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UniProtKB/Swiss-Prot protein knowledgebase release 2011_02 statistics
                    
                    
                    1.  INTRODUCTION
                    
                    Release 2011_02 of 08-Feb-11 of UniProtKB/Swiss-Prot contains 525207 sequence entries,
                    comprising 185522689 amino acids abstracted from 195412 references. 
                    
                    840 sequences have been added since release 2011_01, the sequence data of
                    138 existing entries has been updated and the annotations of
                    381020 entries have been revised.
                    
                    Number of fragments: 8829
                    Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 29937
                    
                    
                    Protein existence (PE):           entries     %
                    
                    1: Evidence at protein level        72139   13.7%
                    2: Evidence at transcript level     68656   13.1%
                    3: Inferred from homology          368426   70.1%
                    4: Predicted                        14331    2.7%
                    5: Uncertain                         1655    0.3%
                    
                    The growth of the database is summarized below.
                    
                    
                    
                    
                    2.  TAXONOMIC ORIGIN
                    
                    Total number of species represented in this release of UniProtKB/Swiss-Prot: 12398
                    
                    The first twenty species represent 109529 sequences:  20.9 % of the total
                    number of entries.
                    
                    
                    2.1 Table of the frequency of occurrence of species
                    
                    Species represented 1x: 5298
                    2x: 1771
                    3x:  940
                    4x:  604
                    5x:  443
                    6x:  355
                    7x:  260
                    8x:  210
                    9x:  195
                    10x:  104
                    11- 20x:  620
                    21- 50x:  391
                    51-100x:  183
                    >100x: 1024
                    
