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         UniProtKB/Swiss-Prot protein knowledgebase release 2012_06 statistics


1.  INTRODUCTION

Release 2012_06 of 13-Jun-12 of UniProtKB/Swiss-Prot contains 536489 sequence entries,
comprising 190389898 amino acids abstracted from 210586 references. 

478 sequences have been added since release 2012_05, the sequence data of
82 existing entries has been updated and the annotations of
77483 entries have been revised.

Number of fragments: 9016
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 32270


Protein existence (PE):           entries     %

1: Evidence at protein level        75050     14%
2: Evidence at transcript level     67986   12.7%
3: Inferred from homology          377161   70.3%
4: Predicted                        14394    2.7%
5: Uncertain                         1898    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12832

   The first twenty species represent 111953 sequences:  20.9 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5401
                            2x: 1871
                            3x:  972
                            4x:  630
                            5x:  461
                            6x:  375
                            7x:  279
                            8x:  223
                            9x:  196
                           10x:  117
                       11- 20x:  660
                       21- 50x:  395
                       51-100x:  212
                         >100x: 1040


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20237  Homo sapiens (Human)
       2      16537  Mus musculus (Mouse)
       3      11247  Arabidopsis thaliana (Mouse-ear cress)
       4       7766  Rattus norvegicus (Rat)
       5       6619  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5938  Bos taurus (Bovine)
       7       5089  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4188  Bacillus subtilis (strain 168)
      10       4126  Dictyostelium discoideum (Slime mold)
      11       3356  Caenorhabditis elegans
      12       3349  Xenopus laevis (African clawed frog)
      13       3156  Drosophila melanogaster (Fruit fly)
      14       2891  Oryza sativa subsp. japonica (Rice)
      15       2830  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2248  Gallus gallus (Chicken)
      17       2218  Pongo abelii (Sumatran orangutan)
      18       2011  Escherichia coli O157:H7
      19       1929  Mycobacterium tuberculosis
      20       1787  Methanocaldococcus jannaschii  
      21       1769  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1678  Shigella flexneri
      24       1674  Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
      25       1660  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      26       1407  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1244  Mycobacterium bovis
      29       1226  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1032  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1018  Yersinia pestis
      33       1010  Archaeoglobus fulgidus 
      34        948  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
      35        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        903  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        886  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis (strain SC-B67)
      48        878  Shigella sonnei (strain Ss046)
      49        869  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        864  Yersinia pseudotuberculosis
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      54        832  Neurospora crassa 
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        825  Escherichia coli (strain UTI89 / UPEC)
      57        821  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        802  Canis familiaris (Dog) (Canis lupus familiaris)
      60        795  Vibrio parahaemolyticus
      61        791  Escherichia coli (strain SMS-3-5 / SECEC)
      62        783  Erwinia carotovora subsp. atroseptica (strain SCRI 1043 / ATCC BAA-672) 
      63        780  Aquifex aeolicus (strain VF5)
      64        775  Pasteurella multocida (strain Pm70)
      65        771  Escherichia coli (strain K12 / DH10B)
      66        771  Emericella nidulans  
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Staphylococcus epidermidis (strain ATCC 12228)
      75        756  Escherichia coli (strain SE11)
      76        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      77        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      78        752  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        738  Staphylococcus aureus (strain NCTC 8325)
      82        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      83        734  Bacillus anthracis
      84        734  Bacillus halodurans 
      85        733  Vibrio vulnificus
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Enterobacter sp. (strain 638)
      93        713  Salmonella agona (strain SL483)
      94        713  Escherichia coli O1:K1 / APEC
      95        713  Salmonella newport (strain SL254)
      96        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      97        712  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      98        712  Salmonella schwarzengrund (strain CVM19633)
