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         UniProtKB/Swiss-Prot protein knowledgebase release 2012_03 statistics


1.  INTRODUCTION

Release 2012_03 of 21-Mar-12 of UniProtKB/Swiss-Prot contains 535248 sequence entries,
comprising 189901164 amino acids abstracted from 208076 references. 

570 sequences have been added since release 2012_02, the sequence data of
127 existing entries has been updated and the annotations of
121706 entries have been revised.

Number of fragments: 8994
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 31176


Protein existence (PE):           entries     %

1: Evidence at protein level        74284   13.9%
2: Evidence at transcript level     67762   12.7%
3: Inferred from homology          376894   70.4%
4: Predicted                        14424    2.7%
5: Uncertain                         1884    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12759

   The first twenty species represent 111504 sequences:  20.8 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5376
                            2x: 1859
                            3x:  961
                            4x:  629
                            5x:  461
                            6x:  374
                            7x:  274
                            8x:  218
                            9x:  197
                           10x:  112
                       11- 20x:  657
                       21- 50x:  393
                       51-100x:  209
                         >100x: 1039


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20254  Homo sapiens (Human)
       2      16513  Mus musculus (Mouse)
       3      11072  Arabidopsis thaliana (Mouse-ear cress)
       4       7710  Rattus norvegicus (Rat)
       5       6619  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5898  Bos taurus (Bovine)
       7       4982  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4244  Bacillus subtilis
      10       4124  Dictyostelium discoideum (Slime mold)
      11       3347  Caenorhabditis elegans
      12       3337  Xenopus laevis (African clawed frog)
      13       3146  Drosophila melanogaster (Fruit fly)
      14       2839  Oryza sativa subsp. japonica (Rice)
      15       2799  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2235  Gallus gallus (Chicken)
      17       2217  Pongo abelii (Sumatran orangutan)
      18       2011  Escherichia coli O157:H7
      19       1929  Mycobacterium tuberculosis
      20       1797  Salmonella typhimurium
      21       1787  Methanocaldococcus jannaschii  
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1678  Shigella flexneri
      24       1675  Escherichia coli O6
      25       1634  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      26       1407  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1244  Mycobacterium bovis
      29       1222  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      30       1170  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1029  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1015  Yersinia pestis
      33       1002  Archaeoglobus fulgidus 
      34        957  Vibrio cholerae
      35        930  Salmonella paratyphi A
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        901  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        886  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis
      48        878  Shigella sonnei (strain Ss046)
      49        868  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        864  Yersinia pseudotuberculosis
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      54        832  Neurospora crassa 
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        824  Escherichia coli (strain UTI89 / UPEC)
      57        819  Shigella dysenteriae serotype 1 (strain Sd197)
      58        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      59        801  Canis familiaris (Dog) (Canis lupus familiaris)
      60        795  Vibrio parahaemolyticus
      61        791  Escherichia coli (strain SMS-3-5 / SECEC)
      62        784  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
      63        779  Aquifex aeolicus (strain VF5)
      64        774  Pasteurella multocida (strain Pm70)
      65        771  Escherichia coli (strain K12 / DH10B)
      66        766  Emericella nidulans  
      67        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      68        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      69        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Streptomyces coelicolor
      75        757  Staphylococcus epidermidis (strain ATCC 12228)
      76        756  Escherichia coli (strain SE11)
      77        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      78        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        744  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        737  Staphylococcus aureus (strain NCTC 8325)
      82        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      83        734  Bacillus halodurans 
      84        733  Bacillus anthracis
      85        733  Vibrio vulnificus
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Enterobacter sp. (strain 638)
      93        713  Salmonella agona (strain SL483)
      94        713  Escherichia coli O1:K1 / APEC
      95        713  Salmonella newport (strain SL254)
