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                    UniProtKB/Swiss-Prot protein knowledgebase release 2011_07 statistics
                    
                    
                    1.  INTRODUCTION
                    
                    Release 2011_07 of 28-Jun-11 of UniProtKB/Swiss-Prot contains 530264 sequence entries,
                    comprising 187941074 amino acids abstracted from 199650 references. 
                    
                    1691 sequences have been added since release 2011_06, the sequence data of
                    144 existing entries has been updated and the annotations of
                    129194 entries have been revised.
                    
                    Number of fragments: 8899
                    Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 30506
                    
                    
                    Protein existence (PE):           entries     %
                    
                    1: Evidence at protein level        73427   13.8%
                    2: Evidence at transcript level     68948     13%
                    3: Inferred from homology          371577   70.1%
                    4: Predicted                        14446    2.7%
                    5: Uncertain                         1866    0.4%
                    
                    The growth of the database is summarized below.
                    
                    
                    
                    
                    2.  TAXONOMIC ORIGIN
                    
                    Total number of species represented in this release of UniProtKB/Swiss-Prot: 12539
                    
                    The first twenty species represent 110398 sequences:  20.8 % of the total
                    number of entries.
                    
                    
                    2.1 Table of the frequency of occurrence of species
                    
                    Species represented 1x: 5310
                    2x: 1822
                    3x:  949
                    4x:  620
                    5x:  449
                    6x:  360
                    7x:  257
                    8x:  216
                    9x:  193
                    10x:  109
                    11- 20x:  635
                    21- 50x:  387
                    51-100x:  200
                    >100x: 1032
                    