      99        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     100        710  Salmonella heidelberg (strain SL476)
     101        702  Salmonella dublin (strain CT_02021853)
     102        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     103        696  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
     104        696  Klebsiella pneumoniae (strain 342)
     105        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     106        692  Zea mays (Maize)
     107        688  Pan troglodytes (Chimpanzee)
     108        688  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     110        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     111        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     112        676  Pseudomonas putida (strain KT2440)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        670  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        654  Bradyrhizobium japonicum (strain USDA 110)
     120        653  Debaryomyces hansenii   
     121        652  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        649  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     123        645  Escherichia coli
     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     128        634  Shewanella oneidensis (strain MR-1)
     129        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     130        632  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        615  Treponema pallidum (strain Nichols)
     133        613  Methanothermobacter thermautotrophicus  
     134        612  Staphylococcus haemolyticus (strain JCSC1435)
     135        606  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     136        602  Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
     137        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     138        602  Staphylococcus saprophyticus subsp. saprophyticus 
     139        601  Salmonella paratyphi C (strain RKS4594)
     140        601  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     141        601  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
     142        601  Oryza sativa subsp. indica (Rice)
     143        600  Yersinia pestis bv. Antiqua (strain Angola)
     144        590  Bacillus cereus (strain ATCC 10987)
     145        590  Listeria innocua serovar 6a (strain CLIP 11262)
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        576  Neisseria meningitidis serogroup B (strain MC58)
     149        576  Brucella suis biovar 1 (strain 1330)
     150        574  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     151        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        568  Caenorhabditis briggsae
     154        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     155        566  Pseudomonas syringae pv. syringae (strain B728a)
     156        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     157        564  Vibrio fischeri (strain ATCC 700601 / ES114)
     158        564  Caulobacter crescentus (strain ATCC 19089 / CB15)
     159        564  Pseudomonas aeruginosa (strain UCBPP-PA14)
     160        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     161        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     162        561  Bacillus cereus (strain ZK / E33L)
     163        556  Xanthomonas axonopodis pv. citri (strain 306)
     164        556  Clostridium acetobutylicum 
     165        552  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     166        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     167        552  Pseudomonas fluorescens (strain Pf0-1)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        533  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     172        529  Sodalis glossinidius (strain morsitans)
     173        529  Listeria monocytogenes serotype 4b (strain F2365)
     174        527  Streptococcus pneumoniae
     175        526  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
     176        522  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     177        522  Xylella fastidiosa
     178        515  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
     179        514  Chromobacterium violaceum 
     180        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     181        511  Pseudomonas aeruginosa (strain PA7)
     182        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     184        508  Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253)
     185        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     186        507  Geobacillus kaustophilus (strain HTA426)
     187        506  Staphylococcus aureus (strain Newman)
     188        501  Deinococcus radiodurans 
     189        500  Pseudomonas entomophila (strain L48)
     190        499  Brucella abortus biovar 1 (strain 9-941)
     191        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     192        496  Corynebacterium glutamicum 
     193        496  Bacillus clausii (strain KSM-K16)
     194        495  Burkholderia pseudomallei (strain K96243)
