: Evidence at protein level        75291     14%
2: Evidence at transcript level     67989   12.7%
3: Inferred from homology          377238   70.3%
4: Predicted                        14375    2.7%
5: Uncertain                         1896    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12838

   The first twenty species represent 112076 sequences:  20.9 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5403
                            2x: 1872
                            3x:  974
                            4x:  631
                            5x:  460
                            6x:  374
                            7x:  280
                            8x:  224
                            9x:  194
                           10x:  117
                       11- 20x:  661
                       21- 50x:  396
                       51-100x:  211
                         >100x: 1041


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20231  Homo sapiens (Human)
       2      16540  Mus musculus (Mouse)
       3      11340  Arabidopsis thaliana (Mouse-ear cress)
       4       7773  Rattus norvegicus (Rat)
       5       6619  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5942  Bos taurus (Bovine)
       7       5089  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4188  Bacillus subtilis (strain 168)
      10       4126  Dictyostelium discoideum (Slime mold)
      11       3358  Caenorhabditis elegans
      12       3350  Xenopus laevis (African clawed frog)
      13       3158  Drosophila melanogaster (Fruit fly)
      14       2893  Oryza sativa subsp. japonica (Rice)
      15       2831  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2249  Gallus gallus (Chicken)
      17       2218  Pongo abelii (Sumatran orangutan)
      18       2012  Escherichia coli O157:H7
      19       1941  Mycobacterium tuberculosis
      20       1787  Methanocaldococcus jannaschii  
      21       1769  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1678  Shigella flexneri
      24       1674  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
      25       1662  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      26       1407  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1240  Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
      29       1226  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1032  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1018  Yersinia pestis
      33       1010  Archaeoglobus fulgidus 
      34        948  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
      35        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        903  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        886  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis (strain SC-B67)
      48        878  Shigella sonnei (strain Ss046)
      49        869  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        863  Yersinia pseudotuberculosis serotype I (strain IP32953)
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      54        832  Neurospora crassa 
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        825  Escherichia coli (strain UTI89 / UPEC)
      57        821  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        802  Canis familiaris (Dog) (Canis lupus familiaris)
      60        791  Escherichia coli (strain SMS-3-5 / SECEC)
      61        786  Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)
      62        783  Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) 
      63        780  Aquifex aeolicus (strain VF5)
      64        775  Pasteurella multocida (strain Pm70)
      65        771  Escherichia coli (strain K12 / DH10B)
      66        771  Emericella nidulans  
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Staphylococcus epidermidis (strain ATCC 12228)
      75        756  Escherichia coli (strain SE11)
      76        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      77        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      78        752  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        738  Staphylococcus aureus (strain NCTC 8325)
      82        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      83        734  Bacillus anthracis
      84        734  Bacillus halodurans 
      85        732  Vibrio vulnificus (strain CMCP6)
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Enterobacter sp. (strain 638)
      93        713  Salmonella agona (strain SL483)
      94        713  Escherichia coli O1:K1 / APEC
      95        713  Salmonella newport (strain SL254)
      96        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      97        712  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      98        712  Salmonella schwarzengrund (strain CVM19633)
      99        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     100        710  Salmonella heidelberg (strain SL476)
     101        702  Salmonella dublin (strain CT_02021853)
     102        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     103        696  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
     104        696  Klebsiella pneumoniae (strain 342)
     105        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     106        692  Zea mays (Maize)
     107        688  Pan troglodytes (Chimpanzee)
     108        688  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     110        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     111        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     112        676  Pseudomonas putida (strain KT2440)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        670  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae (strain TN)
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        654  Bradyrhizobium japonicum (strain USDA 110)
     120        653  Debaryomyces hansenii   
     121        652  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        649  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     123        645  Escherichia coli
     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     128        634  Shewanella oneidensis (strain MR-1)
     129        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     130        632  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        615  Treponema pallidum (strain Nichols)
     133        613  Methanothermobacter thermautotrophicus  
     134        612  Staphylococcus haemolyticus (strain JCSC1435)
     135        606  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     136        602  Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
     137        602  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
