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         UniProtKB/Swiss-Prot protein knowledgebase release 2012_05 statistics


1.  INTRODUCTION

Release 2012_05 of 16-May-12 of UniProtKB/Swiss-Prot contains 536029 sequence entries,
comprising 190235160 amino acids abstracted from 209686 references. 

347 sequences have been added since release 2012_04, the sequence data of
108 existing entries has been updated and the annotations of
440046 entries have been revised.

Number of fragments: 9008
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 32131


Protein existence (PE):           entries     %

1: Evidence at protein level        74752   13.9%
2: Evidence at transcript level     68095   12.7%
3: Inferred from homology          376875   70.3%
4: Predicted                        14409    2.7%
5: Uncertain                         1898    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12807

   The first twenty species represent 111847 sequences:  20.9 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5396
                            2x: 1865
                            3x:  970
                            4x:  629
                            5x:  461
                            6x:  372
                            7x:  275
                            8x:  223
                            9x:  196
                           10x:  115
                       11- 20x:  660
                       21- 50x:  396
                       51-100x:  209
                         >100x: 1040


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20244  Homo sapiens (Human)
       2      16529  Mus musculus (Mouse)
       3      11206  Arabidopsis thaliana (Mouse-ear cress)
       4       7750  Rattus norvegicus (Rat)
       5       6619  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5930  Bos taurus (Bovine)
       7       5088  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4188  Bacillus subtilis (strain 168)
      10       4126  Dictyostelium discoideum (Slime mold)
      11       3355  Caenorhabditis elegans
      12       3348  Xenopus laevis (African clawed frog)
      13       3156  Drosophila melanogaster (Fruit fly)
      14       2867  Oryza sativa subsp. japonica (Rice)
      15       2821  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2244  Gallus gallus (Chicken)
      17       2218  Pongo abelii (Sumatran orangutan)
      18       2011  Escherichia coli O157:H7
      19       1929  Mycobacterium tuberculosis
      20       1787  Methanocaldococcus jannaschii  
      21       1762  Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1678  Shigella flexneri
      24       1675  Escherichia coli O6
      25       1655  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      26       1407  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1244  Mycobacterium bovis
      29       1223  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1029  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1015  Yersinia pestis
      33       1010  Archaeoglobus fulgidus 
      34        946  Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
      35        930  Salmonella paratyphi A (strain ATCC 9150 / SARB42)
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        901  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        886  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis (strain SC-B67)
      48        878  Shigella sonnei (strain Ss046)
      49        868  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        864  Yersinia pseudotuberculosis
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      54        832  Neurospora crassa 
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        824  Escherichia coli (strain UTI89 / UPEC)
      57        819  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        802  Canis familiaris (Dog) (Canis lupus familiaris)
      60        795  Vibrio parahaemolyticus
      61        791  Escherichia coli (strain SMS-3-5 / SECEC)
      62        784  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
      63        780  Aquifex aeolicus (strain VF5)
      64        774  Pasteurella multocida (strain Pm70)
      65        771  Escherichia coli (strain K12 / DH10B)
      66        771  Emericella nidulans  
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        757  Staphylococcus epidermidis (strain ATCC 12228)
      75        756  Escherichia coli (strain SE11)
      76        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      77        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      78        751  Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        738  Staphylococcus aureus (strain NCTC 8325)
      82        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      83        734  Bacillus anthracis
      84        734  Bacillus halodurans 
      85        733  Vibrio vulnificus
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Enterobacter sp. (strain 638)
      93        713  Salmonella agona (strain SL483)
      94        713  Escherichia coli O1:K1 / APEC
      95        713  Salmonella newport (strain SL254)