                    
                    2.2  Table of the most represented species
                    
                    ------  ---------  --------------------------------------------
                    Number  Frequency  Species
                    ------  ---------  --------------------------------------------
                    1      20237  Homo sapiens (Human)
                    2      16376  Mus musculus (Mouse)
                    3      10553  Arabidopsis thaliana (Mouse-ear cress)
                    4       7628  Rattus norvegicus (Rat)
                    5       6620  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
                    6       5855  Bos taurus (Bovine)
                    7       4976  Schizosaccharomyces pombe (strain ATCC 38366 / 972) (Fission yeast)
                    8       4430  Escherichia coli (strain K12)
                    9       4244  Bacillus subtilis
                    10       4129  Dictyostelium discoideum (Slime mold)
                    11       3332  Caenorhabditis elegans
                    12       3317  Xenopus laevis (African clawed frog)
                    13       3124  Drosophila melanogaster (Fruit fly)
                    14       2752  Oryza sativa subsp. japonica (Rice)
                    15       2742  Danio rerio (Zebrafish) (Brachydanio rerio)
                    16       2214  Pongo abelii (Sumatran orangutan)
                    17       2210  Gallus gallus (Chicken)
                    18       2000  Escherichia coli O157:H7
                    19       1872  Mycobacterium tuberculosis
                    20       1787  Methanocaldococcus jannaschii  
                    21       1784  Salmonella typhimurium
                    22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
                    23       1677  Shigella flexneri
                    24       1674  Escherichia coli O6
                    25       1608  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
                    26       1392  Sus scrofa (Pig)
                    27       1344  Salmonella typhi
                    28       1285  Pseudomonas aeruginosa
                    29       1243  Mycobacterium bovis
                    30       1167  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
                    31       1025  Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1)
                    32       1001  Yersinia pestis
                    33        997  Archaeoglobus fulgidus 
                    34        948  Vibrio cholerae
                    35        929  Salmonella paratyphi A
                    36        924  Staphylococcus aureus (strain N315)
                    37        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
                    38        916  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
                    39        913  Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
                    40        909  Acanthamoeba polyphaga mimivirus (APMV)
                    41        897  Staphylococcus aureus (strain COL)
                    42        895  Kluyveromyces lactis   
                    43        895  Staphylococcus aureus (strain MW2)
                    44        889  Staphylococcus aureus (strain MSSA476)
                    45        887  Staphylococcus aureus (strain MRSA252)
                    46        886  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
                    47        884  Oryctolagus cuniculus (Rabbit)
                    48        881  Salmonella choleraesuis
                    49        877  Shigella sonnei (strain Ss046)
                    50        864  Yersinia pseudotuberculosis
                    51        854  Candida glabrata   
                    52        846  Candida albicans (Yeast)
                    53        841  Escherichia coli O9:H4 (strain HS)
                    54        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
                    55        826  Shigella boydii serotype 4 (strain Sb227)
                    56        823  Escherichia coli (strain UTI89 / UPEC)
                    57        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
                    58        809  Shigella dysenteriae serotype 1 (strain Sd197)
                    59        804  Neurospora crassa 
                    60        795  Vibrio parahaemolyticus
                    61        791  Canis familiaris (Dog) (Canis lupus familiaris)
                    62        790  Escherichia coli (strain SMS-3-5 / SECEC)
                    63        779  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
                    64        774  Aquifex aeolicus
                    65        772  Pasteurella multocida (strain Pm70)
                    66        770  Escherichia coli (strain K12 / DH10B)
                    67        764  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
                    68        764  Escherichia coli (strain K12 / MC4100 / BW2952)
                    69        762  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
                    70        762  Escherichia coli (strain 55989 / EAEC)
                    71        761  Escherichia coli O8 (strain IAI1)
                    72        759  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
                    73        758  Shigella flexneri serotype 5b (strain 8401)
                    74        756  Escherichia coli (strain SE11)
                    75        756  Staphylococcus epidermidis (strain ATCC 12228)
                    76        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
                    77        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
                    78        753  Streptomyces coelicolor
                    79        751  Emericella nidulans (Aspergillus nidulans)
                    80        746  Escherichia coli O157:H7 (strain EC4115 / EHEC)
                    81        742  Photorhabdus luminescens subsp. laumondii (strain TT01)
                    82        733  Bacillus halodurans
                    83        733  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
                    84        731  Escherichia coli O81 (strain ED1a)
                    85        731  Vibrio vulnificus
                    86        726  Bacillus anthracis
                    87        720  Salmonella enteritidis PT4 (strain P125109)
                    88        716  Vibrio vulnificus (strain YJ016)
                    89        716  Staphylococcus aureus (strain NCTC 8325)
                    90        715  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
                    91        713  Yersinia pestis bv. Antiqua (strain Nepal516)
                    92        713  Salmonella paratyphi A (strain AKU_12601)
                    93        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
                    94        712  Salmonella agona (strain SL483)
                    95        712  Salmonella newport (strain SL254)
                    96        711  Escherichia coli O1:K1 / APEC
                    97        710  Salmonella heidelberg (strain SL476)
                    98        709  Yersinia pestis bv. Antiqua (strain Antiqua)
                    99        709  Salmonella schwarzengrund (strain CVM19633)
                    100        708  Enterobacter sp. (strain 638)
                    101        706  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
                    102        701  Salmonella dublin (strain CT_02021853)
                    103        698  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
                    104        693  Klebsiella pneumoniae (strain 342)
                    105        691  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
                    106        687  Mycoplasma pneumoniae
                    107        686  Pan troglodytes (Chimpanzee)
                    108        685  Nostoc sp. (strain PCC 7120 / UTEX 2576)
                    109        684  Pseudomonas syringae pv. tomato
                    110        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
                    111        679  Zea mays (Maize)
                    112        674  Pseudomonas putida (strain KT2440)
                    113        673  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
                    114        668  Mycobacterium leprae
                    115        666  Staphylococcus aureus (strain USA300)
                    116        666  Yersinia pestis (strain Pestoides F)
                    117        663  Serratia proteamaculans (strain 568)
                    118        658  Rhizobium sp. (strain NGR234)
                    119        650  Bradyrhizobium japonicum
                    120        646  Debaryomyces hansenii   
                    121        642  Bacillus cereus (strain ATCC 14579 / DSM 31)
                    122        642  Staphylococcus aureus (strain bovine RF122 / ET3-1)
                    123        640  Escherichia coli
                    124        637  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
                    125        637  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
                    126        633  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
