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         UniProtKB/Swiss-Prot protein knowledgebase release 2012_01 statistics


1.  INTRODUCTION

Release 2012_01 of 25-Jan-12 of UniProtKB/Swiss-Prot contains 534242 sequence entries,
comprising 189454791 amino acids abstracted from 206707 references. 

599 sequences have been added since release 2011_12, the sequence data of
161 existing entries has been updated and the annotations of
330457 entries have been revised.

Number of fragments: 8989
Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 30917


Protein existence (PE):           entries     %

1: Evidence at protein level        73864   13.8%
2: Evidence at transcript level     69920   13.1%
3: Inferred from homology          374128     70%
4: Predicted                        14450    2.7%
5: Uncertain                         1880    0.4%

The growth of the database is summarized below.

   


2.  TAXONOMIC ORIGIN

   Total number of species represented in this release of UniProtKB/Swiss-Prot: 12712

   The first twenty species represent 111093 sequences:  20.8 % of the total
   number of entries.


   2.1 Table of the frequency of occurrence of species

        Species represented 1x: 5357
                            2x: 1851
                            3x:  958
                            4x:  627
                            5x:  462
                            6x:  371
                            7x:  273
                            8x:  214
                            9x:  196
                           10x:  111
                       11- 20x:  654
                       21- 50x:  391
                       51-100x:  209
                         >100x: 1038