      96        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      97        712  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      98        712  Salmonella schwarzengrund (strain CVM19633)
      99        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     100        710  Salmonella heidelberg (strain SL476)
     101        702  Salmonella dublin (strain CT_02021853)
     102        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     103        696  Klebsiella pneumoniae (strain 342)
     104        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     105        692  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
     106        689  Zea mays (Maize)
     107        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     108        687  Pan troglodytes (Chimpanzee)
     109        687  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     110        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     111        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     112        675  Pseudomonas putida (strain KT2440)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        669  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        657  Bradyrhizobium japonicum
     120        653  Debaryomyces hansenii   
     121        651  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        643  Escherichia coli
     123        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     124        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     125        642  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     126        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     127        635  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     128        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     129        630  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     130        629  Shewanella oneidensis
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        615  Treponema pallidum (strain Nichols)
     133        612  Staphylococcus haemolyticus (strain JCSC1435)
     134        610  Methanobacterium thermoautotrophicum (strain Delta H)
     135        605  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     136        605  Listeria monocytogenes
     137        602  Xanthomonas campestris pv. campestris
     138        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     139        602  Staphylococcus saprophyticus subsp. saprophyticus 
     140        601  Salmonella paratyphi C (strain RKS4594)
     141        601  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     142        600  Yersinia pestis bv. Antiqua (strain Angola)
     143        594  Oryza sativa subsp. indica (Rice)
     144        590  Bacillus cereus (strain ATCC 10987)
     145        590  Listeria innocua
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        586  Rickettsia prowazekii (strain Madrid E)
     148        576  Brucella suis biovar 1 (strain 1330)
     149        574  Neisseria meningitidis serogroup B (strain MC58)
     150        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     151        572  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     154        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     155        565  Pseudomonas syringae pv. syringae (strain B728a)
     156        564  Caulobacter crescentus (Caulobacter vibrioides)
     157        564  Caenorhabditis briggsae
     158        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     159        562  Vibrio fischeri (strain ATCC 700601 / ES114)
     160        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     161        560  Bacillus cereus (strain ZK / E33L)
     162        559  Clostridium acetobutylicum
     163        558  Pseudomonas aeruginosa (strain UCBPP-PA14)
     164        556  Xanthomonas axonopodis pv. citri (Citrus canker)
     165        552  Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
     166        552  Pseudomonas fluorescens (strain Pf0-1)
     167        551  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        544  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        532  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     171        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     172        529  Sodalis glossinidius (strain morsitans)
     173        529  Listeria monocytogenes serotype 4b (strain F2365)
     174        527  Streptococcus pneumoniae
     175        524  Thermotoga maritima
     176        522  Xylella fastidiosa
     177        521  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     178        515  Bordetella pertussis
     179        514  Chromobacterium violaceum 
     180        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     181        511  Pseudomonas aeruginosa (strain PA7)
     182        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     184        509  Bordetella parapertussis
     185        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     186        507  Geobacillus kaustophilus (strain HTA426)
     187        506  Staphylococcus aureus (strain Newman)
     188        501  Deinococcus radiodurans
     189        500  Pseudomonas entomophila (strain L48)
     190        499  Corynebacterium glutamicum (Brevibacterium flavum)
     191        499  Brucella abortus biovar 1 (strain 9-941)