                    127        629  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
                    128        626  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
                    129        621  Shewanella oneidensis
                    130        615  Treponema pallidum
                    131        615  Enterobacter sakazakii (strain ATCC BAA-894)
                    132        614  Ralstonia solanacearum (Pseudomonas solanacearum)
                    133        611  Staphylococcus haemolyticus (strain JCSC1435)
                    134        611  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
                    135        605  Rhizobium loti (Mesorhizobium loti)
                    136        605  Methanobacterium thermoautotrophicum (strain Delta H)
                    137        602  Staphylococcus saprophyticus subsp. saprophyticus 
                    138        600  Yersinia pestis bv. Antiqua (strain Angola)
                    139        600  Salmonella paratyphi C (strain RKS4594)
                    140        599  Listeria monocytogenes
                    141        598  Photobacterium profundum (Photobacterium sp. (strain SS9))
                    142        590  Bacillus cereus (strain ATCC 10987)
                    143        590  Xanthomonas campestris pv. campestris
                    144        589  Listeria innocua
                    145        586  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
                    146        585  Rickettsia prowazekii
                    147        584  Helicobacter pylori (Campylobacter pylori)
                    148        581  Lactococcus lactis subsp. lactis (Streptococcus lactis)
                    149        579  Neisseria meningitidis serogroup B
                    150        576  Brucella suis
                    151        572  Brucella melitensis
                    152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum 
                    153        569  Bacillus thuringiensis subsp. konkukian
                    154        565  Helicobacter pylori J99 (Campylobacter pylori J99)
                    155        565  Pseudomonas syringae pv. syringae (strain B728a)
                    156        562  Buchnera aphidicola subsp. Schizaphis graminum
                    157        561  Caulobacter crescentus (Caulobacter vibrioides)
                    158        561  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
                    159        560  Oryza sativa subsp. indica (Rice)
                    160        560  Bacillus cereus (strain ZK / E33L)
                    161        558  Pseudomonas aeruginosa (strain UCBPP-PA14)
                    162        556  Neisseria meningitidis serogroup A
                    163        556  Clostridium acetobutylicum
                    164        556  Xanthomonas axonopodis pv. citri (Citrus canker)
                    165        554  Vibrio fischeri (strain ATCC 700601 / ES114)
                    166        552  Pseudomonas fluorescens (strain Pf0-1)
                    167        551  Oceanobacillus iheyensis (strain DSM 14371 / JCM 11309 / KCTC 3954 / HTE831)
                    168        551  Caenorhabditis briggsae
                    169        545  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
                    170        543  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
                    171        529  Listeria monocytogenes serotype 4b (strain F2365)
                    172        526  Sodalis glossinidius (strain morsitans)
                    173        526  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
                    174        525  Streptococcus pneumoniae
                    175        522  Xylella fastidiosa
                    176        521  Bordetella bronchiseptica (Alcaligenes bronchisepticus)
                    177        517  Thermotoga maritima
                    178        513  Chromobacterium violaceum
                    179        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
                    180        511  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
                    181        507  Bordetella parapertussis
                    182        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
                    183        507  Pseudomonas aeruginosa (strain PA7)
                    184        507  Haemophilus ducreyi
                    185        507  Bordetella pertussis
                    186        507  Geobacillus kaustophilus
                    187        505  Staphylococcus aureus (strain Newman)
                    188        500  Pseudomonas entomophila (strain L48)
                    189        499  Deinococcus radiodurans
                    190        498  Brucella abortus
                    191        497  Rickettsia conorii
                    192        496  Bacillus clausii (strain KSM-K16)
                    193        494  Haemophilus influenzae (strain 86-028NP)
                    194        493  Corynebacterium glutamicum (Brevibacterium flavum)
                    195        493  Streptomyces avermitilis
                    196        491  Xanthomonas campestris pv. campestris (strain 8004)
                    197        490  Bacillus amyloliquefaciens (strain FZB42)
                    198        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
                    199        490  Clostridium perfringens
                    200        487  Burkholderia pseudomallei (Pseudomonas pseudomallei)
                    201        487  Shewanella sp. (strain MR-7)
                    202        484  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
                    203        484  Mannheimia succiniciproducens (strain MBEL55E)
                    204        484  Pseudomonas aeruginosa (strain LESB58)
                    205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
                    206        484  Shewanella sp. (strain MR-4)
                    207        483  Proteus mirabilis (strain HI4320)
                    208        483  Mycoplasma genitalium
                    209        475  Acinetobacter sp. (strain ADP1)
                    210        475  Thermosynechococcus elongatus (strain BP-1)
                    211        475  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
                    212        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
                    213        474  Pyrococcus horikoshii 
                    214        474  Enterococcus faecalis (Streptococcus faecalis)
                    215        473  Pseudomonas putida (strain F1 / ATCC 700007)
                    216        472  Brucella abortus (strain 2308)
                    217        467  Rhodopseudomonas palustris
                    218        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
                    219        465  Pyrococcus abyssi (strain GE5 / Orsay)
                    220        465  Pseudomonas putida (strain GB-1)
                    221        464  Lactobacillus plantarum
                    222        464  Shewanella frigidimarina (strain NCIMB 400)
                    223        463  Methanosarcina mazei  
                    224        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
                    225        462  Shewanella sp. (strain ANA-3)
                    226        461  Burkholderia mallei (Pseudomonas mallei)
                    227        461  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
                    228        460  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
                    229        460  Aspergillus oryzae (strain ATCC 42149 / RIB 40)
                    230        460  Halobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) 
                    231        459  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
                    232        458  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
                    233        455  Staphylococcus aureus (strain JH1)
                    234        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
                    235        453  Rickettsia felis (Rickettsia azadi)
                    236        452  Ovis aries (Sheep)
                    237        452  Shewanella baltica (strain OS185)
                    238        452  Pseudomonas putida (strain W619)
                    239        450  Methylococcus capsulatus
                    240        450  Streptococcus mutans
                    241        449  Staphylococcus aureus (strain JH9)
                    242        449  Aeromonas salmonicida (strain A449)
                    243        448  Thermoanaerobacter tengcongensis
                    244        448  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
                    245        447  Mycobacterium paratuberculosis
                    246        447  Vibrio fischeri (strain MJ11)
                    247        446  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
                    248        444  Nicotiana tabacum (Common tobacco)
                    249        444  Hahella chejuensis (strain KCTC 2396)
                    250        444  Pseudomonas mendocina (strain ymp)
                    
