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                    UniProtKB/Swiss-Prot protein knowledgebase release 2010_06 statistics
                    
                    
                    1.  INTRODUCTION
                    
                    Release 2010_06 of 18-May-10 of UniProtKB/Swiss-Prot contains 517100 sequence entries,
                    comprising 182146551 amino acids abstracted from 188943 references. 
                    
                    507 sequences have been added since release 2010_05, the sequence data of
                    744 existing entries has been updated and the annotations of
                    24184 entries have been revised.
                    
                    Number of fragments: 8651
                    Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 29156
                    
                    
                    Protein existence (PE):           entries     %
                    
                    1: Evidence at protein level        69384   13.4%
                    2: Evidence at transcript level     66875   12.9%
                    3: Inferred from homology          364897   70.6%
                    4: Predicted                        14345    2.8%
                    5: Uncertain                         1599    0.3%
                    
                    The growth of the database is summarized below.
                    
                    
                    
                    
                    2.  TAXONOMIC ORIGIN
                    
                    Total number of species represented in this release of UniProtKB/Swiss-Prot: 12079
                    
                    The first twenty species represent 107865 sequences:  20.9 % of the total
                    number of entries.
                    
                    
                    2.1 Table of the frequency of occurrence of species
                    
                    Species represented 1x: 5243
                    2x: 1703
                    3x:  894
                    4x:  572
                    5x:  427
                    6x:  351
                    7x:  241
                    8x:  204
                    9x:  185
                    10x:  103
                    11- 20x:  594
                    21- 50x:  371
                    51-100x:  175
                    >100x: 1016
                    
