Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
                    UniProtKB/Swiss-Prot protein knowledgebase release 2010_07 statistics
                    
                    
                    1.  INTRODUCTION
                    
                    Release 2010_07 of 15-Jun-10 of UniProtKB/Swiss-Prot contains 517802 sequence entries,
                    comprising 182492287 amino acids abstracted from 189513 references. 
                    
                    757 sequences have been added since release 2010_06, the sequence data of
                    147 existing entries has been updated and the annotations of
                    199689 entries have been revised.
                    
                    Number of fragments: 8701
                    Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 29209
                    
                    
                    Protein existence (PE):           entries     %
                    
                    1: Evidence at protein level        69728   13.5%
                    2: Evidence at transcript level     66952   12.9%
                    3: Inferred from homology          365184   70.5%
                    4: Predicted                        14345    2.8%
                    5: Uncertain                         1593    0.3%
                    
                    The growth of the database is summarized below.
                    
                    
                    
                    
                    2.  TAXONOMIC ORIGIN
                    
                    Total number of species represented in this release of UniProtKB/Swiss-Prot: 12100
                    
                    The first twenty species represent 108051 sequences:  20.9 % of the total
                    number of entries.
                    
                    
                    2.1 Table of the frequency of occurrence of species
                    
                    Species represented 1x: 5252
                    2x: 1706
                    3x:  894
                    4x:  574
                    5x:  427
                    6x:  353
                    7x:  241
                    8x:  205
                    9x:  185
                    10x:  104
                    11- 20x:  596
                    21- 50x:  372
                    51-100x:  174
                    >100x: 1017
                    
