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         UniProtKB/Swiss-Prot protein knowledgebase release 2012_02 statistics


1.  INTRODUCTION

Release 2012_02 of 22-Feb-12 of UniProtKB/Swiss-Prot contains 534695 sequence entries,
comprising 189667883 amino acids abstracted from 207395 references. 

468 sequences have been added since release 2012_01, the sequence data of
116 existing entries has been updated and the annotations of
456192 entries have been revised.

Number of fragments: 8976
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 31041


Protein existence (PE):           entries     %

1: Evidence at protein level        74107   13.9%
2: Evidence at transcript level     69984   13.1%
3: Inferred from homology          374279     70%
4: Predicted                        14442    2.7%
5: Uncertain                         1883    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12726

   The first twenty species represent 111314 sequences:  20.8 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5365
                            2x: 1849
                            3x:  955
                            4x:  628
                            5x:  463
                            6x:  374
                            7x:  272
                            8x:  218
                            9x:  198
                           10x:  110
                       11- 20x:  655
                       21- 50x:  392
                       51-100x:  209
                         >100x: 1038


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20246  Homo sapiens (Human)
       2      16473  Mus musculus (Mouse)
       3      11018  Arabidopsis thaliana (Mouse-ear cress)
       4       7690  Rattus norvegicus (Rat)
       5       6619  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5885  Bos taurus (Bovine)
       7       4976  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4431  Escherichia coli (strain K12)
       9       4244  Bacillus subtilis
      10       4122  Dictyostelium discoideum (Slime mold)
      11       3344  Caenorhabditis elegans
      12       3331  Xenopus laevis (African clawed frog)
      13       3141  Drosophila melanogaster (Fruit fly)
      14       2835  Oryza sativa subsp. japonica (Rice)
      15       2782  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2229  Gallus gallus (Chicken)
      17       2217  Pongo abelii (Sumatran orangutan)
      18       2011  Escherichia coli O157:H7
      19       1925  Mycobacterium tuberculosis
      20       1795  Salmonella typhimurium
      21       1787  Methanocaldococcus jannaschii  
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1678  Shigella flexneri
      24       1675  Escherichia coli O6
      25       1623  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      26       1407  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1244  Mycobacterium bovis
      29       1221  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      30       1169  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1026  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1013  Yersinia pestis
      33       1000  Archaeoglobus fulgidus 
      34        955  Vibrio cholerae
      35        930  Salmonella paratyphi A
      36        926  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        901  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        885  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis
      48        878  Shigella sonnei (strain Ss046)
      49        868  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        864  Yersinia pseudotuberculosis
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      54        830  Neurospora crassa 
      55        829  Shigella boydii serotype 4 (strain Sb227)
      56        824  Escherichia coli (strain UTI89 / UPEC)
      57        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      58        817  Shigella dysenteriae serotype 1 (strain Sd197)
      59        799  Canis familiaris (Dog) (Canis lupus familiaris)
      60        795  Vibrio parahaemolyticus
      61        791  Escherichia coli (strain SMS-3-5 / SECEC)
      62        783  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
      63        777  Aquifex aeolicus (strain VF5)
      64        773  Pasteurella multocida (strain Pm70)
      65        771  Escherichia coli (strain K12 / DH10B)
      66        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      67        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      68        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      69        764  Emericella nidulans  
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Streptomyces coelicolor
      75        757  Staphylococcus epidermidis (strain ATCC 12228)
      76        756  Escherichia coli (strain SE11)
      77        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      78        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        743  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      82        734  Bacillus halodurans 
      83        734  Staphylococcus aureus (strain NCTC 8325)
      84        733  Vibrio vulnificus
      85        732  Bacillus anthracis
      86        731  Escherichia coli O81 (strain ED1a)
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Enterobacter sp. (strain 638)
      93        713  Salmonella agona (strain SL483)