     195        495  Haemophilus influenzae (strain 86-028NP)
     196        494  Proteus mirabilis (strain HI4320)
     197        494  Streptomyces avermitilis
     198        492  Bacillus amyloliquefaciens (strain FZB42)
     199        491  Xanthomonas campestris pv. campestris (strain 8004)
     200        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     201        489  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     202        487  Shewanella sp. (strain MR-7)
     203        485  Mannheimia succiniciproducens (strain MBEL55E)
     204        484  Pseudomonas aeruginosa (strain LESB58)
     205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     206        484  Shewanella sp. (strain MR-4)
     207        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     208        481  Thermosynechococcus elongatus (strain BP-1)
     209        480  Acinetobacter sp. (strain ADP1)
     210        478  Pyrococcus horikoshii 
     211        476  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     212        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     213        474  Pseudomonas putida (strain F1 / ATCC 700007)
     214        473  Brucella abortus (strain 2308)
     215        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     216        467  Clostridium perfringens (strain 13 / Type A)
     217        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     218        466  Shewanella frigidimarina (strain NCIMB 400)
     219        466  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 
     220        466  Pseudomonas putida (strain GB-1)
     221        465  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     222        465  Pyrococcus abyssi (strain GE5 / Orsay)
     223        465  Methanosarcina mazei  
     224        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     225        463  Shewanella sp. (strain ANA-3)
     226        462  Burkholderia mallei (strain ATCC 23344)
     227        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     228        462  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     229        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     230        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     231        458  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     232        458  Enterococcus faecalis (strain ATCC 700802 / V583)
     233        455  Staphylococcus aureus (strain JH1)
     234        455  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     235        455  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     236        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     237        453  Ovis aries (Sheep)
     238        453  Pseudomonas putida (strain W619)
     239        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     240        452  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     241        452  Streptococcus mutans
     242        452  Shewanella baltica (strain OS185)
     243        451  Aeromonas salmonicida (strain A449)
     244        449  Mycobacterium paratuberculosis
     245        449  Thermoanaerobacter tengcongensis  
     246        449  Staphylococcus aureus (strain JH9)
     247        449  Hahella chejuensis (strain KCTC 2396)
     248        447  Vibrio fischeri (strain MJ11)
     249        447  Nicotiana tabacum (Common tobacco)
     250        445  Pseudomonas mendocina (strain ymp)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18908 (  4%)
    Bacteria         328119 ( 61%)
    Eukaryota        173361 ( 32%)
    Viruses           16101 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20238 ( 12%)           (  4%)
     Other Mammalia         45653 ( 26%)           (  9%)
     Other Vertebrata       17078 ( 10%)           (  3%)
     Viridiplantae          32564 ( 19%)           (  6%)
     Fungi                  30734 ( 18%)           (  6%)
     Insecta                 8380 (  5%)           (  2%)
     Nematoda                4230 (  2%)           (  1%)
     Other                  14484 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8667             1001-1100     3706
                 51- 100   41187             1101-1200     2572
                101- 150   57349             1201-1300     1998
                151- 200   57528             1301-1400     1853
                201- 250   56286             1401-1500     1498
                251- 300   49627             1501-1600      723
                301- 350   49835             1601-1700      559
                351- 400   43070             1701-1800      455
                401- 450   35277             1801-1900      418
                451- 500   28389             1901-2000      341
                501- 550   20146             2001-2100      209
                551- 600   14444             2101-2200      282
                601- 650   12173             2201-2300      292
                651- 700    8789             2301-2400      171
                701- 750    7240             2401-2500      136
                751- 800    5130             >2500         1078
                801- 850    4493
                851- 900    4997
                901- 950    3844
                951-1000    2711