                    
                    2.2  Table of the most represented species
                    
                    ------  ---------  --------------------------------------------
                    Number  Frequency  Species
                    ------  ---------  --------------------------------------------
                    1      20294  Homo sapiens (Human)
                    2      16266  Mus musculus (Mouse)
                    3       9013  Arabidopsis thaliana (Mouse-ear cress)
                    4       7498  Rattus norvegicus (Rat)
                    5       6577  Saccharomyces cerevisiae (Baker's yeast)
                    6       5767  Bos taurus (Bovine)
                    7       4975  Schizosaccharomyces pombe (Fission yeast)
                    8       4432  Escherichia coli (strain K12)
                    9       4254  Bacillus subtilis
                    10       4243  Dictyostelium discoideum (Slime mold)
                    11       3290  Caenorhabditis elegans
                    12       3234  Xenopus laevis (African clawed frog)
                    13       3075  Drosophila melanogaster (Fruit fly)
                    14       2629  Danio rerio (Zebrafish) (Brachydanio rerio)
                    15       2397  Oryza sativa subsp. japonica (Rice)
                    16       2210  Pongo abelii (Sumatran orangutan)
                    17       2163  Gallus gallus (Chicken)
                    18       1993  Escherichia coli O157:H7
                    19       1782  Methanocaldococcus jannaschii (Methanococcus jannaschii)
                    20       1773  Haemophilus influenzae
                    21       1768  Salmonella typhimurium
                    22       1668  Escherichia coli O6
                    23       1666  Shigella flexneri
                    24       1659  Mycobacterium tuberculosis
                    25       1536  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
                    26       1367  Sus scrofa (Pig)
                    27       1341  Salmonella typhi
                    28       1280  Pseudomonas aeruginosa
                    29       1213  Mycobacterium bovis
                    30       1162  Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)
                    31       1015  Synechocystis sp. (strain PCC 6803)
                    32        996  Yersinia pestis
                    33        991  Archaeoglobus fulgidus
                    34        941  Vibrio cholerae
                    35        929  Salmonella paratyphi A
                    36        923  Staphylococcus aureus (strain N315)
                    37        922  Staphylococcus aureus (strain Mu50 / ATCC 700699)
                    38        913  Rhizobium meliloti (Sinorhizobium meliloti)
                    39        909  Acanthamoeba polyphaga mimivirus (APMV)
                    40        896  Staphylococcus aureus (strain COL)
                    41        894  Staphylococcus aureus (strain MW2)
                    42        888  Staphylococcus aureus (strain MSSA476)
                    43        885  Staphylococcus aureus (strain MRSA252)
                    44        882  Oryctolagus cuniculus (Rabbit)
                    45        879  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
                    46        879  Salmonella choleraesuis
                    47        869  Shigella sonnei (strain Ss046)
                    48        863  Yersinia pseudotuberculosis
                    49        835  Escherichia coli O9:H4 (strain HS)
                    50        829  Escherichia coli O139:H28 (strain E24377A / ETEC)
                    51        824  Shigella boydii serotype 4 (strain Sb227)
                    52        819  Ashbya gossypii (Yeast) (Eremothecium gossypii)
                    53        818  Escherichia coli (strain UTI89 / UPEC)
                    54        814  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
                    55        800  Shigella dysenteriae serotype 1 (strain Sd197)
                    56        798  Candida albicans (Yeast)
                    57        794  Vibrio parahaemolyticus
                    58        791  Kluyveromyces lactis (Yeast) (Candida sphaerica)
                    59        785  Escherichia coli (strain SMS-3-5 / SECEC)
                    60        778  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
                    61        777  Pasteurella multocida
                    62        773  Aquifex aeolicus
                    63        773  Neurospora crassa
                    64        765  Canis familiaris (Dog) (Canis lupus familiaris)
                    65        765  Escherichia coli (strain K12 / DH10B)
                    66        759  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
                    67        759  Escherichia coli (strain K12 / BW2952)
                    68        757  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
                    69        757  Escherichia coli (strain 55989 / EAEC)
                    70        757  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
                    71        756  Escherichia coli O8 (strain IAI1)
                    72        756  Staphylococcus epidermidis (strain ATCC 12228)
                    73        751  Escherichia coli O45:K1 (strain S88 / ExPEC)
                    74        750  Escherichia coli (strain SE11)
                    75        750  Shigella flexneri serotype 5b (strain 8401)
                    76        749  Candida glabrata (Yeast) (Torulopsis glabrata)
                    77        748  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
                    78        742  Escherichia coli O157:H7 (strain EC4115 / EHEC)
                    79        738  Streptomyces coelicolor
                    80        738  Photorhabdus luminescens subsp. laumondii
                    81        731  Vibrio vulnificus
                    82        730  Bacillus halodurans
                    83        726  Escherichia coli O81 (strain ED1a)
                    84        722  Bacillus anthracis
                    85        722  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
                    86        719  Salmonella enteritidis PT4 (strain P125109)
                    87        715  Vibrio vulnificus (strain YJ016)
                    88        715  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
                    89        713  Yersinia pestis bv. Antiqua (strain Nepal516)
                    90        713  Salmonella paratyphi A (strain AKU_12601)
                    91        712  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
                    92        711  Staphylococcus aureus (strain NCTC 8325)
                    93        710  Salmonella newport (strain SL254)
                    94        709  Salmonella heidelberg (strain SL476)
                    95        709  Yersinia pestis bv. Antiqua (strain Antiqua)
                    96        709  Salmonella agona (strain SL483)
                    97        708  Salmonella schwarzengrund (strain CVM19633)
                    98        706  Escherichia coli O1:K1 / APEC
                    99        699  Salmonella dublin (strain CT_02021853)
                    100        697  Enterobacter sp. (strain 638)
                    101        696  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
                    102        696  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
                    103        687  Mycoplasma pneumoniae
                    104        686  Pan troglodytes (Chimpanzee)
                    105        685  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
                    106        684  Pseudomonas syringae pv. tomato
                    107        682  Salmonella gallinarum (strain 287/91 / NCTC 13346)
                    108        682  Klebsiella pneumoniae (strain 342)
                    109        676  Anabaena sp. (strain PCC 7120)
                    110        670  Pseudomonas putida (strain KT2440)
                    111        666  Yersinia pestis (strain Pestoides F)
                    112        665  Staphylococcus aureus (strain USA300)
                    113        664  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
                    114        662  Mycobacterium leprae
                    115        658  Rhizobium sp. (strain NGR234)
                    116        653  Serratia proteamaculans (strain 568)
                    117        653  Zea mays (Maize)
                    118        650  Emericella nidulans (Aspergillus nidulans)
                    119        645  Escherichia coli
                    120        645  Bradyrhizobium japonicum
                    121        641  Staphylococcus aureus (strain bovine RF122 / ET3-1)
                    122        638  Bacillus cereus (strain ATCC 14579 / DSM 31)
                    123        637  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
                    124        635  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
                    125        633  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