     192        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     193        496  Bacillus clausii (strain KSM-K16)
     194        495  Haemophilus influenzae (strain 86-028NP)
     195        494  Burkholderia pseudomallei (Pseudomonas pseudomallei)
     196        494  Streptomyces avermitilis
     197        493  Proteus mirabilis (strain HI4320)
     198        492  Bacillus amyloliquefaciens (strain FZB42)
     199        491  Xanthomonas campestris pv. campestris (strain 8004)
     200        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     201        490  Clostridium perfringens
     202        487  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     203        487  Shewanella sp. (strain MR-7)
     204        485  Mannheimia succiniciproducens (strain MBEL55E)
     205        484  Pseudomonas aeruginosa (strain LESB58)
     206        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     207        484  Shewanella sp. (strain MR-4)
     208        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     209        481  Thermosynechococcus elongatus (strain BP-1)
     210        480  Acinetobacter sp. (strain ADP1)
     211        479  Enterococcus faecalis (Streptococcus faecalis)
     212        476  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     213        475  Pyrococcus horikoshii 
     214        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     215        474  Pseudomonas putida (strain F1 / ATCC 700007)
     216        473  Brucella abortus (strain 2308)
     217        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     218        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     219        466  Shewanella frigidimarina (strain NCIMB 400)
     220        466  Pseudomonas putida (strain GB-1)
     221        466  Halobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) 
     222        465  Pyrococcus abyssi (strain GE5 / Orsay)
     223        465  Methanosarcina mazei  
     224        464  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     225        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     226        463  Shewanella sp. (strain ANA-3)
     227        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     228        462  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     229        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     230        461  Burkholderia mallei (Pseudomonas mallei)
     231        460  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     232        458  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     233        455  Staphylococcus aureus (strain JH1)
     234        455  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     235        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     236        453  Ovis aries (Sheep)
     237        453  Pseudomonas putida (strain W619)
     238        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     239        452  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     240        452  Shewanella baltica (strain OS185)
     241        451  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     242        451  Streptococcus mutans
     243        451  Aeromonas salmonicida (strain A449)
     244        449  Mycobacterium paratuberculosis
     245        449  Thermoanaerobacter tengcongensis  
     246        449  Staphylococcus aureus (strain JH9)
     247        448  Hahella chejuensis (strain KCTC 2396)
     248        447  Vibrio fischeri (strain MJ11)
     249        445  Nicotiana tabacum (Common tobacco)
     250        445  Pseudomonas mendocina (strain ymp)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18834 (  4%)
    Bacteria         327836 ( 61%)
    Eukaryota        172538 ( 32%)
    Viruses           16040 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20255 ( 12%)           (  4%)
     Other Mammalia         45525 ( 26%)           (  9%)
     Other Vertebrata       16953 ( 10%)           (  3%)
     Viridiplantae          32221 ( 19%)           (  6%)
     Fungi                  30594 ( 18%)           (  6%)
     Insecta                 8369 (  5%)           (  2%)
     Nematoda                4217 (  2%)           (  1%)
     Other                  14404 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8691             1001-1100     3696
                 51- 100   41027             1101-1200     2561
                101- 150   57213             1201-1300     1996
                151- 200   57415             1301-1400     1848
                201- 250   56187             1401-1500     1492
                251- 300   49513             1501-1600      722
                301- 350   49702             1601-1700      555
                351- 400   42983             1701-1800      453
                401- 450   35235             1801-1900      419
                451- 500   28326             1901-2000      340
                501- 550   20111             2001-2100      208
                551- 600   14390             2101-2200      277
                601- 650   12139             2201-2300      287
                651- 700    8762             2301-2400      170
                701- 750    7213             2401-2500      136
                751- 800    5111             >2500         1074
                801- 850    4481
                851- 900    4977
                901- 950    3835
                951-1000    2709