      96        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      97        712  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      98        712  Salmonella schwarzengrund (strain CVM19633)
      99        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     100        710  Salmonella heidelberg (strain SL476)
     101        702  Salmonella dublin (strain CT_02021853)
     102        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     103        696  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
     104        696  Klebsiella pneumoniae (strain 342)
     105        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     106        692  Zea mays (Maize)
     107        688  Pan troglodytes (Chimpanzee)
     108        688  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     110        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     111        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     112        675  Pseudomonas putida (strain KT2440)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        670  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        654  Bradyrhizobium japonicum (strain USDA 110)
     120        653  Debaryomyces hansenii   
     121        652  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        649  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     123        644  Escherichia coli
     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     128        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     129        631  Shewanella oneidensis (strain MR-1)
     130        631  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        615  Treponema pallidum (strain Nichols)
     133        613  Methanothermobacter thermautotrophicus  
     134        612  Staphylococcus haemolyticus (strain JCSC1435)
     135        605  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     136        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     137        602  Staphylococcus saprophyticus subsp. saprophyticus 
     138        601  Salmonella paratyphi C (strain RKS4594)
     139        601  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     140        601  Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
     141        601  Oryza sativa subsp. indica (Rice)
     142        600  Yersinia pestis bv. Antiqua (strain Angola)
     143        600  Xanthomonas campestris pv. campestris (strain ATCC 33913 / NCPPB 528 / LMG 568)
     144        590  Bacillus cereus (strain ATCC 10987)
     145        590  Listeria innocua serovar 6a (strain CLIP 11262)
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        576  Brucella suis biovar 1 (strain 1330)
     149        575  Neisseria meningitidis serogroup B (strain MC58)
     150        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     151        572  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     154        566  Caenorhabditis briggsae
     155        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     156        565  Pseudomonas syringae pv. syringae (strain B728a)
     157        564  Caulobacter crescentus (strain ATCC 19089 / CB15)
     158        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     159        562  Vibrio fischeri (strain ATCC 700601 / ES114)
     160        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     161        560  Bacillus cereus (strain ZK / E33L)
     162        559  Pseudomonas aeruginosa (strain UCBPP-PA14)
     163        556  Xanthomonas axonopodis pv. citri (strain 306)
     164        556  Clostridium acetobutylicum 
     165        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     166        552  Pseudomonas fluorescens (strain Pf0-1)
     167        551  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        533  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     172        529  Sodalis glossinidius (strain morsitans)
     173        529  Listeria monocytogenes serotype 4b (strain F2365)
     174        527  Streptococcus pneumoniae
     175        526  Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
     176        522  Xylella fastidiosa
     177        521  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     178        514  Chromobacterium violaceum 
     179        514  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
     180        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     181        511  Pseudomonas aeruginosa (strain PA7)
     182        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     184        509  Bordetella parapertussis
     185        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     186        507  Geobacillus kaustophilus (strain HTA426)
     187        506  Staphylococcus aureus (strain Newman)
     188        501  Deinococcus radiodurans 
     189        500  Pseudomonas entomophila (strain L48)
     190        499  Brucella abortus biovar 1 (strain 9-941)
     191        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     192        496  Corynebacterium glutamicum 
     193        496  Bacillus clausii (strain KSM-K16)
     194        495  Haemophilus influenzae (strain 86-028NP)
     195        494  Proteus mirabilis (strain HI4320)
