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         UniProtKB/Swiss-Prot protein knowledgebase release 2012_04 statistics


1.  INTRODUCTION

Release 2012_04 of 18-Apr-12 of UniProtKB/Swiss-Prot contains 535698 sequence entries,
comprising 190107059 amino acids abstracted from 208953 references. 

491 sequences have been added since release 2012_03, the sequence data of
155 existing entries has been updated and the annotations of
367562 entries have been revised.

Number of fragments: 8997
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 31564


Protein existence (PE):           entries     %

1: Evidence at protein level        74564   13.9%
2: Evidence at transcript level     67824   12.7%
3: Inferred from homology          377002   70.4%
4: Predicted                        14415    2.7%
5: Uncertain                         1893    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12786

   The first twenty species represent 111776 sequences:  20.9 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5390
                            2x: 1859
                            3x:  969
                            4x:  630
                            5x:  461
                            6x:  374
                            7x:  273
                            8x:  221
                            9x:  196
                           10x:  114
                       11- 20x:  656
                       21- 50x:  395
                       51-100x:  209
                         >100x: 1039


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20249  Homo sapiens (Human)
       2      16521  Mus musculus (Mouse)
       3      11145  Arabidopsis thaliana (Mouse-ear cress)
       4       7736  Rattus norvegicus (Rat)
       5       6619  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5916  Bos taurus (Bovine)
       7       5088  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4244  Bacillus subtilis
      10       4125  Dictyostelium discoideum (Slime mold)
      11       3349  Caenorhabditis elegans
      12       3343  Xenopus laevis (African clawed frog)
      13       3149  Drosophila melanogaster (Fruit fly)
      14       2856  Oryza sativa subsp. japonica (Rice)
      15       2810  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2239  Gallus gallus (Chicken)
      17       2218  Pongo abelii (Sumatran orangutan)
      18       2011  Escherichia coli O157:H7
      19       1929  Mycobacterium tuberculosis
      20       1798  Salmonella typhimurium
      21       1787  Methanocaldococcus jannaschii  
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1678  Shigella flexneri
      24       1675  Escherichia coli O6
      25       1646  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      26       1407  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1244  Mycobacterium bovis
      29       1222  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1029  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1015  Yersinia pestis
      33       1004  Archaeoglobus fulgidus 
      34        957  Vibrio cholerae
      35        930  Salmonella paratyphi A
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        901  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        886  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis
      48        878  Shigella sonnei (strain Ss046)
      49        868  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        864  Yersinia pseudotuberculosis
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      54        832  Neurospora crassa 
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        824  Escherichia coli (strain UTI89 / UPEC)
      57        819  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        801  Canis familiaris (Dog) (Canis lupus familiaris)
      60        795  Vibrio parahaemolyticus
      61        791  Escherichia coli (strain SMS-3-5 / SECEC)
      62        784  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
      63        779  Aquifex aeolicus (strain VF5)
      64        774  Pasteurella multocida (strain Pm70)
      65        771  Escherichia coli (strain K12 / DH10B)
      66        766  Emericella nidulans  
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Streptomyces coelicolor
      75        757  Staphylococcus epidermidis (strain ATCC 12228)
      76        756  Escherichia coli (strain SE11)
      77        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      78        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        738  Staphylococcus aureus (strain NCTC 8325)
      82        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      83        734  Bacillus anthracis
      84        734  Bacillus halodurans 
      85        733  Vibrio vulnificus
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Enterobacter sp. (strain 638)
      93        713  Salmonella agona (strain SL483)
      94        713  Escherichia coli O1:K1 / APEC
      95        713  Salmonella newport (strain SL254)
      96        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      97        712  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      98        712  Salmonella schwarzengrund (strain CVM19633)
