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StatusReference proteome
Proteome IDiUP000000588
Taxonomy242619 - Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
StrainATCC BAA-308 / W83
Last modifiedFebruary 27, 2018
Genome assembly and annotationi GCA_000007585.1 from ENA/EMBL
Pan proteomei This proteome is part of the Porphyromonas gingivalis (strain ATCC BAA-308 / W83) pan proteome (fasta)

Porphyromonas gingivalis is a Gram-negative anaerobe. It is a secondary colonizer of the oral cavity and has a role in the initiation and progression of periodontal disease, which is the major cause of tooth loss in industrial nations. It is a chronic inflammatory disease of the periodontium that leads to erosion of the attachment apparatus and supporting bone for teeth and is one of the most frequently occurring infectious diseases in humans. Recently, a number of epidemiological studies have shown significant relationships between periodontal diseases and cardiovascular diseases. P.gingivalis, which is often found in deep periodontal pockets of humans, is asaccharolytic and highly proteolytic and produces a broad array of potential virulence factors involved in tissue colonization and destruction as well as host defense perturbation. P. gingivalis strains are divided into virulent and less-virulent strains; W83 is a virulent strain, typically inducing a necrotic lesion at the site of injection within 24 h. Animal death is among the other symptoms (adapted from PubMed 18524787).


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