                    
                    2.2  Table of the most represented species
                    
                    ------  ---------  --------------------------------------------
                    Number  Frequency  Species
                    ------  ---------  --------------------------------------------
                    1      20282  Homo sapiens (Human)
                    2      16293  Mus musculus (Mouse)
                    3       9099  Arabidopsis thaliana (Mouse-ear cress)
                    4       7512  Rattus norvegicus (Rat)
                    5       6577  Saccharomyces cerevisiae (Baker's yeast)
                    6       5774  Bos taurus (Bovine)
                    7       4975  Schizosaccharomyces pombe (Fission yeast)
                    8       4432  Escherichia coli (strain K12)
                    9       4254  Bacillus subtilis
                    10       4243  Dictyostelium discoideum (Slime mold)
                    11       3290  Caenorhabditis elegans
                    12       3238  Xenopus laevis (African clawed frog)
                    13       3076  Drosophila melanogaster (Fruit fly)
                    14       2633  Danio rerio (Zebrafish) (Brachydanio rerio)
                    15       2448  Oryza sativa subsp. japonica (Rice)
                    16       2211  Pongo abelii (Sumatran orangutan)
                    17       2166  Gallus gallus (Chicken)
                    18       1993  Escherichia coli O157:H7
                    19       1782  Methanocaldococcus jannaschii (Methanococcus jannaschii)
                    20       1773  Haemophilus influenzae
                    21       1768  Salmonella typhimurium
                    22       1668  Escherichia coli O6
                    23       1666  Shigella flexneri
                    24       1659  Mycobacterium tuberculosis
                    25       1537  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
                    26       1370  Sus scrofa (Pig)
                    27       1342  Salmonella typhi
                    28       1280  Pseudomonas aeruginosa
                    29       1213  Mycobacterium bovis
                    30       1162  Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)
                    31       1015  Synechocystis sp. (strain PCC 6803)
                    32        996  Yersinia pestis
                    33        991  Archaeoglobus fulgidus
                    34        941  Vibrio cholerae
                    35        929  Salmonella paratyphi A
                    36        924  Staphylococcus aureus (strain N315)
                    37        923  Staphylococcus aureus (strain Mu50 / ATCC 700699)
                    38        913  Rhizobium meliloti (Sinorhizobium meliloti)
                    39        909  Acanthamoeba polyphaga mimivirus (APMV)
                    40        897  Staphylococcus aureus (strain COL)
                    41        895  Staphylococcus aureus (strain MW2)
                    42        889  Staphylococcus aureus (strain MSSA476)
                    43        886  Staphylococcus aureus (strain MRSA252)
                    44        882  Oryctolagus cuniculus (Rabbit)
                    45        879  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
                    46        879  Salmonella choleraesuis
                    47        869  Shigella sonnei (strain Ss046)
                    48        863  Yersinia pseudotuberculosis
                    49        835  Escherichia coli O9:H4 (strain HS)
                    50        829  Escherichia coli O139:H28 (strain E24377A / ETEC)
                    51        824  Shigella boydii serotype 4 (strain Sb227)
                    52        819  Ashbya gossypii (Yeast) (Eremothecium gossypii)
                    53        818  Escherichia coli (strain UTI89 / UPEC)
                    54        814  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
                    55        800  Shigella dysenteriae serotype 1 (strain Sd197)
                    56        798  Candida albicans (Yeast)
                    57        794  Vibrio parahaemolyticus
                    58        791  Kluyveromyces lactis (Yeast) (Candida sphaerica)
                    59        785  Escherichia coli (strain SMS-3-5 / SECEC)
                    60        778  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
                    61        777  Pasteurella multocida
                    62        773  Aquifex aeolicus
                    63        773  Neurospora crassa
                    64        766  Canis familiaris (Dog) (Canis lupus familiaris)
                    65        765  Escherichia coli (strain K12 / DH10B)
                    66        759  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
                    67        759  Escherichia coli (strain K12 / MC4100 / BW2952)
                    68        757  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
                    69        757  Escherichia coli (strain 55989 / EAEC)
                    70        757  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
                    71        756  Escherichia coli O8 (strain IAI1)
                    72        756  Staphylococcus epidermidis (strain ATCC 12228)
                    73        751  Escherichia coli O45:K1 (strain S88 / ExPEC)
                    74        750  Escherichia coli (strain SE11)
                    75        750  Shigella flexneri serotype 5b (strain 8401)
                    76        749  Candida glabrata (Yeast) (Torulopsis glabrata)
                    77        748  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
                    78        742  Escherichia coli O157:H7 (strain EC4115 / EHEC)
                    79        738  Streptomyces coelicolor
                    80        738  Photorhabdus luminescens subsp. laumondii
                    81        731  Vibrio vulnificus
                    82        730  Bacillus halodurans
                    83        726  Escherichia coli O81 (strain ED1a)
                    84        722  Bacillus anthracis
                    85        722  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
                    86        719  Salmonella enteritidis PT4 (strain P125109)
                    87        715  Vibrio vulnificus (strain YJ016)
                    88        715  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
                    89        713  Yersinia pestis bv. Antiqua (strain Nepal516)
                    90        713  Salmonella paratyphi A (strain AKU_12601)
                    91        712  Staphylococcus aureus (strain NCTC 8325)
                    92        712  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
                    93        710  Salmonella newport (strain SL254)
                    94        709  Salmonella heidelberg (strain SL476)
                    95        709  Yersinia pestis bv. Antiqua (strain Antiqua)
                    96        709  Salmonella agona (strain SL483)
                    97        708  Salmonella schwarzengrund (strain CVM19633)
                    98        706  Escherichia coli O1:K1 / APEC
                    99        699  Salmonella dublin (strain CT_02021853)
                    100        697  Enterobacter sp. (strain 638)
                    101        696  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
                    102        696  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
                    103        693  Emericella nidulans (Aspergillus nidulans)
                    104        687  Mycoplasma pneumoniae
                    105        685  Pan troglodytes (Chimpanzee)
                    106        685  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
                    107        684  Pseudomonas syringae pv. tomato
                    108        682  Salmonella gallinarum (strain 287/91 / NCTC 13346)
                    109        682  Klebsiella pneumoniae (strain 342)
                    110        676  Anabaena sp. (strain PCC 7120)
                    111        670  Pseudomonas putida (strain KT2440)
                    112        666  Staphylococcus aureus (strain USA300)
                    113        666  Yersinia pestis (strain Pestoides F)
                    114        664  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
                    115        662  Mycobacterium leprae
                    116        658  Rhizobium sp. (strain NGR234)
                    117        653  Serratia proteamaculans (strain 568)
                    118        653  Zea mays (Maize)
                    119        645  Escherichia coli
                    120        645  Bradyrhizobium japonicum
                    121        642  Staphylococcus aureus (strain bovine RF122 / ET3-1)
                    122        638  Bacillus cereus (strain ATCC 14579 / DSM 31)
                    123        637  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
                    124        635  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
                    125        633  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