      99        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     100        710  Salmonella heidelberg (strain SL476)
     101        702  Salmonella dublin (strain CT_02021853)
     102        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     103        696  Klebsiella pneumoniae (strain 342)
     104        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     105        692  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
     106        692  Zea mays (Maize)
     107        688  Pan troglodytes (Chimpanzee)
     108        688  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     110        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     111        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     112        675  Pseudomonas putida (strain KT2440)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        670  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        654  Bradyrhizobium japonicum (strain USDA 110)
     120        653  Debaryomyces hansenii   
     121        652  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        649  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     123        643  Escherichia coli
     124        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     125        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     126        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     127        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     128        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     129        631  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     130        629  Shewanella oneidensis (strain MR-1)
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        615  Treponema pallidum (strain Nichols)
     133        612  Staphylococcus haemolyticus (strain JCSC1435)
     134        612  Methanothermobacter thermautotrophicus  
     135        606  Listeria monocytogenes
     136        605  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     137        602  Xanthomonas campestris pv. campestris
     138        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     139        602  Staphylococcus saprophyticus subsp. saprophyticus 
     140        601  Salmonella paratyphi C (strain RKS4594)
     141        601  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     142        600  Yersinia pestis bv. Antiqua (strain Angola)
     143        600  Oryza sativa subsp. indica (Rice)
     144        590  Bacillus cereus (strain ATCC 10987)
     145        590  Listeria innocua
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        576  Brucella suis biovar 1 (strain 1330)
     149        574  Neisseria meningitidis serogroup B (strain MC58)
     150        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     151        572  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     154        566  Caenorhabditis briggsae
     155        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     156        565  Pseudomonas syringae pv. syringae (strain B728a)
     157        564  Caulobacter crescentus (strain ATCC 19089 / CB15)
     158        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     159        562  Vibrio fischeri (strain ATCC 700601 / ES114)
     160        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     161        560  Bacillus cereus (strain ZK / E33L)
     162        558  Pseudomonas aeruginosa (strain UCBPP-PA14)
     163        556  Xanthomonas axonopodis pv. citri (strain 306)
     164        556  Clostridium acetobutylicum 
     165        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     166        552  Pseudomonas fluorescens (strain Pf0-1)
     167        551  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        545  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        533  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     172        529  Sodalis glossinidius (strain morsitans)
     173        529  Listeria monocytogenes serotype 4b (strain F2365)
     174        527  Streptococcus pneumoniae
     175        525  Thermotoga maritima
     176        522  Xylella fastidiosa
     177        521  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     178        514  Chromobacterium violaceum 
     179        514  Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251)
     180        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     181        511  Pseudomonas aeruginosa (strain PA7)
     182        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     184        509  Bordetella parapertussis
     185        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     186        507  Geobacillus kaustophilus (strain HTA426)
     187        506  Staphylococcus aureus (strain Newman)
     188        501  Deinococcus radiodurans 
     189        500  Pseudomonas entomophila (strain L48)
     190        499  Brucella abortus biovar 1 (strain 9-941)
     191        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     192        496  Corynebacterium glutamicum 
     193        496  Bacillus clausii (strain KSM-K16)
     194        495  Haemophilus influenzae (strain 86-028NP)