                    
                    2.2  Table of the most represented species
                    
                    ------  ---------  --------------------------------------------
                    Number  Frequency  Species
                    ------  ---------  --------------------------------------------
                    1      20253  Homo sapiens (Human)
                    2      16339  Mus musculus (Mouse)
                    3      10081  Arabidopsis thaliana (Mouse-ear cress)
                    4       7583  Rattus norvegicus (Rat)
                    5       6583  Saccharomyces cerevisiae (Baker's yeast)
                    6       5818  Bos taurus (Bovine)
                    7       4976  Schizosaccharomyces pombe (Fission yeast)
                    8       4430  Escherichia coli (strain K12)
                    9       4244  Bacillus subtilis
                    10       4203  Dictyostelium discoideum (Slime mold)
                    11       3326  Caenorhabditis elegans
                    12       3286  Xenopus laevis (African clawed frog)
                    13       3106  Drosophila melanogaster (Fruit fly)
                    14       2706  Danio rerio (Zebrafish) (Brachydanio rerio)
                    15       2639  Oryza sativa subsp. japonica (Rice)
                    16       2212  Pongo abelii (Sumatran orangutan)
                    17       2189  Gallus gallus (Chicken)
                    18       1997  Escherichia coli O157:H7
                    19       1782  Methanocaldococcus jannaschii (Methanococcus jannaschii)
                    20       1776  Salmonella typhimurium
                    21       1771  Haemophilus influenzae
                    22       1743  Mycobacterium tuberculosis
                    23       1674  Shigella flexneri
                    24       1671  Escherichia coli O6
                    25       1583  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
                    26       1381  Sus scrofa (Pig)
                    27       1342  Salmonella typhi
                    28       1283  Pseudomonas aeruginosa
                    29       1224  Mycobacterium bovis
                    30       1164  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
                    31       1024  Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1)
                    32        998  Yersinia pestis
                    33        993  Archaeoglobus fulgidus
                    34        944  Vibrio cholerae
                    35        929  Salmonella paratyphi A
                    36        924  Staphylococcus aureus (strain N315)
                    37        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
                    38        913  Rhizobium meliloti (Sinorhizobium meliloti)
                    39        909  Acanthamoeba polyphaga mimivirus (APMV)
                    40        897  Staphylococcus aureus (strain COL)
                    41        895  Staphylococcus aureus (strain MW2)
                    42        889  Staphylococcus aureus (strain MSSA476)
                    43        886  Staphylococcus aureus (strain MRSA252)
                    44        885  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
                    45        883  Oryctolagus cuniculus (Rabbit)
                    46        881  Salmonella choleraesuis
                    47        874  Shigella sonnei (strain Ss046)
                    48        864  Yersinia pseudotuberculosis
                    49        859  Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)  
                    50        841  Escherichia coli O9:H4 (strain HS)
                    51        834  Kluyveromyces lactis (Yeast) (Candida sphaerica)
                    52        834  Escherichia coli O139:H28 (strain E24377A / ETEC)
                    53        825  Shigella boydii serotype 4 (strain Sb227)
                    54        824  Candida albicans (Yeast)
                    55        823  Escherichia coli (strain UTI89 / UPEC)
                    56        819  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
                    57        808  Shigella dysenteriae serotype 1 (strain Sd197)
                    58        794  Vibrio parahaemolyticus
                    59        793  Candida glabrata (Yeast) (Torulopsis glabrata)
                    60        790  Escherichia coli (strain SMS-3-5 / SECEC)
                    61        789  Neurospora crassa
                    62        779  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
                    63        777  Pasteurella multocida
                    64        773  Aquifex aeolicus
                    65        770  Escherichia coli (strain K12 / DH10B)
                    66        765  Canis familiaris (Dog) (Canis lupus familiaris)
                    67        764  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
                    68        764  Escherichia coli (strain K12 / MC4100 / BW2952)
                    69        762  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
                    70        762  Escherichia coli (strain 55989 / EAEC)
                    71        761  Escherichia coli O8 (strain IAI1)
                    72        757  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
                    73        756  Escherichia coli (strain SE11)
                    74        756  Shigella flexneri serotype 5b (strain 8401)
                    75        756  Staphylococcus epidermidis (strain ATCC 12228)
                    76        756  Escherichia coli O45:K1 (strain S88 / ExPEC)
                    77        753  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
                    78        750  Streptomyces coelicolor
                    79        746  Escherichia coli O157:H7 (strain EC4115 / EHEC)
                    80        740  Photorhabdus luminescens subsp. laumondii
                    81        731  Escherichia coli O81 (strain ED1a)
                    82        731  Bacillus halodurans
                    83        731  Vibrio vulnificus
                    84        731  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
                    85        728  Emericella nidulans (Aspergillus nidulans)
                    86        724  Bacillus anthracis
                    87        720  Salmonella enteritidis PT4 (strain P125109)
                    88        715  Vibrio vulnificus (strain YJ016)
                    89        715  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
                    90        713  Yersinia pestis bv. Antiqua (strain Nepal516)
                    91        713  Staphylococcus aureus (strain NCTC 8325)
                    92        713  Salmonella paratyphi A (strain AKU_12601)
                    93        712  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
                    94        711  Salmonella agona (strain SL483)
                    95        711  Escherichia coli O1:K1 / APEC
                    96        711  Salmonella newport (strain SL254)
                    97        710  Salmonella heidelberg (strain SL476)
                    98        709  Yersinia pestis bv. Antiqua (strain Antiqua)
                    99        709  Salmonella schwarzengrund (strain CVM19633)
                    100        704  Enterobacter sp. (strain 638)
                    101        703  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
                    102        700  Salmonella dublin (strain CT_02021853)
                    103        697  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
                    104        691  Klebsiella pneumoniae (strain 342)
                    105        687  Mycoplasma pneumoniae
                    106        686  Pan troglodytes (Chimpanzee)
                    107        686  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
                    108        685  Nostoc sp. (strain PCC 7120 / UTEX 2576)
                    109        684  Pseudomonas syringae pv. tomato
                    110        682  Salmonella gallinarum (strain 287/91 / NCTC 13346)
                    111        671  Pseudomonas putida (strain KT2440)
                    112        669  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
                    113        668  Mycobacterium leprae
                    114        667  Zea mays (Maize)
                    115        666  Staphylococcus aureus (strain USA300)
                    116        666  Yersinia pestis (strain Pestoides F)
                    117        660  Serratia proteamaculans (strain 568)
                    118        658  Rhizobium sp. (strain NGR234)
                    119        650  Bradyrhizobium japonicum
                    120        644  Escherichia coli
                    121        642  Staphylococcus aureus (strain bovine RF122 / ET3-1)
                    122        638  Bacillus cereus (strain ATCC 14579 / DSM 31)
                    123        637  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
                    124        635  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
                    125        633  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
