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                    UniProtKB/Swiss-Prot protein knowledgebase release 2010_05 statistics
                    
                    
                    1.  INTRODUCTION
                    
                    Release 2010_05 of 20-Apr-10 of UniProtKB/Swiss-Prot contains 516603 sequence entries,
                    comprising 181919312 amino acids abstracted from 188500 references. 
                    
                    554 sequences have been added since release 2010_04, the sequence data of
                    139 existing entries has been updated and the annotations of
                    165063 entries have been revised.
                    
                    Number of fragments: 8631
                    Number of additional sequences produced by alternative splicing, initiation or promoter usage, or ribosomal frameshifting: 29032
                    
                    
                    Protein existence (PE):           entries     %
                    
                    1: Evidence at protein level        69219   13.4%
                    2: Evidence at transcript level     66826   12.9%
                    3: Inferred from homology          364612   70.6%
                    4: Predicted                        14353    2.8%
                    5: Uncertain                         1593    0.3%
                    
                    The growth of the database is summarized below.
                    
                    
                    
                    
                    2.  TAXONOMIC ORIGIN
                    
                    Total number of species represented in this release of UniProtKB/Swiss-Prot: 12072
                    
                    The first twenty species represent 107711 sequences:  20.8 % of the total
                    number of entries.
                    
                    
                    2.1 Table of the frequency of occurrence of species
                    
                    Species represented 1x: 5240
                    2x: 1702
                    3x:  892
                    4x:  573
                    5x:  426
                    6x:  351
                    7x:  241
                    8x:  205
                    9x:  184
                    10x:  106
                    11- 20x:  590
                    21- 50x:  372
                    51-100x:  175
                    >100x: 1015
                    