   


   The average sequence length in UniProtKB/Swiss-Prot is 354 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2250


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  741
                       2x:  283
                       3x:  151
                       4x:  113
                       5x:   86
                       6x:   79
                       7x:   50
                       8x:   42
                       9x:   32
                      10x:   25
                  11- 20x:  181
                  21- 50x:  189
                  51-100x:  100
                    >100x:  178


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        20172   Journal of Biological Chemistry
    2         9177   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5472   Journal of Bacteriology
    4         4912   Biochemical and Biophysical Research Communications
    5         4569   Gene
    6         4456   Nucleic Acids Research
    7         4273   Biochemistry
    8         4240   FEBS Letters
    9         4109   The EMBO Journal
   10         3838   Molecular and Cellular Biology
   11         3582   Nature
   12         3402   Journal of Molecular Biology
   13         3191   European Journal of Biochemistry
   14         3144   Biochimica et Biophysica Acta
   15         2943   Cell
   16         2499   Genomics
   17         2407   Journal of Virology
   18         2369   Biochemical Journal
   19         2363   Science
   20         1952   Molecular Microbiology
   21         1796   Journal of Cell Biology
   22         1674   Plant Physiology
   23         1594   Plant Molecular Biology
   24         1538   Genes and Development
   25         1509   The American Journal of Human Genetics
   26         1504   Virology
   27         1453   Nature Genetics
   28         1417   Human Molecular Genetics
   29         1381   Oncogene
   30         1322   Molecular and General Genetics
   31         1284   Development
   32         1245   Human Mutation
   33         1220   Molecular Biology of the Cell
   34         1219   Journal of Biochemistry
   35         1167   The Plant Cell
   36         1131   Journal of Immunology
   37         1074   Genetics
   38         1055   Molecular Cell
   39         1035   The Plant Journal
   40         1022   Structure
   41         1002   Journal of General Virology
   42          939   Blood
   43          918   Infection and Immunity
   44          898   Archives of Biochemistry and Biophysics
   45          886   Journal of Cell Science
   46          809   Microbiology
   47          803   Developmental Biology
   48          783   Yeast
   49          783   Cancer Research
   50          756   Current Biology
   51          698   FEMS Microbiology Letters
   52          630   Acta Crystallographica, Section D
   53          623   Protein Science
   54          620   Human Genetics
   55          619   Journal of Neuroscience
   56          616   Nature Structural Biology
   57          614   Mechanisms of Development
   58          600   Applied and Environmental Microbiology
   59          597   Toxicon
   60          574   Neuron
   61          559   Journal of Clinical Investigation
   62          536   Current Genetics
   63          517   American Journal of Physiology
   64          508   The Journal of Experimental Medicine
   65          478   Mammalian Genome
   66          478   Molecular Endocrinology
   67          457   Proteins
   68          454   Journal of Neurochemistry
   69          453   Immunogenetics
   70          441   The Journal of Clinical Endocrinology and Metabolism
   71          428   Molecular and Biochemical Parasitology
   72          425   Endocrinology
   73          413   Nature Cell Biology
   74          412   Bioscience, Biotechnology, and Biochemistry
   75          408   Plant and Cell Physiology
   76          392   Journal of Medical Genetics
   77          391   Journal of Molecular Evolution
   78          373   Molecular Biology and Evolution
   79          373   DNA and Cell Biology
   80          366   PLoS ONE
   81          364   DNA Sequence
   82          360   Experimental Cell Research
   83          331   Peptides
   84          325   Brain Research. Molecular Brain Research
   85          321   Tissue Antigens
   86          316   Comparative Biochemistry and Physiology
   87          305   Antimicrobial Agents and Chemotherapy
   88          305   Developmental Cell
   89          301   RNA
   90          299   Journal of Investigative Dermatology
   91          299   Molecular Pharmacology
   92          293   Biological Chemistry Hoppe-Seyler
   93          279   Cytogenetics and Cell Genetics
   94          277   Nature Structural and Molecular Biology
   95          274   Biology of Reproduction
   96          273   Neurology
   97          272   Planta
   98          265   The FEBS Journal
   99          263   Developmental Dynamics
  100          262   Virus Research
  101          257   Genome Research
  102          253   Journal of General Microbiology
  103          242   Molecular Plant-Microbe Interactions
  104          241   Immunity
  105          237   EMBO Reports
  106          232   Biochimie
  107          229   The New England Journal of Medicine
  108          228   Genes to Cells
  109          226   Eukaryotic Cell
  110          226   European Journal of Immunology
  111          221   The FASEB Journal
  112          219   Annals of Neurology
  113          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  114          217   European Journal of Human Genetics
  115          211   DNA Research
  116          204   Journal of Human Genetics
  117          195   Investigative Ophthalmology and Visual Science
  118          187   Archives of Microbiology
  119          187   Archives of Virology
  120          183   Molecular and Cellular Endocrinology
  121          182   Journal of the American Chemical Society
  122          179   Journal of Cellular Biochemistry
  123          177   American Journal of Medical Genetics. Part A
  124          175   Molecular Immunology
  125          175   BMC Genomics
  126          172   Glycobiology
  127          171   Insect Biochemistry and Molecular Biology
  128          170   Clinical Genetics
  129          169   Diabetes
  130          168   American Journal of Medical Genetics
  131          168   Nature Immunology
  132          167   Molecular Phylogenetics and Evolution
  133          165   Journal of Medicinal Chemistry
  134          159   International Journal of Cancer
  135          159   DNA
  136          158   Molecular Reproduction and Development
  137          156   Circulation Research
  138          155   Hemoglobin
  139          154   Bioorganicheskaia Khimiia
  140          148   Acta Crystallographica, Section F
  141          148   Molecular Genetics and Metabolism
  142          148   Biological Chemistry
  143          147   Molecular and Cellular Neuroscience
  144          146   Journal of Experimental Botany
  145          146   Molecular Genetics and Genomics
  146          140   British Journal of Haematology
  147          139   Phytochemistry
  148          139   Animal Genetics
  149          138   General and Comparative Endocrinology
  150          138   PLoS Genetics