      94        713  Escherichia coli O1:K1 / APEC
      95        713  Salmonella newport (strain SL254)
      96        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      97        712  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      98        712  Salmonella schwarzengrund (strain CVM19633)
      99        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     100        710  Salmonella heidelberg (strain SL476)
     101        702  Salmonella dublin (strain CT_02021853)
     102        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     103        696  Klebsiella pneumoniae (strain 342)
     104        695  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     105        690  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
     106        689  Zea mays (Maize)
     107        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     108        687  Pan troglodytes (Chimpanzee)
     109        687  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     110        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     111        678  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     112        675  Pseudomonas putida (strain KT2440)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        669  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        656  Bradyrhizobium japonicum
     120        653  Debaryomyces hansenii   
     121        648  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        643  Escherichia coli
     123        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     124        642  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     125        641  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     126        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     127        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     128        632  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     129        629  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     130        628  Shewanella oneidensis
     131        622  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        615  Treponema pallidum (strain Nichols)
     133        612  Staphylococcus haemolyticus (strain JCSC1435)
     134        608  Methanobacterium thermoautotrophicum (strain Delta H)
     135        605  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     136        602  Photobacterium profundum (Photobacterium sp. (strain SS9))
     137        602  Listeria monocytogenes
     138        602  Staphylococcus saprophyticus subsp. saprophyticus 
     139        601  Salmonella paratyphi C (strain RKS4594)
     140        601  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     141        600  Yersinia pestis bv. Antiqua (strain Angola)
     142        600  Xanthomonas campestris pv. campestris
     143        593  Oryza sativa subsp. indica (Rice)
     144        590  Bacillus cereus (strain ATCC 10987)
     145        590  Listeria innocua
     146        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     147        585  Rickettsia prowazekii (strain Madrid E)
     148        581  Neisseria meningitidis serogroup B
     149        576  Brucella suis biovar 1 (strain 1330)
     150        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     151        572  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     154        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     155        565  Pseudomonas syringae pv. syringae (strain B728a)
     156        563  Caulobacter crescentus (Caulobacter vibrioides)
     157        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     158        562  Caenorhabditis briggsae
     159        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     160        561  Vibrio fischeri (strain ATCC 700601 / ES114)
     161        560  Bacillus cereus (strain ZK / E33L)
     162        558  Clostridium acetobutylicum
     163        558  Pseudomonas aeruginosa (strain UCBPP-PA14)
     164        556  Neisseria meningitidis serogroup A
     165        556  Xanthomonas axonopodis pv. citri (Citrus canker)
     166        552  Pseudomonas fluorescens (strain Pf0-1)
     167        551  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        544  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     171        530  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     172        529  Listeria monocytogenes serotype 4b (strain F2365)
     173        528  Sodalis glossinidius (strain morsitans)
     174        527  Streptococcus pneumoniae
     175        523  Thermotoga maritima
     176        522  Xylella fastidiosa
     177        520  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     178        514  Chromobacterium violaceum
     179        512  Bordetella pertussis
     180        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     181        511  Pseudomonas aeruginosa (strain PA7)
     182        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     184        508  Bordetella parapertussis
     185        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     186        507  Geobacillus kaustophilus (strain HTA426)
     187        506  Staphylococcus aureus (strain Newman)
     188        501  Deinococcus radiodurans
     189        500  Pseudomonas entomophila (strain L48)
     190        499  Brucella abortus biovar 1 (strain 9-941)
     191        498  Corynebacterium glutamicum (Brevibacterium flavum)