     196        494  Streptomyces avermitilis
     197        493  Burkholderia pseudomallei (strain K96243)
     198        492  Bacillus amyloliquefaciens (strain FZB42)
     199        491  Xanthomonas campestris pv. campestris (strain 8004)
     200        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     201        490  Clostridium perfringens
     202        488  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     203        487  Shewanella sp. (strain MR-7)
     204        485  Mannheimia succiniciproducens (strain MBEL55E)
     205        484  Pseudomonas aeruginosa (strain LESB58)
     206        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     207        484  Shewanella sp. (strain MR-4)
     208        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     209        481  Thermosynechococcus elongatus (strain BP-1)
     210        480  Acinetobacter sp. (strain ADP1)
     211        476  Pyrococcus horikoshii 
     212        476  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     213        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     214        474  Pseudomonas putida (strain F1 / ATCC 700007)
     215        473  Brucella abortus (strain 2308)
     216        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     217        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     218        466  Shewanella frigidimarina (strain NCIMB 400)
     219        466  Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 
     220        466  Pseudomonas putida (strain GB-1)
     221        465  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     222        465  Pyrococcus abyssi (strain GE5 / Orsay)
     223        465  Methanosarcina mazei  
     224        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     225        463  Shewanella sp. (strain ANA-3)
     226        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     227        462  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     228        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     229        461  Burkholderia mallei (Pseudomonas mallei)
     230        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     231        458  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     232        458  Enterococcus faecalis (strain ATCC 700802 / V583)
     233        455  Staphylococcus aureus (strain JH1)
     234        455  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     235        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     236        453  Ovis aries (Sheep)
     237        453  Pseudomonas putida (strain W619)
     238        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     239        452  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     240        452  Shewanella baltica (strain OS185)
     241        451  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     242        451  Streptococcus mutans
     243        451  Aeromonas salmonicida (strain A449)
     244        449  Mycobacterium paratuberculosis
     245        449  Thermoanaerobacter tengcongensis  
     246        449  Staphylococcus aureus (strain JH9)
     247        449  Hahella chejuensis (strain KCTC 2396)
     248        447  Vibrio fischeri (strain MJ11)
     249        446  Nicotiana tabacum (Common tobacco)
     250        445  Pseudomonas mendocina (strain ymp)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18877 (  4%)
    Bacteria         327969 ( 61%)
    Eukaryota        173117 ( 32%)
    Viruses           16066 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20245 ( 12%)           (  4%)
     Other Mammalia         45620 ( 26%)           (  9%)
     Other Vertebrata       17040 ( 10%)           (  3%)
     Viridiplantae          32434 ( 19%)           (  6%)
     Fungi                  30729 ( 18%)           (  6%)
     Insecta                 8380 (  5%)           (  2%)
     Nematoda                4227 (  2%)           (  1%)
     Other                  14442 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8667             1001-1100     3703
                 51- 100   41145             1101-1200     2571
                101- 150   57290             1201-1300     1996
                151- 200   57477             1301-1400     1855
                201- 250   56236             1401-1500     1496
                251- 300   49590             1501-1600      723
                301- 350   49789             1601-1700      557
                351- 400   43017             1701-1800      454
                401- 450   35266             1801-1900      418
                451- 500   28369             1901-2000      342
                501- 550   20137             2001-2100      209
                551- 600   14431             2101-2200      281
                601- 650   12163             2201-2300      292
                651- 700    8781             2301-2400      171
                701- 750    7227             2401-2500      136
                751- 800    5122             >2500         1078
                801- 850    4488
                851- 900    4993
                901- 950    3839
                951-1000    2712