                    
                    2.2  Table of the most represented species
                    
                    ------  ---------  --------------------------------------------
                    Number  Frequency  Species
                    ------  ---------  --------------------------------------------
                    1      20277  Homo sapiens (Human)
                    2      16245  Mus musculus (Mouse)
                    3       8978  Arabidopsis thaliana (Mouse-ear cress)
                    4       7495  Rattus norvegicus (Rat)
                    5       6577  Saccharomyces cerevisiae (Baker's yeast)
                    6       5757  Bos taurus (Bovine)
                    7       4974  Schizosaccharomyces pombe (Fission yeast)
                    8       4422  Escherichia coli (strain K12)
                    9       4254  Bacillus subtilis
                    10       4238  Dictyostelium discoideum (Slime mold)
                    11       3287  Caenorhabditis elegans
                    12       3228  Xenopus laevis (African clawed frog)
                    13       3070  Drosophila melanogaster (Fruit fly)
                    14       2617  Danio rerio (Zebrafish) (Brachydanio rerio)
                    15       2374  Oryza sativa subsp. japonica (Rice)
                    16       2210  Pongo abelii (Sumatran orangutan)
                    17       2160  Gallus gallus (Chicken)
                    18       1993  Escherichia coli O157:H7
                    19       1782  Methanocaldococcus jannaschii (Methanococcus jannaschii)
                    20       1773  Haemophilus influenzae
                    21       1768  Salmonella typhimurium
                    22       1668  Escherichia coli O6
                    23       1666  Shigella flexneri
                    24       1644  Mycobacterium tuberculosis
                    25       1532  Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
                    26       1366  Sus scrofa (Pig)
                    27       1341  Salmonella typhi
                    28       1280  Pseudomonas aeruginosa
                    29       1213  Mycobacterium bovis
                    30       1162  Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey)
                    31       1015  Synechocystis sp. (strain PCC 6803)
                    32        996  Yersinia pestis
                    33        991  Archaeoglobus fulgidus
                    34        941  Vibrio cholerae
                    35        929  Salmonella paratyphi A
                    36        923  Staphylococcus aureus (strain N315)
                    37        922  Staphylococcus aureus (strain Mu50 / ATCC 700699)
                    38        913  Rhizobium meliloti (Sinorhizobium meliloti)
                    39        909  Acanthamoeba polyphaga mimivirus (APMV)
                    40        896  Staphylococcus aureus (strain COL)
                    41        894  Staphylococcus aureus (strain MW2)
                    42        888  Staphylococcus aureus (strain MSSA476)
                    43        885  Staphylococcus aureus (strain MRSA252)
                    44        882  Oryctolagus cuniculus (Rabbit)
                    45        879  Escherichia coli O6:K15:H31 (strain 536 / UPEC)
                    46        879  Salmonella choleraesuis
                    47        869  Shigella sonnei (strain Ss046)
                    48        863  Yersinia pseudotuberculosis
                    49        835  Escherichia coli O9:H4 (strain HS)
                    50        829  Escherichia coli O139:H28 (strain E24377A / ETEC)
                    51        824  Shigella boydii serotype 4 (strain Sb227)
                    52        818  Escherichia coli (strain UTI89 / UPEC)
                    53        818  Ashbya gossypii (Yeast) (Eremothecium gossypii)
                    54        814  Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks)
                    55        800  Shigella dysenteriae serotype 1 (strain Sd197)
                    56        797  Candida albicans (Yeast)
                    57        794  Vibrio parahaemolyticus
                    58        790  Kluyveromyces lactis (Yeast) (Candida sphaerica)
                    59        785  Escherichia coli (strain SMS-3-5 / SECEC)
                    60        778  Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum)
                    61        777  Pasteurella multocida
                    62        773  Aquifex aeolicus
                    63        772  Neurospora crassa
                    64        765  Canis familiaris (Dog) (Canis lupus familiaris)
                    65        765  Escherichia coli (strain K12 / DH10B)
                    66        759  Escherichia coli O127:H6 (strain E2348/69 / EPEC)
                    67        759  Escherichia coli (strain K12 / BW2952)
                    68        757  Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)
                    69        757  Escherichia coli (strain 55989 / EAEC)
                    70        757  Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
                    71        756  Escherichia coli O8 (strain IAI1)
                    72        756  Staphylococcus epidermidis (strain ATCC 12228)
                    73        751  Escherichia coli O45:K1 (strain S88 / ExPEC)
                    74        750  Escherichia coli (strain SE11)
                    75        750  Shigella flexneri serotype 5b (strain 8401)
                    76        748  Escherichia coli O7:K1 (strain IAI39 / ExPEC)
                    77        748  Candida glabrata (Yeast) (Torulopsis glabrata)
                    78        742  Escherichia coli O157:H7 (strain EC4115 / EHEC)
                    79        738  Streptomyces coelicolor
                    80        738  Photorhabdus luminescens subsp. laumondii
                    81        731  Vibrio vulnificus
                    82        730  Bacillus halodurans
                    83        726  Escherichia coli O81 (strain ED1a)
                    84        722  Bacillus anthracis
                    85        722  Yersinia enterocolitica serotype O:8 / biotype 1B (strain 8081)
                    86        719  Salmonella enteritidis PT4 (strain P125109)
                    87        715  Vibrio vulnificus (strain YJ016)
                    88        715  Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)
                    89        713  Yersinia pestis bv. Antiqua (strain Nepal516)
                    90        713  Salmonella paratyphi A (strain AKU_12601)
                    91        712  Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
                    92        711  Staphylococcus aureus (strain NCTC 8325)
                    93        710  Salmonella newport (strain SL254)
                    94        709  Salmonella heidelberg (strain SL476)
                    95        709  Yersinia pestis bv. Antiqua (strain Antiqua)
                    96        709  Salmonella agona (strain SL483)
                    97        708  Salmonella schwarzengrund (strain CVM19633)
                    98        706  Escherichia coli O1:K1 / APEC
                    99        699  Salmonella dublin (strain CT_02021853)
                    100        697  Enterobacter sp. (strain 638)
                    101        696  Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
                    102        696  Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)
                    103        687  Mycoplasma pneumoniae
                    104        686  Pan troglodytes (Chimpanzee)
                    105        685  Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CDC 0568-73)
                    106        684  Pseudomonas syringae pv. tomato
                    107        682  Salmonella gallinarum (strain 287/91 / NCTC 13346)
                    108        682  Klebsiella pneumoniae (strain 342)
                    109        676  Anabaena sp. (strain PCC 7120)
                    110        670  Pseudomonas putida (strain KT2440)
                    111        666  Yersinia pestis (strain Pestoides F)
                    112        665  Staphylococcus aureus (strain USA300)
                    113        664  Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)
                    114        661  Mycobacterium leprae
                    115        658  Rhizobium sp. (strain NGR234)
                    116        653  Serratia proteamaculans (strain 568)
                    117        652  Zea mays (Maize)
                    118        647  Escherichia coli
                    119        645  Bradyrhizobium japonicum
                    120        641  Staphylococcus aureus (strain bovine RF122 / ET3-1)
                    121        638  Bacillus cereus (strain ATCC 14579 / DSM 31)
                    122        637  Yersinia pseudotuberculosis serotype O:3 (strain YPIII)
                    123        635  Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980)
                    124        633  Yersinia pseudotuberculosis serotype IB (strain PB1/+)
                    125        627  Emericella nidulans (Aspergillus nidulans)