                    126        626  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
                    127        621  Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
                    128        621  Shewanella oneidensis
                    129        615  Treponema pallidum
                    130        614  Ralstonia solanacearum (Pseudomonas solanacearum)
                    131        613  Enterobacter sakazakii (strain ATCC BAA-894)
                    132        610  Staphylococcus haemolyticus (strain JCSC1435)
                    133        609  Yarrowia lipolytica (Candida lipolytica)
                    134        605  Rhizobium loti (Mesorhizobium loti)
                    135        603  Methanobacterium thermoautotrophicum
                    136        602  Staphylococcus saprophyticus subsp. saprophyticus 
                    137        600  Salmonella paratyphi C (strain RKS4594)
                    138        598  Yersinia pestis bv. Antiqua (strain Angola)
                    139        597  Photobacterium profundum (Photobacterium sp. (strain SS9))
                    140        597  Listeria monocytogenes
                    141        590  Bacillus cereus (strain ATCC 10987)
                    142        590  Xanthomonas campestris pv. campestris
                    143        589  Aspergillus fumigatus (Sartorya fumigata)
                    144        588  Listeria innocua
                    145        585  Rickettsia prowazekii
                    146        584  Helicobacter pylori (Campylobacter pylori)
                    147        584  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
                    148        581  Lactococcus lactis subsp. lactis (Streptococcus lactis)
                    149        579  Neisseria meningitidis serogroup B
                    150        576  Brucella suis
                    151        572  Brucella melitensis
                    152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum 
                    153        569  Bacillus thuringiensis subsp. konkukian
                    154        565  Helicobacter pylori J99 (Campylobacter pylori J99)
                    155        565  Pseudomonas syringae pv. syringae (strain B728a)
                    156        562  Buchnera aphidicola subsp. Schizaphis graminum
                    157        560  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
                    158        560  Bacillus cereus (strain ZK / E33L)
                    159        557  Pseudomonas aeruginosa (strain UCBPP-PA14)
                    160        556  Neisseria meningitidis serogroup A
                    161        555  Xanthomonas axonopodis pv. citri (Citrus canker)
                    162        553  Vibrio fischeri (strain ATCC 700601 / ES114)
                    163        553  Oryza sativa subsp. indica (Rice)
                    164        552  Pseudomonas fluorescens (strain Pf0-1)
                    165        549  Oceanobacillus iheyensis
                    166        548  Clostridium acetobutylicum
                    167        548  Caenorhabditis briggsae
                    168        547  Caulobacter crescentus (Caulobacter vibrioides)
                    169        545  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
                    170        543  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
                    171        529  Listeria monocytogenes serotype 4b (strain F2365)
                    172        524  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
                    173        523  Sodalis glossinidius (strain morsitans)
                    174        522  Xylella fastidiosa
                    175        521  Bordetella bronchiseptica (Alcaligenes bronchisepticus)
                    176        519  Streptococcus pneumoniae
                    177        513  Chromobacterium violaceum
                    178        512  Thermotoga maritima
                    179        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
                    180        509  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
                    181        507  Bordetella parapertussis
                    182        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
                    183        507  Pseudomonas aeruginosa (strain PA7)
                    184        506  Haemophilus ducreyi
                    185        506  Bordetella pertussis
                    186        505  Staphylococcus aureus (strain Newman)
                    187        504  Geobacillus kaustophilus
                    188        500  Pseudomonas entomophila (strain L48)
                    189        498  Deinococcus radiodurans
                    190        498  Brucella abortus
                    191        497  Rickettsia conorii
                    192        496  Bacillus clausii (strain KSM-K16)
                    193        493  Corynebacterium glutamicum (Brevibacterium flavum)
                    194        492  Haemophilus influenzae (strain 86-028NP)
                    195        492  Streptomyces avermitilis
                    196        490  Xanthomonas campestris pv. campestris (strain 8004)
                    197        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
                    198        490  Clostridium perfringens
                    199        488  Bacillus amyloliquefaciens (strain FZB42)
                    200        487  Burkholderia pseudomallei (Pseudomonas pseudomallei)
                    201        487  Shewanella sp. (strain MR-7)
                    202        484  Pseudomonas aeruginosa (strain LESB58)
                    203        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
                    204        484  Shewanella sp. (strain MR-4)
                    205        483  Mannheimia succiniciproducens (strain MBEL55E)
                    206        483  Mycoplasma genitalium
                    207        482  Proteus mirabilis (strain HI4320)
                    208        482  Methanosarcina acetivorans
                    209        475  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
                    210        474  Acinetobacter sp. (strain ADP1)
                    211        474  Thermosynechococcus elongatus (strain BP-1)
                    212        473  Pseudomonas putida (strain F1 / ATCC 700007)
                    213        472  Burkholderia sp. (strain 383) (Burkholderia cepacia 
                    214        472  Brucella abortus (strain 2308)
                    215        469  Enterococcus faecalis (Streptococcus faecalis)
                    216        466  Pyrococcus horikoshii
                    217        465  Rhodopseudomonas palustris
                    218        465  Xanthomonas campestris pv. vesicatoria (strain 85-10)
                    219        465  Pseudomonas putida (strain GB-1)
                    220        464  Shewanella frigidimarina (strain NCIMB 400)
                    221        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
                    222        462  Shewanella sp. (strain ANA-3)
                    223        461  Burkholderia mallei (Pseudomonas mallei)
                    224        461  Lactobacillus plantarum
                    225        461  Methanosarcina mazei (Methanosarcina frisia)
                    226        460  Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) 
                    227        459  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
                    228        459  Pyrococcus abyssi
                    229        457  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
                    230        457  Cupriavidus pinatubonensis (strain JMP134 / LMG 1197) (Alcaligenes eutrophus) 
                    231        455  Staphylococcus aureus (strain JH1)
                    232        454  Halobacterium salinarium (Halobacterium halobium)
                    233        453  Rickettsia felis (Rickettsia azadi)
                    234        453  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
                    235        452  Shewanella baltica (strain OS185)
                    236        452  Pseudomonas putida (strain W619)
                    237        450  Ovis aries (Sheep)
                    238        449  Staphylococcus aureus (strain JH9)
                    239        449  Methylococcus capsulatus
                    240        449  Streptococcus mutans
                    241        449  Aeromonas salmonicida (strain A449)
                    242        448  Thermoanaerobacter tengcongensis
                    243        448  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
                    244        447  Vibrio fischeri (strain MJ11)
                    245        446  Mycobacterium paratuberculosis
                    246        444  Hahella chejuensis (strain KCTC 2396)
                    247        444  Pseudomonas mendocina (strain ymp)
                    248        443  Dechloromonas aromatica (strain RCB)
                    249        441  Streptococcus pyogenes serotype M6
                    250        441  Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
                    