                    126        620  Shewanella oneidensis
                    127        617  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
                    128        615  Treponema pallidum
                    129        614  Ralstonia solanacearum (Pseudomonas solanacearum)
                    130        608  Staphylococcus haemolyticus (strain JCSC1435)
                    131        608  Enterobacter sakazakii (strain ATCC BAA-894)
                    132        603  Rhizobium loti (Mesorhizobium loti)
                    133        602  Staphylococcus saprophyticus subsp. saprophyticus 
                    134        600  Methanobacterium thermoautotrophicum
                    135        598  Yersinia pestis bv. Antiqua (strain Angola)
                    136        598  Salmonella paratyphi C (strain RKS4594)
                    137        596  Listeria monocytogenes
                    138        595  Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
                    139        595  Photobacterium profundum (Photobacterium sp. (strain SS9))
                    140        594  Yarrowia lipolytica (Candida lipolytica)
                    141        590  Bacillus cereus (strain ATCC 10987)
                    142        589  Xanthomonas campestris pv. campestris
                    143        588  Listeria innocua
                    144        585  Rickettsia prowazekii
                    145        584  Helicobacter pylori (Campylobacter pylori)
                    146        582  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
                    147        581  Lactococcus lactis subsp. lactis (Streptococcus lactis)
                    148        579  Neisseria meningitidis serogroup B
                    149        576  Brucella suis
                    150        572  Brucella melitensis
                    151        572  Buchnera aphidicola subsp. Acyrthosiphon pisum 
                    152        569  Bacillus thuringiensis subsp. konkukian
                    153        565  Helicobacter pylori J99 (Campylobacter pylori J99)
                    154        562  Buchnera aphidicola subsp. Schizaphis graminum
                    155        560  Bacillus cereus (strain ZK / E33L)
                    156        560  Pseudomonas syringae pv. syringae (strain B728a)
                    157        557  Pseudomonas aeruginosa (strain UCBPP-PA14)
                    158        556  Neisseria meningitidis serogroup A
                    159        556  Aspergillus fumigatus (Sartorya fumigata)
                    160        555  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
                    161        555  Xanthomonas axonopodis pv. citri (Citrus canker)
                    162        553  Vibrio fischeri (strain ATCC 700601 / ES114)
                    163        551  Pseudomonas fluorescens (strain Pf0-1)
                    164        549  Oceanobacillus iheyensis
                    165        545  Caulobacter crescentus (Caulobacter vibrioides)
                    166        545  Clostridium acetobutylicum
                    167        545  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
                    168        538  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
                    169        529  Listeria monocytogenes serotype 4b (strain F2365)
                    170        523  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
                    171        522  Sodalis glossinidius (strain morsitans)
                    172        521  Bordetella bronchiseptica (Alcaligenes bronchisepticus)
                    173        521  Xylella fastidiosa
                    174        519  Streptococcus pneumoniae
                    175        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
                    176        510  Chromobacterium violaceum
                    177        509  Thermotoga maritima
                    178        509  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
                    179        507  Bordetella parapertussis
                    180        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
                    181        507  Pseudomonas aeruginosa (strain PA7)
                    182        505  Bordetella pertussis
                    183        504  Staphylococcus aureus (strain Newman)
                    184        504  Haemophilus ducreyi
                    185        504  Geobacillus kaustophilus
                    186        502  Caenorhabditis briggsae
                    187        500  Pseudomonas entomophila (strain L48)
                    188        498  Brucella abortus
                    189        497  Rickettsia conorii
                    190        497  Deinococcus radiodurans
                    191        496  Bacillus clausii (strain KSM-K16)
                    192        492  Haemophilus influenzae (strain 86-028NP)
                    193        492  Oryza sativa subsp. indica (Rice)
                    194        490  Xanthomonas campestris pv. campestris (strain 8004)
                    195        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
                    196        490  Clostridium perfringens
                    197        488  Bacillus amyloliquefaciens (strain FZB42)
                    198        487  Burkholderia pseudomallei (Pseudomonas pseudomallei)
                    199        487  Shewanella sp. (strain MR-7)
                    200        485  Corynebacterium glutamicum (Brevibacterium flavum)
                    201        484  Pseudomonas aeruginosa (strain LESB58)
                    202        484  Staphylococcus aureus (strain Mu3 / ATCC 700698)
                    203        484  Shewanella sp. (strain MR-4)
                    204        483  Mannheimia succiniciproducens (strain MBEL55E)
                    205        483  Mycoplasma genitalium
                    206        482  Streptomyces avermitilis
                    207        480  Proteus mirabilis (strain HI4320)
                    208        478  Methanosarcina acetivorans
                    209        475  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
                    210        472  Burkholderia sp. (strain 383) (Burkholderia cepacia 
                    211        472  Pseudomonas putida (strain F1 / ATCC 700007)
                    212        472  Brucella abortus (strain 2308)
                    213        472  Thermosynechococcus elongatus (strain BP-1)
                    214        469  Acinetobacter sp. (strain ADP1)
                    215        468  Enterococcus faecalis (Streptococcus faecalis)
                    216        465  Pyrococcus horikoshii
                    217        465  Xanthomonas campestris pv. vesicatoria (strain 85-10)
                    218        465  Pseudomonas putida (strain GB-1)
                    219        464  Rhodopseudomonas palustris
                    220        464  Shewanella frigidimarina (strain NCIMB 400)
                    221        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
                    222        462  Shewanella sp. (strain ANA-3)
                    223        461  Burkholderia mallei (Pseudomonas mallei)
                    224        460  Ralstonia eutropha  (Cupriavidus necator 
                    225        459  Lactobacillus plantarum
                    226        457  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
                    227        457  Pyrococcus abyssi
                    228        457  Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus)
                    229        457  Methanosarcina mazei (Methanosarcina frisia)
                    230        455  Staphylococcus aureus (strain JH1)
                    231        455  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
                    232        453  Rickettsia felis (Rickettsia azadi)
                    233        453  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
                    234        452  Shewanella baltica (strain OS185)
                    235        452  Pseudomonas putida (strain W619)
                    236        452  Halobacterium salinarium (Halobacterium halobium)
                    237        449  Staphylococcus aureus (strain JH9)
                    238        449  Streptococcus mutans
                    239        448  Thermoanaerobacter tengcongensis
                    240        447  Methylococcus capsulatus
                    241        447  Ovis aries (Sheep)
                    242        447  Aeromonas salmonicida (strain A449)
                    243        446  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
                    244        445  Vibrio fischeri (strain MJ11)
                    245        444  Pseudomonas mendocina (strain ymp)
                    246        443  Hahella chejuensis (strain KCTC 2396)
                    247        441  Streptococcus pyogenes serotype M6
                    248        441  Dechloromonas aromatica (strain RCB)
                    249        440  Pyrococcus furiosus
                    250        439  Mycobacterium paratuberculosis
                    