     192        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     193        496  Bacillus clausii (strain KSM-K16)
     194        494  Haemophilus influenzae (strain 86-028NP)
     195        494  Streptomyces avermitilis
     196        493  Burkholderia pseudomallei (Pseudomonas pseudomallei)
     197        492  Proteus mirabilis (strain HI4320)
     198        492  Bacillus amyloliquefaciens (strain FZB42)
     199        491  Xanthomonas campestris pv. campestris (strain 8004)
     200        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     201        490  Clostridium perfringens
     202        487  Shewanella sp. (strain MR-7)
     203        486  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     204        485  Mannheimia succiniciproducens (strain MBEL55E)
     205        484  Pseudomonas aeruginosa (strain LESB58)
     206        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     207        484  Shewanella sp. (strain MR-4)
     208        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     209        480  Acinetobacter sp. (strain ADP1)
     210        478  Thermosynechococcus elongatus (strain BP-1)
     211        476  Enterococcus faecalis (Streptococcus faecalis)
     212        476  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     213        475  Pyrococcus horikoshii 
     214        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     215        474  Pseudomonas putida (strain F1 / ATCC 700007)
     216        473  Brucella abortus (strain 2308)
     217        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     218        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     219        466  Shewanella frigidimarina (strain NCIMB 400)
     220        466  Pseudomonas putida (strain GB-1)
     221        466  Halobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) 
     222        465  Pyrococcus abyssi (strain GE5 / Orsay)
     223        465  Methanosarcina mazei  
     224        464  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     225        463  Shewanella sp. (strain ANA-3)
     226        462  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     227        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     228        462  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     229        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     230        461  Burkholderia mallei (Pseudomonas mallei)
     231        458  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     232        458  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     233        455  Staphylococcus aureus (strain JH1)
     234        455  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     235        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     236        453  Pseudomonas putida (strain W619)
     237        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     238        452  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     239        452  Ovis aries (Sheep)
     240        452  Shewanella baltica (strain OS185)
     241        451  Streptococcus mutans
     242        451  Aeromonas salmonicida (strain A449)
     243        450  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     244        449  Thermoanaerobacter tengcongensis  
     245        449  Staphylococcus aureus (strain JH9)
     246        448  Mycobacterium paratuberculosis
     247        448  Hahella chejuensis (strain KCTC 2396)
     248        447  Vibrio fischeri (strain MJ11)
     249        445  Nicotiana tabacum (Common tobacco)
     250        445  Pseudomonas mendocina (strain ymp)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18798 (  4%)
    Bacteria         327658 ( 61%)
    Eukaryota        172223 ( 32%)
    Viruses           16016 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20247 ( 12%)           (  4%)
     Other Mammalia         45441 ( 26%)           (  8%)
     Other Vertebrata       16891 ( 10%)           (  3%)
     Viridiplantae          32152 ( 19%)           (  6%)
     Fungi                  30554 ( 18%)           (  6%)
     Insecta                 8356 (  5%)           (  2%)
     Nematoda                4212 (  2%)           (  1%)
     Other                  14370 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8682             1001-1100     3690
                 51- 100   41017             1101-1200     2561
                101- 150   57183             1201-1300     1993
                151- 200   57392             1301-1400     1846
                201- 250   56078             1401-1500     1492
                251- 300   49431             1501-1600      725
                301- 350   49656             1601-1700      543
                351- 400   42935             1701-1800      453
                401- 450   35211             1801-1900      418
                451- 500   28279             1901-2000      336
                501- 550   20084             2001-2100      206
                551- 600   14374             2101-2200      277
                601- 650   12133             2201-2300      287
                651- 700    8757             2301-2400      170
                701- 750    7208             2401-2500      136
                751- 800    5108             >2500         1071
                801- 850    4479
                851- 900    4975
                901- 950    3827
                951-1000    2706