   2.2  Table of the most represented species

  ------  ---------  --------------------------------------------
  Number  Frequency  Species
  ------  ---------  --------------------------------------------
       1      20242  Homo sapiens (Human)
       2      16428  Mus musculus (Mouse)
       3      10910  Arabidopsis thaliana (Mouse-ear cress)
       4       7682  Rattus norvegicus (Rat)
       5       6619  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
       6       5879  Bos taurus (Bovine)
       7       4976  Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
       8       4430  Escherichia coli (strain K12)
       9       4244  Bacillus subtilis
      10       4122  Dictyostelium discoideum (Slime mold)
      11       3341  Caenorhabditis elegans
      12       3327  Xenopus laevis (African clawed frog)
      13       3137  Drosophila melanogaster (Fruit fly)
      14       2827  Oryza sativa subsp. japonica (Rice)
      15       2773  Danio rerio (Zebrafish) (Brachydanio rerio)
      16       2224  Gallus gallus (Chicken)
      17       2216  Pongo abelii (Sumatran orangutan)
      18       2011  Escherichia coli O157:H7
      19       1911  Mycobacterium tuberculosis
      20       1794  Salmonella typhimurium
      21       1787  Methanocaldococcus jannaschii  
      22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
      23       1678  Shigella flexneri
      24       1675  Escherichia coli O6
      25       1616  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
      26       1407  Sus scrofa (Pig)
      27       1346  Salmonella typhi
      28       1244  Mycobacterium bovis
      29       1221  Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
      30       1169  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
      31       1026  Synechocystis sp. (strain PCC 6803 / Kazusa)
      32       1011  Yersinia pestis
      33       1000  Archaeoglobus fulgidus 
      34        954  Vibrio cholerae
      35        930  Salmonella paratyphi A
      36        925  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
      37        925  Staphylococcus aureus (strain N315)
      38        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
      39        909  Acanthamoeba polyphaga mimivirus (APMV)
      40        901  Kluyveromyces lactis   
      41        899  Staphylococcus aureus (strain COL)
      42        895  Staphylococcus aureus (strain MW2)
      43        889  Staphylococcus aureus (strain MSSA476)
      44        888  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
      45        888  Staphylococcus aureus (strain MRSA252)
      46        884  Oryctolagus cuniculus (Rabbit)
      47        882  Salmonella choleraesuis
      48        878  Shigella sonnei (strain Ss046)
      49        868  Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
      50        864  Yersinia pseudotuberculosis
      51        861  Candida glabrata   
      52        841  Escherichia coli O9:H4 (strain HS)
      53        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
      54        829  Shigella boydii serotype 4 (strain Sb227)
      55        828  Neurospora crassa 
      56        824  Escherichia coli (strain UTI89 / UPEC)
      57        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
      58        817  Shigella dysenteriae serotype 1 (strain Sd197)
      59        799  Canis familiaris (Dog) (Canis lupus familiaris)
      60        795  Vibrio parahaemolyticus
      61        791  Escherichia coli (strain SMS-3-5 / SECEC)
      62        783  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
      63        776  Aquifex aeolicus (strain VF5)
      64        773  Pasteurella multocida (strain Pm70)
      65        771  Escherichia coli (strain K12 / DH10B)
      66        765  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
      67        765  Escherichia coli (strain K12 / MC4100 / BW2952)
      68        764  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
      69        763  Emericella nidulans  
      70        762  Escherichia coli (strain 55989 / EAEC)
      71        761  Escherichia coli O8 (strain IAI1)
      72        760  Shigella flexneri serotype 5b (strain 8401)
      73        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
      74        758  Streptomyces coelicolor
      75        757  Staphylococcus epidermidis (strain ATCC 12228)
      76        756  Escherichia coli (strain SE11)
      77        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
      78        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
      79        748  Escherichia coli O157:H7 (strain EC4115 / EHEC)
      80        743  Photorhabdus luminescens subsp. laumondii (strain TT01)
      81        735  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
      82        734  Bacillus halodurans 
      83        734  Staphylococcus aureus (strain NCTC 8325)
      84        733  Vibrio vulnificus
      85        731  Escherichia coli O81 (strain ED1a)
      86        730  Bacillus anthracis
      87        721  Salmonella enteritidis PT4 (strain P125109)
      88        717  Vibrio vulnificus (strain YJ016)
      89        716  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
      90        715  Yersinia pestis bv. Antiqua (strain Nepal516)
      91        714  Salmonella paratyphi A (strain AKU_12601)
      92        713  Enterobacter sp. (strain 638)
      93        713  Salmonella agona (strain SL483)
      94        713  Escherichia coli O1:K1 / APEC
      95        713  Salmonella newport (strain SL254)
      96        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
      97        712  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
      98        712  Salmonella schwarzengrund (strain CVM19633)
      99        711  Yersinia pestis bv. Antiqua (strain Antiqua)
     100        710  Salmonella heidelberg (strain SL476)
     101        702  Salmonella dublin (strain CT_02021853)
     102        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
     103        696  Klebsiella pneumoniae (strain 342)
     104        694  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
     105        689  Zea mays (Maize)
     106        687  Mycoplasma pneumoniae (strain ATCC 29342 / M129)
     107        687  Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
     108        687  Nostoc sp. (strain PCC 7120 / UTEX 2576)
     109        686  Pan troglodytes (Chimpanzee)
     110        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
     111        677  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
     112        675  Pseudomonas putida (strain KT2440)
     113        675  Pseudomonas syringae pv. tomato (strain DC3000)
     114        669  Serratia proteamaculans (strain 568)
     115        668  Mycobacterium leprae
     116        667  Yersinia pestis (strain Pestoides F)
     117        666  Staphylococcus aureus (strain USA300)
     118        658  Rhizobium sp. (strain NGR234)
     119        656  Bradyrhizobium japonicum
     120        653  Debaryomyces hansenii   
     121        646  Bacillus cereus (strain ATCC 14579 / DSM 31)
     122        643  Escherichia coli
     123        643  Staphylococcus aureus (strain bovine RF122 / ET3-1)
     124        641  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
     125        639  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
     126        638  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
     127        634  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
     128        629  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