                    
                    
                    2.3  Taxonomic distribution of the sequences
                    
                    
                    
                    Kingdom        sequences (% of the database)
                    Archaea           18199 (  4%)
                    Bacteria         323544 ( 62%)
                    Eukaryota        161187 ( 31%)
                    Viruses           14872 (  3%)
                    
                    
                    Within Eukaryota:
                    
                    
                    
                    Category            sequences (% of Eukaryota) (% of the complete database)
                    Human                  20283 ( 13%)           (  4%)
                    Other Mammalia         44784 ( 28%)           (  9%)
                    Other Vertebrata       16155 ( 10%)           (  3%)
                    Viridiplantae          29147 ( 18%)           (  6%)
                    Fungi                  26040 ( 16%)           (  5%)
                    Insecta                 7892 (  5%)           (  2%)
                    Nematoda                4070 (  3%)           (  1%)
                    Other                  12816 (  8%)           (  2%)
                    
                    
                    
                    3.  SEQUENCE SIZE
                    
                    Repartition of the sequences by size (excluding fragments)
                    
                    From   To  Number             From   To   Number
                    1-  50    8419             1001-1100     3482
                    51- 100   39971             1101-1200     2441
                    101- 150   55868             1201-1300     1923
                    151- 200   55981             1301-1400     1788
                    201- 250   54660             1401-1500     1424
                    251- 300   48029             1501-1600      636
                    301- 350   48499             1601-1700      507
                    351- 400   41474             1701-1800      419
                    401- 450   33919             1801-1900      394
                    451- 500   27221             1901-2000      321
                    501- 550   19330             2001-2100      198
                    551- 600   13757             2101-2200      263
                    601- 650   11520             2201-2300      274
                    651- 700    8220             2301-2400      168
                    701- 750    6833             2401-2500      129
                    751- 800    4861             >2500         1011
                    801- 850    4206
                    851- 900    4784
                    901- 950    3636
                    951-1000    2535
                    
                    
                    
                    
                    The average sequence length in UniProtKB/Swiss-Prot is 352 amino acids.
                    
                    The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
                    The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.
                    
                    
                    4.  JOURNAL CITATIONS
                    
                    Note: the following citation statistics reflect the number of distinct
                    journal citations.
                    
                    Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2069
                    
                    
                    4.1 Table of the frequency of journal citations
                    
                    Journals cited 1x:  662
                    2x:  288
                    3x:  143
                    4x:  105
                    5x:   85
                    6x:   65
                    7x:   33
                    8x:   36
                    9x:   36
                    10x:   26
                    11- 20x:  169
                    21- 50x:  165
                    51-100x:   96
                    >100x:  160
                    