                    
                    
                    2.3  Taxonomic distribution of the sequences
                    
                    
                    
                    Kingdom        sequences (% of the database)
                    Archaea           18397 (  4%)
                    Bacteria         325301 ( 62%)
                    Eukaryota        166219 ( 32%)
                    Viruses           15290 (  3%)
                    
                    
                    Within Eukaryota:
                    
                    
                    
                    Category            sequences (% of Eukaryota) (% of the complete database)
                    Human                  20254 ( 12%)           (  4%)
                    Other Mammalia         45006 ( 27%)           (  9%)
                    Other Vertebrata       16502 ( 10%)           (  3%)
                    Viridiplantae          30629 ( 18%)           (  6%)
                    Fungi                  27485 ( 17%)           (  5%)
                    Insecta                 8207 (  5%)           (  2%)
                    Nematoda                4176 (  3%)           (  1%)
                    Other                  13960 (  8%)           (  3%)
                    
                    
                    
                    3.  SEQUENCE SIZE
                    
                    Repartition of the sequences by size (excluding fragments)
                    
                    From   To  Number             From   To   Number
                    1-  50    8630             1001-1100     3587
                    51- 100   40552             1101-1200     2485
                    101- 150   56449             1201-1300     1963
                    151- 200   56477             1301-1400     1808
                    201- 250   55318             1401-1500     1438
                    251- 300   48551             1501-1600      641
                    301- 350   48990             1601-1700      520
                    351- 400   42170             1701-1800      435
                    401- 450   34541             1801-1900      402
                    451- 500   27692             1901-2000      329
                    501- 550   19572             2001-2100      202
                    551- 600   13980             2101-2200      269
                    601- 650   11757             2201-2300      281
                    651- 700    8476             2301-2400      168
                    701- 750    6994             2401-2500      130
                    751- 800    5003             >2500         1038
                    801- 850    4359
                    851- 900    4876
                    901- 950    3704
                    951-1000    2591
                    
                    
                    
                    
                    The average sequence length in UniProtKB/Swiss-Prot is 353 amino acids.
                    
                    The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
                    The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.
                    
                    
                    4.  JOURNAL CITATIONS
                    
                    Note: the following citation statistics reflect the number of distinct
                    journal citations.
                    
                    Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2114
                    
                    
                    4.1 Table of the frequency of journal citations
                    
                    Journals cited 1x:  686
                    2x:  277
                    3x:  151
                    4x:  101
                    5x:   92
                    6x:   68
                    7x:   35
                    8x:   42
                    9x:   30
                    10x:   24
                    11- 20x:  172
                    21- 50x:  173
                    51-100x:  100
                    >100x:  163
                    