   


   The average sequence length in UniProtKB/Swiss-Prot is 354 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2244


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  739
                       2x:  287
                       3x:  145
                       4x:  116
                       5x:   88
                       6x:   76
                       7x:   50
                       8x:   40
                       9x:   33
                      10x:   25
                  11- 20x:  179
                  21- 50x:  188
                  51-100x:  100
                    >100x:  178


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        20106   Journal of Biological Chemistry
    2         9143   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5450   Journal of Bacteriology
    4         4901   Biochemical and Biophysical Research Communications
    5         4564   Gene
    6         4451   Nucleic Acids Research
    7         4248   Biochemistry
    8         4228   FEBS Letters
    9         4093   The EMBO Journal
   10         3823   Molecular and Cellular Biology
   11         3570   Nature
   12         3384   Journal of Molecular Biology
   13         3189   European Journal of Biochemistry
   14         3136   Biochimica et Biophysica Acta
   15         2934   Cell
   16         2498   Genomics
   17         2383   Journal of Virology
   18         2367   Biochemical Journal
   19         2353   Science
   20         1947   Molecular Microbiology
   21         1792   Journal of Cell Biology
   22         1659   Plant Physiology
   23         1584   Plant Molecular Biology
   24         1530   Genes and Development
   25         1501   Virology
   26         1495   The American Journal of Human Genetics
   27         1445   Nature Genetics
   28         1408   Human Molecular Genetics
   29         1377   Oncogene
   30         1320   Molecular and General Genetics
   31         1282   Development
   32         1241   Human Mutation
   33         1216   Journal of Biochemistry
   34         1209   Molecular Biology of the Cell
   35         1158   The Plant Cell
   36         1126   Journal of Immunology
   37         1062   Genetics
   38         1048   Molecular Cell
   39         1027   The Plant Journal
   40         1010   Structure
   41          999   Journal of General Virology
   42          930   Blood
   43          918   Infection and Immunity
   44          892   Archives of Biochemistry and Biophysics
   45          879   Journal of Cell Science
   46          803   Microbiology
   47          796   Developmental Biology
   48          782   Yeast
   49          779   Cancer Research
   50          753   Current Biology
   51          697   FEMS Microbiology Letters
   52          628   Acta Crystallographica, Section D
   53          620   Human Genetics
   54          616   Protein Science
   55          616   Journal of Neuroscience
   56          616   Nature Structural Biology
   57          614   Mechanisms of Development
   58          593   Toxicon
   59          591   Applied and Environmental Microbiology
   60          571   Neuron
   61          556   Journal of Clinical Investigation
   62          536   Current Genetics
   63          517   American Journal of Physiology
   64          506   The Journal of Experimental Medicine
   65          478   Mammalian Genome
   66          476   Molecular Endocrinology
   67          453   Immunogenetics
   68          452   Journal of Neurochemistry
   69          452   Proteins
   70          441   The Journal of Clinical Endocrinology and Metabolism
   71          428   Molecular and Biochemical Parasitology
   72          424   Endocrinology
   73          410   Nature Cell Biology
   74          410   Bioscience, Biotechnology, and Biochemistry
   75          407   Plant and Cell Physiology
   76          391   Journal of Molecular Evolution
   77          390   Journal of Medical Genetics
   78          374   DNA and Cell Biology
   79          372   Molecular Biology and Evolution
   80          362   DNA Sequence
   81          360   Experimental Cell Research
   82          346   PLoS ONE
   83          330   Peptides
   84          325   Brain Research. Molecular Brain Research
   85          321   Tissue Antigens
   86          316   Comparative Biochemistry and Physiology
   87          304   Antimicrobial Agents and Chemotherapy
   88          302   Developmental Cell
   89          299   Molecular Pharmacology
   90          298   RNA
   91          297   Journal of Investigative Dermatology
   92          293   Biological Chemistry Hoppe-Seyler
   93          279   Cytogenetics and Cell Genetics
   94          274   Biology of Reproduction
   95          272   Neurology
   96          270   Nature Structural and Molecular Biology
   97          267   Planta
   98          263   The FEBS Journal
   99          262   Developmental Dynamics
  100          262   Virus Research
  101          256   Genome Research
  102          252   Journal of General Microbiology
  103          242   Molecular Plant-Microbe Interactions
  104          238   Immunity
  105          235   EMBO Reports
  106          231   Biochimie
  107          226   The New England Journal of Medicine
  108          226   Eukaryotic Cell
  109          226   European Journal of Immunology
  110          226   Genes to Cells
  111          221   The FASEB Journal
  112          218   Annals of Neurology
  113          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  114          215   European Journal of Human Genetics
  115          211   DNA Research
  116          204   Journal of Human Genetics
  117          195   Investigative Ophthalmology and Visual Science
  118          187   Archives of Microbiology
  119          187   Archives of Virology
  120          183   Molecular and Cellular Endocrinology
  121          179   Journal of Cellular Biochemistry
  122          178   Journal of the American Chemical Society
  123          174   American Journal of Medical Genetics. Part A
  124          173   Molecular Immunology
  125          172   BMC Genomics
  126          171   Glycobiology
  127          171   Insect Biochemistry and Molecular Biology
  128          169   Diabetes
  129          169   Clinical Genetics
  130          168   American Journal of Medical Genetics
  131          167   Nature Immunology
  132          167   Molecular Phylogenetics and Evolution
  133          164   Journal of Medicinal Chemistry
  134          159   International Journal of Cancer
  135          159   DNA
  136          158   Molecular Reproduction and Development
  137          156   Circulation Research
  138          155   Hemoglobin
  139          154   Bioorganicheskaia Khimiia
  140          148   Molecular Genetics and Metabolism
  141          148   Biological Chemistry
  142          147   Molecular and Cellular Neuroscience
  143          145   Acta Crystallographica, Section F
  144          145   Molecular Genetics and Genomics
  145          142   Journal of Experimental Botany
  146          139   British Journal of Haematology
  147          139   Animal Genetics
  148          138   General and Comparative Endocrinology
  149          138   Protein Expression and Purification
  150          136   Phytochemistry


