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UniProtKB/Swiss-Prot protein knowledgebase release 2010_12 statistics
                    
                    
                    1.  INTRODUCTION
                    
                    Release 2010_12 of 30-Nov-10 of UniProtKB/Swiss-Prot contains 523151 sequence entries,
                    comprising 184678199 amino acids abstracted from 193537 references. 
                    
                    1150 sequences have been added since release 2010_11, the sequence data of
                    317 existing entries has been updated and the annotations of
                    470133 entries have been revised.
                    
                    Number of fragments: 8803
                    Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 29739
                    
                    
                    Protein existence (PE):           entries     %
                    
                    1: Evidence at protein level        71573   13.7%
                    2: Evidence at transcript level     68043     13%
                    3: Inferred from homology          367566   70.3%
                    4: Predicted                        14300    2.7%
                    5: Uncertain                         1669    0.3%
                    
                    The growth of the database is summarized below.
                    
                    
                    
                    
                    2.  TAXONOMIC ORIGIN
                    
                    Total number of species represented in this release of UniProtKB/Swiss-Prot: 12317
                    
                    The first twenty species represent 109199 sequences:  20.9 % of the total
                    number of entries.
                    
                    
                    2.1 Table of the frequency of occurrence of species
                    
                    Species represented 1x: 5290
                    2x: 1758
                    3x:  921
                    4x:  608
                    5x:  434
                    6x:  353
                    7x:  250
                    8x:  213
                    9x:  192
                    10x:  104
                    11- 20x:  610
                    21- 50x:  383
                    51-100x:  178
                    >100x: 1023
                    