                    
                    
                    2.3  Taxonomic distribution of the sequences
                    
                    
                    
                    Kingdom        sequences (% of the database)
                    Archaea           18617 (  4%)
                    Bacteria         326045 ( 61%)
                    Eukaryota        169645 ( 32%)
                    Viruses           15957 (  3%)
                    
                    
                    Within Eukaryota:
                    
                    
                    
                    Category            sequences (% of Eukaryota) (% of the complete database)
                    Human                  20238 ( 12%)           (  4%)
                    Other Mammalia         45189 ( 27%)           (  9%)
                    Other Vertebrata       16714 ( 10%)           (  3%)
                    Viridiplantae          31318 ( 18%)           (  6%)
                    Fungi                  29756 ( 18%)           (  6%)
                    Insecta                 8269 (  5%)           (  2%)
                    Nematoda                4186 (  2%)           (  1%)
                    Other                  13975 (  8%)           (  3%)
                    
                    
                    
                    3.  SEQUENCE SIZE
                    
                    Repartition of the sequences by size (excluding fragments)
                    
                    From   To  Number             From   To   Number
                    1-  50    8642             1001-1100     3631
                    51- 100   40758             1101-1200     2545
                    101- 150   56914             1201-1300     1985
                    151- 200   56801             1301-1400     1840
                    201- 250   55698             1401-1500     1487
                    251- 300   48934             1501-1600      720
                    301- 350   49317             1601-1700      536
                    351- 400   42576             1701-1800      447
                    401- 450   34930             1801-1900      410
                    451- 500   28004             1901-2000      335
                    501- 550   19835             2001-2100      206
                    551- 600   14242             2101-2200      274
                    601- 650   11991             2201-2300      284
                    651- 700    8665             2301-2400      168
                    701- 750    7155             2401-2500      136
                    751- 800    5060             >2500         1058
                    801- 850    4437
                    851- 900    4944
                    901- 950    3751
                    951-1000    2649
                    
                    
                    
                    
                    The average sequence length in UniProtKB/Swiss-Prot is 354 amino acids.
                    
                    The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
                    The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.
                    
                    
                    4.  JOURNAL CITATIONS
                    
                    Note: the following citation statistics reflect the number of distinct
                    journal citations.
                    
                    Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2145
                    
                    
                    4.1 Table of the frequency of journal citations
                    
                    Journals cited 1x:  698
                    2x:  280
                    3x:  147
                    4x:  108
                    5x:   94
                    6x:   69
                    7x:   34
                    8x:   37
                    9x:   34
                    10x:   29
                    11- 20x:  166
                    21- 50x:  184
                    51-100x:   96
                    >100x:  169
                    