   


   The average sequence length in UniProtKB/Swiss-Prot is 354 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2217


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  721
                       2x:  287
                       3x:  146
                       4x:  107
                       5x:   99
                       6x:   77
                       7x:   46
                       8x:   37
                       9x:   31
                      10x:   28
                  11- 20x:  175
                  21- 50x:  186
                  51-100x:  100
                    >100x:  177


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        19870   Journal of Biological Chemistry
    2         9076   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5389   Journal of Bacteriology
    4         4856   Biochemical and Biophysical Research Communications
    5         4557   Gene
    6         4425   Nucleic Acids Research
    7         4205   Biochemistry
    8         4192   FEBS Letters
    9         4061   The EMBO Journal
   10         3788   Molecular and Cellular Biology
   11         3534   Nature
   12         3355   Journal of Molecular Biology
   13         3179   European Journal of Biochemistry
   14         3109   Biochimica et Biophysica Acta
   15         2916   Cell
   16         2497   Genomics
   17         2348   Biochemical Journal
   18         2341   Journal of Virology
   19         2324   Science
   20         1920   Molecular Microbiology
   21         1769   Journal of Cell Biology
   22         1625   Plant Physiology
   23         1571   Plant Molecular Biology
   24         1516   Genes and Development
   25         1496   Virology
   26         1473   The American Journal of Human Genetics
   27         1429   Nature Genetics
   28         1402   Human Molecular Genetics
   29         1372   Oncogene
   30         1318   Molecular and General Genetics
   31         1270   Development
   32         1211   Human Mutation
   33         1207   Journal of Biochemistry
   34         1191   Molecular Biology of the Cell
   35         1134   The Plant Cell
   36         1117   Journal of Immunology
   37         1049   Genetics
   38         1023   Molecular Cell
   39          998   Structure
   40          993   The Plant Journal
   41          989   Journal of General Virology
   42          918   Blood
   43          915   Infection and Immunity
   44          885   Archives of Biochemistry and Biophysics
   45          869   Journal of Cell Science
   46          797   Microbiology
   47          787   Developmental Biology
   48          780   Yeast
   49          767   Cancer Research
   50          742   Current Biology
   51          691   FEMS Microbiology Letters
   52          617   Acta Crystallographica, Section D
   53          616   Human Genetics
   54          615   Nature Structural Biology
   55          612   Mechanisms of Development
   56          610   Protein Science
   57          603   Journal of Neuroscience
   58          587   Applied and Environmental Microbiology
   59          570   Neuron
   60          565   Toxicon
   61          553   Journal of Clinical Investigation
   62          536   Current Genetics
   63          515   American Journal of Physiology
   64          503   The Journal of Experimental Medicine
   65          478   Mammalian Genome
   66          467   Molecular Endocrinology
   67          453   Immunogenetics
   68          448   Journal of Neurochemistry
   69          441   Proteins
   70          436   The Journal of Clinical Endocrinology and Metabolism
   71          427   Molecular and Biochemical Parasitology
   72          421   Endocrinology
   73          401   Bioscience, Biotechnology, and Biochemistry
   74          397   Nature Cell Biology
   75          396   Plant and Cell Physiology
   76          389   Journal of Molecular Evolution
   77          386   Journal of Medical Genetics
   78          373   DNA and Cell Biology
   79          368   Molecular Biology and Evolution
   80          361   DNA Sequence
   81          354   Experimental Cell Research
   82          325   Peptides
   83          325   Brain Research. Molecular Brain Research
   84          321   Tissue Antigens
   85          312   Comparative Biochemistry and Physiology
   86          303   PLoS ONE
   87          299   Molecular Pharmacology
   88          295   Antimicrobial Agents and Chemotherapy
   89          293   Biological Chemistry Hoppe-Seyler
   90          292   Journal of Investigative Dermatology
   91          290   Developmental Cell
   92          287   RNA
   93          277   Cytogenetics and Cell Genetics
   94          273   Biology of Reproduction
   95          271   Neurology
   96          261   Developmental Dynamics
   97          261   Virus Research
   98          260   Planta
   99          257   Genome Research
  100          257   Nature Structural and Molecular Biology
  101          256   The FEBS Journal
  102          252   Journal of General Microbiology
  103          242   Molecular Plant-Microbe Interactions
  104          233   Immunity
  105          227   EMBO Reports
  106          224   European Journal of Immunology
  107          222   Genes to Cells
  108          220   Biochimie
  109          218   The New England Journal of Medicine
  110          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  111          217   Annals of Neurology
  112          216   Eukaryotic Cell
  113          213   The FASEB Journal
  114          210   European Journal of Human Genetics
  115          210   DNA Research
  116          199   Journal of Human Genetics
  117          190   Investigative Ophthalmology and Visual Science
  118          186   Archives of Virology
  119          182   Molecular and Cellular Endocrinology
  120          178   Archives of Microbiology
  121          174   Journal of the American Chemical Society
  122          172   American Journal of Medical Genetics. Part A
  123          171   Molecular Immunology
  124          170   BMC Genomics
  125          170   Journal of Cellular Biochemistry
  126          169   Diabetes
  127          169   Insect Biochemistry and Molecular Biology
  128          167   Glycobiology
  129          167   American Journal of Medical Genetics
  130          167   Molecular Phylogenetics and Evolution
  131          166   Clinical Genetics
  132          163   Nature Immunology
  133          160   Journal of Medicinal Chemistry
  134          159   DNA
  135          158   International Journal of Cancer
  136          156   Molecular Reproduction and Development
  137          155   Hemoglobin
  138          153   Circulation Research
  139          153   Bioorganicheskaia Khimiia
  140          146   Molecular and Cellular Neuroscience
  141          146   Molecular Genetics and Metabolism
  142          144   Biological Chemistry
  143          142   Molecular Genetics and Genomics
  144          139   British Journal of Haematology
  145          138   General and Comparative Endocrinology
  146          138   Acta Crystallographica, Section F
  147          138   Animal Genetics
  148          134   Protein Expression and Purification
  149          133   Journal of Experimental Botany
  150          133   Proteomics