     195        494  Proteus mirabilis (strain HI4320)
     196        494  Streptomyces avermitilis
     197        493  Burkholderia pseudomallei (strain K96243)
     198        492  Bacillus amyloliquefaciens (strain FZB42)
     199        491  Xanthomonas campestris pv. campestris (strain 8004)
     200        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     201        490  Clostridium perfringens
     202        488  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     203        487  Shewanella sp. (strain MR-7)
     204        485  Mannheimia succiniciproducens (strain MBEL55E)
     205        484  Pseudomonas aeruginosa (strain LESB58)
     206        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     207        484  Shewanella sp. (strain MR-4)
     208        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     209        481  Thermosynechococcus elongatus (strain BP-1)
     210        480  Acinetobacter sp. (strain ADP1)
     211        476  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     212        475  Pyrococcus horikoshii 
     213        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     214        474  Pseudomonas putida (strain F1 / ATCC 700007)
     215        473  Brucella abortus (strain 2308)
     216        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     217        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     218        466  Shewanella frigidimarina (strain NCIMB 400)
     219        466  Pseudomonas putida (strain GB-1)
     220        466  Halobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) 
     221        465  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     222        465  Pyrococcus abyssi (strain GE5 / Orsay)
     223        465  Methanosarcina mazei  
     224        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     225        463  Shewanella sp. (strain ANA-3)
     226        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     227        462  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     228        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     229        461  Burkholderia mallei (Pseudomonas mallei)
     230        461  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     231        458  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     232        458  Enterococcus faecalis (strain ATCC 700802 / V583)
     233        455  Staphylococcus aureus (strain JH1)
     234        455  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     235        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     236        453  Ovis aries (Sheep)
     237        453  Pseudomonas putida (strain W619)
     238        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     239        452  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     240        452  Shewanella baltica (strain OS185)
     241        451  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     242        451  Streptococcus mutans
     243        451  Aeromonas salmonicida (strain A449)
     244        449  Mycobacterium paratuberculosis
     245        449  Thermoanaerobacter tengcongensis  
     246        449  Staphylococcus aureus (strain JH9)
     247        449  Hahella chejuensis (strain KCTC 2396)
     248        447  Vibrio fischeri (strain MJ11)
     249        446  Nicotiana tabacum (Common tobacco)
     250        445  Pseudomonas mendocina (strain ymp)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18845 (  4%)
    Bacteria         327907 ( 61%)
    Eukaryota        172880 ( 32%)
    Viruses           16066 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20250 ( 12%)           (  4%)
     Other Mammalia         45580 ( 26%)           (  9%)
     Other Vertebrata       16994 ( 10%)           (  3%)
     Viridiplantae          32329 ( 19%)           (  6%)
     Fungi                  30717 ( 18%)           (  6%)
     Insecta                 8373 (  5%)           (  2%)
     Nematoda                4221 (  2%)           (  1%)
     Other                  14416 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8668             1001-1100     3697
                 51- 100   41126             1101-1200     2569
                101- 150   57262             1201-1300     1997
                151- 200   57456             1301-1400     1848
                201- 250   56216             1401-1500     1494
                251- 300   49553             1501-1600      724
                301- 350   49720             1601-1700      555
                351- 400   43000             1701-1800      453
                401- 450   35253             1801-1900      418
                451- 500   28348             1901-2000      341
                501- 550   20133             2001-2100      209
                551- 600   14416             2101-2200      281
                601- 650   12153             2201-2300      292
                651- 700    8776             2301-2400      171
                701- 750    7227             2401-2500      136
                751- 800    5116             >2500         1079
                801- 850    4486
                851- 900    4980
                901- 950    3838
                951-1000    2710