                    
                    2.2  Table of the most represented species
                    
                    ------  ---------  --------------------------------------------
                    Number  Frequency  Species
                    ------  ---------  --------------------------------------------
                    1      20258  Homo sapiens (Human)
                    2      16327  Mus musculus (Mouse)
                    3       9842  Arabidopsis thaliana (Mouse-ear cress)
                    4       7560  Rattus norvegicus (Rat)
                    5       6582  Saccharomyces cerevisiae (Baker's yeast)
                    6       5803  Bos taurus (Bovine)
                    7       4976  Schizosaccharomyces pombe (Fission yeast)
                    8       4429  Escherichia coli (strain K12)
                    9       4254  Bacillus subtilis
                    10       4250  Dictyostelium discoideum (Slime mold)
                    11       3314  Caenorhabditis elegans
                    12       3278  Xenopus laevis (African clawed frog)
                    13       3097  Drosophila melanogaster (Fruit fly)
                    14       2694  Danio rerio (Zebrafish) (Brachydanio rerio)
                    15       2597  Oryza sativa subsp. japonica (Rice)
                    16       2211  Pongo abelii (Sumatran orangutan)
                    17       2179  Gallus gallus (Chicken)
                    18       1993  Escherichia coli O157:H7
                    19       1782  Methanocaldococcus jannaschii (Methanococcus jannaschii)
                    20       1773  Salmonella typhimurium
                    21       1773  Haemophilus influenzae
                    22       1721  Mycobacterium tuberculosis
                    23       1669  Shigella flexneri
                    24       1667  Escherichia coli O6
                    25       1569  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
                    26       1376  Sus scrofa (Pig)
                    27       1342  Salmonella typhi
                    28       1283  Pseudomonas aeruginosa
                    29       1223  Mycobacterium bovis
                    30       1161  Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
                    31       1018  Synechocystis sp. (strain PCC 6803)
                    32        998  Yersinia pestis
                    33        993  Archaeoglobus fulgidus
                    34        942  Vibrio cholerae
                    35        929  Salmonella paratyphi A
                    36        924  Staphylococcus aureus (strain N315)
                    37        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
                    38        913  Rhizobium meliloti (Sinorhizobium meliloti)
                    39        909  Acanthamoeba polyphaga mimivirus (APMV)
                    40        897  Staphylococcus aureus (strain COL)
                    41        895  Staphylococcus aureus (strain MW2)
                    42        889  Staphylococcus aureus (strain MSSA476)
                    43        886  Staphylococcus aureus (strain MRSA252)
                    44        882  Oryctolagus cuniculus (Rabbit)
                    45        881  Salmonella choleraesuis
                    46        879  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
                    47        871  Shigella sonnei (strain Ss046)
                    48        864  Yersinia pseudotuberculosis
                    49        851  Ashbya gossypii (Yeast) (Eremothecium gossypii)
                    50        835  Escherichia coli O9:H4 (strain HS)
                    51        829  Escherichia coli O139:H28 (strain E24377A / ETEC)
                    52        826  Kluyveromyces lactis (Yeast) (Candida sphaerica)
                    53        825  Shigella boydii serotype 4 (strain Sb227)
                    54        820  Candida albicans (Yeast)
                    55        817  Escherichia coli (strain UTI89 / UPEC)
                    56        814  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
                    57        804  Shigella dysenteriae serotype 1 (strain Sd197)
                    58        794  Vibrio parahaemolyticus
                    59        785  Escherichia coli (strain SMS-3-5 / SECEC)
                    60        785  Candida glabrata (Yeast) (Torulopsis glabrata)
                    61        785  Neurospora crassa
                    62        778  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
                    63        777  Pasteurella multocida
                    64        773  Aquifex aeolicus
                    65        765  Canis familiaris (Dog) (Canis lupus familiaris)
                    66        765  Escherichia coli (strain K12 / DH10B)
                    67        759  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
                    68        759  Escherichia coli (strain K12 / MC4100 / BW2952)
                    69        757  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
                    70        757  Escherichia coli (strain 55989 / EAEC)
                    71        757  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
                    72        756  Escherichia coli O8 (strain IAI1)
                    73        756  Staphylococcus epidermidis (strain ATCC 12228)
                    74        751  Escherichia coli O45:K1 (strain S88 / ExPEC)
                    75        750  Escherichia coli (strain SE11)
                    76        750  Shigella flexneri serotype 5b (strain 8401)
                    77        748  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
                    78        746  Streptomyces coelicolor
                    79        742  Escherichia coli O157:H7 (strain EC4115 / EHEC)
                    80        738  Photorhabdus luminescens subsp. laumondii
                    81        731  Bacillus halodurans
                    82        731  Vibrio vulnificus
                    83        726  Escherichia coli O81 (strain ED1a)
                    84        725  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
                    85        724  Bacillus anthracis
                    86        722  Emericella nidulans (Aspergillus nidulans)
                    87        720  Salmonella enteritidis PT4 (strain P125109)
                    88        715  Vibrio vulnificus (strain YJ016)
                    89        715  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
                    90        713  Yersinia pestis bv. Antiqua (strain Nepal516)
                    91        713  Salmonella paratyphi A (strain AKU_12601)
                    92        712  Staphylococcus aureus (strain NCTC 8325)
                    93        712  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
                    94        711  Salmonella agona (strain SL483)
                    95        711  Salmonella newport (strain SL254)
                    96        710  Salmonella heidelberg (strain SL476)
                    97        709  Yersinia pestis bv. Antiqua (strain Antiqua)
                    98        709  Salmonella schwarzengrund (strain CVM19633)
                    99        706  Escherichia coli O1:K1 / APEC
                    100        700  Salmonella dublin (strain CT_02021853)
                    101        699  Enterobacter sp. (strain 638)
                    102        698  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
                    103        697  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
                    104        687  Mycoplasma pneumoniae
                    105        686  Pan troglodytes (Chimpanzee)
                    106        686  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
                    107        686  Klebsiella pneumoniae (strain 342)
                    108        684  Pseudomonas syringae pv. tomato
                    109        682  Salmonella gallinarum (strain 287/91 / NCTC 13346)
                    110        678  Nostoc sp. (strain PCC 7120 / UTEX 2576)
                    111        671  Pseudomonas putida (strain KT2440)
                    112        668  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
                    113        667  Mycobacterium leprae
                    114        666  Staphylococcus aureus (strain USA300)
                    115        666  Yersinia pestis (strain Pestoides F)
                    116        664  Zea mays (Maize)
                    117        658  Rhizobium sp. (strain NGR234)
                    118        655  Serratia proteamaculans (strain 568)
                    119        649  Bradyrhizobium japonicum
                    120        644  Escherichia coli
                    121        642  Staphylococcus aureus (strain bovine RF122 / ET3-1)
                    122        638  Bacillus cereus (strain ATCC 14579 / DSM 31)
                    123        637  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
                    124        635  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
                    125        633  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
