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                    UniProtKB/Swiss-Prot protein knowledgebase release 2011_06 statistics
                    
                    
                    1.  INTRODUCTION
                    
                    Release 2011_06 of 31-May-11 of UniProtKB/Swiss-Prot contains 529056 sequence entries,
                    comprising 187423367 amino acids abstracted from 198689 references. 
                    
                    1032 sequences have been added since release 2011_05, the sequence data of
                    178 existing entries has been updated and the annotations of
                    321084 entries have been revised.
                    
                    Number of fragments: 8886
                    Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 30393
                    
                    
                    Protein existence (PE):           entries     %
                    
                    1: Evidence at protein level        73155   13.8%
                    2: Evidence at transcript level     68818     13%
                    3: Inferred from homology          370825   70.1%
                    4: Predicted                        14391    2.7%
                    5: Uncertain                         1867    0.4%
                    
                    The growth of the database is summarized below.
                    
                    
                    
                    
                    2.  TAXONOMIC ORIGIN
                    
                    Total number of species represented in this release of UniProtKB/Swiss-Prot: 12510
                    
                    The first twenty species represent 110202 sequences:  20.8 % of the total
                    number of entries.
                    
                    
                    2.1 Table of the frequency of occurrence of species
                    
                    Species represented 1x: 5302
                    2x: 1815
                    3x:  946
                    4x:  617
                    5x:  452
                    6x:  363
                    7x:  256
                    8x:  214
                    9x:  194
                    10x:  107
                    11- 20x:  628
                    21- 50x:  387
                    51-100x:  199
                    >100x: 1030
                    