                    126        620  Shewanella oneidensis
                    127        617  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
                    128        615  Treponema pallidum
                    129        613  Ralstonia solanacearum (Pseudomonas solanacearum)
                    130        608  Staphylococcus haemolyticus (strain JCSC1435)
                    131        608  Enterobacter sakazakii (strain ATCC BAA-894)
                    132        603  Rhizobium loti (Mesorhizobium loti)
                    133        602  Staphylococcus saprophyticus subsp. saprophyticus 
                    134        600  Methanobacterium thermoautotrophicum
                    135        598  Yersinia pestis bv. Antiqua (strain Angola)
                    136        598  Salmonella paratyphi C (strain RKS4594)
                    137        596  Listeria monocytogenes
                    138        595  Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
                    139        595  Photobacterium profundum (Photobacterium sp. (strain SS9))
                    140        594  Yarrowia lipolytica (Candida lipolytica)
                    141        590  Bacillus cereus (strain ATCC 10987)
                    142        589  Xanthomonas campestris pv. campestris
                    143        588  Listeria innocua
                    144        585  Rickettsia prowazekii
                    145        584  Helicobacter pylori (Campylobacter pylori)
                    146        582  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
                    147        581  Lactococcus lactis subsp. lactis (Streptococcus lactis)
                    148        579  Neisseria meningitidis serogroup B
                    149        576  Brucella suis
                    150        572  Brucella melitensis
                    151        572  Buchnera aphidicola subsp. Acyrthosiphon pisum 
                    152        569  Bacillus thuringiensis subsp. konkukian
                    153        565  Helicobacter pylori J99 (Campylobacter pylori J99)
                    154        562  Buchnera aphidicola subsp. Schizaphis graminum
                    155        560  Bacillus cereus (strain ZK / E33L)
                    156        560  Pseudomonas syringae pv. syringae (strain B728a)
                    157        557  Pseudomonas aeruginosa (strain UCBPP-PA14)
                    158        556  Neisseria meningitidis serogroup A
                    159        555  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
                    160        555  Xanthomonas axonopodis pv. citri (Citrus canker)
                    161        553  Vibrio fischeri (strain ATCC 700601 / ES114)
                    162        551  Pseudomonas fluorescens (strain Pf0-1)
                    163        549  Oceanobacillus iheyensis
                    164        545  Caulobacter crescentus (Caulobacter vibrioides)
                    165        545  Clostridium acetobutylicum
                    166        545  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
                    167        538  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
                    168        529  Listeria monocytogenes serotype 4b (strain F2365)
                    169        523  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
                    170        522  Sodalis glossinidius (strain morsitans)
                    171        522  Aspergillus fumigatus (Sartorya fumigata)
                    172        521  Bordetella bronchiseptica (Alcaligenes bronchisepticus)
                    173        521  Xylella fastidiosa
                    174        519  Streptococcus pneumoniae
                    175        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
                    176        510  Chromobacterium violaceum
                    177        509  Thermotoga maritima
                    178        509  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
                    179        507  Bordetella parapertussis
                    180        507  Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)
                    181        507  Pseudomonas aeruginosa (strain PA7)
                    182        505  Bordetella pertussis
                    183        504  Haemophilus ducreyi
                    184        504  Geobacillus kaustophilus
                    185        503  Staphylococcus aureus (strain Newman)
                    186        500  Pseudomonas entomophila (strain L48)
                    187        498  Brucella abortus
                    188        497  Rickettsia conorii
                    189        496  Bacillus clausii (strain KSM-K16)
                    190        493  Deinococcus radiodurans
                    191        492  Haemophilus influenzae (strain 86-028NP)
                    192        492  Oryza sativa subsp. indica (Rice)
                    193        492  Caenorhabditis briggsae
                    194        490  Xanthomonas campestris pv. campestris (strain 8004)
                    195        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
                    196        490  Clostridium perfringens
                    197        488  Bacillus amyloliquefaciens (strain FZB42)
                    198        487  Burkholderia pseudomallei (Pseudomonas pseudomallei)
                    199        487  Shewanella sp. (strain MR-7)
                    200        485  Corynebacterium glutamicum (Brevibacterium flavum)
                    201        484  Pseudomonas aeruginosa (strain LESB58)
                    202        484  Shewanella sp. (strain MR-4)
                    203        483  Mannheimia succiniciproducens (strain MBEL55E)
                    204        483  Mycoplasma genitalium
                    205        483  Staphylococcus aureus (strain Mu3 / ATCC 700698)
                    206        482  Streptomyces avermitilis
                    207        480  Proteus mirabilis (strain HI4320)
                    208        478  Methanosarcina acetivorans
                    209        475  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
                    210        472  Burkholderia sp. (strain 383) (Burkholderia cepacia 
                    211        472  Pseudomonas putida (strain F1 / ATCC 700007)
                    212        472  Brucella abortus (strain 2308)
                    213        472  Thermosynechococcus elongatus (strain BP-1)
                    214        469  Acinetobacter sp. (strain ADP1)
                    215        468  Enterococcus faecalis (Streptococcus faecalis)
                    216        465  Pyrococcus horikoshii
                    217        465  Xanthomonas campestris pv. vesicatoria (strain 85-10)
                    218        465  Pseudomonas putida (strain GB-1)
                    219        464  Rhodopseudomonas palustris
                    220        464  Shewanella frigidimarina (strain NCIMB 400)
                    221        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
                    222        462  Shewanella sp. (strain ANA-3)
                    223        461  Burkholderia mallei (Pseudomonas mallei)
                    224        460  Ralstonia eutropha  (Cupriavidus necator 
                    225        458  Lactobacillus plantarum
                    226        457  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
                    227        457  Pyrococcus abyssi
                    228        457  Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus)
                    229        457  Methanosarcina mazei (Methanosarcina frisia)
                    230        455  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
                    231        454  Staphylococcus aureus (strain JH1)
                    232        453  Rickettsia felis (Rickettsia azadi)
                    233        453  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
                    234        452  Shewanella baltica (strain OS185)
                    235        452  Pseudomonas putida (strain W619)
                    236        452  Halobacterium salinarium (Halobacterium halobium)
                    237        449  Streptococcus mutans
                    238        448  Staphylococcus aureus (strain JH9)
                    239        448  Thermoanaerobacter tengcongensis
                    240        447  Methylococcus capsulatus
                    241        447  Ovis aries (Sheep)
                    242        447  Aeromonas salmonicida (strain A449)
                    243        446  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
                    244        445  Vibrio fischeri (strain MJ11)
                    245        444  Pseudomonas mendocina (strain ymp)
                    246        443  Hahella chejuensis (strain KCTC 2396)
                    247        441  Streptococcus pyogenes serotype M6
                    248        441  Dechloromonas aromatica (strain RCB)
                    249        440  Pyrococcus furiosus
                    250        439  Mycobacterium paratuberculosis
                    