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1014901                 1.89                                         
   Journal                            808952     410749      1.51       1                                 
   Submitted to EMBL/GenBank/DDBJ     197015     177137      0.37       2                                 
   Submitted to other databases         6779       6320      0.01       3                                 
   Book citation                         692        678     <0.01       4                                 
   Plant Gene Register                   576        564     <0.01       5                                 
   Thesis                                410        407     <0.01       6                                 
   Unpublished observations              282        278     <0.01       7                                 
   Patent                                189        186     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 321329

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2371298                 4.42                                         
   ALLERGEN                              516        516     <0.01      26                                 
   ALTERNATIVE PRODUCTS                20851      20851      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        4131       4131      0.01      23                                 
   BIOTECHNOLOGY                         325        323     <0.01      28                                 
   CATALYTIC ACTIVITY                 239322     217407      0.45       4                                 
   CAUTION                              7937       7778      0.01      19                                 
   COFACTOR                           104642      96236      0.20       7                                 
   DEVELOPMENTAL STAGE                  9615       9615      0.02      16                                 
   DISEASE                              4976       3338      0.01      21                                 
   DISRUPTION PHENOTYPE                 4585       4585      0.01      22                                 
   DOMAIN                              37445      33172      0.07      10                                 
   ENZYME REGULATION                   10539      10539      0.02      15                                 
   FUNCTION                           411382     394433      0.77       2                                 
   INDUCTION                           14071      14071      0.03      14                                 
   INTERACTION                          9264       9264      0.02      17                                 
   MASS SPECTROMETRY                    5079       3860      0.01      20                                 
   MISCELLANEOUS                       31324      28902      0.06      12                                 
   PATHWAY                            131097     118932      0.24       6                                 
   PHARMACEUTICAL                         85         85     <0.01      29                                 
   POLYMORPHISM                          861        809     <0.01      24                                 
   PTM                                 43197      34266      0.08       8                                 
   RNA EDITING                           623        623     <0.01      25                                 
   SEQUENCE CAUTION                    40397      40397      0.08       9                                 
   SIMILARITY                         633193     511304      1.18       1                                 
   SUBCELLULAR LOCATION               321946     316240      0.60       3                                 
   SUBUNIT                            237613     237613      0.44       5                                 
   TISSUE SPECIFICITY                  37039      37039      0.07      11                                 
   TOXIC DOSE                            498        484     <0.01      27                                 
   WEB RESOURCE                         8745       7015      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3542077                 6.61                                         
   ACT_SITE                           135454      82846      0.25       9                                 
   BINDING                            252431      69053      0.47       4                                 
   CA_BIND                              3813       1581      0.01      35                                 
   CARBOHYD                           106167      27090      0.20      14                                 
   CHAIN                              542774     530209      1.01       1                                 
   COILED                              19794      13604      0.04      26                                 
   COMPBIAS                            53349      28203      0.10      18                                 
   CONFLICT                           125119      43843      0.23      11                                 
   CROSSLNK                             6364       3772      0.01      34                                 
   DISULFID                           104802      28180      0.20      15                                 
   DNA_BIND                            11319      10425      0.02      31                                 
   DOMAIN                             157640      93968      0.29       6                                 
   HELIX                              155384      16137      0.29       7                                 
   INIT_MET                            15198      15198      0.03      27                                 
   INTRAMEM                             1955        861     <0.01      38                                 
   LIPID                               11368       7228      0.02      30                                 
   METAL                              300833      73894      0.56       3                                 
   MOD_RES                            192571      63164      0.36       5                                 