                    
                    2.2  Table of the most represented species
                    
                    ------  ---------  --------------------------------------------
                    Number  Frequency  Species
                    ------  ---------  --------------------------------------------
                    1      20235  Homo sapiens (Human)
                    2      16370  Mus musculus (Mouse)
                    3      10466  Arabidopsis thaliana (Mouse-ear cress)
                    4       7617  Rattus norvegicus (Rat)
                    5       6561  Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
                    6       5847  Bos taurus (Bovine)
                    7       4976  Schizosaccharomyces pombe (strain ATCC 38366 / 972) (Fission yeast)
                    8       4430  Escherichia coli (strain K12)
                    9       4244  Bacillus subtilis
                    10       4158  Dictyostelium discoideum (Slime mold)
                    11       3332  Caenorhabditis elegans
                    12       3313  Xenopus laevis (African clawed frog)
                    13       3123  Drosophila melanogaster (Fruit fly)
                    14       2737  Danio rerio (Zebrafish) (Brachydanio rerio)
                    15       2714  Oryza sativa subsp. japonica (Rice)
                    16       2214  Pongo abelii (Sumatran orangutan)
                    17       2208  Gallus gallus (Chicken)
                    18       1998  Escherichia coli O157:H7
                    19       1872  Mycobacterium tuberculosis
                    20       1787  Methanocaldococcus jannaschii  
                    21       1781  Salmonella typhimurium
                    22       1707  Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
                    23       1674  Shigella flexneri
                    24       1672  Escherichia coli O6
                    25       1602  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
                    26       1388  Sus scrofa (Pig)
                    27       1342  Salmonella typhi
                    28       1285  Pseudomonas aeruginosa
                    29       1243  Mycobacterium bovis
                    30       1167  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
                    31       1025  Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1)
                    32       1000  Yersinia pestis
                    33        997  Archaeoglobus fulgidus 
                    34        946  Vibrio cholerae
                    35        929  Salmonella paratyphi A
                    36        924  Staphylococcus aureus (strain N315)
                    37        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
                    38        913  Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti)
                    39        909  Acanthamoeba polyphaga mimivirus (APMV)
                    40        907  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
                    41        897  Staphylococcus aureus (strain COL)
                    42        895  Staphylococcus aureus (strain MW2)
                    43        889  Staphylococcus aureus (strain MSSA476)
                    44        887  Staphylococcus aureus (strain MRSA252)
                    45        885  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
                    46        884  Oryctolagus cuniculus (Rabbit)
                    47        883  Kluyveromyces lactis   
                    48        881  Salmonella choleraesuis
                    49        876  Shigella sonnei (strain Ss046)
                    50        864  Yersinia pseudotuberculosis
                    51        844  Candida albicans (Yeast)
                    52        841  Escherichia coli O9:H4 (strain HS)
                    53        840  Candida glabrata   
                    54        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
                    55        826  Shigella boydii serotype 4 (strain Sb227)
                    56        823  Escherichia coli (strain UTI89 / UPEC)
                    57        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
                    58        809  Shigella dysenteriae serotype 1 (strain Sd197)
                    59        804  Neurospora crassa
                    60        794  Vibrio parahaemolyticus
                    61        790  Escherichia coli (strain SMS-3-5 / SECEC)
                    62        786  Canis familiaris (Dog) (Canis lupus familiaris)
                    63        779  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
                    64        778  Pasteurella multocida
                    65        774  Aquifex aeolicus
                    66        770  Escherichia coli (strain K12 / DH10B)
                    67        764  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
                    68        764  Escherichia coli (strain K12 / MC4100 / BW2952)
                    69        762  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
                    70        762  Escherichia coli (strain 55989 / EAEC)
                    71        761  Escherichia coli O8 (strain IAI1)
                    72        758  Shigella flexneri serotype 5b (strain 8401)
                    73        757  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
                    74        756  Escherichia coli (strain SE11)
                    75        756  Staphylococcus epidermidis (strain ATCC 12228)
                    76        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
                    77        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
                    78        753  Streptomyces coelicolor
                    79        750  Emericella nidulans (Aspergillus nidulans)
                    80        746  Escherichia coli O157:H7 (strain EC4115 / EHEC)
                    81        741  Photorhabdus luminescens subsp. laumondii
                    82        732  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
                    83        731  Escherichia coli O81 (strain ED1a)
                    84        731  Bacillus halodurans
                    85        731  Vibrio vulnificus
                    86        724  Bacillus anthracis
                    87        720  Salmonella enteritidis PT4 (strain P125109)
                    88        716  Vibrio vulnificus (strain YJ016)
                    89        715  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
                    90        714  Staphylococcus aureus (strain NCTC 8325)
                    91        713  Yersinia pestis bv. Antiqua (strain Nepal516)
                    92        713  Salmonella paratyphi A (strain AKU_12601)
                    93        713  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
                    94        712  Salmonella agona (strain SL483)
                    95        712  Salmonella newport (strain SL254)
                    96        711  Escherichia coli O1:K1 / APEC
                    97        710  Salmonella heidelberg (strain SL476)
                    98        709  Yersinia pestis bv. Antiqua (strain Antiqua)
                    99        709  Salmonella schwarzengrund (strain CVM19633)
                    100        707  Enterobacter sp. (strain 638)
                    101        706  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
                    102        700  Salmonella dublin (strain CT_02021853)
                    103        697  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
                    104        692  Klebsiella pneumoniae (strain 342)
                    105        689  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
                    106        687  Mycoplasma pneumoniae
                    107        686  Pan troglodytes (Chimpanzee)
                    108        685  Nostoc sp. (strain PCC 7120 / UTEX 2576)
                    109        684  Pseudomonas syringae pv. tomato
                    110        683  Salmonella gallinarum (strain 287/91 / NCTC 13346)
                    111        679  Zea mays (Maize)
                    112        673  Pseudomonas putida (strain KT2440)
                    113        672  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
                    114        668  Mycobacterium leprae
                    115        666  Staphylococcus aureus (strain USA300)
                    116        666  Yersinia pestis (strain Pestoides F)
                    117        662  Serratia proteamaculans (strain 568)
                    118        658  Rhizobium sp. (strain NGR234)
                    119        650  Bradyrhizobium japonicum
                    120        646  Debaryomyces hansenii   
                    121        642  Staphylococcus aureus (strain bovine RF122 / ET3-1)
                    122        640  Escherichia coli
                    123        639  Bacillus cereus (strain ATCC 14579 / DSM 31)
                    124        637  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
                    125        636  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
                    126        633  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