                    
                    
                    2.3  Taxonomic distribution of the sequences
                    
                    
                    
                    Kingdom        sequences (% of the database)
                    Archaea           18199 (  4%)
                    Bacteria         323480 ( 63%)
                    Eukaryota        160566 ( 31%)
                    Viruses           14855 (  3%)
                    
                    
                    Within Eukaryota:
                    
                    
                    
                    Category            sequences (% of Eukaryota) (% of the complete database)
                    Human                  20295 ( 13%)           (  4%)
                    Other Mammalia         44695 ( 28%)           (  9%)
                    Other Vertebrata       16098 ( 10%)           (  3%)
                    Viridiplantae          28998 ( 18%)           (  6%)
                    Fungi                  25736 ( 16%)           (  5%)
                    Insecta                 7881 (  5%)           (  2%)
                    Nematoda                4060 (  3%)           (  1%)
                    Other                  12803 (  8%)           (  2%)
                    
                    
                    
                    3.  SEQUENCE SIZE
                    
                    Repartition of the sequences by size (excluding fragments)
                    
                    From   To  Number             From   To   Number
                    1-  50    8399             1001-1100     3476
                    51- 100   39955             1101-1200     2430
                    101- 150   55842             1201-1300     1924
                    151- 200   55936             1301-1400     1789
                    201- 250   54614             1401-1500     1423
                    251- 300   47996             1501-1600      634
                    301- 350   48428             1601-1700      502
                    351- 400   41439             1701-1800      415
                    401- 450   33874             1801-1900      391
                    451- 500   27194             1901-2000      321
                    501- 550   19274             2001-2100      197
                    551- 600   13741             2101-2200      261
                    601- 650   11498             2201-2300      274
                    651- 700    8195             2301-2400      168
                    701- 750    6816             2401-2500      129
                    751- 800    4838             >2500         1007
                    801- 850    4152
                    851- 900    4764
                    901- 950    3620
                    951-1000    2533
                    
                    
                    
                    
                    The average sequence length in UniProtKB/Swiss-Prot is 352 amino acids.
                    
                    The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
                    The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.
                    
                    
                    4.  JOURNAL CITATIONS
                    
                    Note: the following citation statistics reflect the number of distinct
                    journal citations.
                    
                    Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2062
                    
                    
                    4.1 Table of the frequency of journal citations
                    
                    Journals cited 1x:  659
                    2x:  286
                    3x:  145
                    4x:  101
                    5x:   87
                    6x:   66
                    7x:   34
                    8x:   35
                    9x:   36
                    10x:   27
                    11- 20x:  165
                    21- 50x:  166
                    51-100x:   97
                    >100x:  158
                    