     138        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     139        602  Staphylococcus saprophyticus subsp. saprophyticus 
     140        601  Salmonella paratyphi C (strain RKS4594)
     141        601  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     142        601  Oryza sativa subsp. indica (Rice)
     143        600  Yersinia pestis bv. Antiqua (strain Angola)
     144        590  Bacillus cereus (strain ATCC 10987)
     145        590  Listeria innocua serovar 6a (strain CLIP 11262)
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        576  Neisseria meningitidis serogroup B (strain MC58)
     149        576  Brucella suis biovar 1 (strain 1330)
     150        574  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     151        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        568  Caenorhabditis briggsae
     154        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     155        566  Pseudomonas syringae pv. syringae (strain B728a)
     156        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     157        564  Vibrio fischeri (strain ATCC 700601 / ES114)
     158        564  Caulobacter crescentus (strain ATCC 19089 / CB15)
     159        564  Pseudomonas aeruginosa (strain UCBPP-PA14)
     160        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     161        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     162        561  Bacillus cereus (strain ZK / E33L)
     163        556  Xanthomonas axonopodis pv. citri (strain 306)
     164        556  Clostridium acetobutylicum 
     165        552  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     166        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     167        552  Pseudomonas fluorescens (strain Pf0-1)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        533  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     172        530  Streptococcus pneumoniae
     173        529  Sodalis glossinidius (strain morsitans)
     174        529  Listeria monocytogenes serotype 4b (strain F2365)
     175        526  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
     176        522  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     177        522  Xylella fastidiosa (strain 9a5c)
     178        515  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
     179        514  Chromobacterium violaceum 
     180        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     181        511  Pseudomonas aeruginosa (strain PA7)
     182        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     184        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
     185        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     186        507  Geobacillus kaustophilus (strain HTA426)
     187        506  Staphylococcus aureus (strain Newman)
     188        501  Deinococcus radiodurans 
     189        500  Pseudomonas entomophila (strain L48)
     190        499  Brucella abortus biovar 1 (strain 9-941)
     191        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     192        496  Corynebacterium glutamicum 
     193        496  Bacillus clausii (strain KSM-K16)
     194        495  Burkholderia pseudomallei (strain K96243)
     195        495  Haemophilus influenzae (strain 86-028NP)
     196        494  Proteus mirabilis (strain HI4320)
     197        494  Streptomyces avermitilis 
     198        492  Bacillus amyloliquefaciens (strain FZB42)
     199        491  Xanthomonas campestris pv. campestris (strain 8004)
     200        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     201        489  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     202        487  Shewanella sp. (strain MR-7)
     203        485  Mannheimia succiniciproducens (strain MBEL55E)
     204        484  Pseudomonas aeruginosa (strain LESB58)
     205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     206        484  Shewanella sp. (strain MR-4)
     207        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     208        481  Thermosynechococcus elongatus (strain BP-1)
     209        480  Acinetobacter sp. (strain ADP1)
     210        478  Pyrococcus horikoshii 
     211        476  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     212        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     213        474  Pseudomonas putida (strain F1 / ATCC 700007)
     214        473  Brucella abortus (strain 2308)
     215        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     216        471  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     217        467  Clostridium perfringens (strain 13 / Type A)
     218        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     219        466  Shewanella frigidimarina (strain NCIMB 400)
     220        466  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 
     221        466  Pseudomonas putida (strain GB-1)
     222        465  Pyrococcus abyssi (strain GE5 / Orsay)
     223        465  Methanosarcina mazei  
     224        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     225        463  Shewanella sp. (strain ANA-3)
     226        462  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     227        462  Burkholderia mallei (strain ATCC 23344)
     228        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     229        462  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     230        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     231        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     232        458  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     233        458  Enterococcus faecalis (strain ATCC 700802 / V583)
     234        455  Staphylococcus aureus (strain JH1)
     235        455  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     236        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     237        453  Ovis aries (Sheep)
     238        453  Pseudomonas putida (strain W619)
     239        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     240        452  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     241        452  Streptococcus mutans
     242        452  Shewanella baltica (strain OS185)
     243        451  Aeromonas salmonicida (strain A449)
     244        449  Thermoanaerobacter tengcongensis  
     245        449  Staphylococcus aureus (strain JH9)
     246        449  Hahella chejuensis (strain KCTC 2396)
     247        448  Nicotiana tabacum (Common tobacco)
     248        447  Vibrio fischeri (strain MJ11)
     249        447  Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10)