                    126        621  Shewanella oneidensis
                    127        621  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
                    128        616  Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
                    129        615  Treponema pallidum
                    130        614  Ralstonia solanacearum (Pseudomonas solanacearum)
                    131        609  Staphylococcus haemolyticus (strain JCSC1435)
                    132        608  Enterobacter sakazakii (strain ATCC BAA-894)
                    133        606  Yarrowia lipolytica (Candida lipolytica)
                    134        603  Rhizobium loti (Mesorhizobium loti)
                    135        602  Methanobacterium thermoautotrophicum
                    136        602  Staphylococcus saprophyticus subsp. saprophyticus 
                    137        600  Salmonella paratyphi C (strain RKS4594)
                    138        598  Yersinia pestis bv. Antiqua (strain Angola)
                    139        596  Photobacterium profundum (Photobacterium sp. (strain SS9))
                    140        596  Listeria monocytogenes
                    141        590  Bacillus cereus (strain ATCC 10987)
                    142        590  Xanthomonas campestris pv. campestris
                    143        588  Listeria innocua
                    144        585  Rickettsia prowazekii
                    145        584  Helicobacter pylori (Campylobacter pylori)
                    146        584  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
                    147        584  Aspergillus fumigatus (Sartorya fumigata)
                    148        581  Lactococcus lactis subsp. lactis (Streptococcus lactis)
                    149        579  Neisseria meningitidis serogroup B
                    150        576  Brucella suis
                    151        572  Brucella melitensis
                    152        572  Buchnera aphidicola subsp. Acyrthosiphon pisum 
                    153        569  Bacillus thuringiensis subsp. konkukian
                    154        565  Helicobacter pylori J99 (Campylobacter pylori J99)
                    155        562  Buchnera aphidicola subsp. Schizaphis graminum
                    156        560  Bacillus cereus (strain ZK / E33L)
                    157        560  Pseudomonas syringae pv. syringae (strain B728a)
                    158        557  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
                    159        557  Pseudomonas aeruginosa (strain UCBPP-PA14)
                    160        556  Neisseria meningitidis serogroup A
                    161        555  Xanthomonas axonopodis pv. citri (Citrus canker)
                    162        553  Vibrio fischeri (strain ATCC 700601 / ES114)
                    163        551  Pseudomonas fluorescens (strain Pf0-1)
                    164        549  Oceanobacillus iheyensis
                    165        547  Clostridium acetobutylicum
                    166        545  Caulobacter crescentus (Caulobacter vibrioides)
                    167        545  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
                    168        539  Caenorhabditis briggsae
                    169        538  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
                    170        530  Oryza sativa subsp. indica (Rice)
                    171        529  Listeria monocytogenes serotype 4b (strain F2365)
                    172        524  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
                    173        522  Sodalis glossinidius (strain morsitans)
                    174        522  Xylella fastidiosa
                    175        521  Bordetella bronchiseptica (Alcaligenes bronchisepticus)
                    176        519  Streptococcus pneumoniae
                    177        513  Chromobacterium violaceum
                    178        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
                    179        511  Thermotoga maritima
                    180        509  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
                    181        507  Bordetella parapertussis
                    182        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
                    183        507  Pseudomonas aeruginosa (strain PA7)
                    184        506  Bordetella pertussis
                    185        505  Staphylococcus aureus (strain Newman)
                    186        504  Haemophilus ducreyi
                    187        504  Geobacillus kaustophilus
                    188        500  Pseudomonas entomophila (strain L48)
                    189        498  Deinococcus radiodurans
                    190        498  Brucella abortus
                    191        497  Rickettsia conorii
                    192        496  Bacillus clausii (strain KSM-K16)
                    193        492  Haemophilus influenzae (strain 86-028NP)
                    194        492  Streptomyces avermitilis
                    195        491  Corynebacterium glutamicum (Brevibacterium flavum)
                    196        490  Xanthomonas campestris pv. campestris (strain 8004)
                    197        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
                    198        490  Clostridium perfringens
                    199        488  Bacillus amyloliquefaciens (strain FZB42)
                    200        487  Burkholderia pseudomallei (Pseudomonas pseudomallei)
                    201        487  Shewanella sp. (strain MR-7)
                    202        484  Pseudomonas aeruginosa (strain LESB58)
                    203        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
                    204        484  Shewanella sp. (strain MR-4)
                    205        483  Mannheimia succiniciproducens (strain MBEL55E)
                    206        483  Mycoplasma genitalium
                    207        482  Methanosarcina acetivorans
                    208        481  Proteus mirabilis (strain HI4320)
                    209        475  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
                    210        473  Pseudomonas putida (strain F1 / ATCC 700007)
                    211        472  Burkholderia sp. (strain 383) (Burkholderia cepacia 
                    212        472  Brucella abortus (strain 2308)
                    213        472  Thermosynechococcus elongatus (strain BP-1)
                    214        469  Acinetobacter sp. (strain ADP1)
                    215        469  Enterococcus faecalis (Streptococcus faecalis)
                    216        466  Pyrococcus horikoshii
                    217        465  Rhodopseudomonas palustris
                    218        465  Xanthomonas campestris pv. vesicatoria (strain 85-10)
                    219        465  Pseudomonas putida (strain GB-1)
                    220        464  Shewanella frigidimarina (strain NCIMB 400)
                    221        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
                    222        462  Shewanella sp. (strain ANA-3)
                    223        461  Burkholderia mallei (Pseudomonas mallei)
                    224        461  Lactobacillus plantarum
                    225        460  Ralstonia eutropha  (Cupriavidus necator 
                    226        460  Methanosarcina mazei (Methanosarcina frisia)
                    227        458  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
                    228        458  Pyrococcus abyssi
                    229        457  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
                    230        457  Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus)
                    231        455  Staphylococcus aureus (strain JH1)
                    232        454  Halobacterium salinarium (Halobacterium halobium)
                    233        453  Rickettsia felis (Rickettsia azadi)
                    234        453  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
                    235        452  Shewanella baltica (strain OS185)
                    236        452  Pseudomonas putida (strain W619)
                    237        449  Staphylococcus aureus (strain JH9)
                    238        449  Streptococcus mutans
                    239        449  Ovis aries (Sheep)
                    240        448  Methylococcus capsulatus
                    241        448  Thermoanaerobacter tengcongensis
                    242        448  Aeromonas salmonicida (strain A449)
                    243        446  Mycobacterium paratuberculosis
                    244        446  Vibrio fischeri (strain MJ11)
                    245        446  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
                    246        444  Hahella chejuensis (strain KCTC 2396)
                    247        444  Pseudomonas mendocina (strain ymp)
                    248        443  Dechloromonas aromatica (strain RCB)
                    249        441  Streptococcus pyogenes serotype M6
                    250        441  Nicotiana tabacum (Common tobacco)
                    