   


   The average sequence length in UniProtKB/Swiss-Prot is 354 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2226


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  728
                       2x:  288
                       3x:  144
                       4x:  109
                       5x:   97
                       6x:   75
                       7x:   48
                       8x:   38
                       9x:   33
                      10x:   26
                  11- 20x:  177
                  21- 50x:  185
                  51-100x:  101
                    >100x:  177


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        19961   Journal of Biological Chemistry
    2         9090   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5413   Journal of Bacteriology
    4         4872   Biochemical and Biophysical Research Communications
    5         4558   Gene
    6         4436   Nucleic Acids Research
    7         4216   Biochemistry
    8         4198   FEBS Letters
    9         4073   The EMBO Journal
   10         3800   Molecular and Cellular Biology
   11         3540   Nature
   12         3363   Journal of Molecular Biology
   13         3181   European Journal of Biochemistry
   14         3121   Biochimica et Biophysica Acta
   15         2919   Cell
   16         2499   Genomics
   17         2357   Journal of Virology
   18         2355   Biochemical Journal
   19         2334   Science
   20         1931   Molecular Microbiology
   21         1774   Journal of Cell Biology
   22         1630   Plant Physiology
   23         1574   Plant Molecular Biology
   24         1520   Genes and Development
   25         1499   Virology
   26         1474   The American Journal of Human Genetics
   27         1431   Nature Genetics
   28         1405   Human Molecular Genetics
   29         1375   Oncogene
   30         1318   Molecular and General Genetics
   31         1276   Development
   32         1225   Human Mutation
   33         1209   Journal of Biochemistry
   34         1198   Molecular Biology of the Cell
   35         1136   The Plant Cell
   36         1120   Journal of Immunology
   37         1052   Genetics
   38         1036   Molecular Cell
   39         1002   Structure
   40         1002   The Plant Journal
   41          996   Journal of General Virology
   42          923   Blood
   43          915   Infection and Immunity
   44          890   Archives of Biochemistry and Biophysics
   45          871   Journal of Cell Science
   46          798   Microbiology
   47          791   Developmental Biology
   48          781   Yeast
   49          772   Cancer Research
   50          745   Current Biology
   51          692   FEMS Microbiology Letters
   52          622   Acta Crystallographica, Section D
   53          616   Human Genetics
   54          615   Nature Structural Biology
   55          612   Mechanisms of Development
   56          610   Protein Science
   57          607   Journal of Neuroscience
   58          589   Applied and Environmental Microbiology
   59          577   Toxicon
   60          570   Neuron
   61          553   Journal of Clinical Investigation
   62          536   Current Genetics
   63          515   American Journal of Physiology
   64          504   The Journal of Experimental Medicine
   65          478   Mammalian Genome
   66          474   Molecular Endocrinology
   67          453   Immunogenetics
   68          449   Journal of Neurochemistry
   69          446   Proteins
   70          436   The Journal of Clinical Endocrinology and Metabolism
   71          427   Molecular and Biochemical Parasitology
   72          422   Endocrinology
   73          403   Nature Cell Biology
   74          402   Bioscience, Biotechnology, and Biochemistry
   75          398   Plant and Cell Physiology
   76          390   Journal of Molecular Evolution
   77          386   Journal of Medical Genetics
   78          373   DNA and Cell Biology
   79          369   Molecular Biology and Evolution
   80          361   DNA Sequence
   81          355   Experimental Cell Research
   82          327   Peptides
   83          325   Brain Research. Molecular Brain Research
   84          321   Tissue Antigens
   85          317   PLoS ONE
   86          314   Comparative Biochemistry and Physiology
   87          299   Molecular Pharmacology
   88          297   Antimicrobial Agents and Chemotherapy
   89          296   Developmental Cell
   90          293   Biological Chemistry Hoppe-Seyler
   91          292   Journal of Investigative Dermatology
   92          290   RNA
   93          277   Cytogenetics and Cell Genetics
   94          273   Biology of Reproduction
   95          271   Neurology
   96          263   Nature Structural and Molecular Biology
   97          262   Developmental Dynamics
   98          262   Virus Research
   99          261   Planta
  100          257   Genome Research
  101          256   The FEBS Journal
  102          252   Journal of General Microbiology
  103          242   Molecular Plant-Microbe Interactions
  104          235   Immunity
  105          230   EMBO Reports
  106          226   European Journal of Immunology
  107          224   Biochimie
  108          223   Genes to Cells
  109          218   The New England Journal of Medicine
  110          218   Eukaryotic Cell
  111          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  112          217   Annals of Neurology
  113          213   The FASEB Journal
  114          211   DNA Research
  115          210   European Journal of Human Genetics
  116          200   Journal of Human Genetics
  117          192   Investigative Ophthalmology and Visual Science
  118          186   Archives of Virology
  119          182   Molecular and Cellular Endocrinology
  120          179   Archives of Microbiology
  121          176   Journal of the American Chemical Society
  122          175   Journal of Cellular Biochemistry
  123          173   American Journal of Medical Genetics. Part A
  124          172   Molecular Immunology
  125          170   BMC Genomics
  126          169   Diabetes
  127          169   Insect Biochemistry and Molecular Biology
  128          167   Glycobiology
  129          167   Clinical Genetics
  130          167   American Journal of Medical Genetics
  131          167   Molecular Phylogenetics and Evolution
  132          164   Nature Immunology
  133          160   Journal of Medicinal Chemistry
  134          159   DNA
  135          158   International Journal of Cancer
  136          156   Molecular Reproduction and Development
  137          155   Circulation Research
  138          155   Hemoglobin
  139          153   Bioorganicheskaia Khimiia
  140          146   Molecular and Cellular Neuroscience
  141          146   Molecular Genetics and Metabolism
  142          144   Biological Chemistry
  143          142   Molecular Genetics and Genomics
  144          139   British Journal of Haematology
  145          138   General and Comparative Endocrinology
  146          138   Acta Crystallographica, Section F
  147          138   Animal Genetics
  148          135   Protein Expression and Purification
  149          134   Phytochemistry
  150          133   Journal of Experimental Botany