     250        445  Pseudomonas mendocina (strain ymp)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18914 (  4%)
    Bacteria         328171 ( 61%)
    Eukaryota        173505 ( 32%)
    Viruses           16199 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20232 ( 12%)           (  4%)
     Other Mammalia         45668 ( 26%)           (  9%)
     Other Vertebrata       17097 ( 10%)           (  3%)
     Viridiplantae          32666 ( 19%)           (  6%)
     Fungi                  30735 ( 18%)           (  6%)
     Insecta                 8382 (  5%)           (  2%)
     Nematoda                4232 (  2%)           (  1%)
     Other                  14493 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8668             1001-1100     3707
                 51- 100   41206             1101-1200     2573
                101- 150   57377             1201-1300     2004
                151- 200   57551             1301-1400     1859
                201- 250   56311             1401-1500     1499
                251- 300   49666             1501-1600      724
                301- 350   49853             1601-1700      560
                351- 400   43088             1701-1800      456
                401- 450   35296             1801-1900      418
                451- 500   28399             1901-2000      341
                501- 550   20153             2001-2100      209
                551- 600   14463             2101-2200      282
                601- 650   12183             2201-2300      293
                651- 700    8798             2301-2400      171
                701- 750    7244             2401-2500      136
                751- 800    5132             >2500         1078
                801- 850    4501
                851- 900    5001
                901- 950    3847
                951-1000    2717

   


   The average sequence length in UniProtKB/Swiss-Prot is 354 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2253


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  743
                       2x:  282
                       3x:  150
                       4x:  115
                       5x:   85
                       6x:   77
                       7x:   51
                       8x:   44
                       9x:   30
                      10x:   28
                  11- 20x:  180
                  21- 50x:  190
                  51-100x:  100
                    >100x:  178


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        20235   Journal of Biological Chemistry
    2         9205   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5495   Journal of Bacteriology
    4         4925   Biochemical and Biophysical Research Communications
    5         4570   Gene
    6         4467   Nucleic Acids Research
    7         4282   Biochemistry
    8         4257   FEBS Letters
    9         4121   The EMBO Journal
   10         3842   Molecular and Cellular Biology
   11         3588   Nature
   12         3425   Journal of Molecular Biology
   13         3192   European Journal of Biochemistry
   14         3149   Biochimica et Biophysica Acta
   15         2950   Cell
   16         2499   Genomics
   17         2438   Journal of Virology
   18         2375   Biochemical Journal
   19         2368   Science
   20         1960   Molecular Microbiology
   21         1798   Journal of Cell Biology
   22         1691   Plant Physiology
   23         1597   Plant Molecular Biology
   24         1543   Genes and Development
   25         1527   The American Journal of Human Genetics
   26         1507   Virology
   27         1455   Nature Genetics
   28         1420   Human Molecular Genetics
   29         1385   Oncogene
   30         1324   Molecular and General Genetics
   31         1292   Development
   32         1260   Human Mutation
   33         1226   Molecular Biology of the Cell
   34         1219   Journal of Biochemistry
   35         1180   The Plant Cell
   36         1137   Journal of Immunology
   37         1084   Genetics
   38         1070   Molecular Cell
   39         1048   The Plant Journal
   40         1030   Structure
   41         1006   Journal of General Virology
   42          946   Blood
   43          919   Infection and Immunity
   44          901   Archives of Biochemistry and Biophysics
   45          890   Journal of Cell Science
   46          811   Microbiology
   47          804   Developmental Biology
   48          784   Cancer Research
   49          783   Yeast
   50          761   Current Biology
   51          701   FEMS Microbiology Letters
   52          635   Acta Crystallographica, Section D
   53          625   Journal of Neuroscience
   54          623   Protein Science
   55          621   Human Genetics
   56          616   Nature Structural Biology
   57          614   Mechanisms of Development
   58          604   Applied and Environmental Microbiology
   59          602   Toxicon
   60          576   Neuron
   61          559   Journal of Clinical Investigation
   62          536   Current Genetics
   63          518   American Journal of Physiology
   64          512   The Journal of Experimental Medicine
   65          478   Mammalian Genome
   66          478   Molecular Endocrinology
   67          460   Proteins
   68          454   Immunogenetics
   69          454   Journal of Neurochemistry
   70          441   The Journal of Clinical Endocrinology and Metabolism
   71          428   Endocrinology
   72          428   Molecular and Biochemical Parasitology
   73          417   Nature Cell Biology
   74          416   Bioscience, Biotechnology, and Biochemistry
   75          414   Plant and Cell Physiology
   76          395   Journal of Medical Genetics
   77          392   Journal of Molecular Evolution
   78          382   PLoS ONE
   79          373   Molecular Biology and Evolution
   80          373   DNA and Cell Biology
   81          364   DNA Sequence
   82          360   Experimental Cell Research
   83          333   Peptides
   84          325   Brain Research. Molecular Brain Research
   85          321   Tissue Antigens
   86          317   Comparative Biochemistry and Physiology
   87          307   Developmental Cell
   88          305   Antimicrobial Agents and Chemotherapy
   89          304   RNA
   90          301   Journal of Investigative Dermatology
   91          300   Molecular Pharmacology
   92          293   Biological Chemistry Hoppe-Seyler
   93          280   Nature Structural and Molecular Biology
   94          279   Cytogenetics and Cell Genetics
   95          275   Planta
   96          275   Neurology
   97          274   Biology of Reproduction
   98          268   The FEBS Journal
   99          264   Developmental Dynamics