                    
                    4.2  List of the most cited journals in UniProtKB/Swiss-Prot
                    
                    Nb    Citations   Journal name
                    --    ---------   -------------------------------------------------------------
                    1        17942   Journal of Biological Chemistry
                    2         8326   Proceedings of the National Academy of Sciences of the U.S.A.
                    3         5016   Journal of Bacteriology
                    4         4511   Biochemical and Biophysical Research Communications
                    5         4500   Gene
                    6         4304   Nucleic Acids Research
                    7         3964   FEBS Letters
                    8         3867   Biochemistry
                    9         3744   The EMBO Journal
                    10         3413   Molecular and Cellular Biology
                    11         3227   Nature
                    12         3099   European Journal of Biochemistry
                    13         3049   Journal of Molecular Biology
                    14         2972   Biochimica et Biophysica Acta
                    15         2675   Cell
                    16         2477   Genomics
                    17         2175   Biochemical Journal
                    18         2131   Science
                    19         2029   Journal of Virology
                    20         1762   Molecular Microbiology
                    21         1572   Journal of Cell Biology
                    22         1495   Plant Molecular Biology
                    23         1365   Genes and Development
                    24         1347   Virology
                    25         1320   Human Molecular Genetics
                    26         1314   Nature Genetics
                    27         1312   Plant Physiology
                    28         1304   Molecular and General Genetics
                    29         1238   The American Journal of Human Genetics
                    30         1180   Oncogene
                    31         1164   Development
                    32         1158   Journal of Biochemistry
                    33         1082   Human Mutation
                    34         1014   Molecular Biology of the Cell
                    35         1008   Journal of Immunology
                    36          982   Genetics
                    37          884   Structure
                    38          879   Infection and Immunity
                    39          871   Journal of General Virology
                    40          859   The Plant Cell
                    41          822   Archives of Biochemistry and Biophysics
                    42          818   Molecular Cell
                    43          796   Blood
                    44          757   Yeast
                    45          751   Microbiology
                    46          740   The Plant Journal
                    47          726   Developmental Biology
                    48          725   Journal of Cell Science
                    49          671   Cancer Research
                    50          655   FEMS Microbiology Letters
                    51          647   Current Biology
                    52          595   Mechanisms of Development
                    53          592   Nature Structural Biology
                    54          590   Human Genetics
                    55          550   Acta Crystallographica, Section D
                    56          549   Protein Science
                    57          534   Applied and Environmental Microbiology
                    58          533   Journal of Neuroscience
                    59          523   Current Genetics
                    60          510   Toxicon
                    61          506   Neuron
                    62          502   Journal of Clinical Investigation
                    63          470   Mammalian Genome
                    64          458   American Journal of Physiology
                    65          449   Immunogenetics
                    66          446   The Journal of Experimental Medicine
                    67          438   Molecular Endocrinology
                    68          419   Molecular and Biochemical Parasitology
                    69          410   Journal of Neurochemistry
                    70          408   The Journal of Clinical Endocrinology and Metabolism
                    71          386   Endocrinology
                    72          378   Journal of Molecular Evolution
                    73          368   Proteins
                    74          366   DNA and Cell Biology
                    75          364   Bioscience, Biotechnology, and Biochemistry
                    76          357   Molecular Biology and Evolution
                    77          356   DNA Sequence
                    78          349   Journal of Medical Genetics
                    79          320   Tissue Antigens
                    80          314   Brain Research. Molecular Brain Research
                    81          299   Plant and Cell Physiology
                    82          296   Experimental Cell Research
                    83          296   Comparative Biochemistry and Physiology
                    84          295   Nature Cell Biology
                    85          294   Peptides
                    86          289   Biological Chemistry Hoppe-Seyler
                    87          282   Antimicrobial Agents and Chemotherapy
                    88          276   Journal of Investigative Dermatology
                    89          275   Cytogenetics and Cell Genetics
                    90          268   Molecular Pharmacology
                    91          258   Biology of Reproduction
                    92          247   Journal of General Microbiology
                    93          246   Genome Research
                    94          246   Developmental Cell
                    95          242   Neurology
                    96          241   Developmental Dynamics
                    97          239   RNA
                    98          232   Virus Research
                    99          215   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
                    100          209   Planta
                    101          205   DNA Research
                    102          204   European Journal of Immunology
                    103          203   Biochimie
                    104          202   Molecular Plant-Microbe Interactions
                    105          201   Annals of Neurology
                    106          197   Genes to Cells
                    107          194   European Journal of Human Genetics
                    108          191   Eukaryotic cell
                    109          188   Immunity
                    110          186   The New England Journal of Medicine
                    111          185   Journal of Human Genetics
                    112          175   Molecular and Cellular Endocrinology
                    113          175   Nature Structural and Molecular Biology
                    114          169   Investigative Ophthalmology and Visual Science
                    115          166   The FEBS Journal
                    116          165   Archives of Microbiology
                    117          163   American Journal of Medical Genetics
                    118          163   Molecular Phylogenetics and Evolution
                    119          160   Insect Biochemistry and Molecular Biology
                    120          160   The FASEB Journal
                    121          159   EMBO Reports
                    122          159   DNA
                    123          153   Molecular Immunology
                    124          153   Hemoglobin
                    125          152   Bioorganicheskaia Khimiia
                    126          150   Diabetes
                    127          149   Molecular Reproduction and Development
                    128          145   Archives of Virology
                    129          144   Glycobiology
                    130          143   Clinical Genetics
                    131          138   International Journal of Cancer
                    132          137   Molecular Genetics and Metabolism
                    133          136   General and Comparative Endocrinology
                    134          136   Animal Genetics
                    135          135   Molecular and Cellular Neuroscience
                    136          131   Journal of the American Chemical Society
                    137          130   British Journal of Haematology
                    138          128   Journal of Cellular Biochemistry
                    139          127   Biological Chemistry
                    140          125   American Journal of Medical Genetics. Part A
                    141          125   Molecular Genetics and Genomics
                    142          124   Nature Immunology
                    143          123   BMC Genomics
                    144          122   Journal of Lipid Research
                    145          122   Agricultural and Biological Chemistry
                    146          118   Circulation Research
                    147          115   Neuroscience Letters
                    148          115   Proteomics
                    149          114   Thrombosis and Haemostasis
                    150          114   Journal of Medicinal Chemistry
                    
                    
                    5.  STATISTICS FOR SOME LINE TYPES
                    
                    The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
                    as well as the number of entries with at least one such line, and the
                    frequency of the lines.
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry
                    ------------------------------------  -------- ---------  ---------
                    
                    References (RL)                       926095                 1.79                                         
                    Journal                            733956     388551      1.42       1                                 
                    Submitted to EMBL/GenBank/DDBJ     179478     166062      0.35       2                                 
                    Submitted to other databases        10594       9185      0.02       3                                 
                    Book citation                         639        625     <0.01       4                                 
                    Plant Gene Register                   560        548     <0.01       5                                 
                    Thesis                                396        393     <0.01       6                                 
                    Unpublished observations              297        293     <0.01       7                                 
                    Patent                                169        167     <0.01       8                                 
                    Worm Breeder's Gazette                  6          6     <0.01       9                                 
                    