   


   The average sequence length in UniProtKB/Swiss-Prot is 354 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2236


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  735
                       2x:  289
                       3x:  144
                       4x:  111
                       5x:   91
                       6x:   75
                       7x:   50
                       8x:   39
                       9x:   34
                      10x:   28
                  11- 20x:  176
                  21- 50x:  186
                  51-100x:  100
                    >100x:  178


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        20052   Journal of Biological Chemistry
    2         9114   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5437   Journal of Bacteriology
    4         4891   Biochemical and Biophysical Research Communications
    5         4561   Gene
    6         4445   Nucleic Acids Research
    7         4236   Biochemistry
    8         4215   FEBS Letters
    9         4086   The EMBO Journal
   10         3811   Molecular and Cellular Biology
   11         3552   Nature
   12         3378   Journal of Molecular Biology
   13         3189   European Journal of Biochemistry
   14         3130   Biochimica et Biophysica Acta
   15         2926   Cell
   16         2500   Genomics
   17         2374   Journal of Virology
   18         2365   Biochemical Journal
   19         2344   Science
   20         1943   Molecular Microbiology
   21         1781   Journal of Cell Biology
   22         1640   Plant Physiology
   23         1580   Plant Molecular Biology
   24         1524   Genes and Development
   25         1501   Virology
   26         1477   The American Journal of Human Genetics
   27         1436   Nature Genetics
   28         1405   Human Molecular Genetics
   29         1376   Oncogene
   30         1319   Molecular and General Genetics
   31         1280   Development
   32         1236   Human Mutation
   33         1216   Journal of Biochemistry
   34         1207   Molecular Biology of the Cell
   35         1144   The Plant Cell
   36         1121   Journal of Immunology
   37         1052   Genetics
   38         1044   Molecular Cell
   39         1014   The Plant Journal
   40         1005   Structure
   41          999   Journal of General Virology
   42          926   Blood
   43          916   Infection and Immunity
   44          892   Archives of Biochemistry and Biophysics
   45          875   Journal of Cell Science
   46          800   Microbiology
   47          795   Developmental Biology
   48          781   Yeast
   49          778   Cancer Research
   50          750   Current Biology
   51          696   FEMS Microbiology Letters
   52          625   Acta Crystallographica, Section D
   53          620   Human Genetics
   54          616   Nature Structural Biology
   55          613   Protein Science
   56          613   Mechanisms of Development
   57          612   Journal of Neuroscience
   58          590   Applied and Environmental Microbiology
   59          589   Toxicon
   60          571   Neuron
   61          554   Journal of Clinical Investigation
   62          536   Current Genetics
   63          516   American Journal of Physiology
   64          506   The Journal of Experimental Medicine
   65          478   Mammalian Genome
   66          475   Molecular Endocrinology
   67          453   Immunogenetics
   68          451   Journal of Neurochemistry
   69          449   Proteins
   70          438   The Journal of Clinical Endocrinology and Metabolism
   71          427   Molecular and Biochemical Parasitology
   72          423   Endocrinology
   73          408   Nature Cell Biology
   74          407   Bioscience, Biotechnology, and Biochemistry
   75          405   Plant and Cell Physiology
   76          391   Journal of Molecular Evolution
   77          386   Journal of Medical Genetics
   78          373   DNA and Cell Biology
   79          370   Molecular Biology and Evolution
   80          362   DNA Sequence
   81          357   Experimental Cell Research
   82          336   PLoS ONE
   83          328   Peptides
   84          325   Brain Research. Molecular Brain Research
   85          321   Tissue Antigens
   86          316   Comparative Biochemistry and Physiology
   87          303   Antimicrobial Agents and Chemotherapy
   88          300   Developmental Cell
   89          299   Molecular Pharmacology
   90          296   Journal of Investigative Dermatology
   91          295   RNA
   92          293   Biological Chemistry Hoppe-Seyler
   93          279   Cytogenetics and Cell Genetics
   94          273   Biology of Reproduction
   95          271   Neurology
   96          266   Nature Structural and Molecular Biology
   97          262   Developmental Dynamics
   98          262   Virus Research
   99          262   Planta
  100          262   The FEBS Journal
  101          256   Genome Research
  102          252   Journal of General Microbiology
  103          242   Molecular Plant-Microbe Interactions
  104          236   Immunity
  105          232   EMBO Reports
  106          226   Biochimie
  107          226   European Journal of Immunology
  108          226   Genes to Cells
  109          221   The New England Journal of Medicine
  110          221   Eukaryotic Cell
  111          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  112          217   Annals of Neurology
  113          215   The FASEB Journal
  114          212   European Journal of Human Genetics
  115          211   DNA Research
  116          201   Journal of Human Genetics
  117          195   Investigative Ophthalmology and Visual Science
  118          187   Archives of Virology
  119          184   Archives of Microbiology
  120          183   Molecular and Cellular Endocrinology
  121          179   Journal of Cellular Biochemistry
  122          177   Journal of the American Chemical Society
  123          173   American Journal of Medical Genetics. Part A
  124          172   Molecular Immunology
  125          172   BMC Genomics
  126          170   Insect Biochemistry and Molecular Biology
  127          169   Diabetes
  128          169   Glycobiology
  129          168   Clinical Genetics
  130          167   American Journal of Medical Genetics
  131          167   Molecular Phylogenetics and Evolution
  132          164   Journal of Medicinal Chemistry
  133          164   Nature Immunology
  134          159   International Journal of Cancer
  135          159   DNA
  136          157   Molecular Reproduction and Development
  137          156   Circulation Research
  138          155   Hemoglobin
  139          153   Bioorganicheskaia Khimiia
  140          147   Molecular and Cellular Neuroscience
  141          147   Molecular Genetics and Metabolism
  142          146   Biological Chemistry
  143          145   Acta Crystallographica, Section F
  144          144   Molecular Genetics and Genomics
  145          139   British Journal of Haematology
  146          139   Animal Genetics
  147          138   General and Comparative Endocrinology
  148          137   Protein Expression and Purification
  149          136   Journal of Experimental Botany
  150          134   Proteomics