  100          262   Virus Research
  101          259   Genome Research
  102          253   Journal of General Microbiology
  103          243   Immunity
  104          242   Molecular Plant-Microbe Interactions
  105          240   EMBO Reports
  106          235   Biochimie
  107          230   The New England Journal of Medicine
  108          229   Genes to Cells
  109          227   Eukaryotic Cell
  110          226   European Journal of Immunology
  111          223   The FASEB Journal
  112          221   Annals of Neurology
  113          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  114          217   European Journal of Human Genetics
  115          211   DNA Research
  116          205   Journal of Human Genetics
  117          196   Investigative Ophthalmology and Visual Science
  118          188   Archives of Microbiology
  119          188   Archives of Virology
  120          183   Molecular and Cellular Endocrinology
  121          183   Journal of the American Chemical Society
  122          180   Journal of Cellular Biochemistry
  123          179   American Journal of Medical Genetics. Part A
  124          177   Molecular Immunology
  125          176   BMC Genomics
  126          174   Nature Immunology
  127          172   Glycobiology
  128          171   Insect Biochemistry and Molecular Biology
  129          171   Clinical Genetics
  130          169   Diabetes
  131          168   American Journal of Medical Genetics
  132          167   Molecular Phylogenetics and Evolution
  133          165   Journal of Medicinal Chemistry
  134          159   International Journal of Cancer
  135          159   DNA
  136          158   Molecular Reproduction and Development
  137          156   Circulation Research
  138          155   Hemoglobin
  139          154   Bioorganicheskaia Khimiia
  140          150   Molecular Genetics and Metabolism
  141          149   Acta Crystallographica, Section F
  142          149   Journal of Experimental Botany
  143          149   Biological Chemistry
  144          148   Molecular and Cellular Neuroscience
  145          146   Molecular Genetics and Genomics
  146          144   PLoS Genetics
  147          141   Phytochemistry
  148          140   British Journal of Haematology
  149          139   Animal Genetics
  150          138   General and Comparative Endocrinology


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1019549                 1.90                                         
   Journal                            813683     412061      1.52       1                                 
   Submitted to EMBL/GenBank/DDBJ     196868     176821      0.37       2                                 
   Submitted to other databases         6836       6374      0.01       3                                 
   Book citation                         698        684     <0.01       4                                 
   Plant Gene Register                   577        565     <0.01       5                                 
   Thesis                                410        407     <0.01       6                                 
   Unpublished observations              283        279     <0.01       7                                 
   Patent                                188        185     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 324059

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2381595                 4.44                                         
   ALLERGEN                              516        516     <0.01      26                                 
   ALTERNATIVE PRODUCTS                20961      20961      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        4202       4202      0.01      23                                 
   BIOTECHNOLOGY                         327        325     <0.01      28                                 
   CATALYTIC ACTIVITY                 240647     218200      0.45       4                                 
   CAUTION                              7966       7807      0.01      19                                 
   COFACTOR                           105722      96663      0.20       7                                 
   DEVELOPMENTAL STAGE                  9531       9531      0.02      16                                 
   DISEASE                              5062       3388      0.01      21                                 
   DISRUPTION PHENOTYPE                 4756       4756      0.01      22                                 
   DOMAIN                              37653      33355      0.07      10                                 
   ENZYME REGULATION                   10621      10621      0.02      15                                 
   FUNCTION                           413083     396080      0.77       2                                 
   INDUCTION                           14324      14324      0.03      14                                 
   INTERACTION                          9335       9335      0.02      17                                 
   MASS SPECTROMETRY                    5096       3873      0.01      20                                 
   MISCELLANEOUS                       31452      29020      0.06      12                                 
   PATHWAY                            131192     119023      0.24       6                                 
   PHARMACEUTICAL                         85         85     <0.01      29                                 
   POLYMORPHISM                          866        814     <0.01      24                                 
   PTM                                 43649      34512      0.08       8                                 
   RNA EDITING                           623        623     <0.01      25                                 
   SEQUENCE CAUTION                    40512      40512      0.08       9                                 
   SIMILARITY                         635037     512087      1.18       1                                 
   SUBCELLULAR LOCATION               322896     317150      0.60       3                                 
   SUBUNIT                            238924     238924      0.45       5                                 
   TISSUE SPECIFICITY                  37304      37304      0.07      11                                 
   TOXIC DOSE                            498        484     <0.01      27                                 
   WEB RESOURCE                         8755       7019      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3612244                 6.73                                         
   ACT_SITE                           135834      83112      0.25       9                                 