                    127        630  Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)
                    128        626  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
                    129        621  Shewanella oneidensis
                    130        615  Treponema pallidum
                    131        614  Enterobacter sakazakii (strain ATCC BAA-894)
                    132        614  Ralstonia solanacearum (Pseudomonas solanacearum)
                    133        611  Staphylococcus haemolyticus (strain JCSC1435)
                    134        610  Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 
                    135        605  Rhizobium loti (Mesorhizobium loti)
                    136        605  Methanobacterium thermoautotrophicum (strain Delta H)
                    137        602  Staphylococcus saprophyticus subsp. saprophyticus 
                    138        600  Yersinia pestis bv. Antiqua (strain Angola)
                    139        600  Salmonella paratyphi C (strain RKS4594)
                    140        598  Photobacterium profundum (Photobacterium sp. (strain SS9))
                    141        598  Listeria monocytogenes
                    142        590  Bacillus cereus (strain ATCC 10987)
                    143        590  Xanthomonas campestris pv. campestris
                    144        589  Listeria innocua
                    145        585  Rickettsia prowazekii
                    146        585  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
                    147        584  Helicobacter pylori (Campylobacter pylori)
                    148        581  Lactococcus lactis subsp. lactis (Streptococcus lactis)
                    149        579  Neisseria meningitidis serogroup B
                    150        576  Brucella suis
                    151        572  Brucella melitensis
                    152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum 
                    153        569  Bacillus thuringiensis subsp. konkukian
                    154        565  Helicobacter pylori J99 (Campylobacter pylori J99)
                    155        565  Pseudomonas syringae pv. syringae (strain B728a)
                    156        562  Buchnera aphidicola subsp. Schizaphis graminum
                    157        561  Caulobacter crescentus (Caulobacter vibrioides)
                    158        560  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
                    159        560  Bacillus cereus (strain ZK / E33L)
                    160        558  Oryza sativa subsp. indica (Rice)
                    161        557  Pseudomonas aeruginosa (strain UCBPP-PA14)
                    162        556  Neisseria meningitidis serogroup A
                    163        556  Clostridium acetobutylicum
                    164        556  Xanthomonas axonopodis pv. citri (Citrus canker)
                    165        554  Vibrio fischeri (strain ATCC 700601 / ES114)
                    166        552  Pseudomonas fluorescens (strain Pf0-1)
                    167        551  Caenorhabditis briggsae
                    168        549  Oceanobacillus iheyensis
                    169        545  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
                    170        543  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
                    171        529  Listeria monocytogenes serotype 4b (strain F2365)
                    172        526  Sodalis glossinidius (strain morsitans)
                    173        526  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
                    174        522  Xylella fastidiosa
                    175        521  Bordetella bronchiseptica (Alcaligenes bronchisepticus)
                    176        521  Streptococcus pneumoniae
                    177        516  Thermotoga maritima
                    178        513  Chromobacterium violaceum
                    179        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
                    180        510  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
                    181        507  Bordetella parapertussis
                    182        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
                    183        507  Pseudomonas aeruginosa (strain PA7)
                    184        507  Haemophilus ducreyi
                    185        506  Bordetella pertussis
                    186        505  Staphylococcus aureus (strain Newman)
                    187        505  Geobacillus kaustophilus
                    188        500  Pseudomonas entomophila (strain L48)
                    189        499  Deinococcus radiodurans
                    190        498  Brucella abortus
                    191        497  Rickettsia conorii
                    192        496  Bacillus clausii (strain KSM-K16)
                    193        494  Haemophilus influenzae (strain 86-028NP)
                    194        493  Corynebacterium glutamicum (Brevibacterium flavum)
                    195        493  Streptomyces avermitilis
                    196        491  Xanthomonas campestris pv. campestris (strain 8004)
                    197        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
                    198        490  Clostridium perfringens
                    199        488  Bacillus amyloliquefaciens (strain FZB42)
                    200        487  Burkholderia pseudomallei (Pseudomonas pseudomallei)
                    201        487  Shewanella sp. (strain MR-7)
                    202        484  Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)
                    203        484  Mannheimia succiniciproducens (strain MBEL55E)
                    204        484  Pseudomonas aeruginosa (strain LESB58)
                    205        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
                    206        484  Shewanella sp. (strain MR-4)
                    207        483  Proteus mirabilis (strain HI4320)
                    208        483  Mycoplasma genitalium
                    209        475  Acinetobacter sp. (strain ADP1)
                    210        475  Thermosynechococcus elongatus (strain BP-1)
                    211        475  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
                    212        474  Burkholderia sp. (strain 383) (Burkholderia cepacia 
                    213        473  Pseudomonas putida (strain F1 / ATCC 700007)
                    214        473  Pyrococcus horikoshii 
                    215        473  Enterococcus faecalis (Streptococcus faecalis)
                    216        472  Brucella abortus (strain 2308)
                    217        467  Rhodopseudomonas palustris
                    218        466  Xanthomonas campestris pv. vesicatoria (strain 85-10)
                    219        465  Pyrococcus abyssi (strain GE5 / Orsay)
                    220        465  Pseudomonas putida (strain GB-1)
                    221        464  Shewanella frigidimarina (strain NCIMB 400)
                    222        463  Lactobacillus plantarum
                    223        463  Methanosarcina mazei  
                    224        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
                    225        462  Shewanella sp. (strain ANA-3)
                    226        461  Burkholderia mallei (Pseudomonas mallei)
                    227        461  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
                    228        460  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
                    229        460  Halobacterium salinarium (strain ATCC 700922 / JCM 11081 / NRC-1) 
                    230        459  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
                    231        459  Aspergillus oryzae (strain ATCC 42149 / RIB 40)
                    232        458  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
                    233        455  Staphylococcus aureus (strain JH1)
                    234        454  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
                    235        453  Rickettsia felis (Rickettsia azadi)
                    236        452  Shewanella baltica (strain OS185)
                    237        452  Pseudomonas putida (strain W619)
                    238        451  Ovis aries (Sheep)
                    239        450  Methylococcus capsulatus
                    240        450  Streptococcus mutans
                    241        449  Staphylococcus aureus (strain JH9)
                    242        449  Aeromonas salmonicida (strain A449)
                    243        448  Thermoanaerobacter tengcongensis
                    244        448  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
                    245        447  Mycobacterium paratuberculosis
                    246        447  Vibrio fischeri (strain MJ11)
                    247        446  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
                    248        444  Hahella chejuensis (strain KCTC 2396)
                    249        444  Pseudomonas mendocina (strain ymp)
                    250        444  Dechloromonas aromatica (strain RCB)
                    