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1006647                 1.88                                         
   Journal                            801572     409174      1.50       1                                 
   Submitted to EMBL/GenBank/DDBJ     196199     176707      0.37       2                                 
   Submitted to other databases         6729       6273      0.01       3                                 
   Book citation                         687        673     <0.01       4                                 
   Plant Gene Register                   576        564     <0.01       5                                 
   Thesis                                406        403     <0.01       6                                 
   Unpublished observations              285        281     <0.01       7                                 
   Patent                                187        184     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 317799

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2357115                 4.41                                         
   ALLERGEN                              515        515     <0.01      26                                 
   ALTERNATIVE PRODUCTS                20358      20358      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        3985       3985      0.01      23                                 
   BIOTECHNOLOGY                         324        322     <0.01      28                                 
   CATALYTIC ACTIVITY                 238512     216612      0.45       4                                 
   CAUTION                              7887       7729      0.01      19                                 
   COFACTOR                           103434      95063      0.19       7                                 
   DEVELOPMENTAL STAGE                  9533       9533      0.02      16                                 
   DISEASE                              4904       3298      0.01      21                                 
   DISRUPTION PHENOTYPE                 4357       4357      0.01      22                                 
   DOMAIN                              36745      32558      0.07      10                                 
   ENZYME REGULATION                   10368      10368      0.02      15                                 
   FUNCTION                           409612     392767      0.77       2                                 
   INDUCTION                           13852      13852      0.03      14                                 
   INTERACTION                          9138       9138      0.02      17                                 
   MASS SPECTROMETRY                    5004       3804      0.01      20                                 
   MISCELLANEOUS                       31148      28736      0.06      12                                 
   PATHWAY                            131183     118986      0.25       6                                 
   PHARMACEUTICAL                         85         85     <0.01      29                                 
   POLYMORPHISM                          848        802     <0.01      24                                 
   PTM                                 42439      33779      0.08       8                                 
   RNA EDITING                           623        623     <0.01      25                                 
   SEQUENCE CAUTION                    40195      40195      0.08       9                                 
   SIMILARITY                         630685     509895      1.18       1                                 
   SUBCELLULAR LOCATION               319652     314117      0.60       3                                 
   SUBUNIT                            235767     235767      0.44       5                                 
   TISSUE SPECIFICITY                  36735      36735      0.07      11                                 
   TOXIC DOSE                            492        478     <0.01      27                                 
   WEB RESOURCE                         8735       7007      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3508748                 6.56                                         
   ACT_SITE                           134334      82112      0.25       9                                 
   BINDING                            246164      67210      0.46       4                                 
   CA_BIND                              3814       1581      0.01      35                                 
   CARBOHYD                           105846      27001      0.20      14                                 
   CHAIN                              541249     528892      1.01       1                                 
   COILED                              19727      13531      0.04      26                                 
   COMPBIAS                            52996      27998      0.10      18                                 
   CONFLICT                           124394      43609      0.23      11                                 
   CROSSLNK                             6280       3725      0.01      34                                 
   DISULFID                           103788      27980      0.19      15                                 
   DNA_BIND                            11286      10395      0.02      31                                 
   DOMAIN                             156473      93242      0.29       6                                 
   HELIX                              152500      15859      0.29       7                                 
   INIT_MET                            15175      15175      0.03      27                                 
   INTRAMEM                             1921        844     <0.01      38                                 
   LIPID                               11358       7211      0.02      30                                 
   METAL                              297218      72741      0.56       3                                 
   MOD_RES                            191507      62961      0.36       5                                 