                    
                    4.2  List of the most cited journals in UniProtKB/Swiss-Prot
                    
                    Nb    Citations   Journal name
                    --    ---------   -------------------------------------------------------------
                    1        17902   Journal of Biological Chemistry
                    2         8294   Proceedings of the National Academy of Sciences of the U.S.A.
                    3         5014   Journal of Bacteriology
                    4         4505   Biochemical and Biophysical Research Communications
                    5         4496   Gene
                    6         4300   Nucleic Acids Research
                    7         3955   FEBS Letters
                    8         3855   Biochemistry
                    9         3735   The EMBO Journal
                    10         3399   Molecular and Cellular Biology
                    11         3218   Nature
                    12         3095   European Journal of Biochemistry
                    13         3040   Journal of Molecular Biology
                    14         2968   Biochimica et Biophysica Acta
                    15         2671   Cell
                    16         2476   Genomics
                    17         2173   Biochemical Journal
                    18         2123   Science
                    19         2025   Journal of Virology
                    20         1760   Molecular Microbiology
                    21         1566   Journal of Cell Biology
                    22         1491   Plant Molecular Biology
                    23         1364   Genes and Development
                    24         1347   Virology
                    25         1311   Nature Genetics
                    26         1310   Human Molecular Genetics
                    27         1304   Molecular and General Genetics
                    28         1303   Plant Physiology
                    29         1213   The American Journal of Human Genetics
                    30         1177   Oncogene
                    31         1158   Journal of Biochemistry
                    32         1158   Development
                    33         1082   Human Mutation
                    34         1012   Molecular Biology of the Cell
                    35         1006   Journal of Immunology
                    36          976   Genetics
                    37          883   Structure
                    38          876   Infection and Immunity
                    39          868   Journal of General Virology
                    40          852   The Plant Cell
                    41          819   Archives of Biochemistry and Biophysics
                    42          811   Molecular Cell
                    43          791   Blood
                    44          756   Yeast
                    45          750   Microbiology
                    46          735   The Plant Journal
                    47          724   Developmental Biology
                    48          724   Journal of Cell Science
                    49          664   Cancer Research
                    50          654   FEMS Microbiology Letters
                    51          643   Current Biology
                    52          591   Mechanisms of Development
                    53          590   Human Genetics
                    54          590   Nature Structural Biology
                    55          549   Protein Science
                    56          549   Acta Crystallographica, Section D
                    57          533   Applied and Environmental Microbiology
                    58          533   Journal of Neuroscience
                    59          523   Current Genetics
                    60          507   Toxicon
                    61          504   Neuron
                    62          500   Journal of Clinical Investigation
                    63          470   Mammalian Genome
                    64          458   American Journal of Physiology
                    65          449   Immunogenetics
                    66          444   The Journal of Experimental Medicine
                    67          438   Molecular Endocrinology
                    68          419   Molecular and Biochemical Parasitology
                    69          408   Journal of Neurochemistry
                    70          402   The Journal of Clinical Endocrinology and Metabolism
                    71          385   Endocrinology
                    72          378   Journal of Molecular Evolution
                    73          365   DNA and Cell Biology
                    74          364   Proteins
                    75          363   Bioscience, Biotechnology, and Biochemistry
                    76          356   DNA Sequence
                    77          353   Molecular Biology and Evolution
                    78          348   Journal of Medical Genetics
                    79          320   Tissue Antigens
                    80          314   Brain Research. Molecular Brain Research
                    81          296   Plant and Cell Physiology
                    82          294   Peptides
                    83          293   Experimental Cell Research
                    84          293   Comparative Biochemistry and Physiology
                    85          290   Nature Cell Biology
                    86          289   Biological Chemistry Hoppe-Seyler
                    87          282   Antimicrobial Agents and Chemotherapy
                    88          276   Journal of Investigative Dermatology
                    89          275   Cytogenetics and Cell Genetics
                    90          268   Molecular Pharmacology
                    91          257   Biology of Reproduction
                    92          247   Journal of General Microbiology
                    93          246   Genome Research
                    94          244   Developmental Cell
                    95          241   Developmental Dynamics
                    96          241   Neurology
                    97          239   RNA
                    98          231   Virus Research
                    99          215   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
                    100          205   DNA Research
                    101          205   Planta
                    102          204   European Journal of Immunology
                    103          202   Molecular Plant-Microbe Interactions
                    104          201   Biochimie
                    105          200   Annals of Neurology
                    106          197   Genes to Cells
                    107          193   European Journal of Human Genetics
                    108          190   Eukaryotic cell
                    109          186   Immunity
                    110          183   Journal of Human Genetics
                    111          182   The New England Journal of Medicine
                    112          175   Molecular and Cellular Endocrinology
                    113          172   Nature Structural and Molecular Biology
                    114          167   Investigative Ophthalmology and Visual Science
                    115          165   Archives of Microbiology
                    116          163   American Journal of Medical Genetics
                    117          163   Molecular Phylogenetics and Evolution
                    118          162   The FEBS Journal
                    119          159   Insect Biochemistry and Molecular Biology
                    120          159   EMBO Reports
                    121          159   DNA
                    122          157   The FASEB Journal
                    123          153   Hemoglobin
                    124          151   Molecular Immunology
                    125          151   Bioorganicheskaia Khimiia
                    126          150   Diabetes
                    127          148   Molecular Reproduction and Development
                    128          145   Archives of Virology
                    129          144   Glycobiology
                    130          143   Clinical Genetics
                    131          137   International Journal of Cancer
                    132          137   Molecular Genetics and Metabolism
                    133          136   General and Comparative Endocrinology
                    134          136   Animal Genetics
                    135          133   Molecular and Cellular Neuroscience
                    136          131   Journal of the American Chemical Society
                    137          130   British Journal of Haematology
                    138          128   Journal of Cellular Biochemistry
                    139          125   Biological Chemistry
                    140          124   Molecular Genetics and Genomics
                    141          123   BMC Genomics
                    142          123   American Journal of Medical Genetics. Part A
                    143          122   Nature Immunology
                    144          120   Journal of Lipid Research
                    145          120   Agricultural and Biological Chemistry
                    146          115   Circulation Research
                    147          115   Neuroscience Letters
                    148          115   Proteomics
                    149          114   Thrombosis and Haemostasis
                    150          113   Protein Expression and Purification
                    
                    
                    5.  STATISTICS FOR SOME LINE TYPES
                    
                    The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
                    as well as the number of entries with at least one such line, and the
                    frequency of the lines.
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry
                    ------------------------------------  -------- ---------  ---------
                    
                    References (RL)                       923665                 1.79                                         
                    Journal                            731921     387946      1.42       1                                 
                    Submitted to EMBL/GenBank/DDBJ     179092     165751      0.35       2                                 
                    Submitted to other databases        10591       9184      0.02       3                                 
                    Book citation                         636        622     <0.01       4                                 
                    Plant Gene Register                   560        548     <0.01       5                                 
                    Thesis                                395        392     <0.01       6                                 
                    Unpublished observations              295        291     <0.01       7                                 
                    Patent                                169        167     <0.01       8                                 
                    Worm Breeder's Gazette                  6          6     <0.01       9                                 
                    