                    
                    2.3  Taxonomic distribution of the sequences
                    
                    Kingdom        sequences (% of the database)
                    Archaea           18599 (  4%)
                    Bacteria         325905 ( 62%)
                    Eukaryota        168716 ( 32%)
                    Viruses           15836 (  3%)
                    
                    Within Eukaryota:
                    Category            sequences (% of Eukaryota) (% of the complete database)
                    Human                  20236 ( 12%)           (  4%)
                    Other Mammalia         45152 ( 27%)           (  9%)
                    Other Vertebrata       16675 ( 10%)           (  3%)
                    Viridiplantae          31170 ( 18%)           (  6%)
                    Fungi                  29070 ( 17%)           (  5%)
                    Insecta                 8264 (  5%)           (  2%)
                    Nematoda                4186 (  2%)           (  1%)
                    Other                  13963 (  8%)           (  3%)
                    
                    
                    
                    3.  SEQUENCE SIZE
                    
                    Repartition of the sequences by size (excluding fragments)
                    
                    From   To  Number             From   To   Number
                    1-  50    8641             1001-1100     3620
                    51- 100   40701             1101-1200     2534
                    101- 150   56789             1201-1300     1978
                    151- 200   56696             1301-1400     1838
                    201- 250   55593             1401-1500     1482
                    251- 300   48797             1501-1600      717
                    301- 350   49232             1601-1700      534
                    351- 400   42465             1701-1800      439
                    401- 450   34863             1801-1900      409
                    451- 500   27927             1901-2000      334
                    501- 550   19792             2001-2100      205
                    551- 600   14190             2101-2200      274
                    601- 650   11939             2201-2300      283
                    651- 700    8647             2301-2400      168
                    701- 750    7134             2401-2500      136
                    751- 800    5051             >2500         1051
                    801- 850    4405
                    851- 900    4930
                    901- 950    3738
                    951-1000    2638
                    
                    The average sequence length in UniProtKB/Swiss-Prot is 354 amino acids.
                    
                    The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
                    The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.
                    
                    
                    4.  JOURNAL CITATIONS
                    
                    Note: the following citation statistics reflect the number of distinct
                    journal citations.
                    
                    Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2137
                    
                    
                    4.1 Table of the frequency of journal citations
                    
                    Journals cited 1x:  696
                    2x:  277
                    3x:  149
                    4x:  105
                    5x:   95
                    6x:   67
                    7x:   36
                    8x:   38
                    9x:   35
                    10x:   25
                    11- 20x:  168
                    21- 50x:  181
                    51-100x:   99
                    >100x:  166
                    