     129        629  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
     130        628  Shewanella oneidensis
     131        621  Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
     132        615  Treponema pallidum (strain Nichols)
     133        612  Staphylococcus haemolyticus (strain JCSC1435)
     134        608  Methanobacterium thermoautotrophicum (strain Delta H)
     135        605  Rhizobium loti (strain MAFF303099) (Mesorhizobium loti)
     136        602  Listeria monocytogenes
     137        602  Staphylococcus saprophyticus subsp. saprophyticus 
     138        601  Salmonella paratyphi C (strain RKS4594)
     139        601  Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum)
     140        601  Photobacterium profundum (Photobacterium sp. (strain SS9))
     141        600  Yersinia pestis bv. Antiqua (strain Angola)
     142        600  Xanthomonas campestris pv. campestris
     143        590  Bacillus cereus (strain ATCC 10987)
     144        590  Listeria innocua
     145        589  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
     146        587  Oryza sativa subsp. indica (Rice)
     147        585  Rickettsia prowazekii (strain Madrid E)
     148        581  Neisseria meningitidis serogroup B
     149        576  Brucella suis biovar 1 (strain 1330)
     150        572  Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
     151        572  Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori)
     152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) 
     153        567  Bacillus thuringiensis subsp. konkukian (strain 97-27)
     154        565  Helicobacter pylori (strain J99) (Campylobacter pylori J99)
     155        565  Pseudomonas syringae pv. syringae (strain B728a)
     156        562  Caulobacter crescentus (Caulobacter vibrioides)
     157        562  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
     158        562  Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)
     159        561  Caenorhabditis briggsae
     160        560  Vibrio fischeri (strain ATCC 700601 / ES114)
     161        560  Bacillus cereus (strain ZK / E33L)
     162        558  Clostridium acetobutylicum
     163        558  Pseudomonas aeruginosa (strain UCBPP-PA14)
     164        556  Neisseria meningitidis serogroup A
     165        556  Xanthomonas axonopodis pv. citri (Citrus canker)
     166        552  Pseudomonas fluorescens (strain Pf0-1)
     167        551  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
     168        546  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
     169        544  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
     170        531  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
     171        530  Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
     172        529  Listeria monocytogenes serotype 4b (strain F2365)
     173        527  Streptococcus pneumoniae
     174        527  Sodalis glossinidius (strain morsitans)
     175        523  Thermotoga maritima
     176        522  Xylella fastidiosa
     177        520  Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 
     178        514  Chromobacterium violaceum
     179        512  Bordetella pertussis
     180        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
     181        511  Pseudomonas aeruginosa (strain PA7)
     182        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
     183        510  Haemophilus ducreyi (strain 35000HP / ATCC 700724)
     184        508  Bordetella parapertussis
     185        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
     186        507  Geobacillus kaustophilus (strain HTA426)
     187        506  Staphylococcus aureus (strain Newman)
     188        501  Deinococcus radiodurans
     189        500  Pseudomonas entomophila (strain L48)
     190        499  Brucella abortus biovar 1 (strain 9-941)
     191        497  Corynebacterium glutamicum (Brevibacterium flavum)
     192        497  Rickettsia conorii (strain ATCC VR-613 / Malish 7)
     193        496  Bacillus clausii (strain KSM-K16)
     194        494  Haemophilus influenzae (strain 86-028NP)
     195        494  Streptomyces avermitilis
     196        493  Burkholderia pseudomallei (Pseudomonas pseudomallei)
     197        492  Bacillus amyloliquefaciens (strain FZB42)
     198        491  Proteus mirabilis (strain HI4320)
     199        491  Xanthomonas campestris pv. campestris (strain 8004)
     200        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
     201        490  Clostridium perfringens
     202        487  Shewanella sp. (strain MR-7)
     203        485  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
     204        485  Mannheimia succiniciproducens (strain MBEL55E)
     205        484  Pseudomonas aeruginosa (strain LESB58)
     206        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
     207        484  Shewanella sp. (strain MR-4)
     208        483  Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
     209        480  Acinetobacter sp. (strain ADP1)
     210        478  Thermosynechococcus elongatus (strain BP-1)
     211        476  Enterococcus faecalis (Streptococcus faecalis)
     212        476  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
     213        475  Pyrococcus horikoshii 
     214        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
     215        474  Pseudomonas putida (strain F1 / ATCC 700007)
     216        473  Brucella abortus (strain 2308)
     217        473  Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
     218        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
     219        466  Shewanella frigidimarina (strain NCIMB 400)
     220        466  Pseudomonas putida (strain GB-1)
     221        465  Pyrococcus abyssi (strain GE5 / Orsay)
     222        464  Halobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) 
     223        463  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
     224        463  Shewanella sp. (strain ANA-3)
     225        463  Methanosarcina mazei  
     226        462  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
     227        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
     228        462  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
     229        462  Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009)
     230        461  Burkholderia mallei (Pseudomonas mallei)
     231        458  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
     232        458  Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
     233        455  Staphylococcus aureus (strain JH1)
     234        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
     235        453  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
     236        453  Pseudomonas putida (strain W619)
     237        453  Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi)
     238        452  Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
     239        452  Ovis aries (Sheep)
     240        452  Shewanella baltica (strain OS185)
     241        451  Aeromonas salmonicida (strain A449)
     242        450  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
     243        450  Streptococcus mutans
     244        449  Thermoanaerobacter tengcongensis  
     245        449  Staphylococcus aureus (strain JH9)
     246        448  Mycobacterium paratuberculosis
     247        448  Hahella chejuensis (strain KCTC 2396)
     248        447  Vibrio fischeri (strain MJ11)
     249        445  Nicotiana tabacum (Common tobacco)
     250        445  Pseudomonas mendocina (strain ymp)