                    126        620  Shewanella oneidensis
                    127        617  Agrobacterium tumefaciens (strain C58 / ATCC 33970)
                    128        615  Treponema pallidum
                    129        613  Ralstonia solanacearum (Pseudomonas solanacearum)
                    130        608  Staphylococcus haemolyticus (strain JCSC1435)
                    131        608  Enterobacter sakazakii (strain ATCC BAA-894)
                    132        603  Rhizobium loti (Mesorhizobium loti)
                    133        602  Staphylococcus saprophyticus subsp. saprophyticus 
                    134        600  Methanobacterium thermoautotrophicum
                    135        598  Yersinia pestis bv. Antiqua (strain Angola)
                    136        598  Salmonella paratyphi C (strain RKS4594)
                    137        596  Listeria monocytogenes
                    138        595  Photobacterium profundum (Photobacterium sp. (strain SS9))
                    139        594  Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
                    140        593  Yarrowia lipolytica (Candida lipolytica)
                    141        590  Bacillus cereus (strain ATCC 10987)
                    142        589  Xanthomonas campestris pv. campestris
                    143        588  Listeria innocua
                    144        585  Rickettsia prowazekii
                    145        584  Helicobacter pylori (Campylobacter pylori)
                    146        582  Pectobacterium carotovorum subsp. carotovorum (strain PC1)
                    147        581  Lactococcus lactis subsp. lactis (Streptococcus lactis)
                    148        579  Neisseria meningitidis serogroup B
                    149        576  Brucella suis
                    150        572  Brucella melitensis
                    151        572  Buchnera aphidicola subsp. Acyrthosiphon pisum 
                    152        567  Bacillus thuringiensis subsp. konkukian
                    153        565  Helicobacter pylori J99 (Campylobacter pylori J99)
                    154        562  Buchnera aphidicola subsp. Schizaphis graminum
                    155        560  Bacillus cereus (strain ZK / E33L)
                    156        560  Pseudomonas syringae pv. syringae (strain B728a)
                    157        557  Pseudomonas aeruginosa (strain UCBPP-PA14)
                    158        556  Neisseria meningitidis serogroup A
                    159        555  Bacillus licheniformis (strain DSM 13 / ATCC 14580)
                    160        555  Xanthomonas axonopodis pv. citri (Citrus canker)
                    161        553  Vibrio fischeri (strain ATCC 700601 / ES114)
                    162        551  Pseudomonas fluorescens (strain Pf0-1)
                    163        549  Oceanobacillus iheyensis
                    164        545  Caulobacter crescentus (Caulobacter vibrioides)
                    165        545  Clostridium acetobutylicum
                    166        545  Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477)
                    167        538  Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6)
                    168        529  Listeria monocytogenes serotype 4b (strain F2365)
                    169        523  Erwinia tasmaniensis (strain DSM 17950 / Et1/99)
                    170        522  Sodalis glossinidius (strain morsitans)
                    171        521  Bordetella bronchiseptica (Alcaligenes bronchisepticus)
                    172        521  Xylella fastidiosa
                    173        519  Streptococcus pneumoniae
                    174        512  Xylella fastidiosa (strain Temecula1 / ATCC 700964)
                    175        510  Chromobacterium violaceum
                    176        510  Aspergillus fumigatus (Sartorya fumigata)
                    177        509  Thermotoga maritima
                    178        509  Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395)
                    179        507  Bordetella parapertussis
                    180        507  Buchnera aphidicola subsp. Baizongia pistaciae
                    181        507  Pseudomonas aeruginosa (strain PA7)
                    182        505  Bordetella pertussis
                    183        504  Haemophilus ducreyi
                    184        504  Geobacillus kaustophilus
                    185        503  Staphylococcus aureus (strain Newman)
                    186        500  Pseudomonas entomophila (strain L48)
                    187        498  Brucella abortus
                    188        497  Rickettsia conorii
                    189        496  Bacillus clausii (strain KSM-K16)
                    190        493  Deinococcus radiodurans
                    191        492  Haemophilus influenzae (strain 86-028NP)
                    192        490  Xanthomonas campestris pv. campestris (strain 8004)
                    193        490  Vibrio harveyi (strain ATCC BAA-1116 / BB120)
                    194        490  Clostridium perfringens
                    195        488  Bacillus amyloliquefaciens (strain FZB42)
                    196        487  Burkholderia pseudomallei (Pseudomonas pseudomallei)
                    197        487  Shewanella sp. (strain MR-7)
                    198        485  Corynebacterium glutamicum (Brevibacterium flavum)
                    199        484  Pseudomonas aeruginosa (strain LESB58)
                    200        484  Shewanella sp. (strain MR-4)
                    201        483  Mannheimia succiniciproducens (strain MBEL55E)
                    202        483  Mycoplasma genitalium
                    203        483  Staphylococcus aureus (strain Mu3 / ATCC 700698)
                    204        483  Caenorhabditis briggsae
                    205        482  Streptomyces avermitilis
                    206        481  Oryza sativa subsp. indica (Rice)
                    207        480  Proteus mirabilis (strain HI4320)
                    208        478  Methanosarcina acetivorans
                    209        475  Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
                    210        472  Burkholderia sp. (strain 383) (Burkholderia cepacia 
                    211        472  Pseudomonas putida (strain F1 / ATCC 700007)
                    212        472  Brucella abortus (strain 2308)
                    213        472  Thermosynechococcus elongatus (strain BP-1)
                    214        469  Acinetobacter sp. (strain ADP1)
                    215        468  Enterococcus faecalis (Streptococcus faecalis)
                    216        465  Pyrococcus horikoshii
                    217        465  Xanthomonas campestris pv. vesicatoria (strain 85-10)
                    218        465  Pseudomonas putida (strain GB-1)
                    219        464  Rhodopseudomonas palustris
                    220        464  Shewanella frigidimarina (strain NCIMB 400)
                    221        462  Anabaena variabilis (strain ATCC 29413 / PCC 7937)
                    222        462  Shewanella sp. (strain ANA-3)
                    223        461  Burkholderia mallei (Pseudomonas mallei)
                    224        460  Ralstonia eutropha  (Cupriavidus necator 
                    225        458  Lactobacillus plantarum
                    226        457  Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
                    227        457  Pyrococcus abyssi
                    228        457  Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus)
                    229        457  Methanosarcina mazei (Methanosarcina frisia)
                    230        455  Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / NCIB 9240)
                    231        454  Staphylococcus aureus (strain JH1)
                    232        453  Rickettsia felis (Rickettsia azadi)
                    233        453  Xanthomonas oryzae pv. oryzae (strain MAFF 311018)
                    234        452  Shewanella baltica (strain OS185)
                    235        452  Pseudomonas putida (strain W619)
                    236        452  Halobacterium salinarium (Halobacterium halobium)
                    237        449  Streptococcus mutans
                    238        448  Staphylococcus aureus (strain JH9)
                    239        448  Thermoanaerobacter tengcongensis
                    240        447  Methylococcus capsulatus
                    241        447  Ovis aries (Sheep)
                    242        447  Aeromonas salmonicida (strain A449)
                    243        446  Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253 / DSM 158)
                    244        445  Vibrio fischeri (strain MJ11)
                    245        444  Pseudomonas mendocina (strain ymp)
                    246        443  Hahella chejuensis (strain KCTC 2396)
                    247        441  Streptococcus pyogenes serotype M6
                    248        441  Dechloromonas aromatica (strain RCB)
                    249        440  Pyrococcus furiosus
                    250        439  Nicotiana tabacum (Common tobacco)
                    