                    
                    
                    2.3  Taxonomic distribution of the sequences
                    
                    
                    
                    Kingdom        sequences (% of the database)
                    Archaea           18372 (  4%)
                    Bacteria         324704 ( 62%)
                    Eukaryota        164985 ( 32%)
                    Viruses           15090 (  3%)
                    
                    
                    Within Eukaryota:
                    
                    
                    
                    Category            sequences (% of Eukaryota) (% of the complete database)
                    Human                  20259 ( 12%)           (  4%)
                    Other Mammalia         44929 ( 27%)           (  9%)
                    Other Vertebrata       16380 ( 10%)           (  3%)
                    Viridiplantae          30264 ( 18%)           (  6%)
                    Fungi                  27177 ( 16%)           (  5%)
                    Insecta                 8164 (  5%)           (  2%)
                    Nematoda                4153 (  3%)           (  1%)
                    Other                  13659 (  8%)           (  3%)
                    
                    
                    
                    3.  SEQUENCE SIZE
                    
                    Repartition of the sequences by size (excluding fragments)
                    
                    From   To  Number             From   To   Number
                    1-  50    8563             1001-1100     3563
                    51- 100   40344             1101-1200     2463
                    101- 150   56324             1201-1300     1929
                    151- 200   56285             1301-1400     1795
                    201- 250   55147             1401-1500     1434
                    251- 300   48373             1501-1600      639
                    301- 350   48877             1601-1700      518
                    351- 400   41915             1701-1800      430
                    401- 450   34454             1801-1900      398
                    451- 500   27610             1901-2000      327
                    501- 550   19544             2001-2100      203
                    551- 600   13939             2101-2200      268
                    601- 650   11686             2201-2300      280
                    651- 700    8342             2301-2400      168
                    701- 750    6936             2401-2500      130
                    751- 800    4983             >2500         1028
                    801- 850    4345
                    851- 900    4845
                    901- 950    3682
                    951-1000    2581
                    
                    
                    
                    
                    The average sequence length in UniProtKB/Swiss-Prot is 353 amino acids.
                    
                    The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
                    The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.
                    
                    
                    4.  JOURNAL CITATIONS
                    
                    Note: the following citation statistics reflect the number of distinct
                    journal citations.
                    
                    Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2103
                    
                    
                    4.1 Table of the frequency of journal citations
                    
                    Journals cited 1x:  679
                    2x:  286
                    3x:  147
                    4x:  102
                    5x:   90
                    6x:   67
                    7x:   35
                    8x:   37
                    9x:   32
                    10x:   29
                    11- 20x:  167
                    21- 50x:  171
                    51-100x:  100
                    >100x:  161
                    