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1017414                 1.90                                         
   Journal                            811417     411389      1.51       1                                 
   Submitted to EMBL/GenBank/DDBJ     197007     177053      0.37       2                                 
   Submitted to other databases         6828       6366      0.01       3                                 
   Book citation                         698        684     <0.01       4                                 
   Plant Gene Register                   576        564     <0.01       5                                 
   Thesis                                410        407     <0.01       6                                 
   Unpublished observations              283        279     <0.01       7                                 
   Patent                                189        186     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 322851

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2377206                 4.43                                         
   ALLERGEN                              516        516     <0.01      26                                 
   ALTERNATIVE PRODUCTS                20916      20916      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        4175       4175      0.01      23                                 
   BIOTECHNOLOGY                         326        324     <0.01      28                                 
   CATALYTIC ACTIVITY                 240555     218145      0.45       4                                 
   CAUTION                              7970       7811      0.01      19                                 
   COFACTOR                           105153      96624      0.20       7                                 
   DEVELOPMENTAL STAGE                  9496       9496      0.02      16                                 
   DISEASE                              5029       3369      0.01      21                                 
   DISRUPTION PHENOTYPE                 4657       4657      0.01      22                                 
   DOMAIN                              37569      33278      0.07      10                                 
   ENZYME REGULATION                   10605      10605      0.02      15                                 
   FUNCTION                           412496     395517      0.77       2                                 
   INDUCTION                           14264      14264      0.03      14                                 
   INTERACTION                          9331       9331      0.02      17                                 
   MASS SPECTROMETRY                    5084       3863      0.01      20                                 
   MISCELLANEOUS                       31388      28955      0.06      12                                 
   PATHWAY                            131183     119013      0.24       6                                 
   PHARMACEUTICAL                         85         85     <0.01      29                                 
   POLYMORPHISM                          864        812     <0.01      24                                 
   PTM                                 43374      34344      0.08       8                                 
   RNA EDITING                           623        623     <0.01      25                                 
   SEQUENCE CAUTION                    40451      40451      0.08       9                                 
   SIMILARITY                         633837     511766      1.18       1                                 
   SUBCELLULAR LOCATION               322404     316680      0.60       3                                 
   SUBUNIT                            238398     238398      0.44       5                                 
   TISSUE SPECIFICITY                  37210      37210      0.07      11                                 
   TOXIC DOSE                            498        484     <0.01      27                                 
   WEB RESOURCE                         8749       7017      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3560277                 6.64                                         
   ACT_SITE                           135647      82988      0.25       9                                 
   BINDING                            256344      69823      0.48       4                                 
   CA_BIND                              3813       1581      0.01      35                                 
   CARBOHYD                           106336      27150      0.20      14                                 
   CHAIN                              543251     530668      1.01       1                                 
   COILED                              19848      13634      0.04      26                                 
   COMPBIAS                            53496      28298      0.10      18                                 
   CONFLICT                           125232      43879      0.23      11                                 
   CROSSLNK                             6423       3804      0.01      34                                 
   DISULFID                           105289      28244      0.20      15                                 
   DNA_BIND                            11320      10425      0.02      31                                 
   DOMAIN                             157937      94066      0.29       6                                 
   HELIX                              156896      16276      0.29       7                                 
   INIT_MET                            15198      15198      0.03      27                                 
   INTRAMEM                             1965        871     <0.01      38                                 
   LIPID                               11475       7282      0.02      30                                 
   METAL                              306156      75201      0.57       3                                 
   MOD_RES                            192903      63209      0.36       5                                 