                    
                    4.2  List of the most cited journals in UniProtKB/Swiss-Prot
                    
                    Nb    Citations   Journal name
                    --    ---------   -------------------------------------------------------------
                    1        18860   Journal of Biological Chemistry
                    2         8741   Proceedings of the National Academy of Sciences of the U.S.A.
                    3         5221   Journal of Bacteriology
                    4         4702   Biochemical and Biophysical Research Communications
                    5         4539   Gene
                    6         4384   Nucleic Acids Research
                    7         4080   FEBS Letters
                    8         4071   Biochemistry
                    9         3911   The EMBO Journal
                    10         3580   Molecular and Cellular Biology
                    11         3410   Nature
                    12         3253   Journal of Molecular Biology
                    13         3151   European Journal of Biochemistry
                    14         3048   Biochimica et Biophysica Acta
                    15         2817   Cell
                    16         2491   Genomics
                    17         2246   Biochemical Journal
                    18         2235   Science
                    19         2227   Journal of Virology
                    20         1851   Molecular Microbiology
                    21         1670   Journal of Cell Biology
                    22         1545   Plant Molecular Biology
                    23         1529   Plant Physiology
                    24         1463   Genes and Development
                    25         1446   Virology
                    26         1378   The American Journal of Human Genetics
                    27         1374   Nature Genetics
                    28         1373   Human Molecular Genetics
                    29         1317   Molecular and General Genetics
                    30         1260   Oncogene
                    31         1237   Development
                    32         1186   Journal of Biochemistry
                    33         1163   Human Mutation
                    34         1117   Molecular Biology of the Cell
                    35         1072   The Plant Cell
                    36         1047   Journal of Immunology
                    37         1037   Genetics
                    38          973   Journal of General Virology
                    39          946   Structure
                    40          939   Molecular Cell
                    41          913   The Plant Journal
                    42          903   Infection and Immunity
                    43          854   Archives of Biochemistry and Biophysics
                    44          839   Blood
                    45          809   Journal of Cell Science
                    46          783   Microbiology
                    47          773   Yeast
                    48          762   Developmental Biology
                    49          707   Current Biology
                    50          705   Cancer Research
                    51          683   FEMS Microbiology Letters
                    52          610   Nature Structural Biology
                    53          607   Mechanisms of Development
                    54          605   Human Genetics
                    55          594   Acta Crystallographica, Section D
                    56          588   Protein Science
                    57          575   Applied and Environmental Microbiology
                    58          557   Journal of Neuroscience
                    59          542   Toxicon
                    60          530   Current Genetics
                    61          527   Neuron
                    62          526   Journal of Clinical Investigation
                    63          479   American Journal of Physiology
                    64          474   Mammalian Genome
                    65          462   The Journal of Experimental Medicine
                    66          452   Immunogenetics
                    67          451   Molecular Endocrinology
                    68          426   Molecular and Biochemical Parasitology
                    69          420   Journal of Neurochemistry
                    70          417   The Journal of Clinical Endocrinology and Metabolism
                    71          413   Proteins
                    72          409   Endocrinology
                    73          389   Bioscience, Biotechnology, and Biochemistry
                    74          384   Journal of Molecular Evolution
                    75          373   Journal of Medical Genetics
                    76          368   DNA and Cell Biology
                    77          366   Plant and Cell Physiology
                    78          363   Molecular Biology and Evolution
                    79          359   DNA Sequence
                    80          347   Nature Cell Biology
                    81          325   Experimental Cell Research
                    82          321   Tissue Antigens
                    83          318   Brain Research. Molecular Brain Research
                    84          317   Peptides
                    85          304   Comparative Biochemistry and Physiology
                    86          292   Biological Chemistry Hoppe-Seyler
                    87          292   Antimicrobial Agents and Chemotherapy
                    88          288   Journal of Investigative Dermatology
                    89          278   RNA
                    90          277   Cytogenetics and Cell Genetics
                    91          277   Developmental Cell
                    92          275   Molecular Pharmacology
                    93          267   Biology of Reproduction
                    94          263   Neurology
                    95          256   Virus Research
                    96          255   Genome Research
                    97          251   Journal of General Microbiology
                    98          249   Developmental Dynamics
                    99          247   Planta
                    100          240   Molecular Plant-Microbe Interactions
                    101          234   Nature Structural and Molecular Biology
                    102          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
                    103          214   Annals of Neurology
                    104          214   Genes to Cells
                    105          213   Eukaryotic cell
                    106          211   The FEBS Journal
                    107          210   Biochimie
                    108          210   European Journal of Immunology
                    109          210   Immunity
                    110          208   DNA Research
                    111          205   PLoS ONE
                    112          204   The New England Journal of Medicine
                    113          204   European Journal of Human Genetics
                    114          200   EMBO Reports
                    115          194   Journal of Human Genetics
                    116          192   The FASEB Journal
                    117          184   Archives of Virology
                    118          179   Molecular and Cellular Endocrinology
                    119          179   Investigative Ophthalmology and Visual Science
                    120          172   Archives of Microbiology
                    121          169   Insect Biochemistry and Molecular Biology
                    122          167   Molecular Immunology
                    123          167   American Journal of Medical Genetics
                    124          166   Molecular Phylogenetics and Evolution
                    125          159   Glycobiology
                    126          159   DNA
                    127          159   American Journal of Medical Genetics. Part A
                    128          157   BMC Genomics
                    129          157   Clinical Genetics
                    130          155   Molecular Reproduction and Development
                    131          155   Diabetes
                    132          153   Hemoglobin
                    133          152   Journal of the American Chemical Society
                    134          152   Bioorganicheskaia Khimiia
                    135          150   Journal of Cellular Biochemistry
                    136          149   International Journal of Cancer
                    137          142   Nature Immunology
                    138          142   Molecular Genetics and Metabolism
                    139          141   Molecular Genetics and Genomics
                    140          140   Molecular and Cellular Neuroscience
                    141          138   Animal Genetics
                    142          137   General and Comparative Endocrinology
                    143          137   British Journal of Haematology
                    144          136   Biological Chemistry
                    145          131   Journal of Medicinal Chemistry
                    146          131   Journal of Lipid Research
                    147          129   Proteomics
                    148          126   Thrombosis and Haemostasis
                    149          126   Circulation Research
                    150          124   Protein Expression and Purification
                    
                    
                    5.  STATISTICS FOR SOME LINE TYPES
                    
                    The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
                    as well as the number of entries with at least one such line, and the
                    frequency of the lines.
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry
                    ------------------------------------  -------- ---------  ---------
                    
                    References (RL)                       971392                 1.83        
                    Journal                            776052     402913      1.46       1
                    Submitted to EMBL/GenBank/DDBJ     186654     171631      0.35       2
                    Submitted to other databases         6589       6146      0.01       3
                    Book citation                         646        632     <0.01       4
                    Plant Gene Register                   569        557     <0.01       5
                    Thesis402        399     <0.01       6
                    Unpublished observations              293        289     <0.01       7
                    Patent181        178     <0.01       8
                    Worm Breeder's Gazette                  6          6     <0.01       9
                    