                    
                    4.2  List of the most cited journals in UniProtKB/Swiss-Prot
                    
                    Nb    Citations   Journal name
                    --    ---------   -------------------------------------------------------------
                    1        18337   Journal of Biological Chemistry
                    2         8471   Proceedings of the National Academy of Sciences of the U.S.A.
                    3         5086   Journal of Bacteriology
                    4         4586   Biochemical and Biophysical Research Communications
                    5         4520   Gene
                    6         4316   Nucleic Acids Research
                    7         4021   FEBS Letters
                    8         3960   Biochemistry
                    9         3796   The EMBO Journal
                    10         3471   Molecular and Cellular Biology
                    11         3298   Nature
                    12         3125   Journal of Molecular Biology
                    13         3122   European Journal of Biochemistry
                    14         3006   Biochimica et Biophysica Acta
                    15         2740   Cell
                    16         2481   Genomics
                    17         2207   Biochemical Journal
                    18         2168   Science
                    19         2078   Journal of Virology
                    20         1797   Molecular Microbiology
                    21         1607   Journal of Cell Biology
                    22         1517   Plant Molecular Biology
                    23         1402   Plant Physiology
                    24         1400   Genes and Development
                    25         1378   Virology
                    26         1342   Nature Genetics
                    27         1342   Human Molecular Genetics
                    28         1306   Molecular and General Genetics
                    29         1306   The American Journal of Human Genetics
                    30         1216   Oncogene
                    31         1195   Development
                    32         1173   Journal of Biochemistry
                    33         1107   Human Mutation
                    34         1054   Molecular Biology of the Cell
                    35         1027   Journal of Immunology
                    36         1001   Genetics
                    37          951   The Plant Cell
                    38          909   Structure
                    39          902   Journal of General Virology
                    40          891   Infection and Immunity
                    41          868   Molecular Cell
                    42          838   Archives of Biochemistry and Biophysics
                    43          815   The Plant Journal
                    44          810   Blood
                    45          765   Microbiology
                    46          761   Yeast
                    47          753   Journal of Cell Science
                    48          737   Developmental Biology
                    49          679   Cancer Research
                    50          667   Current Biology
                    51          666   FEMS Microbiology Letters
                    52          599   Nature Structural Biology
                    53          598   Mechanisms of Development
                    54          596   Human Genetics
                    55          570   Acta Crystallographica, Section D
                    56          560   Protein Science
                    57          549   Applied and Environmental Microbiology
                    58          542   Journal of Neuroscience
                    59          529   Toxicon
                    60          526   Current Genetics
                    61          515   Journal of Clinical Investigation
                    62          514   Neuron
                    63          472   Mammalian Genome
                    64          468   American Journal of Physiology
                    65          453   The Journal of Experimental Medicine
                    66          451   Immunogenetics
                    67          446   Molecular Endocrinology
                    68          423   Molecular and Biochemical Parasitology
                    69          414   Journal of Neurochemistry
                    70          412   The Journal of Clinical Endocrinology and Metabolism
                    71          395   Endocrinology
                    72          383   Proteins
                    73          381   Journal of Molecular Evolution
                    74          372   Bioscience, Biotechnology, and Biochemistry
                    75          367   DNA and Cell Biology
                    76          359   Molecular Biology and Evolution
                    77          357   DNA Sequence
                    78          356   Journal of Medical Genetics
                    79          337   Plant and Cell Physiology
                    80          323   Nature Cell Biology
                    81          321   Tissue Antigens
                    82          315   Brain Research. Molecular Brain Research
                    83          310   Peptides
                    84          307   Experimental Cell Research
                    85          299   Comparative Biochemistry and Physiology
                    86          290   Biological Chemistry Hoppe-Seyler
                    87          288   Antimicrobial Agents and Chemotherapy
                    88          282   Journal of Investigative Dermatology
                    89          276   Cytogenetics and Cell Genetics
                    90          270   Molecular Pharmacology
                    91          263   Biology of Reproduction
                    92          261   Developmental Cell
                    93          252   Genome Research
                    94          248   Journal of General Microbiology
                    95          248   Neurology
                    96          244   Developmental Dynamics
                    97          243   RNA
                    98          243   Virus Research
                    99          221   Planta
                    100          219   Molecular Plant-Microbe Interactions
                    101          215   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
                    102          207   European Journal of Immunology
                    103          206   Biochimie
                    104          206   DNA Research
                    105          204   Annals of Neurology
                    106          203   Genes to Cells
                    107          199   Nature Structural and Molecular Biology
                    108          199   Immunity
                    109          197   Eukaryotic cell
                    110          196   The New England Journal of Medicine
                    111          195   European Journal of Human Genetics
                    112          193   The FEBS Journal
                    113          187   Journal of Human Genetics
                    114          178   EMBO Reports
                    115          175   Molecular and Cellular Endocrinology
                    116          174   Investigative Ophthalmology and Visual Science
                    117          171   The FASEB Journal
                    118          166   Archives of Microbiology
                    119          165   American Journal of Medical Genetics
                    120          164   Molecular Phylogenetics and Evolution
                    121          162   Insect Biochemistry and Molecular Biology
                    122          159   Molecular Immunology
                    123          159   DNA
                    124          158   Archives of Virology
                    125          155   Molecular Reproduction and Development
                    126          153   Diabetes
                    127          153   Hemoglobin
                    128          152   Bioorganicheskaia Khimiia
                    129          151   Glycobiology
                    130          148   Clinical Genetics
                    131          145   PLoS ONE
                    132          144   International Journal of Cancer
                    133          144   Journal of the American Chemical Society
                    134          142   Journal of Cellular Biochemistry
                    135          139   Molecular Genetics and Metabolism
                    136          137   General and Comparative Endocrinology
                    137          137   Animal Genetics
                    138          137   Molecular and Cellular Neuroscience
                    139          134   BMC Genomics
                    140          133   Nature Immunology
                    141          133   Biological Chemistry
                    142          130   British Journal of Haematology
                    143          129   American Journal of Medical Genetics. Part A
                    144          129   Molecular Genetics and Genomics
                    145          123   Journal of Lipid Research
                    146          122   Circulation Research
                    147          122   Proteomics
                    148          122   Agricultural and Biological Chemistry
                    149          119   Journal of Medicinal Chemistry
                    150          119   Protein Expression and Purification
                    
                    
                    5.  STATISTICS FOR SOME LINE TYPES
                    
                    The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
                    as well as the number of entries with at least one such line, and the
                    frequency of the lines.
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry
                    ------------------------------------  -------- ---------  ---------
                    
                    References (RL)                       948005                 1.81                                         
                    Journal                            749778     394782      1.43       1                                 
                    Submitted to EMBL/GenBank/DDBJ     185421     171290      0.35       2                                 
                    Submitted to other databases        10722       9282      0.02       3                                 
                    Book citation                         646        632     <0.01       4                                 
                    Plant Gene Register                   565        553     <0.01       5                                 
                    Thesis                                402        399     <0.01       6                                 
                    Unpublished observations              293        289     <0.01       7                                 
                    Patent                                172        170     <0.01       8                                 
                    Worm Breeder's Gazette                  6          6     <0.01       9                                 
                    