   MOTIF                               34881      22548      0.07      24                                 
   MUTAGEN                             39609       9230      0.07      21                                 
   NON_CONS                             2029        741     <0.01      37                                 
   NON_STD                               354        279     <0.01      39                                 
   NON_TER                             12159       9284      0.02      29                                 
   NP_BIND                            114674      71613      0.21      12                                 
   PEPTIDE                              9798       6601      0.02      32                                 
   PROPEP                              12519      10764      0.02      28                                 
   REGION                             113516      60842      0.21      13                                 
   REPEAT                              93414      13834      0.17      16                                 
   SIGNAL                              37703      37693      0.07      22                                 
   SITE                                41530      24317      0.08      20                                 
   STRAND                             153529      15127      0.29       8                                 
   TOPO_DOM                           128838      26624      0.24      10                                 
   TRANSIT                              8055       7960      0.02      33                                 
   TRANSMEM                           353050      72761      0.66       2                                 
   TURN                                36153      12685      0.07      23                                 
   UNSURE                               2993        524      0.01      36                                 
   VAR_SEQ                             42684      18331      0.08      19                                 
   VARIANT                             83984      16659      0.16      17                                 
   ZN_FING                             29276      12810      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15227053                28.38                                                           
   2DBase-Ecoli                           85         85     <0.01     126      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     123      2D gel databases                             
   AGD                                   932        926     <0.01     101      Organism-specific databases                  
   Allergome                            1439        889     <0.01      97      Protein family/group databases               
   ANU-2DPAGE                             27         27     <0.01     132      2D gel databases                             
   ArachnoServer                         763        755     <0.01     107      Organism-specific databases                  
   ArrayExpress                        59794      59794      0.11      42      Gene expression databases                    
   Bgee                                39407      39407      0.07      46      Gene expression databases                    
   BindingDB                             295        295     <0.01     119      Other                                        
   BioCyc                             248492     240040      0.46      22      Enzyme and pathway databases                 
   BRENDA                               4250       4243      0.01      88      Enzyme and pathway databases                 
   CAZy                                 7538       6780      0.01      73      Protein family/group databases               
   CGD                                   677        655     <0.01     108      Organism-specific databases                  
   CleanEx                             30101      29460      0.06      50      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     125      2D gel databases                             
   ConoServer                            915        833     <0.01     103      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     127      2D gel databases                             
   CTD                                 68431      67820      0.13      40      Organism-specific databases                  
   CYGD                                 5594       5591      0.01      77      Organism-specific databases                  
   dictyBase                            4202       4085      0.01      89      Organism-specific databases                  
   DIP                                 13459      13351      0.03      66      Protein-protein interaction databases        
   DisProt                               397        394     <0.01     116      3D structure databases                       
   DMDM                                16770      16768      0.03      62      Polymorphism databases                       
   DNASU                               18627      18555      0.03      58      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     122      2D gel databases                             
   DrugBank                             5318       1627      0.01      79      Other                                        
   EchoBASE                             4167       4163      0.01      91      Organism-specific databases                  
   ECO2DBASE                             352        300     <0.01     118      2D gel databases                             
   EcoGene                              4292       4290      0.01      87      Organism-specific databases                  
   eggNOG                             429543     429543      0.80       9      Phylogenomic databases                       
   EMBL                               923455     525962      1.72       3      Sequence databases                           
   Ensembl                             82323      47662      0.15      34      Genome annotation databases                  