                    
                    4.2  List of the most cited journals in UniProtKB/Swiss-Prot
                    
                    Nb    Citations   Journal name
                    --    ---------   -------------------------------------------------------------
                    1        18773   Journal of Biological Chemistry
                    2         8705   Proceedings of the National Academy of Sciences of the U.S.A.
                    3         5203   Journal of Bacteriology
                    4         4685   Biochemical and Biophysical Research Communications
                    5         4537   Gene
                    6         4376   Nucleic Acids Research
                    7         4074   FEBS Letters
                    8         4054   Biochemistry
                    9         3897   The EMBO Journal
                    10         3564   Molecular and Cellular Biology
                    11         3404   Nature
                    12         3238   Journal of Molecular Biology
                    13         3144   European Journal of Biochemistry
                    14         3042   Biochimica et Biophysica Acta
                    15         2806   Cell
                    16         2488   Genomics
                    17         2242   Biochemical Journal
                    18         2229   Science
                    19         2215   Journal of Virology
                    20         1834   Molecular Microbiology
                    21         1659   Journal of Cell Biology
                    22         1541   Plant Molecular Biology
                    23         1505   Plant Physiology
                    24         1446   Genes and Development
                    25         1430   Virology
                    26         1368   Human Molecular Genetics
                    27         1366   Nature Genetics
                    28         1361   The American Journal of Human Genetics
                    29         1315   Molecular and General Genetics
                    30         1251   Oncogene
                    31         1234   Development
                    32         1185   Journal of Biochemistry
                    33         1159   Human Mutation
                    34         1106   Molecular Biology of the Cell
                    35         1060   The Plant Cell
                    36         1043   Journal of Immunology
                    37         1029   Genetics
                    38          958   Journal of General Virology
                    39          938   Structure
                    40          928   Molecular Cell
                    41          901   The Plant Journal
                    42          900   Infection and Immunity
                    43          851   Archives of Biochemistry and Biophysics
                    44          829   Blood
                    45          798   Journal of Cell Science
                    46          781   Microbiology
                    47          769   Yeast
                    48          761   Developmental Biology
                    49          703   Current Biology
                    50          702   Cancer Research
                    51          680   FEMS Microbiology Letters
                    52          609   Nature Structural Biology
                    53          607   Mechanisms of Development
                    54          602   Human Genetics
                    55          590   Acta Crystallographica, Section D
                    56          583   Protein Science
                    57          574   Applied and Environmental Microbiology
                    58          556   Journal of Neuroscience
                    59          541   Toxicon
                    60          530   Current Genetics
                    61          527   Neuron
                    62          523   Journal of Clinical Investigation
                    63          476   American Journal of Physiology
                    64          474   Mammalian Genome
                    65          460   The Journal of Experimental Medicine
                    66          451   Immunogenetics
                    67          450   Molecular Endocrinology
                    68          426   Molecular and Biochemical Parasitology
                    69          419   Journal of Neurochemistry
                    70          417   The Journal of Clinical Endocrinology and Metabolism
                    71          409   Endocrinology
                    72          405   Proteins
                    73          383   Journal of Molecular Evolution
                    74          383   Bioscience, Biotechnology, and Biochemistry
                    75          372   Journal of Medical Genetics
                    76          367   DNA and Cell Biology
                    77          365   Plant and Cell Physiology
                    78          363   Molecular Biology and Evolution
                    79          359   DNA Sequence
                    80          344   Nature Cell Biology
                    81          321   Tissue Antigens
                    82          318   Experimental Cell Research
                    83          318   Brain Research. Molecular Brain Research
                    84          316   Peptides
                    85          302   Comparative Biochemistry and Physiology
                    86          292   Biological Chemistry Hoppe-Seyler
                    87          290   Antimicrobial Agents and Chemotherapy
                    88          287   Journal of Investigative Dermatology
                    89          276   Cytogenetics and Cell Genetics
                    90          275   Developmental Cell
                    91          274   RNA
                    92          274   Molecular Pharmacology
                    93          267   Biology of Reproduction
                    94          263   Neurology
                    95          253   Genome Research
                    96          252   Virus Research
                    97          251   Journal of General Microbiology
                    98          249   Developmental Dynamics
                    99          243   Planta
                    100          237   Molecular Plant-Microbe Interactions
                    101          227   Nature Structural and Molecular Biology
                    102          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
                    103          214   Annals of Neurology
                    104          212   Genes to Cells
                    105          210   Biochimie
                    106          209   European Journal of Immunology
                    107          208   DNA Research
                    108          208   Immunity
                    109          206   Eukaryotic cell
                    110          206   The FEBS Journal
                    111          204   European Journal of Human Genetics
                    112          202   The New England Journal of Medicine
                    113          195   EMBO Reports
                    114          195   PLoS ONE
                    115          193   Journal of Human Genetics
                    116          185   The FASEB Journal
                    117          179   Investigative Ophthalmology and Visual Science
                    118          178   Molecular and Cellular Endocrinology
                    119          177   Archives of Virology
                    120          170   Archives of Microbiology
                    121          168   Insect Biochemistry and Molecular Biology
                    122          167   American Journal of Medical Genetics
                    123          166   Molecular Immunology
                    124          166   Molecular Phylogenetics and Evolution
                    125          159   DNA
                    126          159   American Journal of Medical Genetics. Part A
                    127          158   Glycobiology
                    128          157   Clinical Genetics
                    129          155   Molecular Reproduction and Development
                    130          155   Diabetes
                    131          153   Hemoglobin
                    132          152   BMC Genomics
                    133          152   Bioorganicheskaia Khimiia
                    134          151   Journal of the American Chemical Society
                    135          149   Journal of Cellular Biochemistry
                    136          147   International Journal of Cancer
                    137          141   Molecular Genetics and Metabolism
                    138          140   Molecular Genetics and Genomics
                    139          140   Molecular and Cellular Neuroscience
                    140          139   Nature Immunology
                    141          138   Animal Genetics
                    142          137   General and Comparative Endocrinology
                    143          136   Biological Chemistry
                    144          132   British Journal of Haematology
                    145          130   Journal of Lipid Research
                    146          128   Proteomics
                    147          127   Journal of Medicinal Chemistry
                    148          124   Circulation Research
                    149          123   Protein Expression and Purification
                    150          122   Thrombosis and Haemostasis
                    
                    
                    5.  STATISTICS FOR SOME LINE TYPES
                    
                    The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
                    as well as the number of entries with at least one such line, and the
                    frequency of the lines.
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry
                    ------------------------------------  -------- ---------  ---------
                    
                    References (RL)                       967388                 1.83        
                    Journal                            772485     401783      1.46       1
                    Submitted to EMBL/GenBank/DDBJ     186225     171318      0.35       2
                    Submitted to other databases         6586       6143      0.01       3
                    Book citation                         646        632     <0.01       4
                    Plant Gene Register                   568        556     <0.01       5
                    Thesis402        399     <0.01       6
                    Unpublished observations              293        289     <0.01       7
                    Patent177        175     <0.01       8
                    Worm Breeder's Gazette                  6          6     <0.01       9
                    
