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UniProtKB advanced search options

The table below lists the different options available in the “Advanced search” menu for the UniProt Knowledgebase. Columns 2 to 4 correspond to the submenu levels that are provided for some sections, after clicking on the (sub-)section name in the advanced search interface.

The 2-letter codes in square brackets (e.g. “[DE]”, “[CC]”) correspond to the line codes used in the flat text files.

UniProtKB AC
Entry Name [ID]
Protein Name [DE]
Gene Name [GN]
Organism [OS]
Taxonomy [OC]
Virus host
Protein Existence [PE]
 Evidence at protein level
 Evidence at transcript level
 Inferred from homology
 Enzyme Classification [EC]
 Biophysicochemical properties
  Kinetic parameters
  pH dependence
  Redox potential
  Temperature dependence
 Catalytic Activity
 CofactorEvidence type
 Enzyme regulationEvidence type
 Function [CCEvidence type
  AnyEvidence type
  Active siteEvidence type
  Metal bindingEvidence type
  Binding siteEvidence type
  OtherEvidence type
 Calcium binding
 DNA binding
 Nucleotide binding
Subcellular location
 Subcellular location [CCEvidence type
 TransmembraneEvidence type
 Topological domainEvidence type
 IntramembraneEvidence type
Pathology & Biotech
 DiseaseEvidence type
 Allergenic propertiesEvidence type
 Toxic dose
 Biotechnological use
 Pharmaceutical use
 Disruption phenotype
 MutagenesisEvidence type
PTM / Processing
 Post-translational modification [CCEvidence type
 Modified residue [FTEvidence type
 Lipidation [FTEvidence type
 Glycosylation [FTEvidence type
 Disulfide bond [FTEvidence type
 Cross-link [FTEvidence type
 Molecule Processing
  AnyEvidence type
  ChainEvidence type
  Initiator methionineEvidence type
  PeptideEvidence type
  Signal peptideEvidence type
  PropeptideEvidence type
  Transit peptideEvidence type
 Developmental stage
 InductionEvidence type
 Tissue specificity
 Binary interaction
 Subunit structureEvidence type
 3D structure
 Secondary structure
  Beta strand
 Mass (Da)
 Sequence length
 Alternative products
  AnyEvidence type
  Alternative promoter usageEvidence type
  Alternative splicingEvidence type
  Alternative initiationEvidence type
  Ribosomal frameshiftingEvidence type
 Sequence caution
  Erroneous initiation
  Erroneous termination
  Erroneous gene model prediction
  Erroneous translation
  Miscellaneous discrepancy
 Mass spectrometry
 RNA EditingEvidence type
 Natural variations
  Natural variant
  Alternative sequence
 Non-standard residueEvidence type
 Non-adjacent residues
 Non-terminal residue
 Sequence conflict
 Sequence uncertainty
 Encoded in
 Sequence from? [RC]
Family and Domains
 Domain [FTEvidence type
 Domain comments [CCEvidence type
 Protein family
 Coiled-coilEvidence type
 Compositional bias
 MotifEvidence type
 RegionEvidence type
 RepeatEvidence type
 Sequence similaritiesEvidence type
 Zinc fingerEvidence type
 2D gel databasesDatabase list
 3D structure databasesDatabase list
 Enzyme and pathways databasesDatabase list
 Family and domain databasesDatabase list
 Protein family/group databasesDatabase list
 Gene expression databasesDatabase list
 Genome annotation databasesDatabase list
 Organism-specific databasesDatabase list
 Other databasesDatabase list
 Phylogenomic databasesDatabase list
 Protein-protein interaction databasesDatabase list
 Chemistry databasesDatabase list
 Polymorphism databasesDatabase list
 Proteomic databasesDatabase list
 Protocols and materials databasesDatabase list
 PTM databasesDatabase list
 Sequence databasesDatabase list
Web resource
Date of
 Date of creation
 Date of last entry modification
 Date of last sequence modification
Gene Ontology [GO]
Keyword [KW]
Literature Citation
 Proteome ID
 Proteome Component
Cited for
UniRef ID
UniParc ID
Jobs (last 7 days)
 Retrieve/ID mapping

See also:
Simple full text search
Query fields for UniProtKB
How can I query UniProtKB annotations by evidence? - A guide to evidence codes and labels in entry view and advanced search

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