                    Total number of distinct authors cited in UniProtKB/Swiss-Prot: 288505
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Comments (CC)                        2213067                 4.28                                         
                    ALLERGEN                              464        464     <0.01      26                                 
                    ALTERNATIVE PRODUCTS                18805      18805      0.04      13                                 
                    BIOPHYSICOCHEMICAL PROPERTIES        3046       3046      0.01      22                                 
                    BIOTECHNOLOGY                         273        271     <0.01      28                                 
                    CATALYTIC ACTIVITY                 219465     200187      0.42       5                                 
                    CAUTION                              7010       6866      0.01      19                                 
                    COFACTOR                            99714      91599      0.19       7                                 
                    DEVELOPMENTAL STAGE                  8836       8836      0.02      16                                 
                    DISEASE                              4239       2845      0.01      21                                 
                    DISRUPTION PHENOTYPE                 2626       2626      0.01      23                                 
                    DOMAIN                              31824      28155      0.06      11                                 
                    ENZYME REGULATION                    7895       7895      0.02      18                                 
                    FUNCTION                           385436     369371      0.75       2                                 
                    INDUCTION                           11704      11704      0.02      15                                 
                    INTERACTION                         12397      12397      0.02      14                                 
                    MASS SPECTROMETRY                    4320       3266      0.01      20                                 
                    MISCELLANEOUS                       30208      27932      0.06      12                                 
                    PATHWAY                            126896     115880      0.25       6                                 
                    PHARMACEUTICAL                         83         83     <0.01      29                                 
                    POLYMORPHISM                          783        748     <0.01      24                                 
                    PTM                                 35570      28800      0.07       9                                 
                    RNA EDITING                           603        603     <0.01      25                                 
                    SEQUENCE CAUTION                    37893      37893      0.07       8                                 
                    SIMILARITY                         601918     492445      1.16       1                                 
                    SUBCELLULAR LOCATION               298276     293202      0.58       3                                 
                    SUBUNIT                            221150     221150      0.43       4                                 
                    TISSUE SPECIFICITY                  32916      32916      0.06      10                                 
                    TOXIC DOSE                            420        409     <0.01      27                                 
                    WEB RESOURCE                         8297       6586      0.02      17                                 
                    
                    Total number of comment topics: 29
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Features (FT)                        3224736                 6.24                                         
                    ACT_SITE                           128764      76864      0.25       9                                 
                    BINDING                            200803      56831      0.39       4                                 
                    CA_BIND                              3655       1481      0.01      35                                 
                    CARBOHYD                            98165      25070      0.19      13                                 
                    CHAIN                              523566     512325      1.01       1                                 
                    COILED                              18159      12309      0.04      26                                 
                    COMPBIAS                            49308      25701      0.10      18                                 
                    CONFLICT                           116432      40874      0.23      10                                 
                    CROSSLNK                             4823       3131      0.01      34                                 
                    DISULFID                            95655      25516      0.18      14                                 
                    DNA_BIND                            10930      10063      0.02      29                                 
                    DOMAIN                             143982      85870      0.28       6                                 
                    HELIX                              130450      13645      0.25       8                                 
                    INIT_MET                            14820      14820      0.03      27                                 
                    LIPID                               10534       6705      0.02      30                                 
                    METAL                              273601      67415      0.53       3                                 
                    MOD_RES                            179599      59613      0.35       5                                 
                    MOTIF                               32149      20718      0.06      22                                 
                    MUTAGEN                             30740       7307      0.06      24                                 
                    NON_CONS                             1656        657     <0.01      36                                 
                    NON_STD                               349        274     <0.01      38                                 
                    NON_TER                             11708       8915      0.02      28                                 
                    NP_BIND                            104578      68365      0.20      12                                 
                    PEPTIDE                              8581       5492      0.02      32                                 
                    PROPEP                              10530       8882      0.02      31                                 
                    REGION                              92514      50838      0.18      15                                 
                    REPEAT                              88173      13042      0.17      16                                 
                    SIGNAL                              34259      34249      0.07      21                                 
                    SITE                                36853      21811      0.07      20                                 
                    STRAND                             130985      12758      0.25       7                                 
                    TOPO_DOM                           115568      23784      0.22      11                                 
                    TRANSIT                              6507       6421      0.01      33                                 
                    TRANSMEM                           337536      69070      0.65       2                                 
                    TURN                                31124      10776      0.06      23                                 
                    UNSURE                               1112        355     <0.01      37                                 
                    VAR_SEQ                             39015      16748      0.08      19                                 
                    VARIANT                             79363      16480      0.15      17                                 
                    ZN_FING                             28190      12268      0.05      25                                 
                    