                    
                    
                    2.3  Taxonomic distribution of the sequences
                    
                    
                    
                    Kingdom        sequences (% of the database)
                    Archaea           18199 (  4%)
                    Bacteria         323424 ( 63%)
                    Eukaryota        160125 ( 31%)
                    Viruses           14855 (  3%)
                    
                    
                    Within Eukaryota:
                    
                    
                    
                    Category            sequences (% of Eukaryota) (% of the complete database)
                    Human                  20278 ( 13%)           (  4%)
                    Other Mammalia         44634 ( 28%)           (  9%)
                    Other Vertebrata       16057 ( 10%)           (  3%)
                    Viridiplantae          28924 ( 18%)           (  6%)
                    Fungi                  25557 ( 16%)           (  5%)
                    Insecta                 7841 (  5%)           (  2%)
                    Nematoda                4048 (  3%)           (  1%)
                    Other                  12786 (  8%)           (  2%)
                    
                    
                    
                    3.  SEQUENCE SIZE
                    
                    Repartition of the sequences by size (excluding fragments)
                    
                    From   To  Number             From   To   Number
                    1-  50    8385             1001-1100     3472
                    51- 100   39930             1101-1200     2403
                    101- 150   55837             1201-1300     1922
                    151- 200   55931             1301-1400     1786
                    201- 250   54548             1401-1500     1422
                    251- 300   47958             1501-1600      635
                    301- 350   48399             1601-1700      501
                    351- 400   41373             1701-1800      415
                    401- 450   33842             1801-1900      390
                    451- 500   27169             1901-2000      320
                    501- 550   19232             2001-2100      197
                    551- 600   13727             2101-2200      261
                    601- 650   11490             2201-2300      274
                    651- 700    8172             2301-2400      168
                    701- 750    6811             2401-2500      129
                    751- 800    4827             >2500         1007
                    801- 850    4142
                    851- 900    4748
                    901- 950    3618
                    951-1000    2531
                    
                    
                    
                    
                    The average sequence length in UniProtKB/Swiss-Prot is 352 amino acids.
                    
                    The shortest sequence is   GWA_SEPOF (P83570):     2 amino acids.
                    The longest sequence is  TITIN_MOUSE (A2ASS6): 35213 amino acids.
                    
                    
                    4.  JOURNAL CITATIONS
                    
                    Note: the following citation statistics reflect the number of distinct
                    journal citations.
                    
                    Total number of journals cited in this release of UniProtKB/Swiss-Prot: 2059
                    
                    
                    4.1 Table of the frequency of journal citations
                    
                    Journals cited 1x:  663
                    2x:  280
                    3x:  146
                    4x:  100
                    5x:   89
                    6x:   63
                    7x:   36
                    8x:   35
                    9x:   35
                    10x:   26
                    11- 20x:  166
                    21- 50x:  165
                    51-100x:   97
                    >100x:  158
                    