   
   2.3  Taxonomic distribution of the sequences

   

   Kingdom        sequences (% of the database)
    Archaea           18732 (  4%)
    Bacteria         327591 ( 61%)
    Eukaryota        171909 ( 32%)
    Viruses           16010 (  3%)


   Within Eukaryota:

   

    Category            sequences (% of Eukaryota) (% of the complete database)
     Human                  20243 ( 12%)           (  4%)
     Other Mammalia         45362 ( 26%)           (  8%)
     Other Vertebrata       16862 ( 10%)           (  3%)
     Viridiplantae          32007 ( 19%)           (  6%)
     Fungi                  30520 ( 18%)           (  6%)
     Insecta                 8344 (  5%)           (  2%)
     Nematoda                4208 (  2%)           (  1%)
     Other                  14363 (  8%)           (  3%)



3.  SEQUENCE SIZE

   Repartition of the sequences by size (excluding fragments)

               From   To  Number             From   To   Number
                  1-  50    8679             1001-1100     3679
                 51- 100   41008             1101-1200     2558
                101- 150   57126             1201-1300     1991
                151- 200   57322             1301-1400     1847
                201- 250   56042             1401-1500     1492
                251- 300   49421             1501-1600      725
                301- 350   49579             1601-1700      543
                351- 400   42890             1701-1800      453
                401- 450   35196             1801-1900      416
                451- 500   28261             1901-2000      336
                501- 550   20053             2001-2100      206
                551- 600   14353             2101-2200      276
                601- 650   12122             2201-2300      287
                651- 700    8751             2301-2400      170
                701- 750    7194             2401-2500      136
                751- 800    5106             >2500         1061
                801- 850    4476
                851- 900    4971
                901- 950    3824
                951-1000    2703

   


   The average sequence length in UniProtKB/Swiss-Prot is 354 amino acids.