                    Total number of distinct authors cited in UniProtKB/Swiss-Prot: 305203
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Comments (CC)                        2317254                 4.37        
                    ALLERGEN                              504        504     <0.01      26
                    ALTERNATIVE PRODUCTS                20048      20048      0.04      13
                    BIOPHYSICOCHEMICAL PROPERTIES        3682       3682      0.01      23
                    BIOTECHNOLOGY                         316        314     <0.01      28
                    CATALYTIC ACTIVITY                 232357     211690      0.44       4
                    CAUTION                              7668       7515      0.01      19
                    COFACTOR                           102327      94019      0.19       7
                    DEVELOPMENTAL STAGE                  9306       9306      0.02      17
                    DISEASE                              4600       3109      0.01      21
                    DISRUPTION PHENOTYPE                 3785       3785      0.01      22
                    DOMAIN                              34932      30909      0.07      11
                    ENZYME REGULATION                    9641       9641      0.02      16
                    FUNCTION                           402693     385998      0.76       2
                    INDUCTION                           13149      13149      0.02      14
                    INTERACTION                         13061      13061      0.02      15
                    MASS SPECTROMETRY                    4856       3692      0.01      20
                    MISCELLANEOUS                       31246      28835      0.06      12
                    PATHWAY                            129457     118101      0.24       6
                    PHARMACEUTICAL                         85         85     <0.01      29
                    POLYMORPHISM                          831        790     <0.01      24
                    PTM38700      31027      0.07       9
                    RNA EDITING                           621        621     <0.01      25
                    SEQUENCE CAUTION                    39585      39585      0.07       8
                    SIMILARITY                         624659     505420      1.18       1
                    SUBCELLULAR LOCATION               313705     308253      0.59       3
                    SUBUNIT                            230556     230556      0.43       5
                    TISSUE SPECIFICITY                  35708      35708      0.07      10
                    TOXIC DOSE                            468        454     <0.01      27
                    WEB RESOURCE                         8708       6988      0.02      18
                    
                    Total number of comment topics: 29
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Features (FT)                        3423527                 6.46        
                    ACT_SITE                           133438      80430      0.25       9
                    BINDING                            230039      64518      0.43       4
                    CA_BIND                              3783       1563      0.01      35
                    CARBOHYD                           103995      26347      0.20      14
                    CHAIN                              536884     524643      1.01       1
                    COILED                              19424      13293      0.04      26
                    COMPBIAS                            52262      27502      0.10      18
                    CONFLICT                           120347      42267      0.23      11
                    CROSSLNK                             6092       3627      0.01      34
                    DISULFID                           101650      27396      0.19      15
                    DNA_BIND                            11185      10308      0.02      30
                    DOMAIN                             154746      92463      0.29       6
                    HELIX                              145379      15157      0.27       7
                    INIT_MET                            15021      15021      0.03      27
                    INTRAMEM                             1890        824     <0.01      38
                    LIPID                               10985       6972      0.02      31
                    METAL                              292233      71441      0.55       3
                    MOD_RES                            185346      61085      0.35       5
                    MOTIF                               34201      22019      0.06      23
                    MUTAGEN                             35756       8397      0.07      22
                    NON_CONS                             1981        733     <0.01      37
                    NON_STD                               352        277     <0.01      39
                    NON_TER                             12046       9167      0.02      29
                    NP_BIND                            112086      70557      0.21      12
                    PEPTIDE                              9556       6394      0.02      32
                    PROPEP                              12170      10437      0.02      28
                    REGION                             104508      56080      0.20      13
                    REPEAT                              92081      13619      0.17      16
                    SIGNAL                              36728      36718      0.07      21
                    SITE39633      23357      0.07      20
                    STRAND                             142997      14103      0.27       8
                    TOPO_DOM                           123128      25211      0.23      10
                    TRANSIT                              7621       7534      0.01      33
                    TRANSMEM                           346372      71160      0.65       2
                    TURN33784      11845      0.06      24
                    UNSURE                               2515        498     <0.01      36
                    VAR_SEQ                             40621      17500      0.08      19
                    VARIANT                             81667      16554      0.15      17
                    ZN_FING                             29025      12607      0.05      25
                    