                    Total number of distinct authors cited in UniProtKB/Swiss-Prot: 295924
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Comments (CC)                        2261598                 4.32                                         
                    ALLERGEN                              495        495     <0.01      26                                 
                    ALTERNATIVE PRODUCTS                19220      19220      0.04      13                                 
                    BIOPHYSICOCHEMICAL PROPERTIES        3338       3338      0.01      22                                 
                    BIOTECHNOLOGY                         282        280     <0.01      28                                 
                    CATALYTIC ACTIVITY                 228004     207696      0.44       4                                 
                    CAUTION                              7230       7082      0.01      19                                 
                    COFACTOR                           101474      93238      0.19       7                                 
                    DEVELOPMENTAL STAGE                  9086       9086      0.02      17                                 
                    DISEASE                              4407       2984      0.01      21                                 
                    DISRUPTION PHENOTYPE                 3168       3168      0.01      23                                 
                    DOMAIN                              33230      29401      0.06      11                                 
                    ENZYME REGULATION                    9377       9377      0.02      16                                 
                    FUNCTION                           392267     376013      0.75       2                                 
                    INDUCTION                           12428      12428      0.02      15                                 
                    INTERACTION                         12759      12759      0.02      14                                 
                    MASS SPECTROMETRY                    4643       3526      0.01      20                                 
                    MISCELLANEOUS                       30707      28339      0.06      12                                 
                    PATHWAY                            128412     117344      0.25       6                                 
                    PHARMACEUTICAL                         84         84     <0.01      29                                 
                    POLYMORPHISM                          807        769     <0.01      24                                 
                    PTM                                 37309      30080      0.07       9                                 
                    RNA EDITING                           613        613     <0.01      25                                 
                    SEQUENCE CAUTION                    38562      38562      0.07       8                                 
                    SIMILARITY                         610937     498462      1.17       1                                 
                    SUBCELLULAR LOCATION               303871     298694      0.58       3                                 
                    SUBUNIT                            225370     225370      0.43       5                                 
                    TISSUE SPECIFICITY                  34533      34533      0.07      10                                 
                    TOXIC DOSE                            456        445     <0.01      27                                 
                    WEB RESOURCE                         8529       6814      0.02      18                                 
                    
                    Total number of comment topics: 29
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Features (FT)                        3321809                 6.35                                         
                    ACT_SITE                           130934      78958      0.25       9                                 
                    BINDING                            216009      60320      0.41       4                                 
                    CA_BIND                              3765       1552      0.01      35                                 
                    CARBOHYD                           101751      25778      0.19      13                                 
                    CHAIN                              529712     517821      1.01       1                                 
                    COILED                              18676      12732      0.04      26                                 
                    COMPBIAS                            50410      26377      0.10      18                                 
                    CONFLICT                           118323      41522      0.23      11                                 
                    CROSSLNK                             5944       3562      0.01      34                                 
                    DISULFID                            98799      26534      0.19      14                                 
                    DNA_BIND                            10989      10121      0.02      30                                 
                    DOMAIN                             147399      88222      0.28       6                                 
                    HELIX                              137754      14393      0.26       7                                 
                    INIT_MET                            14895      14895      0.03      27                                 
                    INTRAMEM                             1576        742     <0.01      38                                 
                    LIPID                               10666       6789      0.02      31                                 
                    METAL                              283019      69752      0.54       3                                 
                    MOD_RES                            181969      60264      0.35       5                                 
                    MOTIF                               32765      21041      0.06      23                                 
                    MUTAGEN                             32984       7828      0.06      22                                 
                    NON_CONS                             1902        721     <0.01      37                                 
                    NON_STD                               351        276     <0.01      39                                 
                    NON_TER                             11929       9069      0.02      28                                 
                    NP_BIND                            108266      68882      0.21      12                                 
                    PEPTIDE                              9192       6085      0.02      32                                 
                    PROPEP                              11636       9975      0.02      29                                 
                    REGION                              97863      52903      0.19      15                                 
                    REPEAT                              90369      13335      0.17      16                                 
                    SIGNAL                              35719      35709      0.07      21                                 
                    SITE                                38404      22857      0.07      20                                 
                    STRAND                             136798      13412      0.26       8                                 
                    TOPO_DOM                           118763      24447      0.23      10                                 
                    TRANSIT                              7137       7050      0.01      33                                 
                    TRANSMEM                           341632      70017      0.65       2                                 
                    TURN                                32454      11314      0.06      24                                 
                    UNSURE                               2264        445     <0.01      36                                 
                    VAR_SEQ                             39733      17082      0.08      19                                 
                    VARIANT                             80493      16549      0.15      17                                 
                    ZN_FING                             28565      12429      0.05      25                                 
                    