   The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
   The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.


4.  JOURNAL CITATIONS

   Note: the following citation statistics reflect the number of distinct
         journal citations.

   Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2212


   4.1 Table of the frequency of journal citations

        Journals cited 1x:  719
                       2x:  284
                       3x:  150
                       4x:  104
                       5x:  101
                       6x:   75
                       7x:   45
                       8x:   41
                       9x:   28
                      10x:   29
                  11- 20x:  174
                  21- 50x:  185
                  51-100x:  102
                    >100x:  175


   4.2  List of the most cited journals in UniProtKB/Swiss-Prot

   Nb    Citations   Journal name
   --    ---------   -------------------------------------------------------------
    1        19797   Journal of Biological Chemistry
    2         9026   Proceedings of the National Academy of Sciences of the U.S.A.
    3         5366   Journal of Bacteriology
    4         4841   Biochemical and Biophysical Research Communications
    5         4553   Gene
    6         4418   Nucleic Acids Research
    7         4182   FEBS Letters
    8         4178   Biochemistry
    9         4052   The EMBO Journal
   10         3781   Molecular and Cellular Biology
   11         3522   Nature
   12         3340   Journal of Molecular Biology
   13         3178   European Journal of Biochemistry
   14         3107   Biochimica et Biophysica Acta
   15         2909   Cell
   16         2496   Genomics
   17         2340   Journal of Virology
   18         2340   Biochemical Journal
   19         2317   Science
   20         1903   Molecular Microbiology
   21         1762   Journal of Cell Biology
   22         1610   Plant Physiology
   23         1565   Plant Molecular Biology
   24         1512   Genes and Development
   25         1495   Virology
   26         1467   The American Journal of Human Genetics
   27         1424   Nature Genetics
   28         1398   Human Molecular Genetics
   29         1372   Oncogene
   30         1318   Molecular and General Genetics
   31         1268   Development
   32         1211   Human Mutation
   33         1205   Journal of Biochemistry
   34         1189   Molecular Biology of the Cell
   35         1127   The Plant Cell
   36         1113   Journal of Immunology
   37         1048   Genetics
   38         1017   Molecular Cell
   39          994   Structure
   40          989   Journal of General Virology
   41          981   The Plant Journal
   42          916   Blood
   43          915   Infection and Immunity
   44          880   Archives of Biochemistry and Biophysics
   45          865   Journal of Cell Science
   46          793   Microbiology
   47          786   Developmental Biology
   48          779   Yeast
   49          766   Cancer Research
   50          741   Current Biology
   51          687   FEMS Microbiology Letters
   52          615   Human Genetics
   53          615   Nature Structural Biology
   54          615   Acta Crystallographica, Section D
   55          611   Mechanisms of Development
   56          609   Protein Science
   57          598   Journal of Neuroscience
   58          583   Applied and Environmental Microbiology
   59          566   Neuron
   60          564   Toxicon
   61          553   Journal of Clinical Investigation
   62          536   Current Genetics
   63          511   American Journal of Physiology
   64          503   The Journal of Experimental Medicine
   65          478   Mammalian Genome
   66          467   Molecular Endocrinology
   67          453   Immunogenetics
   68          443   Journal of Neurochemistry
   69          437   Proteins
   70          436   The Journal of Clinical Endocrinology and Metabolism
   71          426   Molecular and Biochemical Parasitology
   72          421   Endocrinology
   73          398   Bioscience, Biotechnology, and Biochemistry
   74          394   Nature Cell Biology
   75          389   Journal of Molecular Evolution
   76          387   Plant and Cell Physiology
   77          385   Journal of Medical Genetics
   78          373   DNA and Cell Biology
   79          368   Molecular Biology and Evolution
   80          361   DNA Sequence
   81          351   Experimental Cell Research
   82          325   Peptides
   83          323   Brain Research. Molecular Brain Research
   84          321   Tissue Antigens
   85          311   Comparative Biochemistry and Physiology
   86          294   PLoS ONE
   87          293   Biological Chemistry Hoppe-Seyler
   88          293   Antimicrobial Agents and Chemotherapy
   89          292   Journal of Investigative Dermatology
   90          288   Developmental Cell
   91          286   Molecular Pharmacology
   92          285   RNA
   93          277   Cytogenetics and Cell Genetics
   94          272   Biology of Reproduction
   95          271   Neurology
   96          261   Developmental Dynamics
   97          261   Virus Research
   98          257   Genome Research
   99          257   Planta
  100          255   The FEBS Journal
  101          253   Nature Structural and Molecular Biology
  102          252   Journal of General Microbiology
  103          242   Molecular Plant-Microbe Interactions
  104          233   Immunity
  105          227   EMBO Reports
  106          224   European Journal of Immunology
  107          219   Biochimie
  108          219   Genes to Cells
  109          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
  110          216   The New England Journal of Medicine
  111          216   Eukaryotic Cell
  112          216   Annals of Neurology
  113          212   The FASEB Journal
  114          210   European Journal of Human Genetics
  115          210   DNA Research
  116          199   Journal of Human Genetics
  117          186   Investigative Ophthalmology and Visual Science
  118          186   Archives of Virology
  119          182   Molecular and Cellular Endocrinology
  120          178   Archives of Microbiology
  121          172   American Journal of Medical Genetics. Part A
  122          171   Molecular Immunology
  123          170   BMC Genomics
  124          170   Journal of the American Chemical Society
  125          169   Insect Biochemistry and Molecular Biology
  126          169   Journal of Cellular Biochemistry
  127          168   Diabetes
  128          167   American Journal of Medical Genetics
  129          167   Molecular Phylogenetics and Evolution
  130          166   Glycobiology
  131          166   Clinical Genetics
  132          162   Nature Immunology
  133          159   DNA
  134          158   Journal of Medicinal Chemistry
  135          158   International Journal of Cancer
  136          156   Molecular Reproduction and Development
  137          155   Hemoglobin
  138          153   Bioorganicheskaia Khimiia
  139          149   Circulation Research
  140          146   Molecular Genetics and Metabolism
  141          145   Molecular and Cellular Neuroscience
  142          144   Biological Chemistry
  143          142   Molecular Genetics and Genomics
  144          139   British Journal of Haematology
  145          138   General and Comparative Endocrinology
  146          138   Animal Genetics
  147          135   Acta Crystallographica, Section F
  148          133   Phytochemistry
  149          132   Proteomics
  150          131   Journal of Lipid Research