                    Total number of distinct authors cited in UniProtKB/Swiss-Prot: 289586
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Comments (CC)                        2219414                 4.29                                         
                    ALLERGEN                              464        464     <0.01      26                                 
                    ALTERNATIVE PRODUCTS                18849      18849      0.04      13                                 
                    BIOPHYSICOCHEMICAL PROPERTIES        3093       3093      0.01      22                                 
                    BIOTECHNOLOGY                         275        273     <0.01      28                                 
                    CATALYTIC ACTIVITY                 220796     201457      0.43       5                                 
                    CAUTION                              7037       6897      0.01      19                                 
                    COFACTOR                            99862      91743      0.19       7                                 
                    DEVELOPMENTAL STAGE                  8867       8867      0.02      16                                 
                    DISEASE                              4255       2874      0.01      21                                 
                    DISRUPTION PHENOTYPE                 2694       2694      0.01      23                                 
                    DOMAIN                              31900      28214      0.06      11                                 
                    ENZYME REGULATION                    8432       8432      0.02      17                                 
                    FUNCTION                           386765     370696      0.75       2                                 
                    INDUCTION                           11771      11771      0.02      15                                 
                    INTERACTION                         12527      12527      0.02      14                                 
                    MASS SPECTROMETRY                    4351       3295      0.01      20                                 
                    MISCELLANEOUS                       30226      27959      0.06      12                                 
                    PATHWAY                            126905     116027      0.25       6                                 
                    PHARMACEUTICAL                         84         84     <0.01      29                                 
                    POLYMORPHISM                          785        750     <0.01      24                                 
                    PTM                                 35660      28878      0.07       9                                 
                    RNA EDITING                           611        611     <0.01      25                                 
                    SEQUENCE CAUTION                    38022      38022      0.07       8                                 
                    SIMILARITY                         602847     493135      1.16       1                                 
                    SUBCELLULAR LOCATION               299129     294053      0.58       3                                 
                    SUBUNIT                            221394     221394      0.43       4                                 
                    TISSUE SPECIFICITY                  33106      33106      0.06      10                                 
                    TOXIC DOSE                            421        410     <0.01      27                                 
                    WEB RESOURCE                         8286       6569      0.02      18                                 
                    
                    Total number of comment topics: 29
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Features (FT)                        3235273                 6.25                                         
                    ACT_SITE                           129313      77206      0.25       9                                 
                    BINDING                            203238      57434      0.39       4                                 
                    CA_BIND                              3662       1488      0.01      35                                 
                    CARBOHYD                            99789      25377      0.19      13                                 
                    CHAIN                              524263     513008      1.01       1                                 
                    COILED                              18175      12324      0.04      26                                 
                    COMPBIAS                            49554      25831      0.10      18                                 
                    CONFLICT                           116720      40975      0.23      10                                 
                    CROSSLNK                             4825       3133      0.01      34                                 
                    DISULFID                            96187      25671      0.19      14                                 
                    DNA_BIND                            10942      10074      0.02      29                                 
                    DOMAIN                             144336      86025      0.28       6                                 
                    HELIX                              130441      13643      0.25       8                                 
                    INIT_MET                            14811      14811      0.03      27                                 
                    INTRAMEM                             1473        683     <0.01      37                                 
                    LIPID                               10549       6715      0.02      31                                 
                    METAL                              273825      67479      0.53       3                                 
                    MOD_RES                            179959      59701      0.35       5                                 
                    MOTIF                               32171      20742      0.06      22                                 
                    MUTAGEN                             30972       7369      0.06      24                                 
                    NON_CONS                             1819        684     <0.01      36                                 
                    NON_STD                               349        274     <0.01      39                                 
                    NON_TER                             11790       8967      0.02      28                                 
                    NP_BIND                            104182      67934      0.20      12                                 
                    PEPTIDE                              8602       5512      0.02      32                                 
                    PROPEP                              10556       8907      0.02      30                                 
                    REGION                              92353      50684      0.18      15                                 
                    REPEAT                              88473      13079      0.17      16                                 
                    SIGNAL                              34555      34545      0.07      21                                 
                    SITE                                36960      21858      0.07      20                                 
                    STRAND                             130973      12756      0.25       7                                 
                    TOPO_DOM                           115902      23854      0.22      11                                 
                    TRANSIT                              6542       6456      0.01      33                                 
                    TRANSMEM                           337946      69088      0.65       2                                 
                    TURN                                31119      10775      0.06      23                                 
                    UNSURE                               1114        356     <0.01      38                                 
                    VAR_SEQ                             39086      16781      0.08      19                                 
                    VARIANT                             79519      16493      0.15      17                                 
                    ZN_FING                             28228      12274      0.05      25                                 
                    