   MOTIF                               34803      22479      0.06      24                                 
   MUTAGEN                             39271       9164      0.07      21                                 
   NON_CONS                             2021        738     <0.01      37                                 
   NON_STD                               354        279     <0.01      39                                 
   NON_TER                             12151       9277      0.02      29                                 
   NP_BIND                            114602      71572      0.21      12                                 
   PEPTIDE                              9797       6600      0.02      32                                 
   PROPEP                              12503      10751      0.02      28                                 
   REGION                             112714      60187      0.21      13                                 
   REPEAT                              93368      13829      0.17      16                                 
   SIGNAL                              37547      37537      0.07      22                                 
   SITE                                41382      24256      0.08      20                                 
   STRAND                             151915      15001      0.28       8                                 
   TOPO_DOM                           128272      26511      0.24      10                                 
   TRANSIT                              8028       7933      0.01      33                                 
   TRANSMEM                           352693      72662      0.66       2                                 
   TURN                                35825      12575      0.07      23                                 
   UNSURE                               2992        523      0.01      36                                 
   VAR_SEQ                             42508      18275      0.08      19                                 
   VARIANT                             83732      16651      0.16      17                                 
   ZN_FING                             29264      12802      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15203031                28.36                                                           
   2DBase-Ecoli                           85         85     <0.01     126      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     123      2D gel databases                             
   AGD                                   932        926     <0.01     101      Organism-specific databases                  
   Allergome                            1432        882     <0.01      97      Protein family/group databases               
   ANU-2DPAGE                             26         26     <0.01     132      2D gel databases                             
   ArachnoServer                         763        755     <0.01     107      Organism-specific databases                  
   ArrayExpress                        59774      59774      0.11      42      Gene expression databases                    
   Bgee                                39391      39391      0.07      46      Gene expression databases                    
   BindingDB                             295        295     <0.01     119      Other                                        
   BioCyc                             248425     239973      0.46      22      Enzyme and pathway databases                 
   BRENDA                               4248       4241      0.01      88      Enzyme and pathway databases                 
   CAZy                                 7535       6777      0.01      74      Protein family/group databases               
   CGD                                   677        655     <0.01     108      Organism-specific databases                  
   CleanEx                             30102      29461      0.06      51      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     125      2D gel databases                             
   ConoServer                            915        833     <0.01     103      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     127      2D gel databases                             
   CTD                                 68339      67734      0.13      39      Organism-specific databases                  
   CYGD                                 5594       5591      0.01      78      Organism-specific databases                  
   dictyBase                            4202       4085      0.01      89      Organism-specific databases                  
   DIP                                 13457      13349      0.03      66      Protein-protein interaction databases        
   DisProt                               397        394     <0.01     115      3D structure databases                       
   DMDM                                16774      16772      0.03      62      Polymorphism databases                       
   DNASU                               18334      18263      0.03      58      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     122      2D gel databases                             
   DrugBank                             5318       1627      0.01      79      Other                                        
   EchoBASE                             4167       4163      0.01      91      Organism-specific databases                  
   ECO2DBASE                             352        300     <0.01     117      2D gel databases                             
   EcoGene                              4292       4290      0.01      87      Organism-specific databases                  
   eggNOG                             429389     429389      0.80       9      Phylogenomic databases                       
   EMBL                               922043     525520      1.72       3      Sequence databases                           
   Ensembl                             67578      48170      0.13      40      Genome annotation databases                  