                    
                    4.2  List of the most cited journals in UniProtKB/Swiss-Prot
                    
                    Nb    Citations   Journal name
                    --    ---------   -------------------------------------------------------------
                    1        18492   Journal of Biological Chemistry
                    2         8556   Proceedings of the National Academy of Sciences of the U.S.A.
                    3         5136   Journal of Bacteriology
                    4         4625   Biochemical and Biophysical Research Communications
                    5         4527   Gene
                    6         4339   Nucleic Acids Research
                    7         4046   FEBS Letters
                    8         4016   Biochemistry
                    9         3839   The EMBO Journal
                    10         3508   Molecular and Cellular Biology
                    11         3340   Nature
                    12         3177   Journal of Molecular Biology
                    13         3132   European Journal of Biochemistry
                    14         3017   Biochimica et Biophysica Acta
                    15         2771   Cell
                    16         2483   Genomics
                    17         2221   Biochemical Journal
                    18         2191   Science
                    19         2101   Journal of Virology
                    20         1810   Molecular Microbiology
                    21         1619   Journal of Cell Biology
                    22         1524   Plant Molecular Biology
                    23         1430   Plant Physiology
                    24         1420   Genes and Development
                    25         1388   Virology
                    26         1351   Human Molecular Genetics
                    27         1349   Nature Genetics
                    28         1327   The American Journal of Human Genetics
                    29         1308   Molecular and General Genetics
                    30         1224   Oncogene
                    31         1204   Development
                    32         1179   Journal of Biochemistry
                    33         1137   Human Mutation
                    34         1067   Molecular Biology of the Cell
                    35         1034   Journal of Immunology
                    36         1013   Genetics
                    37          986   The Plant Cell
                    38          926   Journal of General Virology
                    39          921   Structure
                    40          893   Infection and Immunity
                    41          892   Molecular Cell
                    42          841   Archives of Biochemistry and Biophysics
                    43          836   The Plant Journal
                    44          817   Blood
                    45          773   Microbiology
                    46          765   Journal of Cell Science
                    47          763   Yeast
                    48          745   Developmental Biology
                    49          685   Cancer Research
                    50          679   Current Biology
                    51          671   FEMS Microbiology Letters
                    52          603   Nature Structural Biology
                    53          598   Mechanisms of Development
                    54          596   Human Genetics
                    55          577   Acta Crystallographica, Section D
                    56          570   Protein Science
                    57          559   Applied and Environmental Microbiology
                    58          550   Journal of Neuroscience
                    59          530   Toxicon
                    60          527   Current Genetics
                    61          521   Neuron
                    62          517   Journal of Clinical Investigation
                    63          473   Mammalian Genome
                    64          473   American Journal of Physiology
                    65          454   The Journal of Experimental Medicine
                    66          451   Immunogenetics
                    67          446   Molecular Endocrinology
                    68          424   Molecular and Biochemical Parasitology
                    69          416   Journal of Neurochemistry
                    70          412   The Journal of Clinical Endocrinology and Metabolism
                    71          401   Endocrinology
                    72          391   Proteins
                    73          382   Journal of Molecular Evolution
                    74          376   Bioscience, Biotechnology, and Biochemistry
                    75          367   DNA and Cell Biology
                    76          363   Journal of Medical Genetics
                    77          361   Molecular Biology and Evolution
                    78          358   DNA Sequence
                    79          345   Plant and Cell Physiology
                    80          326   Nature Cell Biology
                    81          321   Tissue Antigens
                    82          315   Brain Research. Molecular Brain Research
                    83          313   Experimental Cell Research
                    84          312   Peptides
                    85          301   Comparative Biochemistry and Physiology
                    86          291   Biological Chemistry Hoppe-Seyler
                    87          289   Antimicrobial Agents and Chemotherapy
                    88          284   Journal of Investigative Dermatology
                    89          276   Cytogenetics and Cell Genetics
                    90          271   Molecular Pharmacology
                    91          265   Biology of Reproduction
                    92          264   Developmental Cell
                    93          254   RNA
                    94          253   Genome Research
                    95          249   Neurology
                    96          248   Journal of General Microbiology
                    97          248   Virus Research
                    98          244   Developmental Dynamics
                    99          231   Molecular Plant-Microbe Interactions
                    100          229   Planta
                    101          218   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
                    102          208   Annals of Neurology
                    103          208   Nature Structural and Molecular Biology
                    104          207   Biochimie
                    105          207   European Journal of Immunology
                    106          207   Genes to Cells
                    107          206   DNA Research
                    108          202   Eukaryotic cell
                    109          202   Immunity
                    110          199   The FEBS Journal
                    111          198   The New England Journal of Medicine
                    112          196   European Journal of Human Genetics
                    113          189   Journal of Human Genetics
                    114          181   EMBO Reports
                    115          178   Investigative Ophthalmology and Visual Science
                    116          176   Molecular and Cellular Endocrinology
                    117          173   The FASEB Journal
                    118          169   Archives of Virology
                    119          168   Archives of Microbiology
                    120          165   American Journal of Medical Genetics
                    121          165   Molecular Phylogenetics and Evolution
                    122          162   Insect Biochemistry and Molecular Biology
                    123          162   PLoS ONE
                    124          160   Molecular Immunology
                    125          159   DNA
                    126          156   American Journal of Medical Genetics. Part A
                    127          155   Molecular Reproduction and Development
                    128          153   Diabetes
                    129          153   Hemoglobin
                    130          152   Glycobiology
                    131          152   Bioorganicheskaia Khimiia
                    132          150   Clinical Genetics
                    133          149   Journal of the American Chemical Society
                    134          146   BMC Genomics
                    135          144   International Journal of Cancer
                    136          143   Journal of Cellular Biochemistry
                    137          141   Molecular Genetics and Metabolism
                    138          140   Molecular and Cellular Neuroscience
                    139          137   General and Comparative Endocrinology
                    140          137   Animal Genetics
                    141          136   Nature Immunology
                    142          133   Biological Chemistry
                    143          131   Molecular Genetics and Genomics
                    144          130   British Journal of Haematology
                    145          128   Journal of Lipid Research
                    146          127   Proteomics
                    147          124   Circulation Research
                    148          123   Journal of Medicinal Chemistry
                    149          122   Agricultural and Biological Chemistry
                    150          120   Neuroscience Letters
                    
                    
                    5.  STATISTICS FOR SOME LINE TYPES
                    
                    The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
                    as well as the number of entries with at least one such line, and the
                    frequency of the lines.
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry
                    ------------------------------------  -------- ---------  ---------
                    
                    References (RL)                       955364                 1.82                                         
                    Journal                            756876     397817      1.44       1                                 
                    Submitted to EMBL/GenBank/DDBJ     185636     170974      0.35       2                                 
                    Submitted to other databases        10767       9321      0.02       3                                 
                    Book citation                         646        632     <0.01       4                                 
                    Plant Gene Register                   566        554     <0.01       5                                 
                    Thesis                                402        399     <0.01       6                                 
                    Unpublished observations              293        289     <0.01       7                                 
                    Patent                                172        170     <0.01       8                                 
                    Worm Breeder's Gazette                  6          6     <0.01       9                                 
                    