                    Total number of feature keys: 39
                    
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank      Category
                    ------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
                    Cross-references (DR)               13214353                25.52                                                           
                    2DBase-Ecoli                           85         85     <0.01     119      2D gel databases                             
                    Aarhus/Ghent-2DPAGE                   126         96     <0.01     116      2D gel databases                             
                    AGD                                   825        819     <0.01      95      Organism-specific databases                  
                    ANU-2DPAGE                             23         23     <0.01     125      2D gel databases                             
                    ArachnoServer                         460        456     <0.01     103      Organism-specific databases                  
                    ArrayExpress                        58171      58171      0.11      39      Gene expression databases                    
                    Bgee                                39436      39436      0.08      45      Gene expression databases                    
                    BindingDB                             297        297     <0.01     111      Other                                        
                    BioCyc                             160671     147787      0.31      21      Enzyme and pathway databases                 
                    BRENDA                              65177      62379      0.13      36      Enzyme and pathway databases                 
                    CAZy                                 5782       5151      0.01      71      Protein family/group databases               
                    CGD                                   559        553     <0.01     100      Organism-specific databases                  
                    CleanEx                             30194      29548      0.06      47      Gene expression databases                    
                    COMPLUYEAST-2DPAGE                    101        100     <0.01     118      2D gel databases                             
                    ConoServer                            613        587     <0.01      99      Organism-specific databases                  
                    Cornea-2DPAGE                          67         67     <0.01     120      2D gel databases                             
                    CTD                                 64748      64192      0.13      37      Organism-specific databases                  
                    CYGD                                 6629       6540      0.01      70      Organism-specific databases                  
                    dictyBase                            4370       4242      0.01      78      Organism-specific databases                  
                    DIP                                 11523      11418      0.02      60      Protein-protein interaction databases        
                    DisProt                               397        394     <0.01     106      3D structure databases                       
                    DOSAC-COBS-2DPAGE                     149        147     <0.01     115      2D gel databases                             
                    DrugBank                             5317       1626      0.01      73      Other                                        
                    EchoBASE                             4167       4163      0.01      81      Organism-specific databases                  
                    ECO2DBASE                             352        300     <0.01     110      2D gel databases                             
                    EcoGene                              4399       4397      0.01      77      Organism-specific databases                  
                    eggNOG                             216951     216951      0.42      18      Phylogenomic databases                       
                    EMBL                               855398     507972      1.65       3      Sequence databases                           
                    Ensembl                             74338      57604      0.14      32      Genome annotation databases                  
                    EnsemblBacteria                     97263      84186      0.19      27      Genome annotation databases                  
                    EnsemblFungi                        14378      14224      0.03      57      Genome annotation databases                  
                    EnsemblMetazoa                      12482       8269      0.02      58      Genome annotation databases                  
                    EnsemblPlants                       10139       9060      0.02      62      Genome annotation databases                  
                    EnsemblProtists                      4282       4160      0.01      80      Genome annotation databases                  
                    euHCVdb                                55         44     <0.01     121      Organism-specific databases                  
                    EuPathDB                              233        233     <0.01     114      Organism-specific databases                  
                    FlyBase                              5601       5225      0.01      72      Organism-specific databases                  
                    Gene3D                             235867     193801      0.46      17      Family and domain databases                  
                    GeneCards                           20597      19832      0.04      51      Organism-specific databases                  
                    GeneDB_Spombe                        4977       4932      0.01      75      Organism-specific databases                  
                    GeneFarm                             2697       2682      0.01      87      Organism-specific databases                  
                    GeneID                             477487     450545      0.92       6      Genome annotation databases                  
                    Genevestigator                      64599      64599      0.12      38      Gene expression databases                    
                    GenoList                             7039       7027      0.01      68      Organism-specific databases                  
                    GenomeReviews                      377092     357057      0.73       9      Genome annotation databases                  
                    GermOnline                          41909      41315      0.08      44      Gene expression databases                    
                    GlycoSuiteDB                          280        280     <0.01     112      PTM databases                                
                    GO                                2159049     484004      4.17       1      Ontologies                                   
                    Gramene                              4355       4355      0.01      79      Organism-specific databases                  
                    H-InvDB                             11798      11057      0.02      59      Organism-specific databases                  
                    HAMAP                              307369     307225      0.59      15      Family and domain databases                  
                    HGNC                                19650      19475      0.04      53      Organism-specific databases                  
                    HOGENOM                            360036     360036      0.70      10      Phylogenomic databases                       
                    HOVERGEN                            74396      74396      0.14      31      Phylogenomic databases                       
                    HPA                                  8704       6562      0.02      65      Organism-specific databases                  
                    HSSP                                29044      29044      0.06      48      3D structure databases                       
                    InParanoid                          66178      66178      0.13      35      Phylogenomic databases                       
                    IntAct                              22011      22010      0.04      50      Protein-protein interaction databases        
                    InterPro                          1602127     490902      3.09       2      Family and domain databases                  
                    IPI                                 88862      63709      0.17      29      Sequence databases                           
                    KEGG                               440054     418362      0.85       8      Genome annotation databases                  
                    LegioList                             760        758     <0.01      96      Organism-specific databases                  
                    Leproma                               665        662     <0.01      98      Organism-specific databases                  
                    MaizeGDB                              472        467     <0.01     102      Organism-specific databases                  
                    MEROPS                               9969       9647      0.02      63      Protein family/group databases               
                    MGI                                 16173      16122      0.03      55      Organism-specific databases                  
                    MIM                                 16296      12810      0.03      54      Organism-specific databases                  
                    MINT                                10882      10882      0.02      61      Protein-protein interaction databases        
                    NextBio                             48778      48777      0.09      42      Other                                        
                    NMPDR                              130320     130316      0.25      24      Genome annotation databases                  
                    OGP                                   377        377     <0.01     108      2D gel databases                             
                    OMA                                353944     353944      0.68      11      Phylogenomic databases                       
                    Orphanet                             3810       2185      0.01      85      Organism-specific databases                  
                    OrthoDB                             56187      56187      0.11      40      Phylogenomic databases                       
                    PANTHER                            185389     170170      0.36      20      Family and domain databases                  
                    Pathway_Interaction_DB               4567       1665      0.01      76      Enzyme and pathway databases                 
                    PDB                                 68013      15818      0.13      34      3D structure databases                       
                    PDBsum                              68013      15818      0.13      33      3D structure databases                       
                    PeptideAtlas                         5169       5169      0.01      74      Proteomic databases                          
                    PeroxiBase                            678        666     <0.01      97      Protein family/group databases               
                    Pfam                               673874     475214      1.30       4      Family and domain databases                  
                    PharmGKB                            15797      15786      0.03      56      Organism-specific databases                  
                    PHCI-2DPAGE                           247        247     <0.01     113      2D gel databases                             
                    PhosphoSite                         20423      20423      0.04      52      PTM databases                                
                    PhosSite                              352        352     <0.01     109      PTM databases                                
                    PhylomeDB                          121562     121562      0.23      25      Phylogenomic databases                       
                    PIR                                115356     105370      0.22      26      Sequence databases                           
                    PIRSF                               82615      82615      0.16      30      Family and domain databases                  
                    PMAP-CutDB                           1395       1395     <0.01      90      Other                                        
                    PMMA-2DPAGE                            52         52     <0.01     122      2D gel databases                             
                    PptaseDB                               34         34     <0.01     123      Protein family/group databases               
                    PRIDE                               53853      53853      0.10      41      Proteomic databases                          
                    PRINTS                             136684     118295      0.26      23      Family and domain databases                  
                    ProDom                              27813      27484      0.05      49      Family and domain databases                  
                    ProMEX                                446        446     <0.01     104      Proteomic databases                          
                    PROSITE                            459138     292372      0.89       7      Family and domain databases                  
                    ProtClustDB                        324285     324285      0.63      13      Phylogenomic databases                       
                    PseudoCAP                            1219       1210     <0.01      92      Organism-specific databases                  
                    Rat-heart-2DPAGE                       28         28     <0.01     124      2D gel databases                             
                    Reactome                             7332       4258      0.01      67      Enzyme and pathway databases                 
                    REBASE                                378        358     <0.01     107      Protein family/group databases               
                    RefSeq                             499040     450929      0.96       5      Sequence databases                           
                    REPRODUCTION-2DPAGE                  1252       1031     <0.01      91      2D gel databases                             
                    RGD                                  7392       7388      0.01      66      Organism-specific databases                  
                    SGD                                  6641       6556      0.01      69      Organism-specific databases                  
                    Siena-2DPAGE                          103        103     <0.01     117      2D gel databases                             
                    SMART                              142159     109611      0.27      22      Family and domain databases                  
                    SMR                                346662     346662      0.67      12      3D structure databases                       
                    STRING                             203789     203751      0.39      19      Protein-protein interaction databases        
                    SUPFAM                             312989     247796      0.60      14      Family and domain databases                  
                    SWISS-2DPAGE                         1183       1181     <0.01      93      2D gel databases                             
                    TAIR                                 9181       9070      0.02      64      Organism-specific databases                  
                    TCDB                                 3359       3318      0.01      86      Protein family/group databases               
                    TIGR                                34023      33256      0.07      46      Genome annotation databases                  
                    TIGRFAMs                           280705     261936      0.54      16      Family and domain databases                  
                    TubercuList                          1683       1647     <0.01      89      Organism-specific databases                  
                    UCD-2DPAGE                            512        502     <0.01     101      2D gel databases                             
                    UCSC                                48528      39558      0.09      43      Genome annotation databases                  
                    UniGene                             93946      82698      0.18      28      Sequence databases                           
                    VectorBase                            426        412     <0.01     105      Genome annotation databases                  
                    World-2DPAGE                          915        904     <0.01      94      2D gel databases                             
                    WormBase                             3846       3761      0.01      84      Organism-specific databases                  
                    WormPep                              4066       3282      0.01      83      Organism-specific databases                  
                    Xenbase                              4098       4025      0.01      82      Organism-specific databases                  
                    ZFIN                                 2575       2564     <0.01      88      Organism-specific databases                  
                    