                    
                    4.2  List of the most cited journals in UniProtKB/Swiss-Prot
                    
                    Nb    Citations   Journal name
                    --    ---------   -------------------------------------------------------------
                    1        17851   Journal of Biological Chemistry
                    2         8277   Proceedings of the National Academy of Sciences of the U.S.A.
                    3         5011   Journal of Bacteriology
                    4         4496   Biochemical and Biophysical Research Communications
                    5         4494   Gene
                    6         4294   Nucleic Acids Research
                    7         3945   FEBS Letters
                    8         3847   Biochemistry
                    9         3725   The EMBO Journal
                    10         3395   Molecular and Cellular Biology
                    11         3212   Nature
                    12         3088   European Journal of Biochemistry
                    13         3031   Journal of Molecular Biology
                    14         2965   Biochimica et Biophysica Acta
                    15         2664   Cell
                    16         2472   Genomics
                    17         2170   Biochemical Journal
                    18         2111   Science
                    19         2024   Journal of Virology
                    20         1758   Molecular Microbiology
                    21         1558   Journal of Cell Biology
                    22         1491   Plant Molecular Biology
                    23         1359   Genes and Development
                    24         1347   Virology
                    25         1310   Nature Genetics
                    26         1307   Human Molecular Genetics
                    27         1304   Molecular and General Genetics
                    28         1297   Plant Physiology
                    29         1210   The American Journal of Human Genetics
                    30         1171   Oncogene
                    31         1155   Journal of Biochemistry
                    32         1147   Development
                    33         1082   Human Mutation
                    34         1009   Molecular Biology of the Cell
                    35         1005   Journal of Immunology
                    36          975   Genetics
                    37          882   Structure
                    38          875   Infection and Immunity
                    39          868   Journal of General Virology
                    40          846   The Plant Cell
                    41          818   Archives of Biochemistry and Biophysics
                    42          802   Molecular Cell
                    43          791   Blood
                    44          756   Yeast
                    45          750   Microbiology
                    46          729   The Plant Journal
                    47          722   Journal of Cell Science
                    48          720   Developmental Biology
                    49          663   Cancer Research
                    50          652   FEMS Microbiology Letters
                    51          642   Current Biology
                    52          590   Mechanisms of Development
                    53          590   Human Genetics
                    54          588   Nature Structural Biology
                    55          548   Acta Crystallographica, Section D
                    56          545   Protein Science
                    57          531   Applied and Environmental Microbiology
                    58          530   Journal of Neuroscience
                    59          523   Current Genetics
                    60          507   Toxicon
                    61          500   Journal of Clinical Investigation
                    62          500   Neuron
                    63          469   Mammalian Genome
                    64          457   American Journal of Physiology
                    65          449   Immunogenetics
                    66          444   The Journal of Experimental Medicine
                    67          437   Molecular Endocrinology
                    68          419   Molecular and Biochemical Parasitology
                    69          407   Journal of Neurochemistry
                    70          399   The Journal of Clinical Endocrinology and Metabolism
                    71          385   Endocrinology
                    72          378   Journal of Molecular Evolution
                    73          365   DNA and Cell Biology
                    74          363   Proteins
                    75          361   Bioscience, Biotechnology, and Biochemistry
                    76          356   DNA Sequence
                    77          353   Molecular Biology and Evolution
                    78          348   Journal of Medical Genetics
                    79          319   Tissue Antigens
                    80          314   Brain Research. Molecular Brain Research
                    81          296   Plant and Cell Physiology
                    82          293   Peptides
                    83          292   Experimental Cell Research
                    84          289   Biological Chemistry Hoppe-Seyler
                    85          289   Comparative Biochemistry and Physiology
                    86          289   Nature Cell Biology
                    87          282   Antimicrobial Agents and Chemotherapy
                    88          276   Journal of Investigative Dermatology
                    89          275   Cytogenetics and Cell Genetics
                    90          268   Molecular Pharmacology
                    91          256   Biology of Reproduction
                    92          247   Journal of General Microbiology
                    93          246   Genome Research
                    94          241   Developmental Dynamics
                    95          241   Developmental Cell
                    96          241   Neurology
                    97          239   RNA
                    98          231   Virus Research
                    99          215   Hoppe-Seyler's Zeitschrift fur Physiologische Chemie
                    100          205   DNA Research
                    101          205   Planta
                    102          203   European Journal of Immunology
                    103          202   Molecular Plant-Microbe Interactions
                    104          201   Biochimie
                    105          200   Annals of Neurology
                    106          196   Genes to Cells
                    107          193   European Journal of Human Genetics
                    108          190   Eukaryotic cell
                    109          185   Immunity
                    110          183   Journal of Human Genetics
                    111          179   The New England Journal of Medicine
                    112          175   Molecular and Cellular Endocrinology
                    113          171   Nature Structural and Molecular Biology
                    114          167   Investigative Ophthalmology and Visual Science
                    115          165   Archives of Microbiology
                    116          163   American Journal of Medical Genetics
                    117          163   Molecular Phylogenetics and Evolution
                    118          159   Insect Biochemistry and Molecular Biology
                    119          159   EMBO Reports
                    120          159   DNA
                    121          158   The FEBS Journal
                    122          155   The FASEB Journal
                    123          153   Hemoglobin
                    124          151   Bioorganicheskaia Khimiia
                    125          150   Molecular Immunology
                    126          149   Diabetes
                    127          148   Molecular Reproduction and Development
                    128          145   Archives of Virology
                    129          143   Glycobiology
                    130          142   Clinical Genetics
                    131          136   General and Comparative Endocrinology
                    132          136   International Journal of Cancer
                    133          136   Animal Genetics
                    134          136   Molecular Genetics and Metabolism
                    135          132   Molecular and Cellular Neuroscience
                    136          130   British Journal of Haematology
                    137          129   Journal of the American Chemical Society
                    138          128   Journal of Cellular Biochemistry
                    139          125   Biological Chemistry
                    140          123   American Journal of Medical Genetics. Part A
                    141          123   Molecular Genetics and Genomics
                    142          122   BMC Genomics
                    143          121   Nature Immunology
                    144          120   Journal of Lipid Research
                    145          120   Agricultural and Biological Chemistry
                    146          114   Thrombosis and Haemostasis
                    147          114   Circulation Research
                    148          114   Neuroscience Letters
                    149          114   Proteomics
                    150          113   Journal of Protein Chemistry
                    
                    
                    5.  STATISTICS FOR SOME LINE TYPES
                    
                    The following table summarizes the total number of some UniProtKB/Swiss-Prot lines,
                    as well as the number of entries with at least one such line, and the
                    frequency of the lines.
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry
                    ------------------------------------  -------- ---------  ---------
                    
                    References (RL)                       921204                 1.78                                         
                    Journal                            729732     387472      1.41       1                                 
                    Submitted to EMBL/GenBank/DDBJ     178782     165502      0.35       2                                 
                    Submitted to other databases        10630       9225      0.02       3                                 
                    Book citation                         636        622     <0.01       4                                 
                    Plant Gene Register                   560        548     <0.01       5                                 
                    Thesis                                395        392     <0.01       6                                 
                    Unpublished observations              294        290     <0.01       7                                 
                    Patent                                169        167     <0.01       8                                 
                    Worm Breeder's Gazette                  6          6     <0.01       9                                 
                    