   MOTIF                               34657      22341      0.06      24                                 
   MUTAGEN                             38471       8979      0.07      21                                 
   NON_CONS                             1967        728     <0.01      37                                 
   NON_STD                               353        278     <0.01      39                                 
   NON_TER                             12112       9247      0.02      29                                 
   NP_BIND                            113323      71022      0.21      12                                 
   PEPTIDE                              9765       6575      0.02      32                                 
   PROPEP                              12442      10696      0.02      28                                 
   REGION                             110157      58957      0.21      13                                 
   REPEAT                              92992      13770      0.17      16                                 
   SIGNAL                              37375      37365      0.07      22                                 
   SITE                                40690      24105      0.08      20                                 
   STRAND                             149267      14743      0.28       8                                 
   TOPO_DOM                           127703      26402      0.24      10                                 
   TRANSIT                              7917       7828      0.01      33                                 
   TRANSMEM                           351730      72438      0.66       2                                 
   TURN                                35190      12356      0.07      23                                 
   UNSURE                               2984        520      0.01      36                                 
   VAR_SEQ                             41239      17790      0.08      19                                 
   VARIANT                             83220      16624      0.16      17                                 
   ZN_FING                             29164      12719      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15217785                28.46                                                           
   2DBase-Ecoli                           85         85     <0.01     124      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     121      2D gel databases                             
   AGD                                   932        926     <0.01      99      Organism-specific databases                  
   Allergome                            1413        868     <0.01      95      Protein family/group databases               
   ANU-2DPAGE                             26         26     <0.01     130      2D gel databases                             
   ArachnoServer                         763        755     <0.01     105      Organism-specific databases                  
   ArrayExpress                        59678      59678      0.11      42      Gene expression databases                    
   Bgee                                39297      39297      0.07      47      Gene expression databases                    
   BindingDB                             295        295     <0.01     117      Other                                        
   BioCyc                             248363     239909      0.46      22      Enzyme and pathway databases                 
   BRENDA                               4241       4234      0.01      86      Enzyme and pathway databases                 
   CAZy                                 7526       6768      0.01      72      Protein family/group databases               
   CGD                                   669        649     <0.01     107      Organism-specific databases                  
   CleanEx                             30110      29468      0.06      51      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     123      2D gel databases                             
   ConoServer                            915        833     <0.01     101      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     125      2D gel databases                             
   CTD                                 68075      67467      0.13      39      Organism-specific databases                  
   CYGD                                 5594       5591      0.01      76      Organism-specific databases                  
   dictyBase                            4199       4083      0.01      87      Organism-specific databases                  
   DIP                                 13453      13345      0.03      65      Protein-protein interaction databases        
   DisProt                               397        394     <0.01     113      3D structure databases                       
   DMDM                                16779      16778      0.03      59      Polymorphism databases                       
   DOSAC-COBS-2DPAGE                     149        147     <0.01     120      2D gel databases                             
   DrugBank                             5318       1627      0.01      77      Other                                        
   EchoBASE                             4167       4163      0.01      88      Organism-specific databases                  
   ECO2DBASE                             352        300     <0.01     115      2D gel databases                             
   EcoGene                              4292       4290      0.01      85      Organism-specific databases                  
   eggNOG                             428639     428639      0.80       9      Phylogenomic databases                       
   EMBL                               916523     524266      1.71       3      Sequence databases                           
   Ensembl                             66485      48014      0.12      40      Genome annotation databases                  
   EnsemblBacteria                     97851      84909      0.18      29      Genome annotation databases                  