                    Total number of feature keys: 38
                    
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank      Category
                    ------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
                    Cross-references (DR)               13065992                25.27                                                           
                    2DBase-Ecoli                           85         85     <0.01     114      2D gel databases                             
                    Aarhus/Ghent-2DPAGE                   126         96     <0.01     111      2D gel databases                             
                    AGD                                   825        819     <0.01      90      Organism-specific databases                  
                    ANU-2DPAGE                             23         23     <0.01     120      2D gel databases                             
                    ArachnoServer                         463        459     <0.01      98      Organism-specific databases                  
                    ArrayExpress                        58133      58133      0.11      38      Gene expression databases                    
                    Bgee                                37730      37699      0.07      44      Gene expression databases                    
                    BindingDB                             297        297     <0.01     106      Other                                        
                    BioCyc                             160647     147764      0.31      21      Enzyme and pathway databases                 
                    BRENDA                              65176      62379      0.13      35      Enzyme and pathway databases                 
                    CAZy                                 5756       5129      0.01      67      Protein family/group databases               
                    CGD                                   559        553     <0.01      95      Organism-specific databases                  
                    CleanEx                             30197      29551      0.06      46      Gene expression databases                    
                    COMPLUYEAST-2DPAGE                    101        100     <0.01     113      2D gel databases                             
                    ConoServer                            613        587     <0.01      94      Organism-specific databases                  
                    Cornea-2DPAGE                          67         67     <0.01     115      2D gel databases                             
                    CTD                                 64416      63856      0.12      37      Organism-specific databases                  
                    CYGD                                 6629       6540      0.01      66      Organism-specific databases                  
                    dictyBase                            4370       4242      0.01      74      Organism-specific databases                  
                    DIP                                 11523      11418      0.02      57      Protein-protein interaction databases        
                    DisProt                               397        394     <0.01     101      3D structure databases                       
                    DOSAC-COBS-2DPAGE                     149        147     <0.01     110      2D gel databases                             
                    DrugBank                             5317       1626      0.01      69      Other                                        
                    EchoBASE                             4167       4163      0.01      76      Organism-specific databases                  
                    ECO2DBASE                             352        300     <0.01     105      2D gel databases                             
                    EcoGene                              4399       4397      0.01      73      Organism-specific databases                  
                    eggNOG                             216813     216813      0.42      18      Phylogenomic databases                       
                    EMBL                               853681     507354      1.65       3      Sequence databases                           
                    Ensembl                             90352      69749      0.17      28      Genome annotation databases                  
                    euHCVdb                                55         44     <0.01     116      Organism-specific databases                  
                    EuPathDB                              233        233     <0.01     109      Organism-specific databases                  
                    FlyBase                              5592       5216      0.01      68      Organism-specific databases                  
                    Gene3D                             235572     193519      0.46      17      Family and domain databases                  
                    GeneCards                           20616      19843      0.04      50      Organism-specific databases                  
                    GeneDB_Spombe                        4977       4932      0.01      71      Organism-specific databases                  
                    GeneFarm                             2697       2682      0.01      82      Organism-specific databases                  
                    GeneID                             476812     449998      0.92       6      Genome annotation databases                  
                    Genevestigator                      64535      64535      0.12      36      Gene expression databases                    
                    GenoList                             7039       7027      0.01      64      Organism-specific databases                  
                    GenomeReviews                      377208     357207      0.73       9      Genome annotation databases                  
                    GermOnline                          41916      41319      0.08      43      Gene expression databases                    
                    GlycoSuiteDB                          280        280     <0.01     107      PTM databases                                
                    GO                                2150235     482983      4.16       1      Ontologies                                   
                    Gramene                              4314       4314      0.01      75      Organism-specific databases                  
                    H-InvDB                             11798      11057      0.02      56      Organism-specific databases                  
                    HAMAP                              307306     307162      0.59      15      Family and domain databases                  
                    HGNC                                19599      19423      0.04      52      Organism-specific databases                  
                    HOGENOM                            359814     359814      0.70      10      Phylogenomic databases                       
                    HOVERGEN                            74377      74377      0.14      31      Phylogenomic databases                       
                    HPA                                  8704       6562      0.02      61      Organism-specific databases                  
                    HSSP                                28983      28983      0.06      47      3D structure databases                       
                    InParanoid                          66079      66079      0.13      34      Phylogenomic databases                       
                    IntAct                              21885      21885      0.04      49      Protein-protein interaction databases        
                    InterPro                          1600315     490279      3.09       2      Family and domain databases                  
                    IPI                                 88680      63586      0.17      29      Sequence databases                           
                    KEGG                               439623     417939      0.85       8      Genome annotation databases                  
                    LegioList                             760        758     <0.01      91      Organism-specific databases                  
                    Leproma                               665        662     <0.01      93      Organism-specific databases                  
                    MaizeGDB                              472        467     <0.01      97      Organism-specific databases                  
                    MEROPS                               9961       9639      0.02      59      Protein family/group databases               
                    MGI                                 16149      16098      0.03      53      Organism-specific databases                  
                    MIM                                 16100      12672      0.03      54      Organism-specific databases                  
                    MINT                                10883      10883      0.02      58      Protein-protein interaction databases        
                    NextBio                             48761      48760      0.09      41      Other                                        
                    NMPDR                              130230     130226      0.25      24      Genome annotation databases                  
                    OGP                                   377        377     <0.01     103      2D gel databases                             
                    OMA                                353782     353782      0.68      11      Phylogenomic databases                       
                    Orphanet                             3810       2185      0.01      80      Organism-specific databases                  
                    OrthoDB                             55949      55949      0.11      39      Phylogenomic databases                       
                    PANTHER                            185237     170022      0.36      20      Family and domain databases                  
                    Pathway_Interaction_DB               4567       1665      0.01      72      Enzyme and pathway databases                 
                    PDB                                 66824      15640      0.13      33      3D structure databases                       
                    PDBsum                              66824      15640      0.13      32      3D structure databases                       
                    PeptideAtlas                         5169       5169      0.01      70      Proteomic databases                          
                    PeroxiBase                            678        666     <0.01      92      Protein family/group databases               
                    Pfam                               673188     474648      1.30       4      Family and domain databases                  
                    PharmGKB                            15803      15792      0.03      55      Organism-specific databases                  
                    PHCI-2DPAGE                           247        247     <0.01     108      2D gel databases                             
                    PhosphoSite                         20421      20421      0.04      51      PTM databases                                
                    PhosSite                              352        352     <0.01     104      PTM databases                                
                    PhylomeDB                          121439     121439      0.23      25      Phylogenomic databases                       
                    PIR                                115288     105309      0.22      26      Sequence databases                           
                    PIRSF                               82570      82570      0.16      30      Family and domain databases                  
                    PMAP-CutDB                           1394       1394     <0.01      85      Other                                        
                    PMMA-2DPAGE                            52         52     <0.01     117      2D gel databases                             
                    PptaseDB                               34         34     <0.01     118      Protein family/group databases               
                    PRIDE                               52154      52154      0.10      40      Proteomic databases                          
                    PRINTS                             136543     118165      0.26      23      Family and domain databases                  
                    ProDom                              27817      27488      0.05      48      Family and domain databases                  
                    ProMEX                                440        440     <0.01      99      Proteomic databases                          
                    PROSITE                            458423     291972      0.89       7      Family and domain databases                  
                    ProtClustDB                        324201     324201      0.63      13      Phylogenomic databases                       
                    PseudoCAP                            1219       1210     <0.01      87      Organism-specific databases                  
                    Rat-heart-2DPAGE                       28         28     <0.01     119      2D gel databases                             
                    Reactome                             7330       4256      0.01      63      Enzyme and pathway databases                 
                    REBASE                                378        358     <0.01     102      Protein family/group databases               
                    RefSeq                             498226     450333      0.96       5      Sequence databases                           
                    REPRODUCTION-2DPAGE                  1251       1030     <0.01      86      2D gel databases                             
                    RGD                                  7379       7375      0.01      62      Organism-specific databases                  
                    SGD                                  6641       6556      0.01      65      Organism-specific databases                  
                    Siena-2DPAGE                          103        103     <0.01     112      2D gel databases                             
                    SMART                              141988     109490      0.27      22      Family and domain databases                  
                    SMR                                346381     346381      0.67      12      3D structure databases                       
                    STRING                             203716     203679      0.39      19      Protein-protein interaction databases        
                    SUPFAM                             312532     247425      0.60      14      Family and domain databases                  
                    SWISS-2DPAGE                         1183       1181     <0.01      88      2D gel databases                             
                    TAIR                                 9095       8984      0.02      60      Organism-specific databases                  
                    TCDB                                 3328       3287      0.01      81      Protein family/group databases               
                    TIGR                                34013      33246      0.07      45      Genome annotation databases                  
                    TIGRFAMs                           280645     261879      0.54      16      Family and domain databases                  
                    TubercuList                          1683       1647     <0.01      84      Organism-specific databases                  
                    UCD-2DPAGE                            512        502     <0.01      96      2D gel databases                             
                    UCSC                                48525      39553      0.09      42      Genome annotation databases                  
                    UniGene                             93757      82535      0.18      27      Sequence databases                           
                    VectorBase                            426        412     <0.01     100      Genome annotation databases                  
                    World-2DPAGE                          915        904     <0.01      89      2D gel databases                             
                    WormBase                             3836       3751      0.01      79      Organism-specific databases                  
                    WormPep                              4065       3282      0.01      78      Organism-specific databases                  
                    Xenbase                              4095       4022      0.01      77      Organism-specific databases                  
                    ZFIN                                 2571       2560     <0.01      83      Organism-specific databases                  
                    