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1012104                 1.89                                         
   Journal                            806589     410445      1.51       1                                 
   Submitted to EMBL/GenBank/DDBJ     196602     176885      0.37       2                                 
   Submitted to other databases         6763       6305      0.01       3                                 
   Book citation                         689        675     <0.01       4                                 
   Plant Gene Register                   576        564     <0.01       5                                 
   Thesis                                407        404     <0.01       6                                 
   Unpublished observations              283        279     <0.01       7                                 
   Patent                                189        186     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 320080

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2367148                 4.42                                         
   ALLERGEN                              516        516     <0.01      26                                 
   ALTERNATIVE PRODUCTS                20733      20733      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        4090       4090      0.01      23                                 
   BIOTECHNOLOGY                         325        323     <0.01      28                                 
   CATALYTIC ACTIVITY                 239042     217106      0.45       4                                 
   CAUTION                              7933       7774      0.01      19                                 
   COFACTOR                           104303      95908      0.19       7                                 
   DEVELOPMENTAL STAGE                  9588       9588      0.02      16                                 
   DISEASE                              4923       3311      0.01      21                                 
   DISRUPTION PHENOTYPE                 4513       4513      0.01      22                                 
   DOMAIN                              37095      32844      0.07      10                                 
   ENZYME REGULATION                   10487      10487      0.02      15                                 
   FUNCTION                           410829     393956      0.77       2                                 
   INDUCTION                           14012      14012      0.03      14                                 
   INTERACTION                          9196       9196      0.02      17                                 
   MASS SPECTROMETRY                    5056       3844      0.01      20                                 
   MISCELLANEOUS                       31250      28832      0.06      12                                 
   PATHWAY                            131279     119116      0.25       6                                 
   PHARMACEUTICAL                         85         85     <0.01      29                                 
   POLYMORPHISM                          857        807     <0.01      24                                 
   PTM                                 43056      34189      0.08       8                                 
   RNA EDITING                           623        623     <0.01      25                                 
   SEQUENCE CAUTION                    40289      40289      0.08       9                                 
   SIMILARITY                         632453     510936      1.18       1                                 
   SUBCELLULAR LOCATION               321433     315880      0.60       3                                 
   SUBUNIT                            237014     237014      0.44       5                                 
   TISSUE SPECIFICITY                  36934      36934      0.07      11                                 
   TOXIC DOSE                            496        482     <0.01      27                                 
   WEB RESOURCE                         8738       7010      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3529864                 6.59                                         
   ACT_SITE                           135536      82775      0.25       9                                 
   BINDING                            248414      67881      0.46       4                                 
   CA_BIND                              3815       1582      0.01      35                                 
   CARBOHYD                           106092      27066      0.20      14                                 
   CHAIN                              542255     529880      1.01       1                                 
   COILED                              19793      13586      0.04      26                                 
   COMPBIAS                            53219      28122      0.10      18                                 
   CONFLICT                           124959      43793      0.23      11                                 
   CROSSLNK                             6355       3767      0.01      34                                 
   DISULFID                           104548      28132      0.20      15                                 
   DNA_BIND                            11306      10412      0.02      31                                 
   DOMAIN                             157278      93747      0.29       6                                 
   HELIX                              154526      16064      0.29       7                                 
   INIT_MET                            15197      15197      0.03      27                                 
   INTRAMEM                             1955        861     <0.01      38                                 
   LIPID                               11368       7227      0.02      30                                 
   METAL                              299927      73542      0.56       3                                 
   MOD_RES                            192354      63119      0.36       5                                 