   EnsemblBacteria                     97881      84933      0.18      28      Genome annotation databases                  
   EnsemblFungi                        16849      16564      0.03      61      Genome annotation databases                  
   EnsemblMetazoa                       9765       8259      0.02      71      Genome annotation databases                  
   EnsemblPlants                       13154      12887      0.02      67      Genome annotation databases                  
   EnsemblProtists                      4398       4283      0.01      86      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     128      Organism-specific databases                  
   EuPathDB                              803        802     <0.01     104      Organism-specific databases                  
   EvolutionaryTrace                   16441      16441      0.03      64      Other                                        
   FlyBase                              5855       5481      0.01      76      Organism-specific databases                  
   Gene3D                             327854     252646      0.61      17      Family and domain databases                  
   GeneCards                           19962      19658      0.04      55      Organism-specific databases                  
   GeneFarm                             3053       3042      0.01      93      Organism-specific databases                  
   GeneID                             488503     466896      0.91       6      Genome annotation databases                  
   GeneTree                            52422      52395      0.10      43      Phylogenomic databases                       
   Genevestigator                      66626      66626      0.12      41      Gene expression databases                    
   GenoList                             7068       7056      0.01      74      Organism-specific databases                  
   GenomeReviews                      376652     357062      0.70      13      Genome annotation databases                  
   GermOnline                          41902      41328      0.08      45      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     120      PTM databases                                
   GO                                2196955     505232      4.10       1      Ontologies                                   
   Gramene                              4773       4773      0.01      82      Organism-specific databases                  
   H-InvDB                              5593       4771      0.01      78      Organism-specific databases                  
   HAMAP                              312132     311929      0.58      18      Family and domain databases                  
   HGNC                                19776      19619      0.04      56      Organism-specific databases                  
   HOGENOM                            384036     384036      0.72      12      Phylogenomic databases                       
   HOVERGEN                            75360      75360      0.14      36      Phylogenomic databases                       
   HPA                                 15757      12090      0.03      65      Organism-specific databases                  
   HSSP                                30279      30279      0.06      49      3D structure databases                       
   InParanoid                          69158      69158      0.13      39      Phylogenomic databases                       
   IntAct                              33322      33322      0.06      48      Protein-protein interaction databases        
   InterPro                          1765279     511741      3.29       2      Family and domain databases                  
   IPI                                 94671      66738      0.18      31      Sequence databases                           
   KEGG                               463504     445594      0.86       8      Genome annotation databases                  
   KO                                 369141     368746      0.69      14      Phylogenomic databases                       
   LegioList                             765        763     <0.01     106      Organism-specific databases                  
   Leproma                               671        668     <0.01     109      Organism-specific databases                  
   MaizeGDB                              487        482     <0.01     114      Organism-specific databases                  
   MEROPS                              10641      10641      0.02      70      Protein family/group databases               
   MGI                                 16443      16398      0.03      63      Organism-specific databases                  
   MIM                                 17548      13356      0.03      60      Organism-specific databases                  
   MINT                                17606      17606      0.03      59      Protein-protein interaction databases        
   NextBio                             69588      69588      0.13      38      Other                                        
   neXtProt                            20096      20096      0.04      54      Organism-specific databases                  
   OGP                                   377        377     <0.01     117      2D gel databases                             
   OMA                                385789     385789      0.72      11      Phylogenomic databases                       
   Orphanet                             4172       2504      0.01      90      Organism-specific databases                  
   OrthoDB                             78048      78048      0.15      35      Phylogenomic databases                       
   PANTHER                            200431     186209      0.37      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      85      Enzyme and pathway databases                 
   PATRIC                             308507     308484      0.58      20      Genome annotation databases                  
   PDB                                 85889      18193      0.16      33      3D structure databases                       