                    Total number of distinct authors cited in UniProtKB/Swiss-Prot: 298901
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Comments (CC)                        2283355                 4.35                                         
                    ALLERGEN                              497        497     <0.01      26                                 
                    ALTERNATIVE PRODUCTS                19698      19698      0.04      13                                 
                    BIOPHYSICOCHEMICAL PROPERTIES        3483       3483      0.01      22                                 
                    BIOTECHNOLOGY                         296        294     <0.01      28                                 
                    CATALYTIC ACTIVITY                 231295     210780      0.44       4                                 
                    CAUTION                              7262       7115      0.01      19                                 
                    COFACTOR                           101916      93653      0.19       7                                 
                    DEVELOPMENTAL STAGE                  9147       9147      0.02      17                                 
                    DISEASE                              4452       3012      0.01      21                                 
                    DISRUPTION PHENOTYPE                 3364       3364      0.01      23                                 
                    DOMAIN                              33731      29806      0.06      11                                 
                    ENZYME REGULATION                    9489       9489      0.02      16                                 
                    FUNCTION                           395137     378657      0.75       2                                 
                    INDUCTION                           12780      12780      0.02      15                                 
                    INTERACTION                         12810      12810      0.02      14                                 
                    MASS SPECTROMETRY                    4765       3615      0.01      20                                 
                    MISCELLANEOUS                       30760      28388      0.06      12                                 
                    PATHWAY                            128617     117541      0.24       6                                 
                    PHARMACEUTICAL                         84         84     <0.01      29                                 
                    POLYMORPHISM                          819        780     <0.01      24                                 
                    PTM                                 37872      30433      0.07       9                                 
                    RNA EDITING                           619        619     <0.01      25                                 
                    SEQUENCE CAUTION                    38871      38871      0.07       8                                 
                    SIMILARITY                         616848     500404      1.17       1                                 
                    SUBCELLULAR LOCATION               307943     302610      0.59       3                                 
                    SUBUNIT                            226680     226680      0.43       5                                 
                    TISSUE SPECIFICITY                  35089      35089      0.07      10                                 
                    TOXIC DOSE                            460        447     <0.01      27                                 
                    WEB RESOURCE                         8571       6854      0.02      18                                 
                    
                    Total number of comment topics: 29
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Features (FT)                        3347886                 6.37                                         
                    ACT_SITE                           131445      79286      0.25       9                                 
                    BINDING                            218967      61430      0.42       4                                 
                    CA_BIND                              3770       1557      0.01      35                                 
                    CARBOHYD                           102223      25892      0.19      13                                 
                    CHAIN                              531714     519649      1.01       1                                 
                    COILED                              18797      12846      0.04      26                                 
                    COMPBIAS                            50780      26592      0.10      18                                 
                    CONFLICT                           118923      41712      0.23      11                                 
                    CROSSLNK                             5970       3578      0.01      34                                 
                    DISULFID                            99823      26831      0.19      15                                 
                    DNA_BIND                            10997      10130      0.02      30                                 
                    DOMAIN                             152088      90912      0.29       6                                 
                    HELIX                              137731      14389      0.26       7                                 
                    INIT_MET                            14948      14948      0.03      27                                 
                    INTRAMEM                             1869        806     <0.01      38                                 
                    LIPID                               10687       6805      0.02      31                                 
                    METAL                              285695      70302      0.54       3                                 
                    MOD_RES                            182922      60603      0.35       5                                 
                    MOTIF                               32937      21186      0.06      23                                 
                    MUTAGEN                             33729       7992      0.06      22                                 
                    NON_CONS                             1916        726     <0.01      37                                 
                    NON_STD                               351        276     <0.01      39                                 
                    NON_TER                             11962       9096      0.02      28                                 
                    NP_BIND                            108502      69341      0.21      12                                 
                    PEPTIDE                              9487       6327      0.02      32                                 
                    PROPEP                              11871      10165      0.02      29                                 
                    REGION                              99875      53874      0.19      14                                 
                    REPEAT                              91312      13455      0.17      16                                 
                    SIGNAL                              36069      36059      0.07      21                                 
                    SITE                                38689      22948      0.07      20                                 
                    STRAND                             136775      13409      0.26       8                                 
                    TOPO_DOM                           120549      24663      0.23      10                                 
                    TRANSIT                              7298       7211      0.01      33                                 
                    TRANSMEM                           342558      70199      0.65       2                                 
                    TURN                                32453      11313      0.06      24                                 
                    UNSURE                               2487        486     <0.01      36                                 
                    VAR_SEQ                             39977      17188      0.08      19                                 
                    VARIANT                             81047      16582      0.15      17                                 
                    ZN_FING                             28693      12459      0.05      25                                 
                    