   BINDING                            259550      70464      0.48       4                                 
   CA_BIND                              3827       1581      0.01      35                                 
   CARBOHYD                           106531      27198      0.20      14                                 
   CHAIN                              543571     530966      1.01       1                                 
   COILED                              19891      13666      0.04      26                                 
   COMPBIAS                            53730      28420      0.10      18                                 
   CONFLICT                           125330      43917      0.23      11                                 
   CROSSLNK                             6448       3821      0.01      34                                 
   DISULFID                           105672      28297      0.20      15                                 
   DNA_BIND                            11328      10433      0.02      31                                 
   DOMAIN                             158859      94337      0.30       8                                 
   HELIX                              169164      16617      0.32       7                                 
   INIT_MET                            15203      15203      0.03      27                                 
   INTRAMEM                             1965        871     <0.01      38                                 
   LIPID                               11528       7316      0.02      30                                 
   METAL                              307509      75769      0.57       3                                 
   MOD_RES                            193209      63241      0.36       5                                 
   MOTIF                               34926      22586      0.07      24                                 
   MUTAGEN                             39851       9294      0.07      22                                 
   NON_CONS                             2027        742     <0.01      37                                 
   NON_STD                               354        279     <0.01      39                                 
   NON_TER                             12170       9294      0.02      29                                 
   NP_BIND                            114779      71706      0.21      12                                 
   PEPTIDE                              9800       6603      0.02      32                                 
   PROPEP                              12526      10771      0.02      28                                 
   REGION                             114634      61382      0.21      13                                 
   REPEAT                              93454      13839      0.17      16                                 
   SIGNAL                              37752      37742      0.07      23                                 
   SITE                                41767      24445      0.08      20                                 
   STRAND                             178020      15727      0.33       6                                 
   TOPO_DOM                           129020      26677      0.24      10                                 
   TRANSIT                              8085       7990      0.02      33                                 
   TRANSMEM                           353254      72855      0.66       2                                 
   TURN                                41402      13469      0.08      21                                 
   UNSURE                               2999        524      0.01      36                                 
   VAR_SEQ                             42757      18375      0.08      19                                 
   VARIANT                             84263      16665      0.16      17                                 
   ZN_FING                             29255      12828      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15352067                28.60                                                           
   2DBase-Ecoli                           85         85     <0.01     125      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     122      2D gel databases                             
   AGD                                   932        926     <0.01     100      Organism-specific databases                  
   Allergome                            1440        891     <0.01      96      Protein family/group databases               
   ANU-2DPAGE                             27         27     <0.01     131      2D gel databases                             
   ArachnoServer                         763        755     <0.01     106      Organism-specific databases                  
   ArrayExpress                        59823      59823      0.11      42      Gene expression databases                    
   Bgee                                39412      39411      0.07      46      Gene expression databases                    
   BindingDB                             295        295     <0.01     118      Other                                        
   BioCyc                             248511     240058      0.46      22      Enzyme and pathway databases                 
   BRENDA                               4250       4243      0.01      87      Enzyme and pathway databases                 
   CAZy                                 7539       6781      0.01      72      Protein family/group databases               
   CGD                                   677        655     <0.01     107      Organism-specific databases                  
   CleanEx                             30097      29456      0.06      49      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     124      2D gel databases                             
   ConoServer                            915        833     <0.01     102      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     126      2D gel databases                             
   CTD                                 68518      67898      0.13      40      Organism-specific databases                  
   CYGD                                 5594       5591      0.01      77      Organism-specific databases                  
   dictyBase                            4203       4086      0.01      88      Organism-specific databases                  
   DIP                                 13561      13455      0.03      65      Protein-protein interaction databases        
   DisProt                               397        394     <0.01     115      3D structure databases                       