                    Total number of distinct authors cited in UniProtKB/Swiss-Prot: 287816
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Comments (CC)                        2209566                 4.28                                         
                    ALLERGEN                              464        464     <0.01      26                                 
                    ALTERNATIVE PRODUCTS                18741      18741      0.04      13                                 
                    BIOPHYSICOCHEMICAL PROPERTIES        3019       3019      0.01      22                                 
                    BIOTECHNOLOGY                         272        270     <0.01      28                                 
                    CATALYTIC ACTIVITY                 219222     199987      0.42       5                                 
                    CAUTION                              6970       6825      0.01      19                                 
                    COFACTOR                            99582      91476      0.19       7                                 
                    DEVELOPMENTAL STAGE                  8807       8807      0.02      16                                 
                    DISEASE                              4232       2837      0.01      21                                 
                    DISRUPTION PHENOTYPE                 2565       2565     <0.01      23                                 
                    DOMAIN                              31749      28089      0.06      11                                 
                    ENZYME REGULATION                    7854       7854      0.02      18                                 
                    FUNCTION                           384947     368896      0.75       2                                 
                    INDUCTION                           11677      11677      0.02      15                                 
                    INTERACTION                         12353      12353      0.02      14                                 
                    MASS SPECTROMETRY                    4305       3251      0.01      20                                 
                    MISCELLANEOUS                       30165      27894      0.06      12                                 
                    PATHWAY                            126682     115734      0.25       6                                 
                    PHARMACEUTICAL                         83         83     <0.01      29                                 
                    POLYMORPHISM                          780        746     <0.01      24                                 
                    PTM                                 35449      28716      0.07       9                                 
                    RNA EDITING                           603        603     <0.01      25                                 
                    SEQUENCE CAUTION                    37770      37770      0.07       8                                 
                    SIMILARITY                         601196     491952      1.16       1                                 
                    SUBCELLULAR LOCATION               297665     292596      0.58       3                                 
                    SUBUNIT                            220877     220877      0.43       4                                 
                    TISSUE SPECIFICITY                  32821      32821      0.06      10                                 
                    TOXIC DOSE                            420        409     <0.01      27                                 
                    WEB RESOURCE                         8296       6585      0.02      17                                 
                    
                    Total number of comment topics: 29
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank
                    ------------------------------------  -------- ---------  ---------  ----
                    Features (FT)                        3219013                 6.23                                         
                    ACT_SITE                           128526      76702      0.25       9                                 
                    BINDING                            200776      57205      0.39       4                                 
                    CA_BIND                              3655       1481      0.01      35                                 
                    CARBOHYD                            97440      24906      0.19      13                                 
                    CHAIN                              523080     511841      1.01       1                                 
                    COILED                              18127      12281      0.04      26                                 
                    COMPBIAS                            49207      25634      0.10      18                                 
                    CONFLICT                           115946      40664      0.22      10                                 
                    CROSSLNK                             4815       3123      0.01      34                                 
                    DISULFID                            95210      25407      0.18      14                                 
                    DNA_BIND                            10900      10033      0.02      29                                 
                    DOMAIN                             143796      85742      0.28       6                                 
                    HELIX                              130476      13651      0.25       8                                 
                    INIT_MET                            14815      14815      0.03      27                                 
                    LIPID                               10526       6703      0.02      30                                 
                    METAL                              273128      67286      0.53       3                                 
                    MOD_RES                            178747      59020      0.35       5                                 
                    MOTIF                               32097      20667      0.06      22                                 
                    MUTAGEN                             30521       7255      0.06      24                                 
                    NON_CONS                             1554        639     <0.01      36                                 
                    NON_STD                               349        274     <0.01      38                                 
                    NON_TER                             11673       8895      0.02      28                                 
                    NP_BIND                            104786      68343      0.20      12                                 
                    PEPTIDE                              8568       5479      0.02      32                                 
                    PROPEP                              10522       8874      0.02      31                                 
                    REGION                              92133      50656      0.18      15                                 
                    REPEAT                              88131      13033      0.17      16                                 
                    SIGNAL                              34038      34028      0.07      21                                 
                    SITE                                36820      21789      0.07      20                                 
                    STRAND                             131016      12764      0.25       7                                 
                    TOPO_DOM                           115451      23736      0.22      11                                 
                    TRANSIT                              6494       6408      0.01      33                                 
                    TRANSMEM                           337225      68974      0.65       2                                 
                    TURN                                31128      10779      0.06      23                                 
                    UNSURE                               1111        354     <0.01      37                                 
                    VAR_SEQ                             38859      16686      0.08      19                                 
                    VARIANT                             79281      16458      0.15      17                                 
                    ZN_FING                             28086      12251      0.05      25                                 
                    
                    Total number of feature keys: 38
                    
                    
                    