                    Total number of feature keys: 39
                    
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank      Category
                    ------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
                    Cross-references (DR)               14325753                27.02                          
                    2DBase-Ecoli                           85         85     <0.01     122      2D gel databases                             
                    Aarhus/Ghent-2DPAGE                   126         96     <0.01     119      2D gel databases                             
                    AGD  922        916     <0.01      97      Organism-specific databases                  
                    Allergome                            1348        816     <0.01      93      Protein family/group databases               
                    ANU-2DPAGE                             23         23     <0.01     128      2D gel databases                             
                    ArachnoServer                         759        755     <0.01     101      Organism-specific databases                  
                    ArrayExpress                        58682      58682      0.11      42      Gene expression databases                    
                    Bgee40079      40076      0.08      46      Gene expression databases                    
                    BindingDB                             296        296     <0.01     115      Other       
                    BioCyc                             252511     243893      0.48      19      Enzyme and pathway databases                 
                    BRENDA                               4193       4187      0.01      84      Enzyme and pathway databases                 
                    CAZy7389       6642      0.01      70      Protein family/group databases               
                    CGD  610        600     <0.01     105      Organism-specific databases                  
                    CleanEx                             30119      29476      0.06      48      Gene expression databases                    
                    COMPLUYEAST-2DPAGE                    101        100     <0.01     121      2D gel databases                             
                    ConoServer                            762        736     <0.01      99      Organism-specific databases                  
                    Cornea-2DPAGE                          67         67     <0.01     123      2D gel databases                             
                    CTD66245      65678      0.12      40      Organism-specific databases                  
                    CYGD5594       5591      0.01      74      Organism-specific databases                  
                    dictyBase                            3992       3992      0.01      86      Organism-specific databases                  
                    DIP12538      12416      0.02      64      Protein-protein interaction databases        
                    DisProt                               397        394     <0.01     111      3D structure databases                       
                    DOSAC-COBS-2DPAGE                     149        147     <0.01     118      2D gel databases                             
                    DrugBank                             5318       1627      0.01      75      Other       
                    EchoBASE                             4167       4163      0.01      85      Organism-specific databases                  
                    ECO2DBASE                             352        300     <0.01     113      2D gel databases                             
                    EcoGene                              4291       4289      0.01      83      Organism-specific databases                  
                    eggNOG                             218985     218985      0.41      20      Phylogenomic databases                       
                    EMBL                               889198     519954      1.68       3      Sequence databases                           
                    Ensembl                             68495      50072      0.13      38      Genome annotation databases                  
                    EnsemblBacteria                     98222      84938      0.19      29      Genome annotation databases                  
                    EnsemblFungi                        15054      14964      0.03      61      Genome annotation databases                  
                    EnsemblMetazoa                      11349       8723      0.02      65      Genome annotation databases                  
                    EnsemblPlants                       16135      14006      0.03      59      Genome annotation databases                  
                    EnsemblProtists                      4401       4284      0.01      82      Genome annotation databases                  
                    euHCVdb55         44     <0.01     124      Organism-specific databases                  
                    EuPathDB                              742        742     <0.01     102      Organism-specific databases                  
                    FlyBase                              5798       5424      0.01      73      Organism-specific databases                  
                    Gene3D                             321077     248718      0.61      16      Family and domain databases                  
                    GeneCards                           20231      19671      0.04      53      Organism-specific databases                  
                    GeneDB_Spombe                        4982       4940      0.01      77      Organism-specific databases                  
                    GeneFarm                             2983       2969      0.01      89      Organism-specific databases                  
                    GeneID                             478785     459322      0.90       6      Genome annotation databases                  
                    GeneTree                           168624     168581      0.32      23      Phylogenomic databases                       
                    Genevestigator                      65962      65962      0.12      41      Gene expression databases                    
                    GenoList                             7056       7044      0.01      71      Organism-specific databases                  
                    GenomeReviews                      376400     356493      0.71      10      Genome annotation databases                  
                    GermOnline                          41913      41339      0.08      45      Gene expression databases                    
                    GlycoSuiteDB                          272        272     <0.01     116      PTM databases
                    GO2126747     496385      4.01       1      Ontologies  
                    Gramene                              4642       4642      0.01      80      Organism-specific databases                  
                    H-InvDB                             13206      12309      0.02      63      Organism-specific databases                  
                    HAMAP                              309590     309443      0.58      17      Family and domain databases                  
                    HGNC19720      19559      0.04      55      Organism-specific databases                  
                    HOGENOM                            363750     363750      0.69      12      Phylogenomic databases                       
                    HOVERGEN                            74906      74906      0.14      36      Phylogenomic databases                       
                    HPA13302      10016      0.03      62      Organism-specific databases                  
                    HSSP29814      29814      0.06      49      3D structure databases                       
                    InParanoid                          67787      67787      0.13      39      Phylogenomic databases                       
                    IntAct                              25596      25596      0.05      51      Protein-protein interaction databases        
                    InterPro                          1760751     504550      3.32       2      Family and domain databases                  
                    IPI91718      65555      0.17      31      Sequence databases                           
                    KEGG                               452050     430767      0.85       8      Genome annotation databases                  
                    LegioList                             761        759     <0.01     100      Organism-specific databases                  
                    Leproma                               671        668     <0.01     104      Organism-specific databases                  
                    MaizeGDB                              477        473     <0.01     109      Organism-specific databases                  
                    MEROPS                              10555      10224      0.02      67      Protein family/group databases               
                    MGI16277      16232      0.03      58      Organism-specific databases                  
                    MIM16802      13020      0.03      57      Organism-specific databases                  
                    MINT17585      17585      0.03      56      Protein-protein interaction databases        
                    NextBio                             49033      49031      0.09      43      Other       
                    neXtProt                            20045      20043      0.04      54      Organism-specific databases                  
                    NMPDR                              132386     132381      0.25      26      Genome annotation databases                  
                    OGP  377        377     <0.01     112      2D gel databases                             
                    OMA371805     371805      0.70      11      Phylogenomic databases                       
                    Orphanet                             3877       2340      0.01      87      Organism-specific databases                  
                    OrthoDB                             77057      77001      0.15      33      Phylogenomic databases                       
                    PANTHER                            169223     160892      0.32      22      Family and domain databases                  
                    Pathway_Interaction_DB               4567       1665      0.01      81      Enzyme and pathway databases                 
                    PDB76461      16952      0.14      35      3D structure databases                       
                    PDBsum                              76461      16952      0.14      34      3D structure databases                       
                    PeptideAtlas                         5164       5164      0.01      76      Proteomic databases                          
                    PeroxiBase                            737        726     <0.01     103      Protein family/group databases               
                    Pfam                               702487     491699      1.32       4      Family and domain databases                  
                    PharmGKB                            15409      15103      0.03      60      Organism-specific databases                  
                    PHCI-2DPAGE                           247        247     <0.01     117      2D gel databases                             
                    PhosphoSite                         23768      23768      0.04      52      PTM databases
                    PhosSite                              351        351     <0.01     114      PTM databases
                    PhylomeDB                          122957     122957      0.23      27      Phylogenomic databases                       
                    PIR116973     106952      0.22      28      Sequence databases                           
                    PIRSF                               86487      86487      0.16      32      Family and domain databases                  
                    PMAP-CutDB                           1396       1396     <0.01      92      Other       
                    PMMA-2DPAGE                            52         52     <0.01     125      2D gel databases                             
                    PptaseDB                               34         34     <0.01     126      Protein family/group databases               
                    PRIDE                               69470      69470      0.13      37      Proteomic databases                          
                    PRINTS                             138396     119995      0.26      25      Family and domain databases                  
                    ProDom                              27856      27677      0.05      50      Family and domain databases                  
                    ProMEX479        479     <0.01     108      Proteomic databases                          
                    PROSITE                            470883     298690      0.89       7      Family and domain databases                  
                    ProtClustDB                        340710     340710      0.64      14      Phylogenomic databases                       
                    ProteinModelPortal                 425594     425594      0.80       9      3D structure databases                       
                    PseudoCAP                            1224       1215     <0.01      95      Organism-specific databases                  
                    Rat-heart-2DPAGE                       28         28     <0.01     127      2D gel databases                             
                    Reactome                             9367       5611      0.02      68      Enzyme and pathway databases                 
                    REBASE442        399     <0.01     110      Protein family/group databases               
                    RefSeq                             502717     459600      0.95       5      Sequence databases                           
                    REPRODUCTION-2DPAGE                  1256       1035     <0.01      94      2D gel databases                             
                    RGD 7531       7527      0.01      69      Organism-specific databases                  
                    SGD 6638       6633      0.01      72      Organism-specific databases                  
                    Siena-2DPAGE                          102        102     <0.01     120      2D gel databases                             
                    SMART                              156744     119344      0.30      24      Family and domain databases                  
                    SMR349691     349691      0.66      13      3D structure databases                       
                    STRING                             206310     206275      0.39      21      Protein-protein interaction databases        
                    SUPFAM                             324589     258281      0.61      15      Family and domain databases                  
                    SWISS-2DPAGE                         1184       1183     <0.01      96      2D gel databases                             
                    TAIR10606      10520      0.02      66      Organism-specific databases                  
                    TCDB3575       3561      0.01      88      Protein family/group databases               
                    TIGR34354      33581      0.06      47      Genome annotation databases                  
                    TIGRFAMs                           286275     266228      0.54      18      Family and domain databases                  
                    TubercuList                          1889       1853     <0.01      91      Organism-specific databases                  
                    UCD-2DPAGE                            510        501     <0.01     107      2D gel databases                             
                    UCSC48629      39664      0.09      44      Genome annotation databases                  
                    UniGene                             93399      85908      0.18      30      Sequence databases                           
                    VectorBase                            537        524     <0.01     106      Genome annotation databases                  
                    World-2DPAGE                          917        906     <0.01      98      2D gel databases                             
                    WormBase                             4643       3820      0.01      79      Organism-specific databases                  
                    Xenbase                              4644       4622      0.01      78      Organism-specific databases                  
                    ZFIN2669       2657      0.01      90      Organism-specific databases                  
                    