   EnsemblBacteria                     97864      84916      0.18      28      Genome annotation databases                  
   EnsemblFungi                        16849      16564      0.03      61      Genome annotation databases                  
   EnsemblMetazoa                       9757       8256      0.02      72      Genome annotation databases                  
   EnsemblPlants                       13068      12824      0.02      68      Genome annotation databases                  
   EnsemblProtists                      4398       4283      0.01      86      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     128      Organism-specific databases                  
   EuPathDB                              803        802     <0.01     104      Organism-specific databases                  
   EvolutionaryTrace                   16432      16432      0.03      64      Other                                        
   FlyBase                              5855       5481      0.01      77      Organism-specific databases                  
   Gene3D                             330435     254525      0.62      17      Family and domain databases                  
   GeneCards                           19965      19661      0.04      55      Organism-specific databases                  
   GeneFarm                             3053       3042      0.01      93      Organism-specific databases                  
   GeneID                             485871     466300      0.91       6      Genome annotation databases                  
   GeneTree                            52374      52347      0.10      43      Phylogenomic databases                       
   Genevestigator                      66591      66591      0.12      41      Gene expression databases                    
   GenoList                             7068       7056      0.01      75      Organism-specific databases                  
   GenomeReviews                      376467     356883      0.70      13      Genome annotation databases                  
   GermOnline                          41903      41329      0.08      45      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     120      PTM databases                                
   GO                                2195902     504788      4.10       1      Ontologies                                   
   Gramene                              4751       4751      0.01      82      Organism-specific databases                  
   H-InvDB                             13248      12334      0.02      67      Organism-specific databases                  
   HAMAP                              311925     311722      0.58      18      Family and domain databases                  
   HGNC                                19773      19616      0.04      56      Organism-specific databases                  
   HOGENOM                            383720     383720      0.72      12      Phylogenomic databases                       
   HOVERGEN                            75333      75333      0.14      35      Phylogenomic databases                       
   HPA                                 15758      12091      0.03      65      Organism-specific databases                  
   HSSP                                30273      30273      0.06      50      3D structure databases                       
   InParanoid                          69118      69118      0.13      38      Phylogenomic databases                       
   IntAct                              33173      33173      0.06      49      Protein-protein interaction databases        
   InterPro                          1760276     511209      3.28       2      Family and domain databases                  
   IPI                                 94518      66660      0.18      31      Sequence databases                           
   KEGG                               463221     445253      0.86       8      Genome annotation databases                  
   KO                                 368939     368529      0.69      14      Phylogenomic databases                       
   LegioList                             764        762     <0.01     106      Organism-specific databases                  
   Leproma                               671        668     <0.01     109      Organism-specific databases                  
   MaizeGDB                              487        482     <0.01     113      Organism-specific databases                  
   MEROPS                              10633      10633      0.02      71      Protein family/group databases               
   MGI                                 16433      16388      0.03      63      Organism-specific databases                  
   MIM                                 17450      13306      0.03      60      Organism-specific databases                  
   MINT                                17603      17603      0.03      59      Protein-protein interaction databases        
   NextBio                             69557      69557      0.13      37      Other                                        
   neXtProt                            20104      20104      0.04      54      Organism-specific databases                  
   OGP                                   377        377     <0.01     116      2D gel databases                             
   OMA                                385581     385581      0.72      11      Phylogenomic databases                       
   Orphanet                             4172       2504      0.01      90      Organism-specific databases                  
   OrthoDB                             78026      78026      0.15      34      Phylogenomic databases                       
   PANTHER                            200488     186272      0.37      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      85      Enzyme and pathway databases                 
   PATRIC                             308378     308356      0.58      20      Genome annotation databases                  
   PDB                                 85219      18077      0.16      32      3D structure databases                       