                    Total number of cross-referenced databases: 125
                    
                    6.  AMINO ACID COMPOSITION
                    
                    6.1  Composition in percent for the complete database
                    
                    Ala (A) 8.27   Gln (Q) 3.94   Leu (L) 9.67   Ser (S) 6.51
                    Arg (R) 5.53   Glu (E) 6.76   Lys (K) 5.85   Thr (T) 5.33
                    Asn (N) 4.05   Gly (G) 7.09   Met (M) 2.42   Trp (W) 1.08
                    Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.91
                    Cys (C) 1.36   Ile (I) 5.99   Pro (P) 4.69   Val (V) 6.87
                    
                    Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00
                    
                    
                    
                    Legend: gray = aliphatic, red = acidic, green = small hydroxy,
                    blue = basic, black = aromatic, white = amide, yellow = sulfur
                    
                    
                    6.2  Classification of the amino acids by their frequency
                    
                    Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
                    Phe, Tyr, Met, His, Cys, Trp
                    
                    
                    7.  MISCELLANEOUS STATISTICS
                    
                    4447 entries are encoded on a mitochondrion, and 3567 are encoded on a plasmid.
                    
                    12175 entries are encoded on a plastid, 
                    of which 21 are encoded on apicoplasts, 
                    11617 on chloroplasts, 
                    44 on organellar chromatophores,
                    145 on cyanelles, 
                    149 on non-photosynthetic plastids and 
                    199 on unspecified types of plastid.
                    
                    Number of entries with at least one sequence correction: 69200