                    Total number of cross-referenced databases: 120
                    
                    6.  AMINO ACID COMPOSITION
                    
                    6.1  Composition in percent for the complete database
                    
                    Ala (A) 8.27   Gln (Q) 3.94   Leu (L) 9.67   Ser (S) 6.50
                    Arg (R) 5.53   Glu (E) 6.76   Lys (K) 5.85   Thr (T) 5.33
                    Asn (N) 4.05   Gly (G) 7.09   Met (M) 2.42   Trp (W) 1.08
                    Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.91
                    Cys (C) 1.36   Ile (I) 5.99   Pro (P) 4.68   Val (V) 6.87
                    
                    Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00
                    
                    
                    
                    Legend: gray = aliphatic, red = acidic, green = small hydroxy,
                    blue = basic, black = aromatic, white = amide, yellow = sulfur
                    
                    
                    6.2  Classification of the amino acids by their frequency
                    
                    Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
                    Phe, Tyr, Met, His, Cys, Trp
                    
                    
                    7.  MISCELLANEOUS STATISTICS
                    
                    4447 entries are encoded on a mitochondrion, and 3558 are encoded on a plasmid.
                    
                    12175 entries are encoded on a plastid, 
                    of which 21 are encoded on apicoplasts, 
                    11617 on chloroplasts, 
                    44 on organellar chromatophores,
                    145 on cyanelles, 
                    149 on non-photosynthetic plastids and 
                    199 on unspecified types of plastid.
                    
                    Number of entries with at least one sequence correction: 69001