                    Total number of distinct authors cited in UniProtKB/Swiss-Prot: 303846
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Comments (CC)                        2309706                 4.37        
                    ALLERGEN                              499        499     <0.01      26
                    ALTERNATIVE PRODUCTS                19965      19965      0.04      13
                    BIOPHYSICOCHEMICAL PROPERTIES        3644       3644      0.01      23
                    BIOTECHNOLOGY                         309        307     <0.01      28
                    CATALYTIC ACTIVITY                 232099     211434      0.44       4
                    CAUTION                              7587       7434      0.01      19
                    COFACTOR                           102175      93876      0.19       7
                    DEVELOPMENTAL STAGE                  9279       9279      0.02      17
                    DISEASE                              4552       3075      0.01      21
                    DISRUPTION PHENOTYPE                 3689       3689      0.01      22
                    DOMAIN                              34624      30634      0.07      11
                    ENZYME REGULATION                    9587       9587      0.02      16
                    FUNCTION                           401370     384823      0.76       2
                    INDUCTION                           13061      13061      0.02      14
                    INTERACTION                         13052      13052      0.02      15
                    MASS SPECTROMETRY                    4824       3665      0.01      20
                    MISCELLANEOUS                       30978      28602      0.06      12
                    PATHWAY                            129299     117953      0.24       6
                    PHARMACEUTICAL                         85         85     <0.01      29
                    POLYMORPHISM                          831        790     <0.01      24
                    PTM38464      30862      0.07       9
                    RNA EDITING                           621        621     <0.01      25
                    SEQUENCE CAUTION                    39420      39420      0.07       8
                    SIMILARITY                         622915     504273      1.18       1
                    SUBCELLULAR LOCATION               312379     306979      0.59       3
                    SUBUNIT                            229711     229711      0.43       5
                    TISSUE SPECIFICITY                  35578      35578      0.07      10
                    TOXIC DOSE                            468        454     <0.01      27
                    WEB RESOURCE                         8641       6923      0.02      18
                    
                    Total number of comment topics: 29
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Features (FT)                        3408751                 6.44        
                    ACT_SITE                           133189      80235      0.25       9
                    BINDING                            228328      63939      0.43       4
                    CA_BIND                              3769       1557      0.01      35
                    CARBOHYD                           103659      26245      0.20      13
                    CHAIN                              535610     523468      1.01       1
                    COILED                              19290      13151      0.04      26
                    COMPBIAS                            51916      27284      0.10      18
                    CONFLICT                           120039      42149      0.23      11
                    CROSSLNK                             6080       3619      0.01      34
                    DISULFID                           101191      27309      0.19      15
                    DNA_BIND                            11169      10293      0.02      30
                    DOMAIN                             154155      92110      0.29       6
                    HELIX                              144025      15038      0.27       7
                    INIT_MET                            14975      14975      0.03      27
                    INTRAMEM                             1874        811     <0.01      38
                    LIPID                               10954       6948      0.02      31
                    METAL                              291153      71036      0.55       3
                    MOD_RES                            184540      60958      0.35       5
                    MOTIF                               33977      21860      0.06      23
                    MUTAGEN                             35334       8309      0.07      22
                    NON_CONS                             1958        729     <0.01      37
                    NON_STD                               351        276     <0.01      39
                    NON_TER                             12028       9154      0.02      29
                    NP_BIND                            111865      70423      0.21      12
                    PEPTIDE                              9511       6349      0.02      32
                    PROPEP                              12102      10383      0.02      28
                    REGION                             103468      55521      0.20      14
                    REPEAT                              91672      13555      0.17      16
                    SIGNAL                              36617      36607      0.07      21
                    SITE39349      23194      0.07      20
                    STRAND                             141990      13999      0.27       8
                    TOPO_DOM                           122358      25024      0.23      10
                    TRANSIT                              7547       7460      0.01      33
                    TRANSMEM                           345581      70960      0.65       2
                    TURN33551      11765      0.06      24
                    UNSURE                               2514        497     <0.01      36
                    VAR_SEQ                             40486      17441      0.08      19
                    VARIANT                             81665      16636      0.15      17
                    ZN_FING                             28911      12551      0.05      25
                    