5.  STATISTICS FOR SOME LINE TYPES

The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
as well as the number of entries with at least one such line, and the
frequency of the lines.

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry
------------------------------------  -------- ---------  ---------

References (RL)                      1003995                 1.88                                         
   Journal                            798602     408748      1.49       1                                 
   Submitted to EMBL/GenBank/DDBJ     196545     176490      0.37       2                                 
   Submitted to other databases         6706       6250      0.01       3                                 
   Book citation                         687        673     <0.01       4                                 
   Plant Gene Register                   576        564     <0.01       5                                 
   Thesis                                403        400     <0.01       6                                 
   Unpublished observations              284        280     <0.01       7                                 
   Patent                                186        183     <0.01       8                                 
   Worm Breeder's Gazette                  6          6     <0.01       9                                 

Total number of distinct authors cited in UniProtKB/Swiss-Prot: 316810

                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Comments (CC)                        2353047                 4.40                                         
   ALLERGEN                              512        512     <0.01      26                                 
   ALTERNATIVE PRODUCTS                20282      20282      0.04      13                                 
   BIOPHYSICOCHEMICAL PROPERTIES        3947       3947      0.01      23                                 
   BIOTECHNOLOGY                         321        319     <0.01      28                                 
   CATALYTIC ACTIVITY                 238186     216349      0.45       4                                 
   CAUTION                              7818       7663      0.01      19                                 
   COFACTOR                           103281      94921      0.19       7                                 
   DEVELOPMENTAL STAGE                  9493       9493      0.02      16                                 
   DISEASE                              4892       3287      0.01      21                                 
   DISRUPTION PHENOTYPE                 4272       4272      0.01      22                                 
   DOMAIN                              36538      32364      0.07      11                                 
   ENZYME REGULATION                   10264      10264      0.02      15                                 
   FUNCTION                           408943     392122      0.77       2                                 
   INDUCTION                           13784      13784      0.03      14                                 
   INTERACTION                          9090       9090      0.02      17                                 
   MASS SPECTROMETRY                    4994       3795      0.01      20                                 
   MISCELLANEOUS                       31099      28677      0.06      12                                 
   PATHWAY                            131097     118905      0.25       6                                 
   PHARMACEUTICAL                         85         85     <0.01      29                                 
   POLYMORPHISM                          847        801     <0.01      24                                 
   PTM                                 42179      33645      0.08       8                                 
   RNA EDITING                           623        623     <0.01      25                                 
   SEQUENCE CAUTION                    40183      40183      0.08       9                                 
   SIMILARITY                         629930     509409      1.18       1                                 
   SUBCELLULAR LOCATION               319235     313707      0.60       3                                 
   SUBUNIT                            235324     235324      0.44       5                                 
   TISSUE SPECIFICITY                  36602      36602      0.07      10                                 
   TOXIC DOSE                            492        478     <0.01      27                                 
   WEB RESOURCE                         8734       7006      0.02      18                                 