   DMDM                                16766      16764      0.03      61      Polymorphism databases                       
   DNASU                               18632      18561      0.03      57      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     121      2D gel databases                             
   DrugBank                             5318       1627      0.01      78      Other                                        
   EchoBASE                             4167       4163      0.01      90      Organism-specific databases                  
   ECO2DBASE                             352        300     <0.01     117      2D gel databases                             
   EcoGene                              4292       4290      0.01      86      Organism-specific databases                  
   eggNOG                             429651     429651      0.80       9      Phylogenomic databases                       
   EMBL                               924468     526252      1.72       3      Sequence databases                           
   Ensembl                             82367      47686      0.15      34      Genome annotation databases                  
   EnsemblBacteria                     97924      84965      0.18      28      Genome annotation databases                  
   EnsemblFungi                        16850      16565      0.03      60      Genome annotation databases                  
   EnsemblMetazoa                       9769       8263      0.02      70      Genome annotation databases                  
   EnsemblPlants                       13260      12982      0.02      66      Genome annotation databases                  
   EnsemblProtists                      4398       4283      0.01      85      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     127      Organism-specific databases                  
   EuPathDB                              803        802     <0.01     103      Organism-specific databases                  
   EvolutionaryTrace                   16448      16448      0.03      62      Other                                        
   FlyBase                              5857       5483      0.01      75      Organism-specific databases                  
   Gene3D                             327935     252707      0.61      17      Family and domain databases                  
   GeneCards                           20038      19730      0.04      54      Organism-specific databases                  
   GeneFarm                             3061       3050      0.01      92      Organism-specific databases                  
   GeneID                             489989     468313      0.91       6      Genome annotation databases                  
   GeneTree                            52439      52412      0.10      43      Phylogenomic databases                       
   Genevestigator                      66690      66690      0.12      41      Gene expression databases                    
   GenoList                             7069       7057      0.01      73      Organism-specific databases                  
   GenomeReviews                      376775     357175      0.70      13      Genome annotation databases                  
   GermOnline                          41902      41328      0.08      45      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     119      PTM databases                                
   GO                                2335853     505572      4.35       1      Ontologies                                   
   Gramene                              4775       4775      0.01      81      Organism-specific databases                  
   H-InvDB                              5595       4773      0.01      76      Organism-specific databases                  
   HAMAP                              312144     311940      0.58      18      Family and domain databases                  
   HGNC                                19773      19617      0.04      55      Organism-specific databases                  
   HOGENOM                            384134     384134      0.72      12      Phylogenomic databases                       
   HOVERGEN                            75362      75362      0.14      37      Phylogenomic databases                       
   HPA                                 15757      12090      0.03      64      Organism-specific databases                  
   HSSP                                30312      30312      0.06      48      3D structure databases                       
   InParanoid                          69237      69237      0.13      39      Phylogenomic databases                       
   IntAct                              33367      33367      0.06      47      Protein-protein interaction databases        
   InterPro                          1767914     512190      3.29       2      Family and domain databases                  
   IPI                                 94808      66836      0.18      31      Sequence databases                           
   KEGG                               463963     445934      0.86       8      Genome annotation databases                  
   KO                                 369511     369120      0.69      14      Phylogenomic databases                       
   LegioList                             765        763     <0.01     105      Organism-specific databases                  
   Leproma                               671        668     <0.01     108      Organism-specific databases                  
   MaizeGDB                              487        482     <0.01     113      Organism-specific databases                  
   MEROPS                              10646      10646      0.02      69      Protein family/group databases               
   MGI                                 16446      16401      0.03      63      Organism-specific databases                  
   MIM                                 17590      13370      0.03      59      Organism-specific databases                  
   MINT                                17608      17608      0.03      58      Protein-protein interaction databases        
   NextBio                             69601      69601      0.13      38      Other                                        
   neXtProt                            20085      20085      0.04      53      Organism-specific databases                  
   OGP                                   377        377     <0.01     116      2D gel databases                             
   OMA                                390064     390064      0.73      11      Phylogenomic databases                       