                    Total number of feature keys: 39
                    
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank      Category
                    ------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
                    Cross-references (DR)               14326322                27.08                          
                    2DBase-Ecoli                           85         85     <0.01     122      2D gel databases                             
                    Aarhus/Ghent-2DPAGE                   126         96     <0.01     119      2D gel databases                             
                    AGD  913        907     <0.01      98      Organism-specific databases                  
                    Allergome                            1338        809     <0.01      93      Protein family/group databases               
                    ANU-2DPAGE                             23         23     <0.01     128      2D gel databases                             
                    ArachnoServer                         759        755     <0.01     101      Organism-specific databases                  
                    ArrayExpress                        58659      58659      0.11      42      Gene expression databases                    
                    Bgee40063      40063      0.08      46      Gene expression databases                    
                    BindingDB                             297        297     <0.01     115      Other       
                    BioCyc                             252412     243801      0.48      19      Enzyme and pathway databases                 
                    BRENDA                               4179       4179      0.01      84      Enzyme and pathway databases                 
                    CAZy7385       6638      0.01      70      Protein family/group databases               
                    CGD  608        598     <0.01     105      Organism-specific databases                  
                    CleanEx                             30124      29482      0.06      48      Gene expression databases                    
                    COMPLUYEAST-2DPAGE                    101        100     <0.01     121      2D gel databases                             
                    ConoServer                            762        736     <0.01      99      Organism-specific databases                  
                    Cornea-2DPAGE                          67         67     <0.01     123      2D gel databases                             
                    CTD66103      65539      0.12      39      Organism-specific databases                  
                    CYGD5572       5532      0.01      74      Organism-specific databases                  
                    dictyBase                            4020       4020      0.01      86      Organism-specific databases                  
                    DIP12502      12380      0.02      64      Protein-protein interaction databases        
                    DisProt                               397        394     <0.01     111      3D structure databases                       
                    DOSAC-COBS-2DPAGE                     149        147     <0.01     118      2D gel databases                             
                    DrugBank                             5318       1627      0.01      75      Other       
                    EchoBASE                             4167       4163      0.01      85      Organism-specific databases                  
                    ECO2DBASE                             352        300     <0.01     113      2D gel databases                             
                    EcoGene                              4291       4289      0.01      83      Organism-specific databases                  
                    eggNOG                             219145     219145      0.41      20      Phylogenomic databases                       
                    EMBL                               886964     518793      1.68       3      Sequence databases                           
                    Ensembl                             68300      49980      0.13      37      Genome annotation databases                  
                    EnsemblBacteria                     98178      84904      0.19      29      Genome annotation databases                  
                    EnsemblFungi                        15045      14898      0.03      61      Genome annotation databases                  
                    EnsemblMetazoa                      11345       8721      0.02      65      Genome annotation databases                  
                    EnsemblPlants                       16003      13887      0.03      59      Genome annotation databases                  
                    EnsemblProtists                      4431       4314      0.01      82      Genome annotation databases                  
                    euHCVdb55         44     <0.01     124      Organism-specific databases                  
                    EuPathDB                              742        742     <0.01     102      Organism-specific databases                  
                    FlyBase                              5796       5422      0.01      73      Organism-specific databases                  
                    Gene3D                             320643     248360      0.61      16      Family and domain databases                  
                    GeneCards                           20239      19680      0.04      53      Organism-specific databases                  
                    GeneDB_Spombe                        4978       4934      0.01      77      Organism-specific databases                  
                    GeneFarm                             2940       2926      0.01      89      Organism-specific databases                  
                    GeneID                             477160     457362      0.90       6      Genome annotation databases                  
                    GeneTree                           168410     168368      0.32      23      Phylogenomic databases                       
                    Genevestigator                      65922      65922      0.12      40      Gene expression databases                    
                    GenoList                             7054       7042      0.01      71      Organism-specific databases                  
                    GenomeReviews                      376464     356571      0.71      10      Genome annotation databases                  
                    GermOnline                          41915      41298      0.08      45      Gene expression databases                    
                    GlycoSuiteDB                          272        272     <0.01     116      PTM databases
                    GO2158212     495822      4.08       1      Ontologies  
                    Gramene                              4609       4609      0.01      80      Organism-specific databases                  
                    H-InvDB                             13206      12309      0.02      63      Organism-specific databases                  
                    HAMAP                              309309     309163      0.58      17      Family and domain databases                  
                    HGNC19710      19549      0.04      55      Organism-specific databases                  
                    HOGENOM                            363733     363733      0.69      12      Phylogenomic databases                       
                    HOVERGEN                            74860      74860      0.14      36      Phylogenomic databases                       
                    HPA13303      10018      0.03      62      Organism-specific databases                  
                    HSSP29823      29823      0.06      49      3D structure databases                       
                    InParanoid                          67685      67685      0.13      38      Phylogenomic databases                       
                    IntAct                              25632      25632      0.05      51      Protein-protein interaction databases        
                    InterPro                          1758095     503624      3.32       2      Family and domain databases                  
                    IPI91482      65423      0.17      31      Sequence databases                           
                    KEGG                               452287     430638      0.85       8      Genome annotation databases                  
                    LegioList                             761        759     <0.01     100      Organism-specific databases                  
                    Leproma                               671        668     <0.01     104      Organism-specific databases                  
                    MaizeGDB                              477        473     <0.01     109      Organism-specific databases                  
                    MEROPS                              10554      10223      0.02      66      Protein family/group databases               
                    MGI16272      16227      0.03      58      Organism-specific databases                  
                    MIM16696      12986      0.03      57      Organism-specific databases                  
                    MINT17540      17540      0.03      56      Protein-protein interaction databases        
                    NextBio                             48964      48962      0.09      43      Other       
                    neXtProt                            20053      20052      0.04      54      Organism-specific databases                  
                    NMPDR                              132247     132242      0.25      26      Genome annotation databases                  
                    OGP  377        377     <0.01     112      2D gel databases                             
                    OMA371826     371826      0.70      11      Phylogenomic databases                       
                    Orphanet                             3877       2340      0.01      87      Organism-specific databases                  
                    OrthoDB                             77222      77166      0.15      33      Phylogenomic databases                       
                    PANTHER                            169071     160743      0.32      22      Family and domain databases                  
                    Pathway_Interaction_DB               4567       1665      0.01      81      Enzyme and pathway databases                 
                    PDB75162      16783      0.14      35      3D structure databases                       
                    PDBsum                              75162      16783      0.14      34      3D structure databases                       
                    PeptideAtlas                         5166       5166      0.01      76      Proteomic databases                          
                    PeroxiBase                            739        728     <0.01     103      Protein family/group databases               
                    Pfam                               701306     490828      1.33       4      Family and domain databases                  
                    PharmGKB                            15410      15105      0.03      60      Organism-specific databases                  
                    PHCI-2DPAGE                           247        247     <0.01     117      2D gel databases                             
                    PhosphoSite                         23766      23766      0.04      52      PTM databases
                    PhosSite                              351        351     <0.01     114      PTM databases
                    PhylomeDB                          123185     123185      0.23      27      Phylogenomic databases                       
                    PIR116836     106806      0.22      28      Sequence databases                           
                    PIRSF                               86383      86383      0.16      32      Family and domain databases                  
                    PMAP-CutDB                           1394       1394     <0.01      92      Other       
                    PMMA-2DPAGE                            52         52     <0.01     125      2D gel databases                             
                    PptaseDB                               34         34     <0.01     126      Protein family/group databases               
                    PRIDE                               62531      62531      0.12      41      Proteomic databases                          
                    PRINTS                             138174     119804      0.26      25      Family and domain databases                  
                    ProDom                              27817      27638      0.05      50      Family and domain databases                  
                    ProMEX478        478     <0.01     108      Proteomic databases                          
                    PROSITE                            469796     298165      0.89       7      Family and domain databases                  
                    ProtClustDB                        340435     340435      0.64      14      Phylogenomic databases                       
                    ProteinModelPortal                 418303     418303      0.79       9      3D structure databases                       
                    PseudoCAP                            1224       1215     <0.01      95      Organism-specific databases                  
                    Rat-heart-2DPAGE                       28         28     <0.01     127      2D gel databases                             
                    Reactome                             9367       5611      0.02      68      Enzyme and pathway databases                 
                    REBASE441        398     <0.01     110      Protein family/group databases               
                    RefSeq                             500846     457628      0.95       5      Sequence databases                           
                    REPRODUCTION-2DPAGE                  1256       1035     <0.01      94      2D gel databases                             
                    RGD 7521       7517      0.01      69      Organism-specific databases                  
                    SGD 6638       6573      0.01      72      Organism-specific databases                  
                    Siena-2DPAGE                          102        102     <0.01     120      2D gel databases                             
                    SMART                              156265     118974      0.30      24      Family and domain databases                  
                    SMR349744     349744      0.66      13      3D structure databases                       
                    STRING                             206456     206421      0.39      21      Protein-protein interaction databases        
                    SUPFAM                             324146     257894      0.61      15      Family and domain databases                  
                    SWISS-2DPAGE                         1184       1183     <0.01      96      2D gel databases                             
                    TAIR10519      10433      0.02      67      Organism-specific databases                  
                    TCDB3567       3552      0.01      88      Protein family/group databases               
                    TIGR34339      33568      0.06      47      Genome annotation databases                  
                    TIGRFAMs                           286140     266105      0.54      18      Family and domain databases                  
                    TubercuList                          1889       1853     <0.01      91      Organism-specific databases                  
                    UCD-2DPAGE                            511        502     <0.01     107      2D gel databases                             
                    UCSC48627      39661      0.09      44      Genome annotation databases                  
                    UniGene                             93494      85985      0.18      30      Sequence databases                           
                    VectorBase                            536        523     <0.01     106      Genome annotation databases                  
                    World-2DPAGE                          917        906     <0.01      97      2D gel databases                             
                    WormBase                             4642       3819      0.01      78      Organism-specific databases                  
                    Xenbase                              4637       4615      0.01      79      Organism-specific databases                  
                    ZFIN2665       2653      0.01      90      Organism-specific databases                  
                    