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1009016                 1.89                                         
   Journal                            803909     409997      1.50       1                                 
   Submitted to EMBL/GenBank/DDBJ     196204     176614      0.37       2                                 
   Submitted to other databases         6755       6296      0.01       3                                 
   Book citation                         687        673     <0.01       4                                 
   Plant Gene Register                   576        564     <0.01       5                                 
   Thesis                                406        403     <0.01       6                                 
   Unpublished observations              284        280     <0.01       7                                 
   Patent                                189        186     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 318763

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2362125                 4.41                                         
   ALLERGEN                              516        516     <0.01      26                                 
   ALTERNATIVE PRODUCTS                20446      20446      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        4021       4021      0.01      23                                 
   BIOTECHNOLOGY                         325        323     <0.01      28                                 
   CATALYTIC ACTIVITY                 238939     216979      0.45       4                                 
   CAUTION                              7912       7754      0.01      19                                 
   COFACTOR                           103708      95334      0.19       7                                 
   DEVELOPMENTAL STAGE                  9550       9550      0.02      16                                 
   DISEASE                              4909       3303      0.01      21                                 
   DISRUPTION PHENOTYPE                 4420       4420      0.01      22                                 
   DOMAIN                              36867      32634      0.07      10                                 
   ENZYME REGULATION                   10445      10445      0.02      15                                 
   FUNCTION                           410264     393418      0.77       2                                 
   INDUCTION                           13909      13909      0.03      14                                 
   INTERACTION                          9196       9196      0.02      17                                 
   MASS SPECTROMETRY                    5023       3822      0.01      20                                 
   MISCELLANEOUS                       31210      28793      0.06      12                                 
   PATHWAY                            131273     119071      0.25       6                                 
   PHARMACEUTICAL                         85         85     <0.01      29                                 
   POLYMORPHISM                          848        802     <0.01      24                                 
   PTM                                 42694      33941      0.08       8                                 
   RNA EDITING                           623        623     <0.01      25                                 
   SEQUENCE CAUTION                    40206      40206      0.08       9                                 
   SIMILARITY                         631745     510464      1.18       1                                 
   SUBCELLULAR LOCATION               320849     315302      0.60       3                                 
   SUBUNIT                            236091     236091      0.44       5                                 
   TISSUE SPECIFICITY                  36818      36818      0.07      11                                 
   TOXIC DOSE                            496        482     <0.01      27                                 
   WEB RESOURCE                         8737       7009      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3517632                 6.57                                         
   ACT_SITE                           134418      82172      0.25       9                                 
   BINDING                            247148      67595      0.46       4                                 
   CA_BIND                              3814       1581      0.01      35                                 
   CARBOHYD                           105965      27039      0.20      14                                 
   CHAIN                              541800     529441      1.01       1                                 
   COILED                              19754      13555      0.04      26                                 
   COMPBIAS                            53088      28055      0.10      18                                 
   CONFLICT                           124698      43707      0.23      11                                 
   CROSSLNK                             6335       3756      0.01      34                                 
   DISULFID                           104306      28060      0.19      15                                 
   DNA_BIND                            11287      10396      0.02      31                                 
   DOMAIN                             156946      93557      0.29       6                                 
   HELIX                              153274      15931      0.29       7                                 
   INIT_MET                            15179      15179      0.03      27                                 
   INTRAMEM                             1921        844     <0.01      38                                 
   LIPID                               11360       7219      0.02      30                                 
   METAL                              298108      72948      0.56       3                                 
   MOD_RES                            191871      63027      0.36       5                                 