                    Total number of feature keys: 39
                    
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank      Category
                    ------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
                    Cross-references (DR)               14214639                27.06                                                           
                    2DBase-Ecoli                           85         85     <0.01     122      2D gel databases                             
                    Aarhus/Ghent-2DPAGE                   126         96     <0.01     119      2D gel databases                             
                    AGD                                   865        859     <0.01      98      Organism-specific databases                  
                    Allergome                            1317        796     <0.01      93      Protein family/group databases               
                    ANU-2DPAGE                             23         23     <0.01     128      2D gel databases                             
                    ArachnoServer                         759        755     <0.01     100      Organism-specific databases                  
                    ArrayExpress                        58494      58494      0.11      41      Gene expression databases                    
                    Bgee                                39554      39534      0.08      47      Gene expression databases                    
                    BindingDB                             297        297     <0.01     115      Other                                        
                    BioCyc                             252108     243494      0.48      19      Enzyme and pathway databases                 
                    BRENDA                              65241      62441      0.12      40      Enzyme and pathway databases                 
                    CAZy                                 7244       6499      0.01      71      Protein family/group databases               
                    CGD                                   587        578     <0.01     104      Organism-specific databases                  
                    CleanEx                             30168      29518      0.06      49      Gene expression databases                    
                    COMPLUYEAST-2DPAGE                    101        100     <0.01     121      2D gel databases                             
                    ConoServer                            613        587     <0.01     103      Organism-specific databases                  
                    Cornea-2DPAGE                          67         67     <0.01     123      2D gel databases                             
                    CTD                                 65575      64992      0.12      38      Organism-specific databases                  
                    CYGD                                 6638       6543      0.01      73      Organism-specific databases                  
                    dictyBase                            4086       4086      0.01      86      Organism-specific databases                  
                    DIP                                 12501      12379      0.02      64      Protein-protein interaction databases        
                    DisProt                               397        394     <0.01     110      3D structure databases                       
                    DOSAC-COBS-2DPAGE                     149        147     <0.01     118      2D gel databases                             
                    DrugBank                             5317       1626      0.01      76      Other                                        
                    EchoBASE                             4167       4163      0.01      85      Organism-specific databases                  
                    ECO2DBASE                             352        300     <0.01     112      2D gel databases                             
                    EcoGene                              4291       4289      0.01      84      Organism-specific databases                  
                    eggNOG                             218695     218695      0.42      20      Phylogenomic databases                       
                    EMBL                               879500     515018      1.67       3      Sequence databases                           
                    Ensembl                             74665      58165      0.14      34      Genome annotation databases                  
                    EnsemblBacteria                     98102      84882      0.19      29      Genome annotation databases                  
                    EnsemblFungi                        14892      14734      0.03      62      Genome annotation databases                  
                    EnsemblMetazoa                      10715       8435      0.02      66      Genome annotation databases                  
                    EnsemblPlants                       15415      13392      0.03      61      Genome annotation databases                  
                    EnsemblProtists                      4449       4329      0.01      82      Genome annotation databases                  
                    euHCVdb                                55         44     <0.01     124      Organism-specific databases                  
                    EuPathDB                              301        301     <0.01     114      Organism-specific databases                  
                    FlyBase                              5766       5392      0.01      75      Organism-specific databases                  
                    Gene3D                             293761     232016      0.56      17      Family and domain databases                  
                    GeneCards                           20431      19796      0.04      54      Organism-specific databases                  
                    GeneDB_Spombe                        4978       4934      0.01      78      Organism-specific databases                  
                    GeneFarm                             2847       2833      0.01      89      Organism-specific databases                  
                    GeneID                             462731     443215      0.88       7      Genome annotation databases                  
                    GeneTree                           187343     163065      0.36      22      Phylogenomic databases                       
                    Genevestigator                      65547      65547      0.12      39      Gene expression databases                    
                    GenoList                             7051       7039      0.01      72      Organism-specific databases                  
                    GenomeReviews                      380562     360484      0.72      10      Genome annotation databases                  
                    GermOnline                          41923      41305      0.08      46      Gene expression databases                    
                    GlycoSuiteDB                          272        272     <0.01     116      PTM databases                                
                    GO                                2132184     492154      4.06       1      Ontologies                                   
                    Gramene                              4539       4539      0.01      81      Organism-specific databases                  
                    H-InvDB                             13207      12309      0.03      63      Organism-specific databases                  
                    HAMAP                              308910     308765      0.59      16      Family and domain databases                  
                    HGNC                                19732      19558      0.04      56      Organism-specific databases                  
                    HOGENOM                            362601     362601      0.69      12      Phylogenomic databases                       
                    HOVERGEN                            74692      74692      0.14      33      Phylogenomic databases                       
                    HPA                                 11296       8335      0.02      65      Organism-specific databases                  
                    HSSP                                29594      29594      0.06      50      3D structure databases                       
                    InParanoid                          67226      67226      0.13      37      Phylogenomic databases                       
                    IntAct                              24505      24505      0.05      52      Protein-protein interaction databases        
                    InterPro                          1712988     500373      3.26       2      Family and domain databases                  
                    IPI                                 90645      64895      0.17      31      Sequence databases                           
                    KEGG                               441412     420297      0.84       8      Genome annotation databases                  
                    LegioList                             761        759     <0.01      99      Organism-specific databases                  
                    Leproma                               671        668     <0.01     102      Organism-specific databases                  
                    MaizeGDB                              477        473     <0.01     107      Organism-specific databases                  
                    MEROPS                              10317       9984      0.02      67      Protein family/group databases               
                    MGI                                 16240      16195      0.03      59      Organism-specific databases                  
                    MIM                                 16528      12914      0.03      58      Organism-specific databases                  
                    MINT                                17513      17513      0.03      57      Protein-protein interaction databases        
                    NextBio                             48906      48904      0.09      44      Other                                        
                    neXtProt                            20098      20098      0.04      55      Organism-specific databases                  
                    NMPDR                              131605     131600      0.25      26      Genome annotation databases                  
                    OGP                                   377        377     <0.01     111      2D gel databases                             
                    OMA                                370700     370700      0.71      11      Phylogenomic databases                       
                    Orphanet                             3759       2285      0.01      87      Organism-specific databases                  
                    OrthoDB                             57158      57158      0.11      42      Phylogenomic databases                       
                    PANTHER                            187025     171528      0.36      23      Family and domain databases                  
                    Pathway_Interaction_DB               4567       1665      0.01      80      Enzyme and pathway databases                 
                    PDB                                 72213      16454      0.14      36      3D structure databases                       
                    PDBsum                              72213      16454      0.14      35      3D structure databases                       
                    PeptideAtlas                         5168       5168      0.01      77      Proteomic databases                          
                    PeroxiBase                            739        728     <0.01     101      Protein family/group databases               
                    Pfam                               697422     488703      1.33       4      Family and domain databases                  
                    PharmGKB                            15421      15115      0.03      60      Organism-specific databases                  
                    PHCI-2DPAGE                           247        247     <0.01     117      2D gel databases                             
                    PhosphoSite                         20437      20437      0.04      53      PTM databases                                
                    PhosSite                              351        351     <0.01     113      PTM databases                                
                    PhylomeDB                          122689     122689      0.23      27      Phylogenomic databases                       
                    PIR                                116213     106200      0.22      28      Sequence databases                           
                    PIRSF                               85433      85433      0.16      32      Family and domain databases                  
                    PMAP-CutDB                           1394       1394     <0.01      92      Other                                        
                    PMMA-2DPAGE                            52         52     <0.01     125      2D gel databases                             
                    PptaseDB                               34         34     <0.01     126      Protein family/group databases               
                    PRIDE                               54384      54384      0.10      43      Proteomic databases                          
                    PRINTS                             137541     119320      0.26      25      Family and domain databases                  
                    ProDom                              27684      27505      0.05      51      Family and domain databases                  
                    ProMEX                                472        472     <0.01     108      Proteomic databases                          
                    PROSITE                            466547     296435      0.89       6      Family and domain databases                  
                    ProtClustDB                        339182     339182      0.65      14      Phylogenomic databases                       
                    ProteinModelPortal                 414335     414335      0.79       9      3D structure databases                       
                    PseudoCAP                            1222       1213     <0.01      95      Organism-specific databases                  
                    Rat-heart-2DPAGE                       28         28     <0.01     127      2D gel databases                             
                    Reactome                             8997       5318      0.02      69      Enzyme and pathway databases                 
                    REBASE                                441        398     <0.01     109      Protein family/group databases               
                    RefSeq                             485723     443516      0.92       5      Sequence databases                           
                    REPRODUCTION-2DPAGE                  1255       1034     <0.01      94      2D gel databases                             
                    RGD                                  7487       7483      0.01      70      Organism-specific databases                  
                    SGD                                  6638       6559      0.01      74      Organism-specific databases                  
                    Siena-2DPAGE                          102        102     <0.01     120      2D gel databases                             
                    SMART                              155663     118556      0.30      24      Family and domain databases                  
                    SMR                                348512     348512      0.66      13      3D structure databases                       
                    STRING                             206037     206016      0.39      21      Protein-protein interaction databases        
                    SUPFAM                             319383     253888      0.61      15      Family and domain databases                  
                    SWISS-2DPAGE                         1184       1183     <0.01      96      2D gel databases                             
                    TAIR                                10137      10051      0.02      68      Organism-specific databases                  
                    TCDB                                 3477       3467      0.01      88      Protein family/group databases               
                    TIGR                                34218      33447      0.07      48      Genome annotation databases                  
                    TIGRFAMs                           285608     265624      0.54      18      Family and domain databases                  
                    TubercuList                          1761       1725     <0.01      91      Organism-specific databases                  
                    UCD-2DPAGE                            511        502     <0.01     106      2D gel databases                             
                    UCSC                                48640      39648      0.09      45      Genome annotation databases                  
                    UniGene                             92957      85119      0.18      30      Sequence databases                           
                    VectorBase                            525        512     <0.01     105      Genome annotation databases                  
                    World-2DPAGE                          916        905     <0.01      97      2D gel databases                             
                    WormBase                             4632       3810      0.01      79      Organism-specific databases                  
                    Xenbase                              4405       4339      0.01      83      Organism-specific databases                  
                    ZFIN                                 2653       2642      0.01      90      Organism-specific databases                  
                    