   PDBsum                              85889      18193      0.16      32      3D structure databases                       
   PeptideAtlas                         5163       5163      0.01      80      Proteomic databases                          
   PeroxiBase                            765        749     <0.01     105      Protein family/group databases               
   Pfam                               707805     493302      1.32       4      Family and domain databases                  
   PharmGKB                            18759      18342      0.03      57      Organism-specific databases                  
   PHCI-2DPAGE                           250        250     <0.01     121      2D gel databases                             
   PhosphoSite                         25553      25553      0.05      53      PTM databases                                
   PhosSite                              515        507     <0.01     111      PTM databases                                
   PhylomeDB                           26636      26636      0.05      52      Phylogenomic databases                       
   PIR                                117852     107737      0.22      27      Sequence databases                           
   PIRSF                               97166      97152      0.18      30      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01      96      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     129      2D gel databases                             
   PomBase                              5014       4956      0.01      81      Organism-specific databases                  
   PptaseDB                               38         38     <0.01     130      Protein family/group databases               
   PRIDE                               72794      72794      0.14      37      Proteomic databases                          
   PRINTS                             137514     120439      0.26      26      Family and domain databases                  
   ProDom                              29259      29080      0.05      51      Family and domain databases                  
   ProMEX                                505        505     <0.01     113      Proteomic databases                          
   PROSITE                            477632     302084      0.89       7      Family and domain databases                  
   ProtClustDB                        342622     342622      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 427557     427557      0.80      10      3D structure databases                       
   PseudoCAP                            1234       1225     <0.01      99      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     131      2D gel databases                             
   Reactome                            11040       7007      0.02      69      Enzyme and pathway databases                 
   REBASE                                402        402     <0.01     115      Protein family/group databases               
   RefSeq                             512291     468239      0.95       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01      98      2D gel databases                             
   RGD                                  7668       7664      0.01      72      Organism-specific databases                  
   SGD                                  6638       6633      0.01      75      Organism-specific databases                  
   Siena-2DPAGE                          103        103     <0.01     124      2D gel databases                             
   SMART                              166758     124817      0.31      25      Family and domain databases                  
   SMR                                211803     211803      0.39      23      3D structure databases                       
   STRING                             308971     308969      0.58      19      Protein-protein interaction databases        
   SUPFAM                             330751     262046      0.62      16      Family and domain databases                  
   SWISS-2DPAGE                         1182       1181     <0.01     100      2D gel databases                             
   TAIR                                11274      11211      0.02      68      Organism-specific databases                  
   TCDB                                 3632       3617      0.01      92      Protein family/group databases               
   TIGR                                34552      33773      0.06      47      Genome annotation databases                  
   TIGRFAMs                           288802     268433      0.54      21      Family and domain databases                  
   TubercuList                          1945       1909     <0.01      95      Organism-specific databases                  
   UCD-2DPAGE                            509        500     <0.01     112      2D gel databases                             
   UCSC                                51185      38934      0.10      44      Genome annotation databases                  
   UniGene                             97538      89114      0.18      29      Sequence databases                           
   VectorBase                            606        588     <0.01     110      Genome annotation databases                  
   World-2DPAGE                          919        908     <0.01     102      2D gel databases                             
   WormBase                             4758       3871      0.01      83      Organism-specific databases                  
   Xenbase                              4695       4690      0.01      84      Organism-specific databases                  
   ZFIN                                 2753       2753      0.01      94      Organism-specific databases                  

Total number of cross-referenced databases: 132

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.56
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.36   Ile (I) 5.96   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4460 entries are encoded on a mitochondrion, and 3664 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 73493