                    Total number of feature keys: 39
                    
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank      Category
                    ------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
                    Cross-references (DR)               13940310                26.65                                                           
                    2DBase-Ecoli                           85         85     <0.01     119      2D gel databases                             
                    Aarhus/Ghent-2DPAGE                   126         96     <0.01     116      2D gel databases                             
                    AGD                                   857        851     <0.01      95      Organism-specific databases                  
                    ANU-2DPAGE                             23         23     <0.01     125      2D gel databases                             
                    ArachnoServer                         759        755     <0.01      97      Organism-specific databases                  
                    ArrayExpress                        58397      58397      0.11      40      Gene expression databases                    
                    Bgee                                39532      39514      0.08      46      Gene expression databases                    
                    BindingDB                             297        297     <0.01     111      Other                                        
                    BioCyc                             251796     243190      0.48      19      Enzyme and pathway databases                 
                    BRENDA                              65224      62424      0.12      39      Enzyme and pathway databases                 
                    CAZy                                 7232       6489      0.01      69      Protein family/group databases               
                    CGD                                   583        574     <0.01     101      Organism-specific databases                  
                    CleanEx                             30176      29526      0.06      48      Gene expression databases                    
                    COMPLUYEAST-2DPAGE                    101        100     <0.01     118      2D gel databases                             
                    ConoServer                            613        587     <0.01     100      Organism-specific databases                  
                    Cornea-2DPAGE                          67         67     <0.01     120      2D gel databases                             
                    CTD                                 65641      64855      0.13      37      Organism-specific databases                  
                    CYGD                                 6638       6542      0.01      72      Organism-specific databases                  
                    dictyBase                            4132       4132      0.01      84      Organism-specific databases                  
                    DIP                                 12493      12371      0.02      63      Protein-protein interaction databases        
                    DisProt                               397        394     <0.01     107      3D structure databases                       
                    DOSAC-COBS-2DPAGE                     149        147     <0.01     115      2D gel databases                             
                    DrugBank                             5317       1626      0.01      74      Other                                        
                    EchoBASE                             4167       4163      0.01      83      Organism-specific databases                  
                    ECO2DBASE                             352        300     <0.01     110      2D gel databases                             
                    EcoGene                              4396       4394      0.01      80      Organism-specific databases                  
                    eggNOG                             218231     218231      0.42      20      Phylogenomic databases                       
                    EMBL                               871572     513033      1.67       3      Sequence databases                           
                    Ensembl                             73659      57428      0.14      33      Genome annotation databases                  
                    EnsemblBacteria                     97624      84482      0.19      28      Genome annotation databases                  
                    EnsemblFungi                        14696      14554      0.03      59      Genome annotation databases                  
                    EnsemblMetazoa                      12824       8424      0.02      62      Genome annotation databases                  
                    EnsemblPlants                       13909      12355      0.03      60      Genome annotation databases                  
                    EnsemblProtists                      4327       4210      0.01      82      Genome annotation databases                  
                    euHCVdb                                55         44     <0.01     121      Organism-specific databases                  
                    EuPathDB                              278        278     <0.01     112      Organism-specific databases                  
                    FlyBase                              5734       5360      0.01      73      Organism-specific databases                  
                    Gene3D                             292233     230853      0.56      17      Family and domain databases                  
                    GeneCards                           20448      19811      0.04      52      Organism-specific databases                  
                    GeneDB_Spombe                        4978       4934      0.01      76      Organism-specific databases                  
                    GeneFarm                             2726       2712      0.01      87      Organism-specific databases                  
                    GeneID                             466332     446812      0.89       6      Genome annotation databases                  
                    Genevestigator                      65322      65322      0.12      38      Gene expression databases                    
                    GenoList                             7048       7036      0.01      70      Organism-specific databases                  
                    GenomeReviews                      380414     360302      0.73      10      Genome annotation databases                  
                    GermOnline                          41927      41308      0.08      45      Gene expression databases                    
                    GlycoSuiteDB                          272        272     <0.01     113      PTM databases                                
                    GO                                2115289     489988      4.04       1      Ontologies                                   
                    Gramene                              4502       4502      0.01      79      Organism-specific databases                  
                    H-InvDB                             13209      12311      0.03      61      Organism-specific databases                  
                    HAMAP                              308504     308359      0.59      16      Family and domain databases                  
                    HGNC                                19715      19537      0.04      54      Organism-specific databases                  
                    HOGENOM                            361910     361910      0.69      12      Phylogenomic databases                       
                    HOVERGEN                            74616      74616      0.14      32      Phylogenomic databases                       
                    HPA                                 11299       8338      0.02      64      Organism-specific databases                  
                    HSSP                                29418      29418      0.06      49      3D structure databases                       
                    InParanoid                          66969      66969      0.13      36      Phylogenomic databases                       
                    IntAct                              24401      24401      0.05      51      Protein-protein interaction databases        
                    InterPro                          1707074     498739      3.26       2      Family and domain databases                  
                    IPI                                 90154      64625      0.17      30      Sequence databases                           
                    KEGG                               437079     416370      0.84       8      Genome annotation databases                  
                    LegioList                             761        759     <0.01      96      Organism-specific databases                  
                    Leproma                               670        667     <0.01      99      Organism-specific databases                  
                    MaizeGDB                              476        472     <0.01     103      Organism-specific databases                  
                    MEROPS                              10297       9964      0.02      65      Protein family/group databases               
                    MGI                                 16229      16183      0.03      57      Organism-specific databases                  
                    MIM                                 16486      12908      0.03      56      Organism-specific databases                  
                    MINT                                17498      17498      0.03      55      Protein-protein interaction databases        
                    NextBio                             48861      48859      0.09      43      Other                                        
                    NMPDR                              131264     131259      0.25      25      Genome annotation databases                  
                    OGP                                   377        377     <0.01     108      2D gel databases                             
                    OMA                                370018     370018      0.71      11      Phylogenomic databases                       
                    Orphanet                             3540       2241      0.01      85      Organism-specific databases                  
                    OrthoDB                             56953      56953      0.11      41      Phylogenomic databases                       
                    PANTHER                            186627     171189      0.36      22      Family and domain databases                  
                    Pathway_Interaction_DB               4567       1665      0.01      78      Enzyme and pathway databases                 
                    PDB                                 70775      16298      0.14      35      3D structure databases                       
                    PDBsum                              70775      16298      0.14      34      3D structure databases                       
                    PeptideAtlas                         5168       5168      0.01      75      Proteomic databases                          
                    PeroxiBase                            738        727     <0.01      98      Protein family/group databases               
                    Pfam                               696077     487364      1.33       4      Family and domain databases                  
                    PharmGKB                            15778      15767      0.03      58      Organism-specific databases                  
                    PHCI-2DPAGE                           247        247     <0.01     114      2D gel databases                             
                    PhosphoSite                         20435      20435      0.04      53      PTM databases                                
                    PhosSite                              352        352     <0.01     109      PTM databases                                
                    PhylomeDB                          122427     122427      0.23      26      Phylogenomic databases                       
                    PIR                                115969     105973      0.22      27      Sequence databases                           
                    PIRSF                               85210      85210      0.16      31      Family and domain databases                  
                    PMAP-CutDB                           1394       1394     <0.01      90      Other                                        
                    PMMA-2DPAGE                            52         52     <0.01     122      2D gel databases                             
                    PptaseDB                               34         34     <0.01     123      Protein family/group databases               
                    PRIDE                               54244      54244      0.10      42      Proteomic databases                          
                    PRINTS                             137460     118993      0.26      24      Family and domain databases                  
                    ProDom                              27747      27568      0.05      50      Family and domain databases                  
                    ProMEX                                467        467     <0.01     104      Proteomic databases                          
                    PROSITE                            464477     295535      0.89       7      Family and domain databases                  
                    ProtClustDB                        325425     325425      0.62      14      Phylogenomic databases                       
                    ProteinModelPortal                 413349     413349      0.79       9      3D structure databases                       
                    PseudoCAP                            1222       1213     <0.01      92      Organism-specific databases                  
                    Rat-heart-2DPAGE                       28         28     <0.01     124      2D gel databases                             
                    Reactome                             8207       4817      0.02      67      Enzyme and pathway databases                 
                    REBASE                                445        402     <0.01     106      Protein family/group databases               
                    RefSeq                             487730     446082      0.93       5      Sequence databases                           
                    REPRODUCTION-2DPAGE                  1255       1034     <0.01      91      2D gel databases                             
                    RGD                                  7464       7460      0.01      68      Organism-specific databases                  
                    SGD                                  6638       6558      0.01      71      Organism-specific databases                  
                    Siena-2DPAGE                          102        102     <0.01     117      2D gel databases                             
                    SMART                              154766     118050      0.30      23      Family and domain databases                  
                    SMR                                347959     347959      0.67      13      3D structure databases                       
                    STRING                             205718     205704      0.39      21      Protein-protein interaction databases        
                    SUPFAM                             316860     251884      0.61      15      Family and domain databases                  
                    SWISS-2DPAGE                         1184       1183     <0.01      93      2D gel databases                             
                    TAIR                                 9912       9812      0.02      66      Organism-specific databases                  
                    TCDB                                 3453       3446      0.01      86      Protein family/group databases               
                    TIGR                                34178      33409      0.07      47      Genome annotation databases                  
                    TIGRFAMs                           284950     265070      0.54      18      Family and domain databases                  
                    TubercuList                          1741       1705     <0.01      89      Organism-specific databases                  
                    UCD-2DPAGE                            511        502     <0.01     102      2D gel databases                             
                    UCSC                                48593      39606      0.09      44      Genome annotation databases                  
                    UniGene                             92868      84570      0.18      29      Sequence databases                           
                    VectorBase                            451        437     <0.01     105      Genome annotation databases                  
                    World-2DPAGE                          915        904     <0.01      94      2D gel databases                             
                    WormBase                             4607       3789      0.01      77      Organism-specific databases                  
                    Xenbase                              4389       4323      0.01      81      Organism-specific databases                  
                    ZFIN                                 2642       2631      0.01      88      Organism-specific databases                  
                    