                    Total number of cross-referenced databases: 128
                    
                    6.  AMINO ACID COMPOSITION
                    
                    6.1  Composition in percent for the complete database
                    
                    Ala (A) 8.27   Gln (Q) 3.93   Leu (L) 9.67   Ser (S) 6.52
                    Arg (R) 5.53   Glu (E) 6.76   Lys (K) 5.85   Thr (T) 5.33
                    Asn (N) 4.05   Gly (G) 7.09   Met (M) 2.42   Trp (W) 1.08
                    Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.92
                    Cys (C) 1.36   Ile (I) 5.98   Pro (P) 4.69   Val (V) 6.87
                    
                    Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00
                    
                    
                    
                    Legend: gray = aliphatic, red = acidic, green = small hydroxy,
                    blue = basic, black = aromatic, white = amide, yellow = sulfur
                    
                    
                    6.2  Classification of the amino acids by their frequency
                    
                    Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
                    Phe, Tyr, Met, His, Cys, Trp
                    
                    
                    7.  MISCELLANEOUS STATISTICS
                    
                    4446 entries are encoded on a mitochondrion, and 3598 are encoded on a plasmid.
                    
                    12184 entries are encoded on a plastid, 
                    of which 21 are encoded on apicoplasts, 
                    11620 on chloroplasts, 
                    50 on organellar chromatophores,
                    145 on cyanelles, 
                    149 on non-photosynthetic plastids and 
                    199 on unspecified types of plastid.
                    
                    Number of entries with at least one sequence correction: 70390