                    Total    Number of  Average
                    Line type / subtype                number   entries    per entry  Rank      Category
                    ------------------------------------  -------- ---------  ---------  ----      -------------------------------------------
                    Cross-references (DR)               13035636                25.23                                                           
                    2DBase-Ecoli                           85         85     <0.01     114      2D gel databases                             
                    Aarhus/Ghent-2DPAGE                   126         96     <0.01     111      2D gel databases                             
                    AGD                                   824        818     <0.01      90      Organism-specific databases                  
                    ANU-2DPAGE                             23         23     <0.01     120      2D gel databases                             
                    ArachnoServer                         463        459     <0.01      98      Organism-specific databases                  
                    ArrayExpress                        58107      58107      0.11      38      Gene expression databases                    
                    Bgee                                37678      37667      0.07      44      Gene expression databases                    
                    BindingDB                             297        297     <0.01     106      Other                                        
                    BioCyc                             160627     147748      0.31      21      Enzyme and pathway databases                 
                    BRENDA                              65175      62378      0.13      35      Enzyme and pathway databases                 
                    CAZy                                 5738       5112      0.01      67      Protein family/group databases               
                    CGD                                   557        552     <0.01      95      Organism-specific databases                  
                    CleanEx                             30198      29552      0.06      46      Gene expression databases                    
                    COMPLUYEAST-2DPAGE                    101        100     <0.01     113      2D gel databases                             
                    ConoServer                            613        588     <0.01      94      Organism-specific databases                  
                    Cornea-2DPAGE                          67         67     <0.01     115      2D gel databases                             
                    CTD                                 63628      63064      0.12      37      Organism-specific databases                  
                    CYGD                                 6629       6540      0.01      66      Organism-specific databases                  
                    dictyBase                            4365       4237      0.01      74      Organism-specific databases                  
                    DIP                                 11520      11415      0.02      57      Protein-protein interaction databases        
                    DisProt                               397        394     <0.01     101      3D structure databases                       
                    DOSAC-COBS-2DPAGE                     149        147     <0.01     110      2D gel databases                             
                    DrugBank                             5317       1626      0.01      69      Other                                        
                    EchoBASE                             4162       4154      0.01      76      Organism-specific databases                  
                    ECO2DBASE                             352        300     <0.01     105      2D gel databases                             
                    EcoGene                              4390       4388      0.01      73      Organism-specific databases                  
                    eggNOG                             216701     216701      0.42      18      Phylogenomic databases                       
                    EMBL                               851185     506894      1.65       3      Sequence databases                           
                    Ensembl                             90180      69679      0.17      28      Genome annotation databases                  
                    euHCVdb                                55         44     <0.01     116      Organism-specific databases                  
                    EuPathDB                              233        233     <0.01     109      Organism-specific databases                  
                    FlyBase                              5556       5180      0.01      68      Organism-specific databases                  
                    Gene3D                             235357     193314      0.46      17      Family and domain databases                  
                    GeneCards                           20617      19844      0.04      50      Organism-specific databases                  
                    GeneDB_Spombe                        4976       4931      0.01      71      Organism-specific databases                  
                    GeneFarm                             2695       2680      0.01      82      Organism-specific databases                  
                    GeneID                             468759     449561      0.91       6      Genome annotation databases                  
                    Genevestigator                      64480      64480      0.12      36      Gene expression databases                    
                    GenoList                             7038       7026      0.01      64      Organism-specific databases                  
                    GenomeReviews                      377058     357080      0.73       9      Genome annotation databases                  
                    GermOnline                          41916      41319      0.08      43      Gene expression databases                    
                    GlycoSuiteDB                          280        280     <0.01     107      PTM databases                                
                    GO                                2148560     482592      4.16       1      Ontologies                                   
                    Gramene                              4294       4294      0.01      75      Organism-specific databases                  
                    H-InvDB                             11799      11058      0.02      56      Organism-specific databases                  
                    HAMAP                              307283     307139      0.59      15      Family and domain databases                  
                    HGNC                                19567      19391      0.04      51      Organism-specific databases                  
                    HOGENOM                            359650     359650      0.70      10      Phylogenomic databases                       
                    HOVERGEN                            74316      74316      0.14      31      Phylogenomic databases                       
                    HPA                                  8704       6562      0.02      61      Organism-specific databases                  
                    HSSP                                28952      28952      0.06      47      3D structure databases                       
                    InParanoid                          65989      65989      0.13      34      Phylogenomic databases                       
                    IntAct                              21852      21852      0.04      49      Protein-protein interaction databases        
                    InterPro                          1598942     489860      3.10       2      Family and domain databases                  
                    IPI                                 88512      63485      0.17      29      Sequence databases                           
                    KEGG                               438218     417189      0.85       8      Genome annotation databases                  
                    LegioList                             760        758     <0.01      91      Organism-specific databases                  
                    Leproma                               664        661     <0.01      93      Organism-specific databases                  
                    MaizeGDB                              472        467     <0.01      97      Organism-specific databases                  
                    MEROPS                               9960       9638      0.02      59      Protein family/group databases               
                    MGI                                 16126      16075      0.03      53      Organism-specific databases                  
                    MIM                                 15890      12488      0.03      54      Organism-specific databases                  
                    MINT                                10881      10881      0.02      58      Protein-protein interaction databases        
                    NextBio                             48726      48725      0.09      41      Other                                        
                    NMPDR                              130185     130181      0.25      24      Genome annotation databases                  
                    OGP                                   377        377     <0.01     103      2D gel databases                             
                    OMA                                353620     353620      0.68      11      Phylogenomic databases                       
                    Orphanet                             3739       2164      0.01      80      Organism-specific databases                  
                    OrthoDB                             55760      55760      0.11      39      Phylogenomic databases                       
                    PANTHER                            185086     169894      0.36      20      Family and domain databases                  
                    Pathway_Interaction_DB               4567       1665      0.01      72      Enzyme and pathway databases                 
                    PDB                                 66820      15638      0.13      32      3D structure databases                       
                    PDBsum                              66815      15638      0.13      33      3D structure databases                       
                    PeptideAtlas                         5169       5169      0.01      70      Proteomic databases                          
                    PeroxiBase                            678        666     <0.01      92      Protein family/group databases               
                    Pfam                               672671     474284      1.30       4      Family and domain databases                  
                    PharmGKB                            15802      15791      0.03      55      Organism-specific databases                  
                    PHCI-2DPAGE                           247        247     <0.01     108      2D gel databases                             
                    PhosphoSite                         19302      19302      0.04      52      PTM databases                                
                    PhosSite                              354        352     <0.01     104      PTM databases                                
                    PhylomeDB                          121363     121363      0.23      25      Phylogenomic databases                       
                    PIR                                115230     105252      0.22      26      Sequence databases                           
                    PIRSF                               82541      82541      0.16      30      Family and domain databases                  
                    PMAP-CutDB                           1394       1394     <0.01      85      Other                                        
                    PMMA-2DPAGE                            52         52     <0.01     117      2D gel databases                             
                    PptaseDB                               34         34     <0.01     118      Protein family/group databases               
                    PRIDE                               52090      52090      0.10      40      Proteomic databases                          
                    PRINTS                             136451     118076      0.26      23      Family and domain databases                  
                    ProDom                              27800      27471      0.05      48      Family and domain databases                  
                    ProMEX                                440        440     <0.01      99      Proteomic databases                          
                    PROSITE                            457981     291717      0.89       7      Family and domain databases                  
                    ProtClustDB                        324133     324133      0.63      13      Phylogenomic databases                       
                    PseudoCAP                            1219       1210     <0.01      87      Organism-specific databases                  
                    Rat-heart-2DPAGE                       28         28     <0.01     119      2D gel databases                             
                    Reactome                             7330       4256      0.01      63      Enzyme and pathway databases                 
                    REBASE                                378        358     <0.01     102      Protein family/group databases               
                    RefSeq                             489760     449876      0.95       5      Sequence databases                           
                    REPRODUCTION-2DPAGE                  1251       1030     <0.01      86      2D gel databases                             
                    RGD                                  7376       7372      0.01      62      Organism-specific databases                  
                    SGD                                  6641       6556      0.01      65      Organism-specific databases                  
                    Siena-2DPAGE                          103        103     <0.01     112      2D gel databases                             
                    SMART                              141828     109372      0.27      22      Family and domain databases                  
                    SMR                                346178     346178      0.67      12      3D structure databases                       
                    STRING                             203654     203632      0.39      19      Protein-protein interaction databases        
                    SUPFAM                             312158     247160      0.60      14      Family and domain databases                  
                    SWISS-2DPAGE                         1183       1181     <0.01      88      2D gel databases                             
                    TAIR                                 9060       8949      0.02      60      Organism-specific databases                  
                    TCDB                                 3304       3263      0.01      81      Protein family/group databases               
                    TIGR                                33998      33231      0.07      45      Genome annotation databases                  
                    TIGRFAMs                           280530     261787      0.54      16      Family and domain databases                  
                    TubercuList                          1669       1633     <0.01      84      Organism-specific databases                  
                    UCD-2DPAGE                            512        502     <0.01      96      2D gel databases                             
                    UCSC                                48500      39527      0.09      42      Genome annotation databases                  
                    UniGene                             93614      82415      0.18      27      Sequence databases                           
                    VectorBase                            423        409     <0.01     100      Genome annotation databases                  
                    World-2DPAGE                          915        904     <0.01      89      2D gel databases                             
                    WormBase                             3824       3739      0.01      79      Organism-specific databases                  
                    WormPep                              4058       3278      0.01      78      Organism-specific databases                  
                    Xenbase                              4088       4015      0.01      77      Organism-specific databases                  
                    ZFIN                                 2562       2551     <0.01      83      Organism-specific databases                  
                    