   MOTIF                               34739      22420      0.06      24                                 
   MUTAGEN                             38975       9104      0.07      21                                 
   NON_CONS                             2018        737     <0.01      37                                 
   NON_STD                               354        279     <0.01      39                                 
   NON_TER                             12137       9266      0.02      29                                 
   NP_BIND                            113838      71267      0.21      12                                 
   PEPTIDE                              9780       6590      0.02      32                                 
   PROPEP                              12481      10735      0.02      28                                 
   REGION                             111739      59458      0.21      13                                 
   REPEAT                              93328      13816      0.17      16                                 
   SIGNAL                              37494      37484      0.07      22                                 
   SITE                                40934      24187      0.08      20                                 
   STRAND                             151243      14933      0.28       8                                 
   TOPO_DOM                           128202      26495      0.24      10                                 
   TRANSIT                              7992       7897      0.01      33                                 
   TRANSMEM                           352503      72630      0.66       2                                 
   TURN                                35648      12515      0.07      23                                 
   UNSURE                               2988        522      0.01      36                                 
   VAR_SEQ                             41860      18156      0.08      19                                 
   VARIANT                             83491      16631      0.16      17                                 
   ZN_FING                             29223      12771      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15161001                28.30                                                           
   2DBase-Ecoli                           85         85     <0.01     126      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     123      2D gel databases                             
   AGD                                   932        926     <0.01     101      Organism-specific databases                  
   Allergome                            1429        880     <0.01      97      Protein family/group databases               
   ANU-2DPAGE                             26         26     <0.01     132      2D gel databases                             
   ArachnoServer                         763        755     <0.01     107      Organism-specific databases                  
   ArrayExpress                        59744      59744      0.11      42      Gene expression databases                    
   Bgee                                39367      39367      0.07      46      Gene expression databases                    
   BindingDB                             295        295     <0.01     119      Other                                        
   BioCyc                             248400     239948      0.46      22      Enzyme and pathway databases                 
   BRENDA                               4246       4239      0.01      88      Enzyme and pathway databases                 
   CAZy                                 7532       6774      0.01      74      Protein family/group databases               
   CGD                                   671        651     <0.01     108      Organism-specific databases                  
   CleanEx                             30104      29463      0.06      51      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     125      2D gel databases                             
   ConoServer                            915        833     <0.01     103      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     127      2D gel databases                             
   CTD                                 68269      67661      0.13      39      Organism-specific databases                  
   CYGD                                 5594       5591      0.01      78      Organism-specific databases                  
   dictyBase                            4202       4086      0.01      89      Organism-specific databases                  
   DIP                                 13454      13346      0.03      67      Protein-protein interaction databases        
   DisProt                               397        394     <0.01     115      3D structure databases                       
   DMDM                                16774      16773      0.03      61      Polymorphism databases                       
   DNASU                               18326      18255      0.03      58      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     122      2D gel databases                             
   DrugBank                             5318       1627      0.01      79      Other                                        
   EchoBASE                             4167       4163      0.01      90      Organism-specific databases                  
   ECO2DBASE                             352        300     <0.01     117      2D gel databases                             
   EcoGene                              4292       4290      0.01      87      Organism-specific databases                  
   eggNOG                             429265     429265      0.80       9      Phylogenomic databases                       
   EMBL                               920102     525207      1.72       3      Sequence databases                           
   Ensembl                             67019      48101      0.13      40      Genome annotation databases                  