Total number of comment topics: 29


                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank
------------------------------------  -------- ---------  ---------  ----
Features (FT)                        3497675                 6.55                                         
   ACT_SITE                           134193      82036      0.25       9                                 
   BINDING                            245525      67022      0.46       4                                 
   CA_BIND                              3792       1568      0.01      35                                 
   CARBOHYD                           105748      26909      0.20      14                                 
   CHAIN                              540792     528441      1.01       1                                 
   COILED                              19693      13505      0.04      26                                 
   COMPBIAS                            52932      27947      0.10      18                                 
   CONFLICT                           124005      43485      0.23      11                                 
   CROSSLNK                             6274       3722      0.01      34                                 
   DISULFID                           103280      27911      0.19      15                                 
   DNA_BIND                            11279      10391      0.02      31                                 
   DOMAIN                             156166      93096      0.29       6                                 
   HELIX                              150804      15698      0.28       7                                 
   INIT_MET                            15155      15155      0.03      27                                 
   INTRAMEM                             1908        831     <0.01      38                                 
   LIPID                               11350       7203      0.02      30                                 
   METAL                              296378      72636      0.55       3                                 
   MOD_RES                            190760      62853      0.36       5                                 
   MOTIF                               34601      22285      0.06      24                                 
   MUTAGEN                             38202       8911      0.07      21                                 
   NON_CONS                             1968        729     <0.01      37                                 
   NON_STD                               353        278     <0.01      39                                 
   NON_TER                             12128       9260      0.02      29                                 
   NP_BIND                            113161      70933      0.21      12                                 
   PEPTIDE                              9760       6573      0.02      32                                 
   PROPEP                              12433      10689      0.02      28                                 
   REGION                             109670      58756      0.21      13                                 
   REPEAT                              92852      13749      0.17      16                                 
   SIGNAL                              37346      37336      0.07      22                                 
   SITE                                40677      24093      0.08      20                                 
   STRAND                             147649      14589      0.28       8                                 
   TOPO_DOM                           127083      26199      0.24      10                                 
   TRANSIT                              7887       7798      0.01      33                                 
   TRANSMEM                           351104      72317      0.66       2                                 
   TURN                                34797      12227      0.07      23                                 
   UNSURE                               2554        503     <0.01      36                                 
   VAR_SEQ                             41100      17717      0.08      19                                 
   VARIANT                             83170      16628      0.16      17                                 
   ZN_FING                             29146      12703      0.05      25                                 