                    Total number of cross-referenced databases: 128
                    
                    6.  AMINO ACID COMPOSITION
                    
                    6.1  Composition in percent for the complete database
                    
                    Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.54
                    Arg (R) 5.53   Glu (E) 6.76   Lys (K) 5.85   Thr (T) 5.34
                    Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
                    Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
                    Cys (C) 1.36   Ile (I) 5.97   Pro (P) 4.70   Val (V) 6.87
                    
                    Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00
                    
                    
                    
                    Legend: gray = aliphatic, red = acidic, green = small hydroxy,
                    blue = basic, black = aromatic, white = amide, yellow = sulfur
                    
                    
                    6.2  Classification of the amino acids by their frequency
                    
                    Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
                    Phe, Tyr, Met, His, Cys, Trp
                    
                    
                    7.  MISCELLANEOUS STATISTICS
                    
                    4446 entries are encoded on a mitochondrion, and 3622 are encoded on a plasmid.
                    
                    12182 entries are encoded on a plastid, 
                    of which 21 are encoded on apicoplasts, 
                    11618 on chloroplasts, 
                    50 on organellar chromatophores,
                    145 on cyanelles, 
                    149 on non-photosynthetic plastids and 
                    199 on unspecified types of plastid.
                    
                    Number of entries with at least one sequence correction: 71424