   EnsemblBacteria                     97861      84913      0.18      28      Genome annotation databases                  
   EnsemblFungi                        16573      16282      0.03      62      Genome annotation databases                  
   EnsemblMetazoa                      10928       8282      0.02      70      Genome annotation databases                  
   EnsemblPlants                       16027      13744      0.03      65      Genome annotation databases                  
   EnsemblProtists                      4433       4309      0.01      86      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     128      Organism-specific databases                  
   EuPathDB                              794        793     <0.01     104      Organism-specific databases                  
   EvolutionaryTrace                   16431      16431      0.03      63      Other                                        
   FlyBase                              5848       5474      0.01      77      Organism-specific databases                  
   Gene3D                             330325     254450      0.62      17      Family and domain databases                  
   GeneCards                           19967      19663      0.04      55      Organism-specific databases                  
   GeneFarm                             3048       3037      0.01      93      Organism-specific databases                  
   GeneID                             485505     465905      0.91       6      Genome annotation databases                  
   GeneTree                            56993      56963      0.11      43      Phylogenomic databases                       
   Genevestigator                      66542      66542      0.12      41      Gene expression databases                    
   GenoList                             7068       7056      0.01      75      Organism-specific databases                  
   GenomeReviews                      376360     356773      0.70      12      Genome annotation databases                  
   GermOnline                          41905      41331      0.08      45      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     120      PTM databases                                
   GO                                2181539     503558      4.07       1      Ontologies                                   
   Gramene                              4743       4743      0.01      82      Organism-specific databases                  
   H-InvDB                             13249      12335      0.02      68      Organism-specific databases                  
   HAMAP                              311858     311655      0.58      18      Family and domain databases                  
   HGNC                                19763      19606      0.04      56      Organism-specific databases                  
   HOGENOM                            365576     365576      0.68      14      Phylogenomic databases                       
   HOVERGEN                            75309      75309      0.14      35      Phylogenomic databases                       
   HPA                                 15759      12092      0.03      66      Organism-specific databases                  
   HSSP                                30211      30211      0.06      50      3D structure databases                       
   InParanoid                          69059      69059      0.13      38      Phylogenomic databases                       
   IntAct                              33025      33025      0.06      49      Protein-protein interaction databases        
   InterPro                          1759629     510937      3.28       2      Family and domain databases                  
   IPI                                 93936      66558      0.18      31      Sequence databases                           
   KEGG                               461575     443697      0.86       8      Genome annotation databases                  
   KO                                 367858     367427      0.69      13      Phylogenomic databases                       
   LegioList                             764        762     <0.01     106      Organism-specific databases                  
   Leproma                               671        668     <0.01     109      Organism-specific databases                  
   MaizeGDB                              487        482     <0.01     113      Organism-specific databases                  
   MEROPS                              10629      10629      0.02      71      Protein family/group databases               
   MGI                                 16425      16380      0.03      64      Organism-specific databases                  
   MIM                                 17389      13296      0.03      60      Organism-specific databases                  
   MINT                                17594      17594      0.03      59      Protein-protein interaction databases        
   NextBio                             69547      69547      0.13      37      Other                                        
   neXtProt                            20090      20090      0.04      54      Organism-specific databases                  
   OGP                                   377        377     <0.01     116      2D gel databases                             
   OMA                                385411     385411      0.72      11      Phylogenomic databases                       
   Orphanet                             4141       2492      0.01      91      Organism-specific databases                  
   OrthoDB                             77999      77999      0.15      34      Phylogenomic databases                       
   PANTHER                            200421     186208      0.37      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      85      Enzyme and pathway databases                 
   PATRIC                             308329     308307      0.58      20      Genome annotation databases                  
   PDB                                 83686      17989      0.16      32      3D structure databases                       