   MOTIF                               34681      22363      0.06      24                                 
   MUTAGEN                             38665       9034      0.07      21                                 
   NON_CONS                             2008        735     <0.01      37                                 
   NON_STD                               353        278     <0.01      39                                 
   NON_TER                             12136       9264      0.02      29                                 
   NP_BIND                            113761      71194      0.21      12                                 
   PEPTIDE                              9769       6579      0.02      32                                 
   PROPEP                              12462      10715      0.02      28                                 
   REGION                             110766      59223      0.21      13                                 
   REPEAT                              93177      13796      0.17      16                                 
   SIGNAL                              37444      37434      0.07      22                                 
   SITE                                40736      24128      0.08      20                                 
   STRAND                             150072      14811      0.28       8                                 
   TOPO_DOM                           128007      26462      0.24      10                                 
   TRANSIT                              7954       7860      0.01      33                                 
   TRANSMEM                           352133      72517      0.66       2                                 
   TURN                                35386      12412      0.07      23                                 
   UNSURE                               2988        522      0.01      36                                 
   VAR_SEQ                             41403      17871      0.08      19                                 
   VARIANT                             83258      16626      0.16      17                                 
   ZN_FING                             29201      12743      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15241820                28.48                                                           
   2DBase-Ecoli                           85         85     <0.01     125      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     122      2D gel databases                             
   AGD                                   932        926     <0.01     100      Organism-specific databases                  
   Allergome                            1421        876     <0.01      96      Protein family/group databases               
   ANU-2DPAGE                             26         26     <0.01     131      2D gel databases                             
   ArachnoServer                         763        755     <0.01     106      Organism-specific databases                  
   ArrayExpress                        59718      59718      0.11      42      Gene expression databases                    
   Bgee                                39344      39344      0.07      47      Gene expression databases                    
   BindingDB                             295        295     <0.01     118      Other                                        
   BioCyc                             248409     239955      0.46      22      Enzyme and pathway databases                 
   BRENDA                               4242       4235      0.01      87      Enzyme and pathway databases                 
   CAZy                                 7526       6768      0.01      73      Protein family/group databases               
   CGD                                   671        651     <0.01     107      Organism-specific databases                  
   CleanEx                             30109      29468      0.06      51      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     124      2D gel databases                             
   ConoServer                            915        833     <0.01     102      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     126      2D gel databases                             
   CTD                                 68226      67618      0.13      39      Organism-specific databases                  
   CYGD                                 5594       5591      0.01      77      Organism-specific databases                  
   dictyBase                            4200       4084      0.01      88      Organism-specific databases                  
   DIP                                 13454      13346      0.03      66      Protein-protein interaction databases        
   DisProt                               397        394     <0.01     114      3D structure databases                       
   DMDM                                16778      16777      0.03      60      Polymorphism databases                       
   DNASU                               18322      18251      0.03      57      Protocols and materials databases            
   DOSAC-COBS-2DPAGE                     149        147     <0.01     121      2D gel databases                             
   DrugBank                             5318       1627      0.01      78      Other                                        
   EchoBASE                             4167       4163      0.01      89      Organism-specific databases                  
   ECO2DBASE                             352        300     <0.01     116      2D gel databases                             
   EcoGene                              4292       4290      0.01      86      Organism-specific databases                  
   eggNOG                             429154     429154      0.80       9      Phylogenomic databases                       
   EMBL                               918127     524778      1.72       3      Sequence databases                           
   Ensembl                             66720      48142      0.12      40      Genome annotation databases                  