                    Total number of cross-referenced databases: 120
                    
                    6.  AMINO ACID COMPOSITION
                    
                    6.1  Composition in percent for the complete database
                    
                    Ala (A) 8.27   Gln (Q) 3.94   Leu (L) 9.67   Ser (S) 6.50
                    Arg (R) 5.53   Glu (E) 6.76   Lys (K) 5.85   Thr (T) 5.32
                    Asn (N) 4.05   Gly (G) 7.09   Met (M) 2.42   Trp (W) 1.08
                    Asp (D) 5.45   His (H) 2.27   Phe (F) 3.86   Tyr (Y) 2.91
                    Cys (C) 1.36   Ile (I) 5.99   Pro (P) 4.68   Val (V) 6.87
                    
                    Asx (B) 0.000  Glx (Z) 0.000  Xaa (X) 0.00
                    
                    
                    
                    Legend: gray = aliphatic, red = acidic, green = small hydroxy,
                    blue = basic, black = aromatic, white = amide, yellow = sulfur
                    
                    
                    6.2  Classification of the amino acids by their frequency
                    
                    Leu, Ala, Gly, Val, Glu, Ser, Ile, Lys, Arg, Asp, Thr, Pro, Asn, Gln,
                    Phe, Tyr, Met, His, Cys, Trp
                    
                    
                    7.  MISCELLANEOUS STATISTICS
                    
                    4446 entries are encoded on a mitochondrion, and 3558 are encoded on a plasmid.
                    
                    12175 entries are encoded on a plastid, 
                    of which 21 are encoded on apicoplasts, 
                    11617 on chloroplasts, 
                    44 on organellar chromatophores,
                    145 on cyanelles, 
                    149 on non-photosynthetic plastids and 
                    199 on unspecified types of plastid.
                    
                    Number of entries with at least one sequence correction: 68739