   PDBsum                              83685      17989      0.16      33      3D structure databases                       
   PeptideAtlas                         5164       5164      0.01      80      Proteomic databases                          
   PeroxiBase                            764        748     <0.01     105      Protein family/group databases               
   Pfam                               701858     491353      1.31       4      Family and domain databases                  
   PharmGKB                            18759      18342      0.04      57      Organism-specific databases                  
   PHCI-2DPAGE                           250        250     <0.01     121      2D gel databases                             
   PhosphoSite                         25550      25550      0.05      53      PTM databases                                
   PhosSite                              351        351     <0.01     118      PTM databases                                
   PhylomeDB                           33416      33416      0.06      48      Phylogenomic databases                       
   PIR                                117719     107618      0.22      27      Sequence databases                           
   PIRSF                               96862      96848      0.18      29      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01      96      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     129      2D gel databases                             
   PomBase                              5013       4955      0.01      81      Organism-specific databases                  
   PptaseDB                               34         34     <0.01     130      Protein family/group databases               
   PRIDE                               71481      71481      0.13      36      Proteomic databases                          
   PRINTS                             137498     120368      0.26      26      Family and domain databases                  
   ProDom                              29242      29063      0.05      52      Family and domain databases                  
   ProMEX                                499        499     <0.01     112      Proteomic databases                          
   PROSITE                            476760     301643      0.89       7      Family and domain databases                  
   ProtClustDB                        342303     342303      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 427184     427184      0.80      10      3D structure databases                       
   PseudoCAP                            1230       1221     <0.01      99      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     131      2D gel databases                             
   Reactome                            10592       6701      0.02      72      Enzyme and pathway databases                 
   REBASE                                402        402     <0.01     114      Protein family/group databases               
   RefSeq                             508168     467302      0.95       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01      98      2D gel databases                             
   RGD                                  7640       7636      0.01      73      Organism-specific databases                  
   SGD                                  6638       6633      0.01      76      Organism-specific databases                  
   Siena-2DPAGE                          102        102     <0.01     124      2D gel databases                             
   SMART                              166517     124642      0.31      25      Family and domain databases                  
   SMR                                210057     210057      0.39      23      3D structure databases                       
   STRING                             308779     308777      0.58      19      Protein-protein interaction databases        
   SUPFAM                             330480     261819      0.62      16      Family and domain databases                  
   SWISS-2DPAGE                         1183       1182     <0.01     100      2D gel databases                             
   TAIR                                11176      11109      0.02      69      Organism-specific databases                  
   TCDB                                 3626       3611      0.01      92      Protein family/group databases               
   TIGR                                34518      33739      0.06      47      Genome annotation databases                  
   TIGRFAMs                           288530     268218      0.54      21      Family and domain databases                  
   TubercuList                          1945       1909     <0.01      95      Organism-specific databases                  
   UCD-2DPAGE                            510        501     <0.01     111      2D gel databases                             
   UCSC                                51161      38910      0.10      44      Genome annotation databases                  
   UniGene                             95890      88218      0.18      30      Sequence databases                           
   VectorBase                            606        588     <0.01     110      Genome annotation databases                  
   World-2DPAGE                          919        908     <0.01     102      2D gel databases                             
   WormBase                             4713       3859      0.01      83      Organism-specific databases                  
   Xenbase                              4678       4673      0.01      84      Organism-specific databases                  
   ZFIN                                 2723       2711      0.01      94      Organism-specific databases                  

Total number of cross-referenced databases: 132

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.55
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.36   Ile (I) 5.96   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4461 entries are encoded on a mitochondrion, and 3646 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 73287