   EnsemblBacteria                     97884      84935      0.18      29      Genome annotation databases                  
   EnsemblFungi                        16559      16267      0.03      61      Genome annotation databases                  
   EnsemblMetazoa                      10917       8276      0.02      69      Genome annotation databases                  
   EnsemblPlants                       15885      13628      0.03      63      Genome annotation databases                  
   EnsemblProtists                      4432       4308      0.01      85      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     127      Organism-specific databases                  
   EuPathDB                              793        792     <0.01     103      Organism-specific databases                  
   FlyBase                              5845       5471      0.01      76      Organism-specific databases                  
   Gene3D                             329891     254067      0.62      17      Family and domain databases                  
   GeneCards                           19974      19670      0.04      55      Organism-specific databases                  
   GeneFarm                             3048       3034      0.01      92      Organism-specific databases                  
   GeneID                             485088     465546      0.91       6      Genome annotation databases                  
   GeneTree                            56913      56883      0.11      43      Phylogenomic databases                       
   Genevestigator                      66479      66479      0.12      41      Gene expression databases                    
   GenoList                             7067       7055      0.01      74      Organism-specific databases                  
   GenomeReviews                      376260     356673      0.70      12      Genome annotation databases                  
   GermOnline                          41906      41332      0.08      46      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     119      PTM databases                                
   GO                                2176476     503082      4.07       1      Ontologies                                   
   Gramene                              4727       4727      0.01      81      Organism-specific databases                  
   H-InvDB                             13250      12336      0.02      67      Organism-specific databases                  
   HAMAP                              311759     311556      0.58      18      Family and domain databases                  
   HGNC                                19762      19605      0.04      56      Organism-specific databases                  
   HOGENOM                            365460     365460      0.68      14      Phylogenomic databases                       
   HOVERGEN                            75276      75276      0.14      36      Phylogenomic databases                       
   HPA                                 15760      12093      0.03      65      Organism-specific databases                  
   HSSP                                30170      30170      0.06      50      3D structure databases                       
   InParanoid                          68993      68993      0.13      38      Phylogenomic databases                       
   IntAct                              33011      33011      0.06      49      Protein-protein interaction databases        
   InterPro                          1760072     510212      3.29       2      Family and domain databases                  
   IPI                                 93496      66427      0.17      32      Sequence databases                           
   KEGG                               458748     437153      0.86       8      Genome annotation databases                  
   KO                                 368549     368099      0.69      13      Phylogenomic databases                       
   LegioList                             764        762     <0.01     105      Organism-specific databases                  
   Leproma                               671        668     <0.01     108      Organism-specific databases                  
   MaizeGDB                              486        481     <0.01     112      Organism-specific databases                  
   MEROPS                              10277      10277      0.02      71      Protein family/group databases               
   MGI                                 16414      16369      0.03      62      Organism-specific databases                  
   MIM                                 17337      13266      0.03      59      Organism-specific databases                  
   MINT                                17588      17588      0.03      58      Protein-protein interaction databases        
   NextBio                             49276      49274      0.09      44      Other                                        
   neXtProt                            20099      20099      0.04      54      Organism-specific databases                  
   OGP                                   377        377     <0.01     115      2D gel databases                             
   OMA                                385229     385229      0.72      11      Phylogenomic databases                       
   Orphanet                             4141       2492      0.01      90      Organism-specific databases                  
   OrthoDB                             77952      77952      0.15      35      Phylogenomic databases                       
   PANTHER                            200334     186125      0.37      24      Family and domain databases                  
   Pathway_Interaction_DB               4568       1666      0.01      84      Enzyme and pathway databases                 
   PATRIC                             308277     308256      0.58      20      Genome annotation databases                  
   PDB                                 82799      17847      0.15      34      3D structure databases                       