   EnsemblFungi                        16535      16243      0.03      60      Genome annotation databases                  
   EnsemblMetazoa                      10891       8262      0.02      68      Genome annotation databases                  
   EnsemblPlants                       15743      13499      0.03      64      Genome annotation databases                  
   EnsemblProtists                      4425       4301      0.01      84      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     126      Organism-specific databases                  
   EuPathDB                              785        784     <0.01     102      Organism-specific databases                  
   FlyBase                              5839       5465      0.01      75      Organism-specific databases                  
   Gene3D                             328152     253401      0.61      17      Family and domain databases                  
   GeneCards                           19975      19668      0.04      55      Organism-specific databases                  
   GeneFarm                             3048       3034      0.01      91      Organism-specific databases                  
   GeneID                             483613     464098      0.90       6      Genome annotation databases                  
   GeneTree                            56760      56731      0.11      43      Phylogenomic databases                       
   Genevestigator                      66416      66416      0.12      41      Gene expression databases                    
   GenoList                             7063       7051      0.01      73      Organism-specific databases                  
   GenomeReviews                      376020     356446      0.70      12      Genome annotation databases                  
   GermOnline                          41906      41332      0.08      46      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     118      PTM databases                                
   GO                                2168969     502275      4.06       1      Ontologies                                   
   Gramene                              4723       4723      0.01      80      Organism-specific databases                  
   H-InvDB                             13251      12337      0.02      66      Organism-specific databases                  
   HAMAP                              311519     311343      0.58      18      Family and domain databases                  
   HGNC                                19756      19597      0.04      56      Organism-specific databases                  
   HOGENOM                            364729     364729      0.68      13      Phylogenomic databases                       
   HOVERGEN                            75077      75077      0.14      36      Phylogenomic databases                       
   HPA                                 15761      12094      0.03      63      Organism-specific databases                  
   HSSP                                30133      30133      0.06      50      3D structure databases                       
   InParanoid                          68932      68932      0.13      38      Phylogenomic databases                       
   IntAct                              33040      33040      0.06      49      Protein-protein interaction databases        
   InterPro                          1775403     509803      3.32       2      Family and domain databases                  
   IPI                                 93192      66275      0.17      32      Sequence databases                           
   KEGG                               458305     436722      0.86       8      Genome annotation databases                  
   KO                                 361260     360795      0.68      14      Phylogenomic databases                       
   LegioList                             763        761     <0.01     104      Organism-specific databases                  
   Leproma                               671        668     <0.01     106      Organism-specific databases                  
   MaizeGDB                              486        481     <0.01     111      Organism-specific databases                  
   MEROPS                              10265      10265      0.02      70      Protein family/group databases               
   MGI                                 16375      16330      0.03      61      Organism-specific databases                  
   MIM                                 17324      13255      0.03      58      Organism-specific databases                  
   MINT                                17583      17583      0.03      57      Protein-protein interaction databases        
   NextBio                             49249      49247      0.09      44      Other                                        
   neXtProt                            20101      20101      0.04      54      Organism-specific databases                  
   OGP                                   377        377     <0.01     114      2D gel databases                             
   OMA                                384921     384921      0.72      11      Phylogenomic databases                       
   Orphanet                             4048       2446      0.01      89      Organism-specific databases                  
   OrthoDB                             77881      77881      0.15      35      Phylogenomic databases                       
   PANTHER                            199934     185789      0.37      24      Family and domain databases                  
   Pathway_Interaction_DB               4567       1665      0.01      83      Enzyme and pathway databases                 
   PATRIC                             308109     308091      0.58      20      Genome annotation databases                  
   PDB                                 81976      17762      0.15      34      3D structure databases                       
   PDBsum                              81976      17762      0.15      33      3D structure databases                       