Total number of feature keys: 39



                                      Total    Number of  Average
   Line type / subtype                number   entries    per entry  Rank      Category
------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
Cross-references (DR)               15234479                28.52                                                           
   2DBase-Ecoli                           85         85     <0.01     125      2D gel databases                             
   Aarhus/Ghent-2DPAGE                   126         96     <0.01     122      2D gel databases                             
   AGD                                   931        925     <0.01     100      Organism-specific databases                  
   Allergome                            1395        850     <0.01      96      Protein family/group databases               
   ANU-2DPAGE                             23         23     <0.01     131      2D gel databases                             
   ArachnoServer                         759        755     <0.01     106      Organism-specific databases                  
   ArrayExpress                        58837      58837      0.11      44      Gene expression databases                    
   Bgee                                40322      40322      0.08      48      Gene expression databases                    
   BindingDB                             296        296     <0.01     118      Other                                        
   BioCyc                             248347     239893      0.46      21      Enzyme and pathway databases                 
   BRENDA                               4237       4230      0.01      87      Enzyme and pathway databases                 
   CAZy                                 7456       6706      0.01      73      Protein family/group databases               
   CGD                                   666        646     <0.01     108      Organism-specific databases                  
   CleanEx                             30109      29466      0.06      51      Gene expression databases                    
   COMPLUYEAST-2DPAGE                     99         98     <0.01     124      2D gel databases                             
   ConoServer                            914        832     <0.01     102      Organism-specific databases                  
   Cornea-2DPAGE                          67         67     <0.01     126      2D gel databases                             
   CTD                                 67780      67172      0.13      41      Organism-specific databases                  
   CYGD                                 5594       5591      0.01      77      Organism-specific databases                  
   dictyBase                            4195       4079      0.01      88      Organism-specific databases                  
   DIP                                 13074      12967      0.02      67      Protein-protein interaction databases        
   DisProt                               397        394     <0.01     114      3D structure databases                       
   DMDM                                16778      16778      0.03      60      Polymorphism databases                       
   DOSAC-COBS-2DPAGE                     149        147     <0.01     121      2D gel databases                             
   DrugBank                             5318       1627      0.01      78      Other                                        
   EchoBASE                             4167       4163      0.01      89      Organism-specific databases                  
   ECO2DBASE                             352        300     <0.01     116      2D gel databases                             
   EcoGene                              4291       4289      0.01      86      Organism-specific databases                  
   eggNOG                             219871     219871      0.41      22      Phylogenomic databases                       
   EMBL                               914788     523836      1.71       3      Sequence databases                           
   Ensembl                             66636      48148      0.12      42      Genome annotation databases                  
   EnsemblBacteria                     97788      84867      0.18      31      Genome annotation databases                  
   EnsemblFungi                        15812      15535      0.03      62      Genome annotation databases                  
   EnsemblMetazoa                      10813       8187      0.02      69      Genome annotation databases                  
   EnsemblPlants                       15800      13475      0.03      63      Genome annotation databases                  
   EnsemblProtists                      4423       4299      0.01      85      Genome annotation databases                  
   euHCVdb                                55         44     <0.01     127      Organism-specific databases                  
   EuPathDB                              784        783     <0.01     103      Organism-specific databases                  
   FlyBase                              5827       5453      0.01      76      Organism-specific databases                  
   Gene3D                             327984     253252      0.61      16      Family and domain databases                  
   GeneCards                           19973      19666      0.04      56      Organism-specific databases                  
   GeneDB_Spombe                        4982       4940      0.01      80      Organism-specific databases                  
   GeneFarm                             3041       3027      0.01      92      Organism-specific databases                  
   GeneID                             485393     465920      0.91       6      Genome annotation databases                  
   GeneTree                           169266     169222      0.32      25      Phylogenomic databases                       
   Genevestigator                      66310      66310      0.12      43      Gene expression databases                    
   GenoList                             7063       7051      0.01      74      Organism-specific databases                  
   GenomeReviews                      375835     356269      0.70      11      Genome annotation databases                  
   GermOnline                          41904      41331      0.08      47      Gene expression databases                    
   GlycoSuiteDB                          272        272     <0.01     119      PTM databases                                
   GO                                2162492     501890      4.05       1      Ontologies                                   
   Gramene                              4714       4714      0.01      81      Organism-specific databases                  
   H-InvDB                             13204      12307      0.02      66      Organism-specific databases                  
   HAMAP                              311377     311201      0.58      17      Family and domain databases                  
   HGNC                                19756      19593      0.04      57      Organism-specific databases                  
   HOGENOM                            364566     364566      0.68      12      Phylogenomic databases                       
   HOVERGEN                            75042      75042      0.14      38      Phylogenomic databases                       
   HPA                                 15758      12091      0.03      65      Organism-specific databases                  
   HSSP                                30066      30066      0.06      52      3D structure databases                       
   InParanoid                          68174      68174      0.13      40      Phylogenomic databases                       
   IntAct                              32955      32955      0.06      50      Protein-protein interaction databases        
   InterPro                          1774242     509391      3.32       2      Family and domain databases                  
   IPI                                 92864      66094      0.17      34      Sequence databases                           
   KEGG                               457919     436314      0.86       8      Genome annotation databases                  
   KO                                 360478     360004      0.67      13      Family and domain databases                  
   LegioList                             763        761     <0.01     105      Organism-specific databases                  
   Leproma                               671        668     <0.01     107      Organism-specific databases                  
   MaizeGDB                              486        481     <0.01     112      Organism-specific databases                  
   MEROPS                              10258      10258      0.02      70      Protein family/group databases               
   MGI                                 16330      16285      0.03      61      Organism-specific databases                  
   MIM                                 17282      13219      0.03      59      Organism-specific databases                  
   MINT                                17579      17579      0.03      58      Protein-protein interaction databases        
   NextBio                             49223      49221      0.09      45      Other                                        
   neXtProt                            20019      20017      0.04      55      Organism-specific databases                  
   NMPDR                              133234     133222      0.25      29      Genome annotation databases                  
   OGP                                   377        377     <0.01     115      2D gel databases                             
   OMA                                384672     384672      0.72      10      Phylogenomic databases                       
   Orphanet                             3972       2408      0.01      90      Organism-specific databases                  
   OrthoDB                             77631      77575      0.15      37      Phylogenomic databases                       
   PANTHER                            199792     185656      0.37      24      Family and domain databases                  
   Pathway_Interaction_DB               4567       1665      0.01      84      Enzyme and pathway databases                 
   PATRIC                             308050     308033      0.58      19      Genome annotation databases                  
   PDB                                 81079      17652      0.15      36      3D structure databases                       
   PDBsum                              81079      17652      0.15      35      3D structure databases                       
   PeptideAtlas                         5164       5164      0.01      79      Proteomic databases                          
   PeroxiBase                            764        747     <0.01     104      Protein family/group databases               
   Pfam                               710283     495372      1.33       4      Family and domain databases                  
   PharmGKB                            15785      15461      0.03      64      Organism-specific databases                  
   PHCI-2DPAGE                           247        247     <0.01     120      2D gel databases                             
   PhosphoSite                         25205      25205      0.05      54      PTM databases                                
   PhosSite                              351        351     <0.01     117      PTM databases                                
   PhylomeDB                          169040     169040      0.32      26      Phylogenomic databases                       
   PIR                                117448     107393      0.22      30      Sequence databases                           
   PIRSF                               96267      96253      0.18      32      Family and domain databases                  
   PMAP-CutDB                           1400       1400     <0.01      95      Other                                        
   PMMA-2DPAGE                            52         52     <0.01     128      2D gel databases                             
   PptaseDB                               34         34     <0.01     129      Protein family/group databases               
   PRIDE                               72838      72838      0.14      39      Proteomic databases                          
   PRINTS                             137323     120194      0.26      28      Family and domain databases                  
   ProDom                              29191      29012      0.05      53      Family and domain databases                  
   ProMEX                                489        489     <0.01     111      Proteomic databases                          
   PROSITE                            474983     300698      0.89       7      Family and domain databases                  
   ProtClustDB                        341549     341549      0.64      14      Phylogenomic databases                       
   ProteinModelPortal                 428368     428368      0.80       9      3D structure databases                       
   PseudoCAP                            1229       1220     <0.01      98      Organism-specific databases                  
   Rat-heart-2DPAGE                       28         28     <0.01     130      2D gel databases                             
   Reactome                            10117       6407      0.02      71      Enzyme and pathway databases                 
   REBASE                                437        400     <0.01     113      Protein family/group databases               
   RefSeq                             506102     466037      0.95       5      Sequence databases                           
   REPRODUCTION-2DPAGE                  1256       1035     <0.01      97      2D gel databases                             
   RGD                                  7587       7583      0.01      72      Organism-specific databases                  
   SGD                                  6638       6633      0.01      75      Organism-specific databases                  
   Siena-2DPAGE                          102        102     <0.01     123      2D gel databases                             
   SMART                              165903     124225      0.31      27      Family and domain databases                  
   SMR                                210951     210951      0.39      23      3D structure databases                       
   STRING                             308395     308394      0.58      18      Protein-protein interaction databases        
   SUPFAM                             329486     261137      0.62      15      Family and domain databases                  
   SWISS-2DPAGE                         1183       1182     <0.01      99      2D gel databases                             
   TAIR                                10960      10874      0.02      68      Organism-specific databases                  
   TCDB                                 3595       3580      0.01      91      Protein family/group databases               
   TIGR                                34491      33713      0.06      49      Genome annotation databases                  
   TIGRFAMs                           288128     267830      0.54      20      Family and domain databases                  
   TubercuList                          1927       1891     <0.01      94      Organism-specific databases                  
   UCD-2DPAGE                            510        501     <0.01     110      2D gel databases                             
   UCSC                                47692      37139      0.09      46      Genome annotation databases                  
   UniGene                             95404      87513      0.18      33      Sequence databases                           
   VectorBase                            568        554     <0.01     109      Genome annotation databases                  
   World-2DPAGE                          918        907     <0.01     101      2D gel databases                             
   WormBase                             4688       3844      0.01      82      Organism-specific databases                  
   Xenbase                              4651       4646      0.01      83      Organism-specific databases                  
   ZFIN                                 2697       2685      0.01      93      Organism-specific databases                  

Total number of cross-referenced databases: 131

6.  AMINO ACID COMPOSITION

   6.1  Composition in percent for the complete database

   Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.55
   Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.85   Thr (T) 5.34
   Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
   Asp (D) 5.46   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
   Cys (C) 1.36   Ile (I) 5.97   Pro (P) 4.70   Val (V) 6.87

   Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00

   

   Legend: gray = aliphatic, red = acidic, green = small hydroxy,
           blue = basic, black = aromatic, white = amide, yellow = sulfur


   6.2  Classification of the amino acids by their frequency

   Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
   Phe, Tyr, Met, His, Cys, Trp


7.  MISCELLANEOUS STATISTICS

4461 entries are encoded on a mitochondrion, and 3637 are encoded on a plasmid.

12188 entries are encoded on a plastid, 
of which 21 are encoded on apicoplasts, 
11623 on chloroplasts, 
51 on organellar chromatophores,
145 on cyanelles, 
149 on non-photosynthetic plastids and 
199 on unspecified types of plastid.

Number of entries with at least one sequence correction: 72993