   PDBsum                              82799      17847      0.15      33      3D structure databases                       
   PeptideAtlas                         5164       5164      0.01      79      Proteomic databases                          
   PeroxiBase                            766        749     <0.01     104      Protein family/group databases               
   Pfam                               700045     490325      1.31       4      Family and domain databases                  
   PharmGKB                            15811      15486      0.03      64      Organism-specific databases                  
   PHCI-2DPAGE                           249        249     <0.01     120      2D gel databases                             
   PhosphoSite                         25548      25548      0.05      53      PTM databases                                
   PhosSite                              351        351     <0.01     117      PTM databases                                
   PhylomeDB                          169367     169367      0.32      25      Phylogenomic databases                       
   PIR                                117670     107578      0.22      28      Sequence databases                           
   PIRSF                               96836      96822      0.18      30      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01      95      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     128      2D gel databases                             
   PomBase                              5014       4954      0.01      80      Organism-specific databases                  
   PptaseDB                               34         34     <0.01     129      Protein family/group databases               
   PRIDE                               74625      74625      0.14      37      Proteomic databases                          
   PRINTS                             137441     120319      0.26      27      Family and domain databases                  
   ProDom                              29184      29005      0.05      52      Family and domain databases                  
   ProMEX                                497        497     <0.01     111      Proteomic databases                          
   PROSITE                            476303     301399      0.89       7      Family and domain databases                  
   ProtClustDB                        342195     342195      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 428922     428922      0.80      10      3D structure databases                       
   PseudoCAP                            1230       1221     <0.01      98      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     130      2D gel databases                             
   Reactome                            10592       6701      0.02      70      Enzyme and pathway databases                 
   REBASE                                402        402     <0.01     113      Protein family/group databases               
   RefSeq                             507453     466891      0.95       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01      97      2D gel databases                             
   RGD                                  7614       7610      0.01      72      Organism-specific databases                  
   SGD                                  6638       6633      0.01      75      Organism-specific databases                  
   Siena-2DPAGE                          102        102     <0.01     123      2D gel databases                             
   SMART                              166295     124484      0.31      26      Family and domain databases                  
   SMR                                211297     211297      0.39      23      3D structure databases                       
   STRING                             308686     308684      0.58      19      Protein-protein interaction databases        
   SUPFAM                             330193     261549      0.62      16      Family and domain databases                  
   SWISS-2DPAGE                         1183       1182     <0.01      99      2D gel databases                             
   TAIR                                11107      11036      0.02      68      Organism-specific databases                  
   TCDB                                 3625       3610      0.01      91      Protein family/group databases               
   TIGR                                34536      33754      0.06      48      Genome annotation databases                  
   TIGRFAMs                           288362     268056      0.54      21      Family and domain databases                  
   TubercuList                          1945       1909     <0.01      94      Organism-specific databases                  
   UCD-2DPAGE                            510        501     <0.01     110      2D gel databases                             
   UCSC                                47753      37204      0.09      45      Genome annotation databases                  
   UniGene                             95710      88049      0.18      31      Sequence databases                           
   VectorBase                            606        588     <0.01     109      Genome annotation databases                  
   World-2DPAGE                          919        908     <0.01     101      2D gel databases                             
   WormBase                             4705       3855      0.01      82      Organism-specific databases                  
   Xenbase                              4666       4661      0.01      83      Organism-specific databases                  
   ZFIN                                 2713       2701      0.01      93      Organism-specific databases                  

Total number of cross-referenced databases: 131

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.55
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.36   Ile (I) 5.97   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4461 entries are encoded on a mitochondrion, and 3644 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 73169