                    Total number of cross-referenced databases: 125
                    
                    6.  AMINO ACID COMPOSITION
                    
                    6.1  Composition in percent for the complete database
                    
                    Ala (A) 8.27   Gln (Q) 3.93   Leu (L) 9.67   Ser (S) 6.52
                    Arg (R) 5.53   Glu (E) 6.76   Lys (K) 5.85   Thr (T) 5.33
                    Asn (N) 4.05   Gly (G) 7.09   Met (M) 2.42   Trp (W) 1.08
                    Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.91
                    Cys (C) 1.36   Ile (I) 5.98   Pro (P) 4.69   Val (V) 6.87
                    
                    Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00
                    
                    
                    
                    Legend: gray = aliphatic, red = acidic, green = small hydroxy,
                    blue = basic, black = aromatic, white = amide, yellow = sulfur
                    
                    
                    6.2  Classification of the amino acids by their frequency
                    
                    Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
                    Phe, Tyr, Met, His, Cys, Trp
                    
                    
                    7.  MISCELLANEOUS STATISTICS
                    
                    4448 entries are encoded on a mitochondrion, and 3587 are encoded on a plasmid.
                    
                    12180 entries are encoded on a plastid, 
                    of which 21 are encoded on apicoplasts, 
                    11620 on chloroplasts, 
                    46 on organellar chromatophores,
                    145 on cyanelles, 
                    149 on non-photosynthetic plastids and 
                    199 on unspecified types of plastid.
                    
                    Number of entries with at least one sequence correction: 69990