   PDBsum                              85218      18077      0.16      33      3D structure databases                       
   PeptideAtlas                         5164       5164      0.01      80      Proteomic databases                          
   PeroxiBase                            765        749     <0.01     105      Protein family/group databases               
   Pfam                               702223     491616      1.31       4      Family and domain databases                  
   PharmGKB                            18757      18340      0.03      57      Organism-specific databases                  
   PHCI-2DPAGE                           250        250     <0.01     121      2D gel databases                             
   PhosphoSite                         25551      25551      0.05      53      PTM databases                                
   PhosSite                              351        351     <0.01     118      PTM databases                                
   PhylomeDB                           33474      33474      0.06      48      Phylogenomic databases                       
   PIR                                117787     107678      0.22      27      Sequence databases                           
   PIRSF                               96888      96874      0.18      30      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01      96      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     129      2D gel databases                             
   PomBase                              5013       4955      0.01      81      Organism-specific databases                  
   PptaseDB                               34         34     <0.01     130      Protein family/group databases               
   PRIDE                               71615      71615      0.13      36      Proteomic databases                          
   PRINTS                             137539     120406      0.26      26      Family and domain databases                  
   ProDom                              29247      29068      0.05      52      Family and domain databases                  
   ProMEX                                504        504     <0.01     112      Proteomic databases                          
   PROSITE                            477226     301910      0.89       7      Family and domain databases                  
   ProtClustDB                        342438     342438      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 427380     427380      0.80      10      3D structure databases                       
   PseudoCAP                            1231       1222     <0.01      99      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     131      2D gel databases                             
   Reactome                            11040       7007      0.02      70      Enzyme and pathway databases                 
   REBASE                                402        402     <0.01     114      Protein family/group databases               
   RefSeq                             509186     467643      0.95       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01      98      2D gel databases                             
   RGD                                  7653       7649      0.01      73      Organism-specific databases                  
   SGD                                  6638       6633      0.01      76      Organism-specific databases                  
   Siena-2DPAGE                          102        102     <0.01     124      2D gel databases                             
   SMART                              166626     124725      0.31      25      Family and domain databases                  
   SMR                                211750     211750      0.40      23      3D structure databases                       
   STRING                             308865     308863      0.58      19      Protein-protein interaction databases        
   SUPFAM                             330590     261905      0.62      16      Family and domain databases                  
   SWISS-2DPAGE                         1183       1182     <0.01     100      2D gel databases                             
   TAIR                                11233      11170      0.02      69      Organism-specific databases                  
   TCDB                                 3630       3615      0.01      92      Protein family/group databases               
   TIGR                                34535      33756      0.06      47      Genome annotation databases                  
   TIGRFAMs                           288619     268280      0.54      21      Family and domain databases                  
   TubercuList                          1945       1909     <0.01      95      Organism-specific databases                  
   UCD-2DPAGE                            510        501     <0.01     111      2D gel databases                             
   UCSC                                51175      38924      0.10      44      Genome annotation databases                  
   UniGene                             97432      89022      0.18      29      Sequence databases                           
   VectorBase                            606        588     <0.01     110      Genome annotation databases                  
   World-2DPAGE                          919        908     <0.01     102      2D gel databases                             
   WormBase                             4737       3866      0.01      83      Organism-specific databases                  
   Xenbase                              4689       4684      0.01      84      Organism-specific databases                  
   ZFIN                                 2722       2709      0.01      94      Organism-specific databases                  

Total number of cross-referenced databases: 132

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.55
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.36   Ile (I) 5.96   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4461 entries are encoded on a mitochondrion, and 3655 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 73422