   Orphanet                             4172       2504      0.01      89      Organism-specific databases                  
   OrthoDB                             78056      78056      0.15      35      Phylogenomic databases                       
   PANTHER                            200460     186238      0.37      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      84      Enzyme and pathway databases                 
   PATRIC                             308554     308530      0.57      20      Genome annotation databases                  
   PDB                                 86658      18246      0.16      33      3D structure databases                       
   PDBsum                              86658      18246      0.16      32      3D structure databases                       
   PeptideAtlas                         5163       5163      0.01      79      Proteomic databases                          
   PeroxiBase                            765        749     <0.01     104      Protein family/group databases               
   Pfam                               709769     494369      1.32       4      Family and domain databases                  
   PharmGKB                            18759      18342      0.03      56      Organism-specific databases                  
   PHCI-2DPAGE                           250        250     <0.01     120      2D gel databases                             
   PhosphoSite                         25549      25549      0.05      52      PTM databases                                
   PhosSite                              515        507     <0.01     110      PTM databases                                
   PhylomeDB                           26660      26660      0.05      51      Phylogenomic databases                       
   PIR                                117953     107833      0.22      27      Sequence databases                           
   PIRSF                               97182      97168      0.18      30      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01      95      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     128      2D gel databases                             
   PomBase                              5014       4956      0.01      80      Organism-specific databases                  
   PptaseDB                               38         38     <0.01     129      Protein family/group databases               
   PRIDE                               75643      75643      0.14      36      Proteomic databases                          
   PRINTS                             137552     120474      0.26      26      Family and domain databases                  
   ProDom                              29269      29090      0.05      50      Family and domain databases                  
   ProMEX                                509        509     <0.01     111      Proteomic databases                          
   PROSITE                            478125     302414      0.89       7      Family and domain databases                  
   ProtClustDB                        342769     342769      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 427636     427636      0.80      10      3D structure databases                       
   PseudoCAP                            1234       1225     <0.01      98      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     130      2D gel databases                             
   Reactome                            11040       7007      0.02      68      Enzyme and pathway databases                 
   REBASE                                402        402     <0.01     114      Protein family/group databases               
   RefSeq                             512723     468603      0.96       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01      97      2D gel databases                             
   RGD                                  7681       7677      0.01      71      Organism-specific databases                  
   SGD                                  6638       6633      0.01      74      Organism-specific databases                  
   Siena-2DPAGE                          103        103     <0.01     123      2D gel databases                             
   SMART                              166810     124854      0.31      25      Family and domain databases                  
   SMR                                211872     211872      0.39      23      3D structure databases                       
   STRING                             309023     309021      0.58      19      Protein-protein interaction databases        
   SUPFAM                             330834     262113      0.62      16      Family and domain databases                  
   SWISS-2DPAGE                         1182       1181     <0.01      99      2D gel databases                             
   TAIR                                11367      11304      0.02      67      Organism-specific databases                  
   TCDB                                 3632       3617      0.01      91      Protein family/group databases               
   TIGRFAMs                           288858     268481      0.54      21      Family and domain databases                  
   TubercuList                          1957       1921     <0.01      94      Organism-specific databases                  
   UCD-2DPAGE                            509        500     <0.01     112      2D gel databases                             
   UCSC                                51881      39746      0.10      44      Genome annotation databases                  
   UniGene                             97666      89224      0.18      29      Sequence databases                           
   VectorBase                            606        588     <0.01     109      Genome annotation databases                  
   World-2DPAGE                          919        908     <0.01     101      2D gel databases                             
   WormBase                             4768       3873      0.01      82      Organism-specific databases                  
   Xenbase                              4698       4693      0.01      83      Organism-specific databases                  
   ZFIN                                 2753       2753      0.01      93      Organism-specific databases                  

Total number of cross-referenced databases: 131

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.25   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.56
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.37   Ile (I) 5.96   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4460 entries are encoded on a mitochondrion, and 3665 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 73578