   PeptideAtlas                         5164       5164      0.01      78      Proteomic databases                          
   PeroxiBase                            764        747     <0.01     103      Protein family/group databases               
   Pfam                               710769     495730      1.33       4      Family and domain databases                  
   PharmGKB                            15809      15484      0.03      62      Organism-specific databases                  
   PHCI-2DPAGE                           247        247     <0.01     119      2D gel databases                             
   PhosphoSite                         25542      25542      0.05      53      PTM databases                                
   PhosSite                              351        351     <0.01     116      PTM databases                                
   PhylomeDB                          169213     169213      0.32      25      Phylogenomic databases                       
   PIR                                117573     107503      0.22      28      Sequence databases                           
   PIRSF                               96345      96331      0.18      30      Family and domain databases                  
   PMAP-CutDB                           1457       1457     <0.01      94      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     127      2D gel databases                             
   PomBase                              5008       4948      0.01      79      Organism-specific databases                  
   PptaseDB                               34         34     <0.01     128      Protein family/group databases               
   PRIDE                               74600      74600      0.14      37      Proteomic databases                          
   PRINTS                             137428     120280      0.26      27      Family and domain databases                  
   ProDom                              29211      29032      0.05      52      Family and domain databases                  
   ProMEX                                495        495     <0.01     110      Proteomic databases                          
   PROSITE                            475473     300997      0.89       7      Family and domain databases                  
   ProtClustDB                        341737     341737      0.64      15      Phylogenomic databases                       
   ProteinModelPortal                 428620     428620      0.80      10      3D structure databases                       
   PseudoCAP                            1229       1220     <0.01      97      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     129      2D gel databases                             
   Reactome                            10590       6700      0.02      69      Enzyme and pathway databases                 
   REBASE                                400        400     <0.01     112      Protein family/group databases               
   RefSeq                             505774     465497      0.95       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01      96      2D gel databases                             
   RGD                                  7594       7590      0.01      71      Organism-specific databases                  
   SGD                                  6638       6633      0.01      74      Organism-specific databases                  
   Siena-2DPAGE                          102        102     <0.01     122      2D gel databases                             
   SMART                              166051     124341      0.31      26      Family and domain databases                  
   SMR                                211222     211222      0.40      23      3D structure databases                       
   STRING                             308517     308515      0.58      19      Protein-protein interaction databases        
   SUPFAM                             329638     261256      0.62      16      Family and domain databases                  
   SWISS-2DPAGE                         1183       1182     <0.01      98      2D gel databases                             
   TAIR                                11062      10982      0.02      67      Organism-specific databases                  
   TCDB                                 3617       3602      0.01      90      Protein family/group databases               
   TIGR                                34506      33726      0.06      48      Genome annotation databases                  
   TIGRFAMs                           288223     267925      0.54      21      Family and domain databases                  
   TubercuList                          1941       1905     <0.01      93      Organism-specific databases                  
   UCD-2DPAGE                            510        501     <0.01     109      2D gel databases                             
   UCSC                                47716      37166      0.09      45      Genome annotation databases                  
   UniGene                             95518      87862      0.18      31      Sequence databases                           
   VectorBase                            568        554     <0.01     108      Genome annotation databases                  
   World-2DPAGE                          919        908     <0.01     100      2D gel databases                             
   WormBase                             4699       3850      0.01      81      Organism-specific databases                  
   Xenbase                              4657       4652      0.01      82      Organism-specific databases                  
   ZFIN                                 2703       2691      0.01      92      Organism-specific databases                  

Total number of cross-referenced databases: 130

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.55
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.84   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.36   Ile (I) 5.97   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4461 entries are encoded on a mitochondrion, and 3639 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 73088