                    Total number of cross-referenced databases: 128
                    
                    6.  AMINO ACID COMPOSITION
                    
                    6.1  Composition in percent for the complete database
                    
                    Ala (A) 8.26   Gln (Q) 3.93   Leu (L) 9.66   Ser (S) 6.54
                    Arg (R) 5.53   Glu (E) 6.75   Lys (K) 5.85   Thr (T) 5.33
                    Asn (N) 4.06   Gly (G) 7.08   Met (M) 2.42   Trp (W) 1.08
                    Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
                    Cys (C) 1.36   Ile (I) 5.97   Pro (P) 4.69   Val (V) 6.87
                    
                    Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00
                    
                    
                    
                    Legend: gray = aliphatic, red = acidic, green = small hydroxy,
                    blue = basic, black = aromatic, white = amide, yellow = sulfur
                    
                    
                    6.2  Classification of the amino acids by their frequency
                    
                    Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
                    Phe, Tyr, Met, His, Cys, Trp
                    
                    
                    7.  MISCELLANEOUS STATISTICS
                    
                    4445 entries are encoded on a mitochondrion, and 3618 are encoded on a plasmid.
                    
                    12183 entries are encoded on a plastid, 
                    of which 21 are encoded on apicoplasts, 
                    11619 on chloroplasts, 
                    50 on organellar chromatophores,
                    145 on cyanelles, 
                    149 on non-photosynthetic plastids and 
                    199 on unspecified types of plastid.
                    
                    Number of entries with at least one sequence correction: 71178